The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
3D Printing Pharmaceuticals: Drug Development to Frontline Care
Open accessAbstract
3D printing (3DP) is forecast to be a highly revolutionary technology within the pharmaceutical sector. In particular, the main benefits of 3DP lie in the production of small batches of medicines, each with tailored dosages, shapes, sizes and release characteristics. The manufacture of medicines in this way may finally lead to the concept of personalised medicines becoming a reality. In the shorter term, 3DP could be extended throughout the drug development process, ranging from preclinical development and clinical trials, through to frontline medical care. In this review, we provide a timely perspective on the motivations and potential applications of 3DP pharmaceuticals, as well as a practical viewpoint on how 3DP could be integrated across the pharmaceutical space.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A New Initiative on Precision Medicine
Collins, F. S., & Varmus, H. (2015) · New England Journal of Medicine · doi:10.1056/nejmp1500523 · Cited by 5,202
What is polypharmacy? A systematic review of definitions
Masnoon, N., Shakib, S., Kalisch-Ellett, L., & Caughey, G. E. (2017) · BMC Geriatrics · doi:10.1186/s12877-017-0621-2 · Cited by 3,293
Clinical development success rates for investigational drugs
Hay, M., Thomas, D. W., Craighead, J. L., Economides, C., & Rosenthal, J. (2014) · Nature Biotechnology · doi:10.1038/nbt.2786 · Cited by 2,536
The Path to Personalized Medicine
Hamburg, M. A., & Collins, F. S. (2010) · New England Journal of Medicine · doi:10.1056/nejmp1006304 · Cited by 1,970
Clinical consequences of polypharmacy in elderly
Maher, R. L., Hanlon, J., & Hajjar, E. R. (2014) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2013.827660 · Cited by 1,938
3D printing with polymers: Challenges among expanding options and opportunities
Stansbury, J. W., & Idacavage, M. J. (2016) · Dental Materials · doi:10.1016/j.dental.2015.09.018 · Cited by 1,732
A new chapter in pharmaceutical manufacturing: 3D-printed drug products
Norman, J., Madurawe, R. D., Moore, C. M. V., Khan, M. A., & Khairuzzaman, A. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.03.001 · Cited by 810
Effect of geometry on drug release from 3D printed tablets
Goyanes, A., Robles Martinez, P., Buanz, A., Basit, A. W., & Gaisford, S. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.04.069 · Cited by 667
Self-citation3D printing in pharmaceutics: A new tool for designing customized drug delivery systems
Goole, J., & Amighi, K. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.12.071 · Cited by 660
Stereolithographic (SLA) 3D printing of oral modified-release dosage forms
Wang, J., Goyanes, A., Gaisford, S., & Basit, A. W. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.03.016 · Cited by 612
Self-citationKhaled, S. A., Burley, J. C., Alexander, M. R., Yang, J., & Roberts, C. J. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.09.028 · Cited by 606
Fused-filament 3D printing (3DP) for fabrication of tablets
Goyanes, A., Buanz, A. B. M., Basit, A. W., & Gaisford, S. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.09.044 · Cited by 587
Self-citationSelective laser sintering (SLS) 3D printing of medicines
Fina, F., Goyanes, A., Gaisford, S., & Basit, A. W. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.06.082 · Cited by 577
Self-citation3D printing of modified-release aminosalicylate (4-ASA and 5-ASA) tablets
Goyanes, A., Buanz, A. B. M., Hatton, G. B., Gaisford, S., & Basit, A. W. (2015) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2014.12.003 · Cited by 570
Self-citationEmergence of 3D Printed Dosage Forms: Opportunities and Challenges
Alhnan, M. A., Okwuosa, T. C., Sadia, M., Wan, K.-W., Ahmed, W., & Arafat, B. (2016) · Pharmaceutical Research · doi:10.1007/s11095-016-1933-1 · Cited by 554
