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Beyond Seizure Control: Treating Comorbidities in Epilepsy via Targeting of the P2X7 Receptor

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Purinergic P2X7 receptor as a potential therapeutic target in depression

Wang, Q., Jin, X., & Guan, W. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115959 · Cited by 22 · see citing works

Reduced P2X receptor levels are associated with antidepressant effect in the learned helplessness model

Ribeiro, D. E., Casarotto, P. C., Staquini, L., Pinto e Silva, M. A., Biojone, C., Wegener, G., & Joca, S. (2019) · PeerJ · doi:10.7717/peerj.7834 · Cited by 21 · see citing works

Purinergic signaling in cognitive impairment and neuropsychiatric symptoms of Alzheimer's disease

Ribeiro, D. E., Petiz, L. L., Glaser, T., Oliveira‐Giacomelli, Á., Andrejew, R., Saab, F. D. A. R., Milanis, M. D. S., Campos, H. C., Arnaud-Sampaio, V. F., de Oliveira, S. L. B., et al. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109371 · Cited by 20 · see citing works

Hypericin Ameliorates Depression-like Behaviors via Neurotrophin Signaling Pathway Mediating m6A Epitranscriptome Modification

Lei, C., Li, N., Chen, J., & Wang, Q. (2023) · Molecules · doi:10.3390/molecules28093859 · Cited by 23 · see citing works

Neuroprotection of exercise: P2X4R and P2X7R regulate BDNF actions

Sun, B.-X., Peng, A., Liu, P., Wang, M., Ding, H., Hu, Y., & Kang, L. (2022) · Purinergic Signalling · doi:10.1007/s11302-022-09879-x · Cited by 19 · see citing works

The P2X7 receptor in mood disorders: Emerging target in immunopsychiatry, from bench to bedside

von Mücke-Heim, I.-A., & Deussing, J. M. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109366 · Cited by 18 · see citing works

The role of microglia in chronic pain and depression: innocent bystander or culprit?

Yin, N., Yan, E., Duan, W., Mao, C., Qin, F., Yang, C., Hu, Y., & Xu, X. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05780-4 · Cited by 18 · see citing works

Beyond monoamines: I. Novel targets and radiotracers for Positron emission tomography imaging in psychiatric disorders

Lopresti, B. J., Royse, S. K., Mathis, C. A., Tollefson, S., & Narendran, R. (2022) · Journal of Neurochemistry · doi:10.1111/jnc.15615 · Cited by 16 · see citing works

High‐Efficiency Ocular Delivery of Brain‐Derived Neurotrophic Factor and Oligomycin for Neuroprotection in Glaucoma

Cao, Y., Yin, X., Wu, L., Huang, D., Wang, Z., Wu, F., Jiang, J., Chen, G., & Wang, Q. (2025) · Advanced Materials · doi:10.1002/adma.202500623 · Cited by 12 · see citing works

P2X7 receptor inhibition alleviates mania-like behavior independently of interleukin-1β

Gölöncsér, F., Baranyi, M., Tod, P., Maácz, F., & Sperlágh, B. (2024) · iScience · doi:10.1016/j.isci.2024.109284 · Cited by 9 · see citing works

Beyond monoamines: II. Novel applications for PET imaging in psychiatric disorders

Royse, S. K., Lopresti, B. J., Mathis, C. A., Tollefson, S., & Narendran, R. (2022) · Journal of Neurochemistry · doi:10.1111/jnc.15657 · Cited by 10 · see citing works

Repeated cannabidiol treatment affects neuroplasticity and endocannabinoid signaling in the prefrontal cortex of the Flinders Sensitive Line (FSL) rat model of depression.

