The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Anti-CD73 in Cancer Immunotherapy: Awakening New Opportunities
Open accessAbstract
In recent years, cancer immunotherapy made significant advances due to a better understanding of the principles underlying tumor biology and immunology. In this context, CD73 is a key molecule, since via degradation of adenosine monophosphate into adenosine, endorses the generation of an immunosuppressed and pro-angiogenic niche within the tumor microenvironment that promotes the onset and progression of cancer. Targeting CD73 results in favorable antitumor effects in pre-clinical models and combined treatments of CD73 blockade with other immune-modulating agents (i.e. anti-CTLA-4 mAb or anti-PD1 mAb) is particularly attractive. Although there is still a long way to go, anti-CD73 therapy, through the development of CD73 monoclonal antibodies, can potentially constitute a new biologic therapy for cancer patients. In this review, we discuss the link between CD73 and the onset, development and spread of tumors, highlighting the potential value of this molecule as a target and as a novel biomarker in the context of personalized cancer therapy
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Metadata
- Authors
- Antonioli, L., Yegutkin, G. G., Pacher, P., Blandizzi, C., & Haskó, G.
- Venue
- Trends in Cancer
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 2
- Issue
- 2
- Pages
- 95-109
- ISSN
- 2405-8025 (ISSN-L)
- 2405-8033
- OpenAlex
- W2276522360
- Cited by
- 213
- References
- 15
- FWCI
- 1.58
- Type
- journal article
- Language
- en
- Open access
- green
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- Antonioli, L., Yegutkin, G. G., Pacher, P., Blandizzi, C., & Haskó, G. (2016). Anti-CD73 in Cancer Immunotherapy: Awakening New Opportunities. Trends in Cancer. https://doi.org/10.1016/j.trecan.2016.01.003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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