CoChat
Sign Up
Cited by 302

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Liver X receptor biology and pharmacology: new pathways, challenges and opportunities

Jakobsson, Tomas, Treuter, Eckardt, Gustafsson, Jan-Åke, Steffensen, Knut R.·2012·Trends in Pharmacological Sciences
DOI 10.1016/j.tips.2012.03.013
Open this paper in CoChat — free account

Abstract

Nuclear receptors (NRs) are master regulators of transcriptional programs that integrate the homeostatic control of almost all biological processes. Their direct mode of ligand regulation and genome interaction is at the core of modern pharmacology. The two liver X receptors LXRα and LXRβ are among the emerging newer drug targets within the NR family. LXRs are best known as nuclear oxysterol receptors and physiological regulators of lipid and cholesterol metabolism that also act in an anti-inflammatory way. Because LXRs control diverse pathways in development, reproduction, metabolism, immunity and inflammation, they have potential as therapeutic targets for diseases as diverse as lipid disorders, atherosclerosis, chronic inflammation, autoimmunity, cancer and neurodegenerative diseases. Recent insights into LXR signaling suggest future targeting strategies aiming at increasing LXR subtype and pathway selectivity. This review discusses the current status of our understanding of LXR biology and pharmacology, with an emphasis on the molecular aspects of LXR signaling that constitute the potential of LXRs as drug targets.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.tips.2012.03.013

