Corticosteroid effects in the brain: U-shape it

How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions

Sapolsky, R. M., Romero, L. M., & Munck, A. U. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.1.0389 · Cited by 7,541

How Do Glucocorticoids Influence Stress Responses? Integrating Permissive, Suppressive, Stimulatory, and Preparative Actions

Sapolsky, R. M. (2000) · Endocrine Reviews · doi:10.1210/er.21.1.55 · Cited by 7,533

Stress and the brain: from adaptation to disease

de Kloet, E. R., Joëls, M., & Holsboer, F. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1683 · Cited by 4,621

Two receptor systems for corticosterone in rat brain: Microdistribution and differential occupation

REUL, J. M. H. M., & KLOET, E. R. D. (1985) · Endocrinology · doi:10.1210/endo-117-6-2505 · Cited by 2,580

Long-Term Potentiation and Memory

LYNCH, M. A. (2004) · Physiological Reviews · doi:10.1152/physrev.00014.2003 · Cited by 1,991

Cloning of Human Mineralocorticoid Receptor Complementary DNA: Structural and Functional Kinship with the Glucocorticoid Receptor

Arriza, J. L., Weinberger, C., Cerelli, G., Glaser, T. M., Handelin, B. L., Housman, D. E., & Evans, R. M. (1987) · Science · doi:10.1126/science.3037703 · Cited by 1,946

Primary structure and expression of a functional human glucocorticoid receptor cDNA

Hollenberg, S. M., Weinberger, C., Ong, E. S., Cerelli, G., Oro, A., Lebo, R., Brad Thompson, E., Rosenfeld, M. G., & Evans, R. M. (1985) · Nature · doi:10.1038/318635a0 · Cited by 1,869

Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated

Funder, J. W., Pearce, P. T., Smith, R., & Smith, A. I. (1988) · Science · doi:10.1126/science.2845584 · Cited by 1,628

The stressed hippocampus, synaptic plasticity and lost memories

Kim, J. J., & Diamond, D. M. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn849 · Cited by 1,543

LOCALISATION OF 11β-HYDROXYSTEROID DEHYDROGENASE—TISSUE SPECIFIC PROTECTOR OF THE MINERALOCORTICOID RECEPTOR

Edwards, C. R. W., Burt, D., Mcintyre, M. A., De Kloet, E. R., Stewart, P. M., Brett, L., Sutanto, W. S., & Monder, C. (1988) · The Lancet · doi:10.1016/s0140-6736(88)90742-8 · Cited by 1,068

The Interplay between the Glucocorticoid Receptor and Nuclear Factor-κB or Activator Protein-1: Molecular Mechanisms for Gene Repression

De Bosscher, K., Vanden Berghe, W., & Haegeman, G. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0006 · Cited by 898

ANTI-ESCHERICHIA COLI ALPHA-HAEMOLYSIN IN CONTROL AND PATIENT SERA

Emody, L., Batai, I., Kerényi, M., Székely, J., & Polyak, L. (1982) · The Lancet · doi:10.1016/s0140-6736(82)90183-0 · Cited by 800

Hormesis: The Dose-Response Revolution

Calabrese, E. J., & Baldwin, L. A. (2003) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.43.100901.140223 · Cited by 795

Selective Retention of Corticosterone by Limbic Structures in Rat Brain

MCEWEN, B. S., WEISS, J. M., & SCHWARTZ, L. S. (1968) · Nature · doi:10.1038/220911a0 · Cited by 711

Inverted-U relationship between the level of peripheral corticosterone and the magnitude of hippocampal primed burst potentiation

Diamond, D. M., Bennett, M. C., Fleshner, M., & Rose, G. M. (1992) · Hippocampus · doi:10.1002/hipo.450020409 · Cited by 688

Stress and Plasticity in the Limbic System

Sapolsky, R. M. (2003) · Neurochemical Research · doi:10.1023/a:1026021307833 · Cited by 484

Translational regulatory mechanisms generate N-terminal glucocorticoid receptor isoforms with unique transcriptional target genes

Lu, N. Z., & Cidlowski, J. A. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.03.025 · Cited by 455

