The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.
The Vast Structural Diversity of Antimicrobial Peptides
Abstract
Antimicrobial peptides (AMPs) occur in all kingdoms of life and are integral to host defense. They have diverse structures and target a variety of organisms, both by nonspecific membrane interactions and via specific targets. Here we discuss the structures of AMPs from the four main classes currently recognized - that is, peptides with (i) α-helical, (ii) β-sheet, (iii) αβ, or (iv) non-αβ elements - as well as the growing pool of complex topologies including various post-translational modifications (PTMs). We propose to group these latter peptides into a fifth class of AMPs. Such peptides exhibit high stability and amenability to chemical engineering, making them of interest for the development of novel antimicrobial agents. Advances and challenges in the development of these peptides towards therapeutic leads are presented.
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Cites
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Self-citationAntimicrobial Peptides: An Emerging Category of Therapeutic Agents
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Cited by
Antimicrobial peptides for combating drug-resistant bacterial infections
Xuan, J., Feng, W., Wang, J., Wang, R., Zhang, B., Bo, L., Chen, Z.-S., Yang, H., & Sun, L. (2023) · Drug Resistance Updates · doi:10.1016/j.drup.2023.100954 · Cited by 665
Antimicrobial Peptides: An Update on Classifications and Databases
Bin Hafeez, A., Jiang, X., Bergen, P. J., & Zhu, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111691 · Cited by 341
Insect antimicrobial peptides: potential weapons to counteract the antibiotic resistance
Manniello, M. D., Moretta, A., Salvia, R., Scieuzo, C., Lucchetti, D., Vogel, H., Sgambato, A., & Falabella, P. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03784-z · Cited by 259
Metadata
- Authors
- Koehbach, J., & Craik, D. J.
- Venue
- Trends in Pharmacological Sciences
- Publisher
- Elsevier BV
- Published
- 2019-07
- Volume
- 40
- Issue
- 7
- Pages
- 517-528
- ISSN
- 0165-6147 (ISSN-L)
- OpenAlex
- W2952714942
- Cited by
- 294
- References
- 103
- FWCI
- 6.69
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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