Cites

7 of 7 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 123

  1. McKenna, 2009, Evolution of NURSA, the nuclear receptor signaling atlas, Mol. Endocrinol., 23, 740, 10.1210/me.2009-0135 · DOI
  2. Gronemeyer, 2004, Principles for modulation of the nuclear receptor superfamily, Nat. Rev. Drug Discov., 3, 950, 10.1038/nrd1551 · DOI
  3. Thomas, 2011, The different roles of ER subtypes in cancer biology and therapy, Nat. Rev. Cancer, 11, 597, 10.1038/nrc3093 · DOI
  4. Knudsen, 2010, Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer, Trends Endocrinol. Metab., 21, 315, 10.1016/j.tem.2010.01.002 · DOI
  5. Moore, 2006, The nuclear receptor superfamily and drug discovery, ChemMedChem, 1, 504, 10.1002/cmdc.200600006 · DOI
  6. Zelcer, 2006, Liver X receptors as integrators of metabolic and inflammatory signaling, J. Clin. Invest., 116, 607, 10.1172/JCI27883 · DOI · Paper page
  7. Bourguet, 2000, Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains, Mol. Cell, 5, 289, 10.1016/S1097-2765(00)80424-4 · DOI
  8. Farnegardh, 2003, The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands, J. Biol. Chem., 278, 38821, 10.1074/jbc.M304842200 · DOI
  9. Apfel, 1994, A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily, Mol. Cell. Biol., 14, 7025
  10. Teboul, 1995, OR-1, a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic acid receptor, Proc. Natl. Acad. Sci. U.S.A., 92, 2096, 10.1073/pnas.92.6.2096 · DOI
  11. Viennois, 2012, Selective liver X receptor modulators (SLiMs): what use in human health?, Mol. Cell. Endocrinol., 351, 129, 10.1016/j.mce.2011.08.036 · DOI
  12. Svensson, 2003, Crystal structure of the heterodimeric complex of LXRα and RXRβ ligand-binding domains in a fully agonistic conformation, EMBO J., 22, 4625, 10.1093/emboj/cdg456 · DOI
  13. Williams, 2003, X-Ray crystal structure of the liver X receptor β ligand binding domain: regulation by a histidine–tryptophan switch, J Biol Chem, 278, 27138, 10.1074/jbc.M302260200 · DOI
  14. Peet, 1998, Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRα, Cell, 93, 693, 10.1016/S0092-8674(00)81432-4 · DOI
  15. Repa, 2000, Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ, Genes Dev., 14, 2819, 10.1101/gad.844900 · DOI
  16. Alberti, 2001, Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRβ-deficient mice, J. Clin. Invest., 107, 565, 10.1172/JCI9794 · DOI
  17. Yvan-Charvet, 2007, Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice, J. Clin. Invest., 117, 3900
  18. Wang, 2007, Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo, J. Clin. Invest., 117, 2216, 10.1172/JCI32057 · DOI
  19. Naik, 2006, Pharmacological activation of liver X receptors promotes reverse cholesterol transport in vivo, Circulation, 113, 90, 10.1161/CIRCULATIONAHA.105.560177 · DOI
  20. Brunham, 2006, Tissue-specific induction of intestinal ABCA1 expression with a liver X receptor agonist raises plasma HDL cholesterol levels, Circ. Res., 99, 672, 10.1161/01.RES.0000244014.19589.8e · DOI · Paper page
  21. Feig, 2010, LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression, J. Clin. Invest., 120, 4415, 10.1172/JCI38911 · DOI
  22. Zelcer, 2009, LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor, Science, 325, 100, 10.1126/science.1168974 · DOI · Paper page
  23. Gerin, 2005, LXRβ is required for adipocyte growth, glucose homeostasis, and β cell function, J. Biol. Chem., 280, 23024, 10.1074/jbc.M412564200 · DOI
  24. Kalaany, 2005, LXRs regulate the balance between fat storage and oxidation, Cell Metab., 1, 231, 10.1016/j.cmet.2005.03.001 · DOI
  25. Korach-Andre, 2010, Separate and overlapping metabolic functions of LXRα and LXRβ in C57Bl/6 female mice, Am. J. Physiol. Endocrinol. Metab., 298, E167, 10.1152/ajpendo.00184.2009 · DOI
  26. Korach-Andre, 2011, Both liver-X receptor (LXR) isoforms control energy expenditure by regulating brown adipose tissue activity, Proc. Natl. Acad. Sci. U.S.A., 108, 403, 10.1073/pnas.1017884108 · DOI
  27. Steffensen, 2004, Genome-wide expression profiling; a panel of mouse tissues discloses novel biological functions of liver X receptors in adrenals, J. Mol. Endocrinol., 33, 609, 10.1677/jme.1.01508 · DOI
  28. Joseph, 2004, LXR-dependent gene expression is important for macrophage survival and the innate immune response, Cell, 119, 299, 10.1016/j.cell.2004.09.032 · DOI
