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Untitled work

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Drug Abuse and Psychosis: New Insights into Drug-induced Psychosis

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Neurological, sensorimotor and cardiorespiratory alterations induced by methoxetamine, ketamine and phencyclidine in mice

Ossato, A., Bilel, S., Gregori, A., Talarico, A., Trapella, C., Gaudio, R. M., De‐Giorgio, F., Tagliaro, F., Neri, M., Fattore, L., et al. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.08.017 · Cited by 46 · see citing works

Maternal P2X7 receptor inhibition prevents autism-like phenotype in male mouse offspring through the NLRP3-IL-1β pathway

Szabó, D., Tod, P., Gölöncsér, F., Román, V., Lendvai, B., Otrokocsi, L., & Sperlágh, B. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.01.015 · Cited by 45 · see citing works

Extracellular ATP Is a Homeostatic Messenger That Mediates Cell–Cell Communication in Physiological Processes and Psychiatric Diseases

Chen, Y., Lin, S., Jin, S., & Gao, T. (2024) · Biological Psychiatry · doi:10.1016/j.biopsych.2024.04.013 · Cited by 42 · see citing works

Association of purinergic receptor P2RX7 gene polymorphisms with depression symptoms

Vereczkei, A., Abdul-Rahman, O., Halmai, Z., Nagy, G., Székely, A., Somogyi, A., Faludi, G., & Nemoda, Z. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.01.006 · Cited by 37 · see citing works

The P2X7 receptor antagonist JNJ-47965567 administered thrice weekly from disease onset does not alter progression of amyotrophic lateral sclerosis in SOD1G93A mice

Ly, D., Dongol, A., Cuthbertson, P., Guy, T. V., Geraghty, N. J., Sophocleous, R. A., Sin, L., Turner, B. J., Watson, D., Yerbury, J. J., et al. (2020) · Purinergic Signalling · doi:10.1007/s11302-020-09692-4 · Cited by 36 · see citing works

Role of P2 receptors in normal brain development and in neurodevelopmental psychiatric disorders

Huang, L., Otrokocsi, L., & Sperlágh, B. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.01.030 · Cited by 34 · see citing works

Beyond Seizure Control: Treating Comorbidities in Epilepsy via Targeting of the P2X7 Receptor

Gil, B., Smith, J., Tang, Y., Illés, P., & Engel, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042380 · Cited by 26 · see citing works

The Role of NMDA Receptors in the Effect of Purinergic P2X7 Receptor on Spontaneous Seizure Activity in WAG/Rij Rats With Genetic Absence Epilepsy

Doǧan, E., Aygün, H., Arslan, G., Rzayev, E., Avcı, B., Ayyıldız, M., & Ağar, E. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00414 · Cited by 26 · see citing works

Regulation of Hippocampal 5-HT Release by P2X7 Receptors in Response to Optogenetic Stimulation of Median Raphe Terminals of Mice

Gölöncsér, F., Baranyi, M., Balázsfi, D., Demeter, K., Haller, J., Freund, T. F. F., Zelena, D., & Sperlágh, B. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00325 · Cited by 25 · see citing works

Disturbances of purinergic system in affective disorders and schizophrenia

Malewska-Kasprzak, M., Permoda‐Osip, A., & RYBAKOWSKI, J. K. (2019) · Psychiatria Polska · doi:10.12740/pp/97335 · Cited by 25 · see citing works

The dualistic role of the purinergic P2Y12-receptor in an in vivo model of Parkinson's disease: Signalling pathway and novel therapeutic targets

Iring, A., Tóth, A., Baranyi, M., Otrokocsi, L., Módis, L., Gölöncsér, F., Varga, B., Hortobágyi, T., Bereczki, D., Dénes, Á., et al. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.106045 · Cited by 24 · see citing works

ATP released from astrocytes modulates action potential threshold and spontaneous excitatory postsynaptic currents in the neonatal rat prefrontal cortex

Beamer, E. H., Kovács, G., & Sperlágh, B. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.10.006 · Cited by 22 · see citing works

A Possible Causal Involvement of Neuroinflammatory, Purinergic P2X7 Receptors in Psychiatric Disorders

Tang, Y., Illes, P., Zhang, Y., Yin, H.-Y., & Rubini, P. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220302152400 · Cited by 20 · see citing works

The potential of the P2X7 receptor as a therapeutic target in a sub-chronic PCP-induced rodent model of schizophrenia

Huang, H., Zheng, S., Chen, M., Xie, L., Li, Z., Guo, M. A., Wang, J., Lu, M., & Zhu, X. (2021) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2021.101993 · Cited by 18 · see citing works

P2X7 Receptor-Dependent Layer-Specific Changes in Neuron-Microglia Reactivity in the Prefrontal Cortex of a Phencyclidine Induced Mouse Model of Schizophrenia

Calovi, S., Mut-Arbona, P., Tod, P., Iring, A., Nicke, A., Mato, S., Vizi, E. S., Tønnesen, J., & Sperlágh, B. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.566251 · Cited by 18 · see citing works