Skowyra, J., Pietrzak, K., & Alhnan, M. A. (2015) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2014.11.009 · Cited by 530
Desktop 3D printing of controlled release pharmaceutical bilayer tablets
Khaled, S. A., Burley, J. C., Alexander, M. R., & Roberts, C. J. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.11.021 · Cited by 511
Goyanes, A., Wang, J., Buanz, A., Martínez-Pacheco, R., Telford, R., Gaisford, S., & Basit, A. W. (2015) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5b00510 · Cited by 511
Self-citation3D printing of tablets containing multiple drugs with defined release profiles
Khaled, S. A., Burley, J. C., Alexander, M. R., Yang, J., & Roberts, C. J. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.07.067 · Cited by 508
Goyanes, A., Det-Amornrat, U., Wang, J., Basit, A. W., & Gaisford, S. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.05.034 · Cited by 490
Self-citation3D Printing technologies for drug delivery: a review
Prasad, L. K., & Smyth, H. (2016) · Drug Development and Industrial Pharmacy · doi:10.3109/03639045.2015.1120743 · Cited by 454
A flexible-dose dispenser for immediate and extended release 3D printed tablets
Pietrzak, K., Isreb, A., & Alhnan, M. A. (2015) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2015.07.027 · Cited by 407
Coupling 3D printing with hot-melt extrusion to produce controlled-release tablets
Zhang, J., Feng, X., Patil, H., Tiwari, R. V., & Repka, M. A. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.12.049 · Cited by 393
Channelled tablets: An innovative approach to accelerating drug release from 3D printed tablets
Sadia, M., Arafat, B., Ahmed, W., Forbes, R. T., & Alhnan, M. A. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.11.022 · Cited by 368
Arcaute, K., Mann, B. K., & Wicker, R. B. (2006) · Annals of Biomedical Engineering · doi:10.1007/s10439-006-9156-y · Cited by 364
Solid free-form fabrication of drug delivery devices
Wu, B. M., Borland, S. W., Giordano, R. A., Cima, L. G., Sachs, E. M., & Cima, M. J. (1996) · Journal of Controlled Release · doi:10.1016/0168-3659(95)00173-5 · Cited by 361
Goyanes, A., Fina, F., Martorana, A., Sedough, D., Gaisford, S., & Basit, A. W. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.05.021 · Cited by 355
Self-citationOral dosage forms fabricated by Three Dimensional Printing™
Katstra, W. E., Palazzolo, R. D., Rowe, C. W., Giritlioglu, B., Teung, P., & Cima, M. J. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00225-4 · Cited by 334
Fabrication of controlled-release budesonide tablets via desktop (FDM) 3D printing
Goyanes, A., Chang, H., Sedough, D., Hatton, G. B., Wang, J., Buanz, A., Gaisford, S., & Basit, A. W. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.10.039 · Cited by 330
Self-citationAdoption of telemedicine: from pilot stage to routine delivery
Zanaboni, P., & Wootton, R. (2012) · BMC Medical Informatics and Decision Making · doi:10.1186/1472-6947-12-1 · Cited by 317
Pharmaceutical applications of Mid-IR and Raman spectroscopy
Wartewig, S., & Neubert, R. H. H. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2005.01.022 · Cited by 316
Patient-specific 3D scanned and 3D printed antimicrobial polycaprolactone wound dressings
Muwaffak, Z., Goyanes, A., Clark, V., Basit, A. W., Hilton, S. T., & Gaisford, S. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.04.077 · Cited by 314
Self-citationFabricating 3D printed orally disintegrating printlets using selective laser sintering
Fina, F., Madla, C. M., Goyanes, A., Zhang, J., Gaisford, S., & Basit, A. W. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.02.015 · Cited by 300
Self-citationMelocchi, A., Parietti, F., Loreti, G., Maroni, A., Gazzaniga, A., & Zema, L. (2015) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2015.07.016 · Cited by 299