  29. Valledor, 2004, Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis, Proc. Natl. Acad. Sci. U.S.A., 101, 17813, 10.1073/pnas.0407749101 · DOI
  30. Gonzalez, 2009, Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR, Immunity, 31, 245, 10.1016/j.immuni.2009.06.018 · DOI
  31. Hong, 2012, Coordinate regulation of neutrophil homeostasis by liver X receptors in mice, J. Clin. Invest., 122, 337, 10.1172/JCI58393 · DOI
  32. Schmuth, 2008, Peroxisome proliferator-activated receptors and liver X receptors in epidermal biology, J. Lipid Res., 49, 499, 10.1194/jlr.R800001-JLR200 · DOI
  33. Cheng, 2010, Activation of liver X receptor reduces global ischemic brain injury by reduction of nuclear factor-κB, Neuroscience, 166, 1101, 10.1016/j.neuroscience.2010.01.024 · DOI
  34. Paterniti, 2010, Liver X receptor agonist treatment regulates inflammatory response after spinal cord trauma, J. Neurochem., 112, 611, 10.1111/j.1471-4159.2009.06471.x · DOI
  35. Morales, 2008, Activation of liver X receptors promotes neuroprotection and reduces brain inflammation in experimental stroke, Circulation, 118, 1450, 10.1161/CIRCULATIONAHA.108.782300 · DOI
  36. Repa, 2007, Liver X receptor activation enhances cholesterol loss from the brain, decreases neuroinflammation, and increases survival of the NPC1 mouse, J. Neurosci., 27, 14470, 10.1523/JNEUROSCI.4823-07.2007 · DOI
  37. Bigini, 2010, Neuropathologic and biochemical changes during disease progression in liver X receptor β−/− mice, a model of adult neuron disease, J. Neuropathol. Exp. Neurol., 69, 593, 10.1097/NEN.0b013e3181df20e1 · DOI
  38. Lee, 2006, Oxysterols suppress inducible nitric oxide synthase expression in lipopolysaccharide-stimulated astrocytes through liver X receptor, Neuroreport, 17, 183, 10.1097/01.wnr.0000198436.52259.40 · DOI
  39. Zelcer, 2007, Attenuation of neuroinflammation and Alzheimer's disease pathology by liver X receptors, Proc. Natl. Acad. Sci. U.S.A., 104, 10601, 10.1073/pnas.0701096104 · DOI · Paper page
  40. Walcher, 2010, LXR activation inhibits chemokine-induced CD4-positive lymphocyte migration, Basic Res. Cardiol., 105, 487, 10.1007/s00395-010-0092-5 · DOI
  41. Walcher, 2006, LXR activation reduces proinflammatory cytokine expression in human CD4-positive lymphocytes, Arterioscler. Thromb. Vasc. Biol., 26, 1022, 10.1161/01.ATV.0000210278.67076.8f · DOI
  42. Heine, 2009, Liver X receptors control IgE expression in B cells, J. Immunol., 182, 5276, 10.4049/jimmunol.0801804 · DOI
  43. Chang, 2007, Liver-X-receptor activator prevents homocysteine-induced production of IgG antibodies from murine B lymphocytes via the ROS–NF-κB pathway, Biochem. Biophys. Res. Commun., 357, 772, 10.1016/j.bbrc.2007.04.016 · DOI
  44. Myhre, 2008, Liver X receptor is a key regulator of cytokine release in human monocytes, Shock, 29, 468, 10.1097/SHK.0b013e31815073cb · DOI
  45. Mallat, 2011, The liver X receptor in hepatic stellate cells: a novel antifibrogenic target?, J. Hepatol., 55, 1452, 10.1016/j.jhep.2011.05.018 · DOI · Paper page
  46. Beaven, 2011, Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease, Gastroenterology, 140, 1052, 10.1053/j.gastro.2010.11.053 · DOI · Paper page
  47. Scholz, 2009, The synthetic liver X receptor agonist GW3965 reduces tissue factor production and inflammatory responses in human islets in vitro, Diabetologia, 52, 1352, 10.1007/s00125-009-1366-z · DOI
  48. Delvecchio, 2007, Liver X receptor stimulates cholesterol efflux and inhibits expression of proinflammatory mediators in human airway smooth muscle cells, Mol. Endocrinol., 21, 1324, 10.1210/me.2007-0017 · DOI
  49. Remen, 2011, Activation of liver X receptor (LXR) inhibits receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclast differentiation in an LXRβ-dependent mechanism, J. Biol. Chem., 286, 33084, 10.1074/jbc.M111.235937 · DOI
  50. Geyeregger, 2007, Liver X receptors regulate dendritic cell phenotype and function through blocked induction of the actin-bundling protein fascin, Blood, 109, 4288, 10.1182/blood-2006-08-043422 · DOI
  51. Villablanca, 2010, Tumor-mediated liver X receptor-α activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses, Nat. Med., 16, 98, 10.1038/nm.2074 · DOI