Dual Role of the P2X7 Receptor in Dendritic Outgrowth during Physiological and Pathological Brain Development

Mut-Arbona, P., Huang, L., Baranyi, M., Tod, P., Iring, A., Calzaferri, F., Rı́os, C. D. L., & Sperlágh, B. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0805-22.2022 · Cited by 17 · see citing works

Reduction of prefrontal purinergic signaling is necessary for the analgesic effect of morphine

Zeng, Y., Luo, H., Gao, Z., Zhu, X., Shen, Y., Li, Y., Hu, J., & Yang, J. (2021) · iScience · doi:10.1016/j.isci.2021.102213 · Cited by 17 · see citing works

Modulation of microglia activation and Alzheimer's disease

Suresh, P., Phasuk, S., & Liu, I. Y. (2021) · Tzu Chi Medical Journal · doi:10.4103/tcmj.tcmj_144_20 · Cited by 14 · see citing works

Increased NLRP3 inflammasome expression in peripheral blood mononuclear cells of patients with schizophrenia: a case-control study

Ünal, G. Ö., Öztürk, K. H., & Inci, H. E. (2022) · International Journal of Psychiatry in Clinical Practice · doi:10.1080/13651501.2022.2106245 · Cited by 13 · see citing works

Elevated Serum Purine Levels in Schizophrenia: A Reverse Translational Study to Identify Novel Inflammatory Biomarkers

Kristóf, Z., Baranyi, M., Tod, P., Mut-Arbona, P., Demeter, K., Bitter, I., & Sperlágh, B. (2022) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyac026 · Cited by 12 · see citing works

Altered purinergic receptor expression in the frontal cortex in schizophrenia

Alnafisah, R. S., Lundh, A., Asah, S. M., Hoeflinger, J., Wolfinger, A., Hamoud, A.-R. A., McCullumsmith, R. E., & O'Donovan, S. M. (2022) · Schizophrenia · doi:10.1038/s41537-022-00312-1 · Cited by 12 · see citing works

P2X7 purinergic receptor modulates dentate gyrus excitatory neurotransmission and alleviates schizophrenia-like symptoms in mouse

Huang, L., Mut-Arbona, P., Varga, B., Török, B., Brunner, J., Arszovszki, A., Iring, A., Kisfali, M., Vizi, E. S., & Sperlágh, B. (2023) · iScience · doi:10.1016/j.isci.2023.107560 · Cited by 10 · see citing works

Glial Purinergic Signaling‐Mediated Oxidative Stress (GPOS) in Neuropsychiatric Disorders

Huang, L., Tang, Y., & Sperlágh, B. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/1075440 · Cited by 9 · see citing works

The Role of Extracellular Vesicles and Microparticles in Central Nervous System Disorders: Mechanisms, Biomarkers, and Therapeutic Potential

Najdaghi, S., Davani, D. N., Fouladseresht, H., Ebrahimi, N., Sullman, M. J. M., Moradi, M., & Eskandari, N. (2024) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-024-01518-w · Cited by 9 · see citing works

P2X7 receptor knockout mice display less aggressive biting behaviour correlating with increased brain activation in the piriform cortex

Smith, K. L., Todd, S. M., Boucher, A. A., Bennett, M. R., & Arnold, J. C. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134575 · Cited by 7 · see citing works

Functional expression of the ATP-gated P2X7 receptor in human iPSC-derived astrocytes

Kesavan, J., Watters, O., de Diego-García, L., Méndez, A. M., Alves, M., Dinkel, K., Hamacher, M., Prehn, J. H. M., Henshall, D. C., & Engel, T. (2023) · Purinergic Signalling · doi:10.1007/s11302-023-09957-8 · Cited by 7 · see citing works

P2X7 receptors modulate acquisition of cue fear extinction and contextual background memory generalization in male mice

Domingos, L. B., da Silva-Júnior, A. F., Diniz, C. R. A. F., Rosa, J., Terzian, A. L. B., & Resstel, L. B. M. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110177 · Cited by 6 · see citing works

P2RX7 Dynamics in CNS Disorders: Molecular Insights and Therapeutic Perspectives

Mithaiwala, A., Thakur, J., & Godad, A. P. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05330-5 · Cited by 4 · see citing works

Angiotensin IV Receptors in the Rat Prefrontal Cortex: Neuronal Expression and NMDA Inhibition

Papp, Z. T., Ribiczey, P., Kató, E., Tóth, Z., Varga, Z. V., Giricz, Z., Hanuska, A., Al‐Khrasani, M., Zsembery, Á., Zelles, T., et al. (2024) · Biomedicines · doi:10.3390/biomedicines13010071 · Cited by 4 · see citing works