Experience-dependent facilitating effect of corticosterone on spatial memory formation in the water maze

Sandi, C., Loscertales, M., & Guaza, C. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01412.x · Cited by 447

Control of neuronal excitability by corticosteroid hormones

Joëls, M., & de Kloet, E. R. (1992) · Trends in Neurosciences · doi:10.1016/0166-2236(92)90345-9 · Cited by 400

Mineralocorticoid and glucocorticoid receptors in the brain. Implications for ion permeability and transmitter systems

Joëls, M., & Ronald de Kloet, E. (1994) · Progress in Neurobiology · doi:10.1016/0301-0082(94)90014-0 · Cited by 392

Effects of glucocorticoids and norepinephrine on the excitability in the hippocampus

Joëls, M., & de Kloet, E. R. (1989) · Science · doi:10.1126/science.2781292 · Cited by 375

Penetration of Dexamethasone into Brain Glucocorticoid Targets Is Enhanced in mdr1A P-Glycoprotein Knockout Mice

Meijer, O. C. (1998) · Endocrinology · doi:10.1210/en.139.4.1789 · Cited by 375

The human glucocorticoid receptor: One gene, multiple proteins and diverse responses

ZHOU, J., & CIDLOWSKI, J. (2005) · Steroids · doi:10.1016/j.steroids.2005.02.006 · Cited by 372

Multidrug Resistance P-Glycoprotein Hampers the Access of Cortisol But Not of Corticosterone to Mouse and Human Brain

Karssen, A. M. (2001) · Endocrinology · doi:10.1210/en.142.6.2686 · Cited by 280

Steroid Hormones and Excitability in the Mammalian Brain

Joëls, M. (1997) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1996.0144 · Cited by 280

Ultradian rhythm of basal corticosterone release in the female rat: dynamic interaction with the response to acute stress

Windle, R. J., Wood, S. A., Shanks, N., Lightman, S. L., & Ingram, C. D. (1998) · Endocrinology · doi:10.1210/en.139.2.443 · Cited by 276

Exposing Rats to a Predator Blocks Primed Burst Potentiation in the Hippocampus In Vitro

Mesches, M. H., Fleshner, M., Heman, K. L., Rose, G. M., & Diamond, D. M. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-14-j0004.1999 · Cited by 276

The Mineralocorticoid Receptor: A Journey Exploring Its Diversity and Specificity of Action

Pascual-Le Tallec, L., & Lombès, M. (2005) · Molecular Endocrinology · doi:10.1210/me.2005-0089 · Cited by 257

Hippocampal glucocorticoid receptor activation enhances voltage-dependent Ca2+ conductances: relevance to brain aging.

Kerr, D. S., Campbell, L. W., Thibault, O., & Landfield, P. W. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.18.8527 · Cited by 243

Postweaning Development of Negative Feedback in the Pituitary-Adrenal System of the Rat

Goldman, L., Winget, C., Hollingshead, G. W., & Levine, S. (1973) · Neuroendocrinology · doi:10.1159/000122169 · Cited by 202

Differential expression and regional distribution of steroid receptor coactivators SRC-1 and SRC-2 in brain and pituitary

Meijer, O. C., Steenbergen, P. J., & de Kloet, E. R. (2000) · Endocrinology · doi:10.1210/endo.141.6.7489 · Cited by 200

Do antidepressants regulate how cortisol affects the brain?

Pariante, C. M., Thomas, S. A., Lovestone, S., Makoff, A., & Kerwin, R. W. (2004) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2003.10.009 · Cited by 194

Corticosteroid actions in hippocampus require DNA binding of glucocorticoid receptor homodimers

Karst, H., Karten, Y. J. G., Reichardt, H. M., de Kloet, E. R., Schütz, G., & Joëls, M. (2000) · Nature Neuroscience · doi:10.1038/79910 · Cited by 171

Mineralocorticoid hormones suppress serotonin-induced hyperpolarization of rat hippocampal CA1 neurons

Joels, M., Hesen, W., & de Kloet, E. (1991) · The Journal of Neuroscience · doi:10.1523/jneurosci.11-08-02288.1991 · Cited by 167