  52. Torocsik, 2010, Activation of liver X receptor sensitizes human dendritic cells to inflammatory stimuli, J. Immunol., 184, 5456, 10.4049/jimmunol.0902399 · DOI
  53. Venteclef, 2010, GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRβ in the hepatic acute phase response, Genes Dev., 24, 381, 10.1101/gad.545110 · DOI · Paper page
  54. Dai, 2007, Effect of T0901317 on hepatic proinflammatory gene expression in apoE−/− mice fed a high-fat/high-cholesterol diet, Inflammation, 30, 105, 10.1007/s10753-007-9026-2 · DOI
  55. Blaschke, 2006, A nuclear receptor corepressor-dependent pathway mediates suppression of cytokine-induced C-reactive protein gene expression by liver X receptor, Circ. Res., 99, e88, 10.1161/01.RES.0000252878.34269.06 · DOI
  56. Wang, 2009, Liver X receptor agonist GW3965 dose-dependently regulates LPS-mediated liver injury and modulates post-transcriptional TNFα production and p38 MAPK activation in liver macrophages, Shock, 32, 548, 10.1097/SHK.0b013e3181a47f85 · DOI
  57. Wang, 2011, Liver X receptor protects against liver injury in sepsis caused by rodent cecal ligation and puncture, Surg. Infect., 12, 283, 10.1089/sur.2010.066 · DOI
  58. Kiss, 2011, Suppression of chronic damage in renal allografts by liver X receptor (LXR) activation relevant contribution of macrophage LXRα, Am. J. Pathol., 179, 92, 10.1016/j.ajpath.2011.03.019 · DOI
  59. Birrell, 2007, Novel role for the liver X nuclear receptor in the suppression of lung inflammatory responses, J. Biol. Chem., 282, 31882, 10.1074/jbc.M703278200 · DOI
  60. Smoak, 2008, Effects of liver X receptor agonist treatment on pulmonary inflammation and host defense, J. Immunol., 180, 3305, 10.4049/jimmunol.180.5.3305 · DOI
  61. Korf, 2009, Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice, J. Clin. Invest., 119, 1626, 10.1172/JCI35288 · DOI
  62. Bruhn, 2010, LXR deficiency confers increased protection against visceral Leishmania infection in mice, PLoS Negl. Trop. Dis., 4, e886, 10.1371/journal.pntd.0000886 · DOI
  63. Gong, 2009, Activation of the liver X receptor prevents lipopolysaccharide-induced lung injury, J. Biol. Chem., 284, 30113, 10.1074/jbc.M109.047753 · DOI
  64. Steinman, 2003, The interaction of immunodeficiency viruses with dendritic cells, Curr. Top. Microbiol. Immunol., 276, 1
  65. Hanley, 2010, PPARγ and LXR signaling inhibit dendritic cell-mediated HIV-1 capture and trans-infection, PLoS Pathog., 6, e1000981, 10.1371/journal.ppat.1000981 · DOI
  66. Morrow, 2010, Stimulation of the liver X receptor pathway inhibits HIV-1 replication via induction of ATP-binding cassette transporter A1, Mol. Pharmacol., 78, 215, 10.1124/mol.110.065029 · DOI
  67. Hanley, 2011, Nuclear receptor signaling inhibits HIV-1 replication in macrophages through multiple trans-repression mechanisms, J. Virol., 85, 10834, 10.1128/JVI.00789-11 · DOI
  68. Asquith, 2009, Liver X receptor agonism promotes articular inflammation in murine collagen-induced arthritis, Arthritis Rheum., 60, 2655, 10.1002/art.24717 · DOI
  69. Asquith, 2011, Simultaneous activation of the liver X receptors (LXRα and LXRβ) drives murine collagen-induced arthritis disease pathology, Ann. Rheum. Dis., 70, 2225, 10.1136/ard.2011.152652 · DOI
  70. Collins-Racie, 2009, Global analysis of nuclear receptor expression and dysregulation in human osteoarthritic articular cartilage: reduced LXR signaling contributes to catabolic metabolism typical of osteoarthritis, Osteoarthr. Cartil., 17, 832, 10.1016/j.joca.2008.12.011 · DOI
  71. Park, 2010, Liver X receptor agonist prevents the evolution of collagen-induced arthritis in mice, Rheumatology (Oxford), 49, 882, 10.1093/rheumatology/keq007 · DOI
  72. Li, 2010, LXR modulation blocks prostaglandin E2 production and matrix degradation in cartilage and alleviates pain in a rat osteoarthritis model, Proc. Natl. Acad. Sci. U.S.A., 107, 3734, 10.1073/pnas.0911377107 · DOI
  73. Koldamova, 2010, The role of ATP-binding cassette transporter A1 in Alzheimer's disease and neurodegeneration, Biochim. Biophys. Acta, 1801, 824, 10.1016/j.bbalip.2010.02.010 · DOI · Paper page
  74. Saijo, 2010, Nuclear receptors, inflammation, and neurodegenerative diseases, Adv. Immunol., 106, 21, 10.1016/S0065-2776(10)06002-5 · DOI
  75. Hindinger, 2006, Liver X receptor activation decreases the severity of experimental autoimmune encephalomyelitis, J. Neurosci. Res., 84, 1225, 10.1002/jnr.21038 · DOI