Establishment and behavioural characterization of a novel constitutive P2X7 receptor knockout mouse line

von Mücke-Heim, I.-A., Oldekamp, J., Metzger, M. W., Kläffgen, S., Tang, H., Walser, S. M., Dedic, N., Rammes, G., Holsboer, F., Wurst, W., et al. (2025) · Purinergic Signalling · doi:10.1007/s11302-025-10074-x · Cited by 4 · see citing works

Repeated administration of a subanesthetic dose of ketamine results in impaired motor and cognitive behavior and differential expression of hippocampal P2X1 and P2X7 receptors in adult mice

Mares-Barbosa, T. B., Cuellar-Santoyo, A. O., Ruiz-Rodríguez, V. M., Hernández-Balderas, K., González-Hernández, O., Portales‐Pérez, D. P., & Estrada‐Sánchez, A. M. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.115441 · Cited by 4 · see citing works

Purinergic P2X Receptors as Therapeutic Targets

Stokes, L., Bidula, S. M., & Sluyter, R. (2024) · Springer eBooks · doi:10.1007/978-3-031-52197-3_13 · Cited by 2 · see citing works

Targeting P2X7 mitigates neurobehavioural alterations in a mouse model of post-acute sequelae of SARS-CoV-2 infection

Szabó, D., Tod, P., Maácz, F., Gölöncsér, F., Iring-Varga, B., Török, B., Zsidei, G., Pályi, B., Kis, Z., & Sperlágh, B. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110566 · Cited by 2 · see citing works

The neuronal P2X7R controversy: Revisiting evidence, methods, and unresolved questions

Kachappilly, N., Pizzo, P., & Basso, E. (2026) · Neuropharmacology · doi:10.1016/j.neuropharm.2026.110876 · Cited by 2 · see citing works

Neuropharmacological targets for schizophrenia treatment: An update

de Lima, C. A. C., Barbosa, M. E. O., de Souza-Júnior, F. J. C., Farias, S. V., Fontes-Júnior, E. A., & Maia, C. D. S. F. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111580 · Cited by 1 · see citing works

The NLRP3 inflammasome: pathophysiology and therapeutic implications for schizophrenia and neuropsychiatric disorders

Im, J., Mai, M., Mimaki, K., Tang, L., Marder, S., & Yang, Y. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03821-y · Cited by 1 · see citing works

O envolvimento do sistema purinérgico na formação e extinção da memória aversiva condicionada em camundongos

Domingos, L. B. (2020) · doi:10.11606/d.17.2020.tde-19082020-223048 · Cited by 1 · see citing works

The Neuroinflammatory P2X7 Receptor in the CNS is an Etiological Factor of Psychiatric Illnesses

Illés, P. (2021) · Current Psychopharmacologye · doi:10.2174/2211556010666211021165254

Extracellular ATP in psychiatric disorders

von Mücke-Heim, I.-A., & Deussing, J. M. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-30250-3.00015-1

PWAS Atlas: a comprehensive knowledgebase of proteome-wide association studies

Lv, F., Qian, Q., Fan, Z., Zhan, Y., Zeng, J., & Xiao, J. (2026) · Nucleic Acids Research · doi:10.1093/nar/gkag967

BindingDB Entry 50001015: 4-Methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate.

BindingDB (2020) · UC San Diego · doi:10.7270/q2qn697t

P2X7 Receptor-Dependent Layer-Specific Changes in Neuron-Microglia Reactivity in the Prefrontal Cortex of a Phencyclidine Induced Mouse Model of Schizophrenia

Calovi, S., Mut-Arbona, P., Tod, P., Iring, A., Nicke, A., Mato, S., Vizi, E. S., Tønnesen, J., & Sperlágh, B. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.566251 · Cited by 18 · see citing works

The potential of the P2X7 receptor as a therapeutic target in a sub-chronic PCP-induced rodent model of schizophrenia

Huang, H., Zheng, S., Chen, M., Xie, L., Li, Z., Guo, M. A., Wang, J., Lu, M., & Zhu, X. (2021) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2021.101993 · Cited by 18 · see citing works

P2X7 purinergic receptor modulates dentate gyrus excitatory neurotransmission and alleviates schizophrenia-like symptoms in mouse

Huang, L., Mut-Arbona, P., Varga, B., Török, B., Brunner, J., Arszovszki, A., Iring, A., Kisfali, M., Vizi, E. S., & Sperlágh, B. (2023) · iScience · doi:10.1016/j.isci.2023.107560 · Cited by 10 · see citing works

The phenothiazine-class antipsychotic drugs prochlorperazine and trifluoperazine are potent allosteric modulators of the human P2X7 receptor

Hempel, C., Nörenberg, W., Sobottka, H., Urban, N. D., Nicke, A., Fischer, W., & Schaefer, M. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.07.027 · Cited by 39 · see citing works

α7 Nicotinic acetylcholine receptor activation prevents behavioral and molecular changes induced by repeated phencyclidine treatment

Thomsen, M. S., Christensen, D. Z., Hansen, H. H., Redrobe, J. P., & Mikkelsen, J. D. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.02.003 · Cited by 78 · see citing works