The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Mind-body interactions in pain: the neurophysiology of anxious and catastrophic pain-related thoughts
Open accessAbstract
The well-accepted biopsychosocial model proposes that the experience of pain and responses to it result from a complex interaction of biological, psychological, and social factors. However, the separation of these constructs is substantially artificial, and we presume that psychological processes have biological effects, that biological processes affect an individual's psychosocial environment, and so on. Considerable research has demonstrated that pain-coping strategies influence perceived pain intensity and physical functioning, and individual differences in styles of pain coping even shape the persistence of long-term pain complaints in some populations. A good deal of this coping research has focused on catastrophizing, which is a generally maladaptive cognitive and emotional mental set that involves feelings of helplessness when in pain, rumination about pain symptoms, and magnification of pain-related complaints. Collectively, catastrophizing has been consistently associated with heightened experiences of pain across a variety of samples. Although catastrophic thinking regarding pain-related symptoms is often classified under the "psychologic" category within the broader biopsychosocial model, we propose that catastrophizing exerts biologic effects that may account for some of its negative consequences. In general, the cognitive and affective processes captured within the construct of catastrophizing may exert effects on the neuromuscular, cardiovascular, immune, and neuroendocrine systems, and on the activity in the pain neuromatrix within the brain. The interface between pain-related neurobiology and processes such as pain-related catastrophizing represents an important avenue for future pain research.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Additionally, catastrophizing has been linked to increased hypervigilance and heightened activity in brain regions involved in threat detection and affective processing.45,46”
From Acceptance and commitment therapy for prevention of chronic pain after total knee arthroplasty. (2026) · cites this paper as [45]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The biopsychosocial approach to chronic pain: Scientific advances and future directions.
Gatchel, R. J., