The DOI matches its Crossref record; 145 of the 145 references it cites were found in a registry or an index.
Re-Emergence of Dendritic Cell Vaccines for Cancer Treatment
Open accessAbstract
Dendritic cells (DC) are essential in immunity due to their role in activating T cells thereby promoting anti-tumorigenic responses. Tumor cells, however, hijack the immune system causing T cell exhaustion and DC dysfunction. Tumor-induced T cell exhaustion may be reversed through immune checkpoint blockade (ICB), however, this treatment fails to show clinical benefit in many patients. While ICB serves to reverse T cell exhaustion, DCs are still necessary to prime, activate and direct the T cells to target tumor cells. In this review we will provide a brief overview of DC function, describe mechanisms by which DC functions are disrupted by the tumor microenvironment and highlight recent developments in DC cancer vaccines.
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Cites
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Cited by
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Metadata
- Authors
- Saxena, M., & Bhardwaj, N.
- Venue
- Trends in Cancer
- Publisher
- Elsevier BV
- Published
- 2018-02
- Volume
- 4
- Issue
- 2
- Pages
- 119-137
- ISSN
- 2405-8025 (ISSN-L)
- 2405-8033
- OpenAlex
- W2784346742
- Cited by
- 305
- References
- 145
- FWCI
- 3.95
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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