Okwuosa, T. C., Pereira, B. C., Arafat, B., Cieszynska, M., Isreb, A., & Alhnan, M. A. (2017) · Pharmaceutical Research · doi:10.1007/s11095-016-2073-3 · Cited by 277
Fabrication of drug-loaded hydrogels with stereolithographic 3D printing
Martinez, P. R., Goyanes, A., Basit, A. W., & Gaisford, S. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.09.003 · Cited by 274
Self-citationSolanki, N. G., Tahsin, M., Shah, A. V., & Serajuddin, A. T. M. (2018) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2017.10.021 · Cited by 272
3D printed multi-compartment capsular devices for two-pulse oral drug delivery
Maroni, A., Melocchi, A., Parietti, F., Foppoli, A., Zema, L., & Gazzaniga, A. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.10.008 · Cited by 268
Paediatric and geriatric drug delivery
Breitkreutz, J., & Boos, J. (2007) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.4.1.37 · Cited by 262
Personalised dosing: Printing a dose of one’s own medicine
Alomari, M., Mohamed, F. H., Basit, A. W., & Gaisford, S. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.12.006 · Cited by 257
Self-citationGoyanes, A., Kobayashi, M., Martínez-Pacheco, R., Gaisford, S., & Basit, A. W. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.06.021 · Cited by 247
Self-citationPatient acceptability of 3D printed medicines
Goyanes, A., Scarpa, M., Kamlow, M., Gaisford, S., Basit, A. W., & Orlu, M. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.07.064 · Cited by 246
Self-citation3D printed orodispersible films with Aripiprazole
Jamróz, W., Kurek, M., Łyszczarz, E., Szafraniec, J., Knapik-Kowalczuk, J., Syrek, K., Paluch, M., & Jachowicz, R. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.05.052 · Cited by 233
Hatton, G. B., Yadav, V., Basit, A. W., & Merchant, H. A. (2015) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.24365 · Cited by 204
Self-citationGenina, N., Boetker, J. P., Colombo, S., Harmankaya, N., Rantanen, J., & Bohr, A. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.10.003 · Cited by 204
Three-Dimensional Printing in Pharmaceutics: Promises and Problems
Yu, D. G., Zhu, L.-M., Branford-White, C. J., & Yang, X. L. (2008) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21284 · Cited by 187
Ku, M. S., & Dulin, W. (2012) · Pharmaceutical Development and Technology · doi:10.3109/10837450.2010.535826 · Cited by 172
Huang, W., Zheng, Q., Sun, W., Xu, H., & Yang, X. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.02.021 · Cited by 159
Recruitment, Retention, and Blinding in Clinical Trials
Page, S. J., & Persch, A. C. (2013) · American Journal of Occupational Therapy · doi:10.5014/ajot.2013.006197 · Cited by 148
Wu, W., Zheng, Q., Guo, X., Sun, J., & Liu, Y. (2009) · Biomedical Materials · doi:10.1088/1748-6041/4/6/065005 · Cited by 139
Li, Q., Wen, H., Jia, D., Guan, X., Pan, H., Yue, Y., Yu, S., Zhu, Z., Xiang, R., & Pan, W. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.03.066 · Cited by 135
Yu, D., Shen, X., Branford-White, C. J., Zhu, L., White, K., & Xiang, Y. (2009) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.61.03.0006 · Cited by 128
Wang, C.-C., Tejwani, M. R., Roach, W. J., Kay, J. L., Yoo, J., Surprenant, H. L., Monkhouse, D. C., & Pryor, T. J. (2006) · Drug Development and Industrial Pharmacy · doi:10.1080/03639040500519300 · Cited by 118
Analysis of Drug Content and Weight Uniformity for Half-Tablets of 6 Commonly Split Medications
Hill, S., Varker, A. S., Karlage, K. L., & Myrdal, P. B. (2009) · Journal of Managed Care Pharmacy · doi:10.18553/jmcp.2009.15.3.253 · Cited by 113
PET/CT imaging of 3D printed devices in the gastrointestinal tract of rodents
Goyanes, Á., Fernández‐Ferreiro, A., Majeed, A., Gómez‐Lado, N., Awad, A., Luaces-Rodríguez, A., Gaisford, S., Aguiar, P., & Basit, A. W. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.11.055 · Cited by 106