Domingos, L. B., Müller, H. K., da Silva, N. R., Filiou, M. D., Nielsen, A. L., Guimarães, F. S., Wegener, G., & Joca, S. R. L. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.109870 · Cited by 10 · see citing works

Association of P2X7 receptor genetic polymorphisms and expression with rheumatoid arthritis susceptibility in a sample of the Iranian population: a case-control study

Bahari, G., Tabasi, F., Hashemi, M. M., Zakeri, Z., & Taheri, M. (2021) · Clinical Rheumatology · doi:10.1007/s10067-021-05645-3 · Cited by 10 · see citing works

The P2X7 receptor in depression: Novel insights and therapeutic implications

Zhong, Y.-T., Pi, C., Zuo, Y., Yan, W., Li, W., Jiang, Y., Lei, T., Zheng, W., Jiang, J., Yang, Y., et al. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.107011 · Cited by 9 · see citing works

Purinergic modulation of major depressive disorder: Experimental findings, pathogenesis and therapeutic opportunities

Ren, X.-Y., Rubini, P., Engel, T., Tang, Y., & Illés, P. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107989 · Cited by 9 · see citing works

Anti-inflammatory and analgesic properties of Polyphyllin VI revealed by network pharmacology and RNA sequencing

Zhang, Z., Wang, T., Luo, Z., Zaib, M. H., Yi, M., Zeng, H., Li, P., Tang, D., Verkhratsky, A., & Nie, H. (2023) · Purinergic Signalling · doi:10.1007/s11302-023-09979-2 · Cited by 9 · see citing works

Scrutinizing the Therapeutic Promise of Purinergic Receptors Targeting Depression

Sikka, P., Behl, T., Chandel, P., Sehgal, A., Singh, S., Makeen, H. A., Albratty, M., Alhazmi, H. A., & Meraya, A. M. (2022) · Neurotoxicity Research · doi:10.1007/s12640-022-00550-2 · Cited by 7 · see citing works

Microglia in the pathogenesis of depression, insomnia and their comorbidity

Liu, F., Guo, D., Gao, T., Diao, M., & Han, Y. (2023) · Brain Behavior and Immunity Integrative · doi:10.1016/j.bbii.2023.100030 · Cited by 8 · see citing works

A novel butyrylcholinesterase inhibitor induces antidepressant, pro-cognitive, and anti-anhedonic effects in Flinders Sensitive Line rats: The role of the ghrelin-dopamine cascade.

Olivier, N., Harvey, B. H., Gobec, S., Shahid, M., Košak, U., Žakelj, S., & Brink, C. (2025) · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · doi:10.1016/j.biopha.2025.118093 · Cited by 7 · see citing works

Ameliorating effect of fluoxetine on tamoxifen-induced memory loss: The role of corticolimbic NMDA receptors and CREB/BDNF/cFos signaling pathways in rats

Sahafi, O. H., Rezayof, A., Ghasemzadeh, Z., Alijanpour, S., & Rahimian, S. (2022) · Brain Research · doi:10.1016/j.brainres.2022.148058 · Cited by 7 · see citing works

An Updated Bio‐Behavioral Profile of the Flinders Sensitive Line Rat: Reviewing the Findings of the Past Decade

Steyn, S. F. (2025) · Pharmacology Research & Perspectives · doi:10.1002/prp2.70058 · Cited by 6 · see citing works

The antidepressant effect of short- and long-term zinc exposition is partly mediated by P2X7 receptors in male mice

Iring-Varga, B., Baranyi, M., Gölöncsér, F., Tod, P., & Sperlágh, B. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1241406 · Cited by 4 · see citing works

Establishment and behavioural characterization of a novel constitutive P2X7 receptor knockout mouse line

von Mücke-Heim, I.-A., Oldekamp, J., Metzger, M. W., Kläffgen, S., Tang, H., Walser, S. M., Dedic, N., Rammes, G., Holsboer, F., Wurst, W., et al. (2025) · Purinergic Signalling · doi:10.1007/s11302-025-10074-x · Cited by 4 · see citing works

Advances in how the peripheral immune system interacts with the brain in health and disease

Ruiz-Rodríguez, V. M., Cuellar-Santoyo, A. O., & Estrada‐Sánchez, A. M. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.12.059 · Cited by 4 · see citing works

Purinergic P2X Receptors as Therapeutic Targets

Stokes, L., Bidula, S. M., & Sluyter, R. (2024) · Springer eBooks · doi:10.1007/978-3-031-52197-3_13 · Cited by 2 · see citing works