Chronic stress attenuates GABAergic inhibition and alters gene expression of parvocellular neurons in rat hypothalamus

Verkuyl, J. M., Hemby, S. E., & Joëls, M. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03568.x · Cited by 163

Multiple Promoters Exist in the Human GR Gene, One of Which Is Activated by Glucocorticoids

Breslin, M. B. (2001) · Molecular Endocrinology · doi:10.1210/me.15.8.1381 · Cited by 161

11β-hydroxysteroid dehydrogenase type 1 as a modulator of glucocorticoid action: from metabolism to memory

Seckl, J. R., & Walker, B. R. (2004) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2004.09.007 · Cited by 139

Assessing the (a)symmetry of concentration-effect curves

Giraldo, J., Vivas, N. M., Vila, E., & Badı́a, A. (2002) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00223-1 · Cited by 135

Protein Inhibitor of Activated Signal Transducer and Activator of Transcription 1 Interacts with the N-Terminal Domain of Mineralocorticoid Receptor and Represses Its Transcriptional Activity: Implication of Small Ubiquitin-Related Modifier 1 Modification

Tallec, L. P.-L., Kirsh, O., Lecomte, M., Viengchareun, S., Zennaro, M., Dejean, A., & Lombès, M. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0299 · Cited by 131

Neurochemical and Behavioral Alterations in Glucocorticoid Receptor-Impaired Transgenic Mice after Chronic Mild Stress

Froger, N., Palazzo, E., Boni, C., Hanoun, N., Saurini, F., Joubert, C., Dutriez-Casteloot, I., Enache, M., Maccari, S., Barden, N., et al. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4132-03.2004 · Cited by 129

Action of Glucocorticoids on Survival of Nerve Cells: Promoting Neurodegeneration or Neuroprotection?1

Ábrahám, I. M., Harkany, T., Horvath, K. M., & Luiten, P. G. M. (2001) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2001.00705.x · Cited by 125

Glucocorticoid receptor-mediated inhibition by corticosterone of 5-ht1a autoreceptor functioning in the rat dorsal raphe nucleus

Laaris, N., Haj‐Dahmane, S., Hamon, M., & Lanfumey, L. (1995) · Neuropharmacology · doi:10.1016/0028-3908(95)00095-n · Cited by 125

Neuronal expression of the drug efflux transporter P-glycoprotein in the rat hippocampus after limbic seizures

Volk, H. A., Burkhardt, K., Potschka, H., Chen, J., Becker, A. J., & Löscher, W. (2003) · Neuroscience · doi:10.1016/j.neuroscience.2003.10.012 · Cited by 125

A New Human MR Splice Variant Is a Ligand-Independent Transactivator Modulating Corticosteroid Action

Zennaro, M., Souque, A., Viengchareun, S., Poisson, E., & Lombès, M. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.9.0689 · Cited by 124

Corticosteroid receptor-dependent modulation of calcium currents in rat hippocampal CA1 neurons

Karst, H., Wadman, W. J., & Joëls, M. (1994) · Brain Research · doi:10.1016/0006-8993(94)91069-3 · Cited by 119

5'-Heterogeneity of the mineralocorticoid receptor messenger ribonucleic acid: differential expression and regulation of splice variants within the rat hippocampus

Kwak, S., Patel, P. D., Thompson, R. C., Akil, H., & Watson, S. J. (1993) · Endocrinology · doi:10.1210/endo.133.5.8404687 · Cited by 116

Effect of Chronic Stress on Synaptic Currents in Rat Hippocampal Dentate Gyrus Neurons

Karst, H., & Joëls, M. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00691.2002 · Cited by 111

Steroid Receptor Coactivator-1 Splice Variants Differentially Affect Corticosteroid Receptor Signaling

Meijer, O. C., Kalkhoven, E., van der Laan, S., Steenbergen, P. J., Houtman, S., Dijkmans, T. F., Pearce, D., & de Kloet, E. R. (2004) · Endocrinology · doi:10.1210/en.2004-0411 · Cited by 108