Self-citationBioequivalence Testing of Topical Drugs
(2009) · CRC Press eBooks · doi:10.3109/9781420081275-12 · Cited by 99
Personalisation of warfarin therapy using thermal ink-jet printing
Vuddanda, P. R., Alomari, M., Dodoo, C. C., Trenfield, S. J., Velaga, S. P., Basit, A. W., & Gaisford, S. (2018) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2018.02.002 · Cited by 95
Self-citationSrivastava, S. C. (2012) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2011.12.004 · Cited by 89
Accuracy of tablet splitting: Comparison study between hand splitting and tablet cutter
Habib, W. A., Alanizi, A. S., Abdelhamid, M. M., & Alanizi, F. K. (2014) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2013.12.014 · Cited by 81
Methodology of oral formulation selection in the pharmaceutical industry
Kuentz, M., Holm, R., & Elder, D. P. (2015) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2015.12.008 · Cited by 81
Three-dimensional printing: review of application in medicine and hepatic surgery
Yao, R., Xu, G., Shuang-Shuang, M., Hua-yu, Y., Sang, X., Wei, S., & Yi-Lei, M. (2016) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2016.0075 · Cited by 71
Salmoria, G. V., Klauss, P., Zepon, Κ. M., & Κanis, L. A. (2012) · The International Journal of Advanced Manufacturing Technology · doi:10.1007/s00170-012-4393-8 · Cited by 67
The practice and clinical implications of tablet splitting in international health
Elliott, I., Mayxay, M., Yeuichaixong, S., Lee, S. J., & Newton, P. N. (2014) · Tropical Medicine & International Health · doi:10.1111/tmi.12309 · Cited by 65
Madathilethu, J., Roberts, M., Peak, M., Blair, J., Prescott, R., & Ford, J. L. (2018) · BMJ Paediatrics Open · doi:10.1136/bmjpo-2017-000198 · Cited by 64
Personalised medicines: More tailored drugs, more tailored delivery
Florence, A. T., & Lee, V. H. L. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.04.047 · Cited by 63
Quantitation of drug content in a low dosage formulation by transmission near infrared spectroscopy
Peroza, C. A., Santos, M. A., & Romañach, R. J. (2006) · AAPS PharmSciTech · doi:10.1208/pt070129 · Cited by 63
Unintended consequences for patients of future personalized pharmacoprinting
Kaae, S. S., Lind, J., Genina, N., & Sporrong, S. K. (2018) · International Journal of Clinical Pharmacy · doi:10.1007/s11096-018-0596-x · Cited by 21
Cited by
3D Printing in Pharmaceutical and Medical Applications – Recent Achievements and Challenges
Jamróz, W., Szafraniec, J., Kurek, M., & Jachowicz, R. (2018) · Pharmaceutical Research · doi:10.1007/s11095-018-2454-x · Cited by 707
3D Printing as a Promising Tool in Personalized Medicine
Vaz, V. M., & Kumar, L. (2021) · AAPS PharmSciTech · doi:10.1208/s12249-020-01905-8 · Cited by 409
Connected healthcare: Improving patient care using digital health technologies
Awad, A., Trenfield, S. J., Pollard, T. D., Ong, J. J., Elbadawi, M., McCoubrey, L. E., Goyanes, A., Gaisford, S., & Basit, A. W. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113958 · Cited by 405
Self-citation3D printing technology; methods, biomedical applications, future opportunities and trends
Bozkurt, Y., & Karayel, E. (2021) · Journal of Materials Research and Technology · doi:10.1016/j.jmrt.2021.07.050 · Cited by 384
3D printing: Principles and pharmaceutical applications of selective laser sintering
Awad, A., Fina, F., Goyanes, A., Gaisford, S., & Basit, A. W. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119594 · Cited by 371
Self-citation
Metadata
- Authors
- Trenfield, S. J., Awad, A., Goyanes, A., Gaisford, S., & Basit, A. W.
- Venue
- Trends in Pharmacological Sciences
- Publisher
- Elsevier BV
- Published
- 2018-05
- Volume
- 39
- Issue
- 5
- Pages
- 440-451
- ISSN
- 0165-6147 (ISSN-L)
- OpenAlex
- W2790244053
- Cited by
- 502
- References
- 67
- FWCI
- 10.55
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