Defining functional states and roles of microglia in neuropsychiatric disorders

Szydłowska, K., Tivanello, R., & Kaminska, B. (2026) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2026.1798151 · Cited by 2 · see citing works

Antidepressants as modulators of P2X7 receptor activity

Vidal, V. N., Teixeira, G. P., Faria, J. V., Oliveira, J. A. D. S., Bello, M. L., Rocha, L., & Faria, R. X. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.12.042 · Cited by 1 · see citing works

Radioneuromodulation of Nucleus Accumbens for Addiction: The First Animal Study

Sözer, A., Şahin, M. Ç., Sözer, B., Sozer, E., Bayık, P., Tokgöz, N., Emmez, H., Kaymaz, M., & Yaman, M. E. (2024) · World Neurosurgery · doi:10.1016/j.wneu.2024.09.043 · Cited by 1 · see citing works

Purinergic Signaling in Depression

Ribeiro, D. E., Kaster, M. P., Ulrich, H., Lisboa, S. F. D. S., & Joca, S. R. L. (2023) · Springer eBooks · doi:10.1007/978-3-031-26945-5_7

Interação dos receptores P2X7 e TRPV1 na ativação do inflamassoma NLRP3 e na liberação de vesículas extracelulares na linhagem murina de micróglia BV2

Bastos, S. (2024) · doi:10.11606/d.17.2024.tde-25072024-110328

Extracellular ATP in psychiatric disorders

von Mücke-Heim, I.-A., & Deussing, J. M. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-30250-3.00015-1

40-Hz transauricular vagal nerve stimulation rescues cognition of 9-month-old APP/PS1 mice via inhibiting hippocampal P2X7 receptor signaling

Yu, Y., Wang, Y., Guo, S., Zhang, J., Bai, Y., Liu, C., Liu, X., Li, X., Jiang, X., Liu, P., et al. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1766813

ATP and major affective disorders: the involvement of P2X receptors in pathophysiology

Mattova, S., Šimko, P., Colzi, E., Štammová, E., Urbanská, N., Grigoroiu‐Serbânescu, M., Coppi, E., & Kisková, T. (2026) · Purinergic Signalling · doi:10.1007/s11302-026-10147-5

Brain-derived neurotrophic factor in diabetes: A promising target for cognitive restoration

Chandak, G., Kumar, B., Kumar, S., Ashique, S., Bhui, U., Pandey, N., Debnath, B., Al-Salem, F. M., Yasmin, S., Brady, M. S. M., et al. (2026) · iScience · doi:10.1016/j.isci.2026.116658

Neurochemical Changes in the Mouse Hippocampus Underlying the Antidepressant Effect of Genetic Deletion of P2X7 Receptors

Csölle, C., Baranyi, M., Zsilla, G., Kittel, Á., Gölöncsér, F., Illes, P., Papp, E., Vizi, E. S., & Sperlágh, B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066547 · Cited by 128 · see citing works

P2X7 Receptor Signaling in Stress and Depression

Ribeiro, D. E., Roncalho, A. L., Glaser, T., Ulrich, H., Wegener, G., & Joca, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112778 · Cited by 129 · see citing works

Recent Advances in the Development of Antidepressants Targeting the Purinergic P2X7 Receptor

Lee, S., Ha, H., Jang, J., & Byun, Y. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220629141418 · Cited by 16 · see citing works

Modulation of P2X7 receptor function alters depressive behavior in rodent models of depression

Sperlágh, B. (2010) · Frontiers in Neuroscience · doi:10.3389/conf.fnins.2010.10.00141 · Cited by 1 · see citing works

A P2X7 receptor antagonist reverses behavioural alterations, microglial activation and neuroendocrine dysregulation in an unpredictable chronic mild stress (UCMS) model of depression in mice

Farooq, R. K., Tanti, A., Ainouche, S., Roger, S., Belzung, C., & Camus, V. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.07.016 · Cited by 83 · see citing works