Absence of Glucocorticoid Receptor-β in Mice

Otto, C., Reichardt, H. M., & Schütz, G. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.42.26665 · Cited by 102

GABAergic transmission in the rat paraventricular nucleus of the hypothalamus is suppressed by corticosterone and stress

Verkuyl, J. M., Karst, H., & Joëls, M. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03846.x · Cited by 98

Antidepressant fluoxetine enhances glucocorticoid receptor function in vitro by modulating membrane steroid transporters

Pariante, C. M., Kim, R. B., Makoff, A., & Kerwin, R. W. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705357 · Cited by 89

Acute stress increases calcium current amplitude in rat hippocampus: temporal changes in physiology and gene expression

Joëls, M., Velzing, E., Nair, S., Verkuyl, J. M., & Karst, H. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02845.x · Cited by 83

Modulation of 5HT1A Responsiveness in CA1 Pyramidal Neurons by in vivo Activation of Corticosteroid Receptors

Hesen, W., & Joëls, M. (1996) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1996.04724.x · Cited by 75

Mineralocorticoid receptor binding, structure and function

Rogerson, F. M., Brennan, F. E., & Fuller, P. J. (2003) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2003.10.021 · Cited by 74

Human mineralocorticoid receptor A and B protein forms produced by alternative translation sites display different transcriptional activities

Tallec, L. P.-L., Demange, C., & Lombès, M. (2004) · European Journal of Endocrinology · doi:10.1530/eje.0.1500585 · Cited by 56

Corticosterone alters 5-HT receptor-mediated hyperpolarization in area CA1 hippocampal pyramidal neurons

BECK, S., CHOI, K., List, T. J., Okuhara, D. Y., & Birnstiel, S. (1996) · Neuropsychopharmacology · doi:10.1016/s0893-133x(96)80056-x · Cited by 55

Models to explain dose-response relationships that exhibit a downturn phase

Pliška, V. (1994) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(94)90145-7 · Cited by 47

Mechanisms of mineralocorticoid action: determinants of receptor specificity and actions of regulated gene products

Bhargava, A., & Pearce, D. (2004) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2004.03.009 · Cited by 43

Biphasic Effects of Adrenal Steroids on Learned Helplessness Behavior Induced by Inescapable Shock

Kademian, S., Bignante, A. E., Lardone, P. J., McEwen, B. S., & Volosin, M. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300577 · Cited by 35

Effect of Adrenalectomy on Miniature Inhibitory Postsynaptic Currents in the Paraventricular Nucleus of the Hypothalamus

Verkuyl, J. M., & Joëls, M. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00401.2002 · Cited by 34

Effect of Corticosteroid Treatment In Vitro on Adrenalectomy‐Induced Impairment of Synaptic Transmission in the Rat Dentate Gyrus

Stienstra, & Joëls, M. (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00436.x · Cited by 24

Effect of Adrenalectomy on Membrane Properties and Synaptic Potentials in Rat Dentate Granule Cells

Joëls, M., Stienstra, C. M., & Karten, Y. J. G. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.2.699 · Cited by 19

Gene therapy to bet on: protecting neurons from stress hormones

AKAMA, K., & MCEWEN, B. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.02.004 · Cited by 8

Physiology and neurobiology of stress and adaptation: central role of the brain

McEwen, B. S. (2007) · Physiological Reviews · doi:10.1152/physrev.00041.2006 · Cited by 5,429

Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators

McEwen, B. S. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.071 · Cited by 1,864

Stress Effects on Neuronal Structure: Hippocampus, Amygdala, and Prefrontal Cortex

McEwen, B. S., Nasca, C., & Gray, J. D. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.171 · Cited by 1,574

Mechanisms of stress in the brain

McEwen, B. S., Bowles, N. P., Gray, J. D., Hill, M. N., Hunter, R. G., Karatsoreos, I. N., & Nasca, C. (2015) · Nature Neuroscience · doi:10.1038/nn.4086 · Cited by 1,386

The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission

Popoli, M., Yan, Z., McEwen, B. S., & Sanacora, G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3138 · Cited by 1,393