  76. Xu, 2009, Liver X receptor agonist regulation of Th17 lymphocyte function in autoimmunity, J. Leukoc. Biol., 86, 401, 10.1189/jlb.1008600 · DOI
  77. Cui, 2011, Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation, J. Clin. Invest., 121, 658, 10.1172/JCI42974 · DOI
  78. Fan, 2008, Expression of liver X receptor β is essential for formation of superficial cortical layers and migration of later-born neurons, Proc. Natl. Acad. Sci. U.S.A., 105, 13445, 10.1073/pnas.0806974105 · DOI · Paper page
  79. Kim, 2008, Liver X receptor beta (LXRβ): a link between β-sitosterol and amyotrophic lateral sclerosis–Parkinson's dementia, Proc. Natl. Acad. Sci. U.S.A., 105, 2094, 10.1073/pnas.0711599105 · DOI · Paper page
  80. Sacchetti, 2009, Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells, Cell Stem Cell, 5, 409, 10.1016/j.stem.2009.08.019 · DOI
  81. Chuu, 2011, Modulation of liver X receptor signaling as a prevention and therapy for colon cancer, Med. Hypothese, 76, 697, 10.1016/j.mehy.2011.01.037 · DOI
  82. Fukuchi, 2004, Antiproliferative effect of liver X receptor agonists on LNCaP human prostate cancer cells, Cancer Res., 64, 7686, 10.1158/0008-5472.CAN-04-2332 · DOI
  83. Chuu, 2006, Inhibition of tumor growth and progression of LNCaP prostate cancer cells in athymic mice by androgen and liver X receptor agonist, Cancer Res., 66, 6482, 10.1158/0008-5472.CAN-06-0632 · DOI
  84. Bensinger, 2008, LXR signaling couples sterol metabolism to proliferation in the acquired immune response, Cell, 134, 97, 10.1016/j.cell.2008.04.052 · DOI · Paper page
  85. Lo Sasso, 2010, Down-regulation of the LXR transcriptome provides the requisite cholesterol levels to proliferating hepatocytes, Hepatology, 51, 1334, 10.1002/hep.23436 · DOI
  86. Wagner, 2003, Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression, Mol. Cell. Biol., 23, 5780, 10.1128/MCB.23.16.5780-5789.2003 · DOI
  87. Boergesen, 2012, Genome-wide profiling of liver X receptor, retinoid X receptor and peroxisome proliferator activated receptor α in mouse liver reveals extensive sharing of binding sites, Mol. Cell. Biol., 32, 852, 10.1128/MCB.06175-11 · DOI
  88. Pehkonen, 2012, Genome-wide landscape of liver X receptor chromatin binding and gene regulation in human macrophages, BMC Genomics, 13, 50, 10.1186/1471-2164-13-50 · DOI
  89. Heinz, 2010, Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities, Mol. Cell, 38, 576, 10.1016/j.molcel.2010.05.004 · DOI · Paper page
  90. Jakobsson, 2009, GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus, Mol. Cell, 34, 510, 10.1016/j.molcel.2009.05.006 · DOI
  91. Li, 2007, SIRT1 deacetylates and positively regulates the nuclear receptor LXR, Mol. Cell, 28, 91, 10.1016/j.molcel.2007.07.032 · DOI
  92. Kim, 2009, Liver X receptor ligands suppress ubiquitination and degradation of LXRα by displacing BARD1/BRCA1, Mol. Endocrinol., 23, 466, 10.1210/me.2008-0295 · DOI
  93. Chen, 2006, Phosphorylation of the liver X receptors, FEBS Lett., 580, 4835, 10.1016/j.febslet.2006.07.074 · DOI
  94. Torra, 2008, Phosphorylation of liver X receptor α selectively regulates target gene expression in macrophages, Mol. Cell. Biol., 28, 2626, 10.1128/MCB.01575-07 · DOI
  95. Yamamoto, 2007, Protein kinase A suppresses sterol regulatory element-binding protein-1C expression via phosphorylation of liver X receptor in the liver, J. Biol. Chem., 282, 11687, 10.1074/jbc.M611911200 · DOI
  96. Anthonisen, 2010, Nuclear receptor liver X receptor is O-GlcNAc-modified in response to glucose, J. Biol. Chem., 285, 1607, 10.1074/jbc.M109.082685 · DOI
  97. Venteclef, 2011, Metabolic nuclear receptor signaling and the inflammatory acute phase response, Trends Endocrinol. Metab., 22, 333, 10.1016/j.tem.2011.04.004 · DOI · Paper page
  98. Bensinger, 2008, Integration of metabolism and inflammation by lipid-activated nuclear receptors, Nature, 454, 470, 10.1038/nature07202 · DOI
  99. Katz, 2009, Safety, pharmacokinetics, and pharmacodynamics of single doses of LXR-623, a novel liver X-receptor agonist, in healthy participants, J. Clin. Pharmacol., 49, 643, 10.1177/0091270009335768 · DOI
  100. Bradley, 2007, Ligand activation of LXR β reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR α and apoE, J. Clin. Invest., 117, 2337, 10.1172/JCI31909 · DOI
