Dendritic-Cell-Based Therapeutic Cancer Vaccines

Palucka, Karolina; Banchereau, Jacques

doi:10.1016/j.immuni.2013.07.004

Cited by 869Immunotherapy and Immune ResponsesCancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Dendritic-Cell-Based Therapeutic Cancer Vaccines

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Palucka, Karolina, Banchereau, Jacques·2013·Immunity

DOI 10.1016/j.immuni.2013.07.004PMC PMC3788678

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Abstract

The past decade has seen tremendous developments in novel cancer therapies through the targeting of tumor-cell-intrinsic pathways whose activity is linked to genetic alterations and the targeting of tumor-cell-extrinsic factors, such as growth factors. Furthermore, immunotherapies are entering the clinic at an unprecedented speed after the demonstration that T cells can efficiently reject tumors and that their antitumor activity can be enhanced with antibodies against immune-regulatory molecules (checkpoint blockade). Current immunotherapy strategies include monoclonal antibodies against tumor cells or immune-regulatory molecules, cell-based therapies such as adoptive transfer of ex-vivo-activated T cells and natural killer cells, and cancer vaccines. Herein, we discuss the immunological basis for therapeutic cancer vaccines and how the current understanding of dendritic cell and T cell biology might enable the development of next-generation curative therapies for individuals with cancer.

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Microorganisms can interact with the microbiome to control metabolic processes, chronic inflammatory processes, and mucosal immunity.
“For instance, reprogrammed immune cells can use the immune system to treat cancer and administer vaccinations, while microorganisms can interact with the microbiome to control metabolic processes, chronic inflammatory processes, and mucosal immunity.320–322”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [321]
Reprogrammed immune cells can use the immune system to treat cancer and administer vaccinations.
“For instance, reprogrammed immune cells can use the immune system to treat cancer and administer vaccinations, while microorganisms can interact with the microbiome to control metabolic processes, chronic inflammatory processes, and mucosal immunity.320–322”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [321]

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Research works printed but not linked: 3

Sandoval F Terme M Nizard M Badoual C Bureau MF Freyburger L Clement O Marcheteau E Gey A Fraisse G 2013b Mucosal Imprinting of Vaccine-Induced CD8+ T Cells Is Crucial to Inhibit the Growth of Mucosal Tumors Sci Transl Med 5 172ra120 PMC4086646 23408053
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Tanchot C Terme M Pere H Tran T Benhamouda N Strioga M Banissi C Galluzzi L Kroemer G Tartour E 2012 Tumor-Infiltrating Regulatory T Cells: Phenotype, Role, Mechanism of Expansion In Situ and Clinical Significance Cancer Microenviron PMC3717062 23104434

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Authors: Palucka, K., & Banchereau, J.
Affiliations: Icahn School of Medicine at Mount Sinai (US)
Corresponding author: Palucka, Karolina
Banchereau, Jacques
ORCID: Palucka, Karolina
Banchereau, Jacques
Venue: Immunity
Publisher: Elsevier BV
Published: 2013-07
Volume: 39
Issue: 1
Pages: 38-48
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2013.07.004
PMC: PMC3788678
OpenAlex: W2089187782
Cited by: 869
References: 164
Citations by year: 2026: 36 · 2025: 51 · 2024: 42 · 2023: 62 · 2022: 47 · 2021: 71 · 2020: 74 · 2019: 80 · 2018: 76 · 2017: 78 · 2016: 90 · 2015: 87 · 2014: 65 · 2013: 9
FWCI: 7.30
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 389 d)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
Funders: National Cancer Institute (CA 078846, P01 CA084514, P01CA084512, R01CA089440, R01CA078846)
National Institute of Allergy and Infectious Diseases (U19AI057234)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: dendritic cells, cancer vaccines, dendritic cell vaccine, T cell biology, tumor immunology, immune checkpoint blockade, adoptive T cell therapy, natural killer cells, cancer immunotherapy, tumor antigens
MeSH terms: Dendritic Cells, Humans, Neoplasms, T-Lymphocytes, Immunotherapy, Adoptive, Models, Immunological, Cancer Vaccines

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