Metabolic nuclear receptor signaling and the inflammatory acute phase response
Abstract
The acute phase response (APR) classically refers to the rapid reprogramming of gene expression and metabolism in response to inflammatory cytokine signaling. As components of the innate immune system, hepatocyte-derived acute phase proteins (APPs) play a central role in restoring tissue homeostasis. Recently, an intriguing 'metaflammatory' facet of the APR became evident with chronically elevated APP levels being connected to metabolic syndrome disorders. The causality of these connections is unclear but could relate to adverse metabolic and inflammatory disturbances, particularly those affecting lipoprotein properties, cholesterol metabolism and atherogenesis. Here we review these aspects with an emphasis on the emerging importance of lipid-sensing nuclear receptors (LXRs, LRH-1, PPARs), in conjunction with anti-inflammatory transrepression pathways, as physiological and pharmacological relevant modulators of the APR.
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While cytokines (including IL-1b, IL-6 and TNF-a) are central regulators of the APR, recent research suggests that an important part of the metabolic regulation in APR is channelled via nuclear receptors, including LXR, PPAR and LHR-1.
“While cytokines (including IL-1b, IL-6 and TNF-a) are central regulators of the APR, recent research suggests that an important part of the metabolic regulation in APR is channelled via nuclear receptors, including LXR, PPAR and LHR-139.”
From Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses (2016) · cites this paper as [39]
If the inflammation-sustaining condition continues, as presumably in the epidemiological SSI groups of the present study, the metabolic modifications may develop further and become chronic.
“However, if the inflammation-sustaining condition continues, as presumably in the epidemiological SSI groups of the present study, the metabolic modifications may develop further and become chronic3968.”
From Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses (2016) · cites this paper as [39]
Both the down-regulation of RCT pathway and up-regulation of the inflammatory pathways could result from a decrease of LXR activity.
“Thus both the down-regulation of RCT pathway and up-regulation of the inflammatory pathways could result from a decrease of LXR activity (Fig. 3).”
From Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses (2016) · cites this paper as [39]
The observed expression changes in the cholesterol transport-related genes are compatible with those in down-regulation of LXR activity.
“However, it can be noted that the observed expression changes in the cholesterol transport-related genes are compatible with those in down-regulation of LXR activity3957 (Fig. 3).”
From Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses (2016) · cites this paper as [39]
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- Authors
- Venteclef, N., Jakobsson, T., Steffensen, K. R., & Treuter, E.
- Affiliations
- Inserm (FR)
- Karolinska Institutet (SE)
- Corresponding author
- Treuter, Eckardt
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2011-08
- Volume
- 22
- Issue
- 8
- Pages
- 333-343
- ISSN
- 1043-2760 (ISSN-L)
- OpenAlex
- W2090976574
- Cited by
- 99
- References
- 84
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 5 · 2023: 9 · 2022: 6 · 2021: 8 · 2020: 6 · 2019: 6 · 2018: 7 · 2017: 6 · 2016: 9 · 2015: 6 · 2014: 6 · 2013: 11 · 2012: 5
- FWCI
- 0.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- acute phase response, nuclear receptors, liver X receptor, LRH-1, peroxisome proliferator-activated receptors, acute phase proteins, metabolic inflammation, metabolic syndrome, lipoprotein metabolism, cholesterol metabolism, atherogenesis, transrepression, inflammation, innate immunity, hepatocytes
- MeSH terms
- Liver X Receptors, Acute-Phase Reaction, Adipose Tissue, Animals, Humans, Lipoproteins, Liver, Signal Transduction, Receptors, Cytoplasmic and Nuclear, Peroxisome Proliferator-Activated Receptors, Orphan Nuclear Receptors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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