  101. Yasuda, 2010, Tissue-specific liver X receptor activation promotes macrophage reverse cholesterol transport in vivo, Arterioscler. Thromb. Vasc. Biol., 30, 781, 10.1161/ATVBAHA.109.195693 · DOI
  102. Lo Sasso, 2010, Intestinal specific LXR activation stimulates reverse cholesterol transport and protects from atherosclerosis, Cell Metab., 12, 187, 10.1016/j.cmet.2010.07.002 · DOI
  103. Hu, 2012, LXRβ activation increases intestinal cholesterol absorption leading to an atherogenic lipoprotein profile, J. Intern. Med., 10.1111/j.1365-2796.2012.02529.x · DOI
  104. Fontaine, 2007, Liver X receptor activation potentiates the lipopolysaccharide response in human macrophages, Circ. Res., 101, 40, 10.1161/CIRCRESAHA.106.135814 · DOI
  105. Hall, 2007, The molecular mechanisms underlying the proinflammatory actions of thiazolidinediones in human macrophages, Mol. Endocrinol., 21, 1756, 10.1210/me.2007-0060 · DOI
  106. Chao, 2008, Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity, J. Med. Chem., 51, 5758, 10.1021/jm800612u · DOI
  107. Wirfalt, 2009, Associations between food patterns defined by cluster analysis and colorectal cancer incidence in the NIH-AARP diet and health study, Eur. J. Clin. Nutr., 63, 707, 10.1038/ejcn.2008.40 · DOI
  108. Plat, 2005, Plant sterols and stanols: effects on mixed micellar composition and LXR (target gene) activation, J. Lipid Res., 46, 2468, 10.1194/jlr.M500272-JLR200 · DOI
  109. Ronco, 1999, Vegetables, fruits, and related nutrients and risk of breast cancer: a case–control study in Uruguay, Nutr. Cancer, 35, 111, 10.1207/S15327914NC352_3 · DOI
  110. McCann, 2005, Intakes of selected nutrients, foods, and phytochemicals and prostate cancer risk in western New York, Nutr. Cancer, 53, 33, 10.1207/s15327914nc5301_4 · DOI
  111. De Stefani, 2000, Plant sterols and risk of stomach cancer: a case–control study in Uruguay, Nutr. Cancer, 37, 140, 10.1207/S15327914NC372_4 · DOI
  112. Mendilaharsu, 1998, Phytosterols and risk of lung cancer: a case–control study in Uruguay, Lung Cancer, 21, 37, 10.1016/S0169-5002(98)00044-0 · DOI
  113. Patel, 2011, LXRβ is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice, J. Clin. Invest., 121, 431, 10.1172/JCI41681 · DOI
  114. Kotokorpi, 2007, Physiological differences between human and rat primary hepatocytes in response to liver X receptor activation by 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyl oxy]phenylacetic acid hydrochloride (GW3965), Mol. Pharmacol., 72, 947, 10.1124/mol.107.037358 · DOI
  115. Repa, 2000, Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers, Science, 289, 1524, 10.1126/science.289.5484.1524 · DOI
  116. Collins, 2002, Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines, J. Med. Chem., 45, 1963, 10.1021/jm0255116 · DOI
  117. Hu, 2007, Further modification on phenyl acetic acid based quinolines as liver X receptor modulators, Bioorg. Med. Chem., 15, 3321, 10.1016/j.bmc.2007.03.013 · DOI
  118. Zuercher, 2010, Discovery of tertiary sulfonamides as potent liver X receptor antagonists, J. Med. Chem., 53, 3412, 10.1021/jm901797p · DOI
  119. Hu, 2010, Identification of phenylsulfone-substituted quinoxaline (WYE-672) as a tissue selective liver X-receptor (LXR) agonist, J. Med. Chem., 53, 3296, 10.1021/jm100034x · DOI
  120. Huang, 2004, Crystal structures of the human SUMO-2 protein at 1.6Å and 1.2Å resolution: implication on the functional differences of SUMO proteins, Eur. J. Biochem., 271, 4114, 10.1111/j.1432-1033.2004.04349.x · DOI
  121. Stenson, 2011, Liver X receptor (LXR) regulates human adipocyte lipolysis, J. Biol. Chem., 286, 370, 10.1074/jbc.M110.179499 · DOI
  122. Perissi, 2004, A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors, Cell, 116, 511, 10.1016/S0092-8674(04)00133-3 · DOI
  123. Huang, 2011, Coronin 2A mediates actin-dependent de-repression of inflammatory response genes, Nature, 470, 414, 10.1038/nature09703 · DOI

Cited by

Sorted by citations

Metadata

Authors
Jakobsson, T., Treuter, E., Gustafsson, J.-Å., & Steffensen, K. R.
Venue
Trends in Pharmacological Sciences
Publisher
Elsevier BV
Published
2012-07
Volume
33
Issue
7
Pages
394-404
ISSN
0165-6147
DOI
10.1016/j.tips.2012.03.013
Cited by
302
References
7
Language
en
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review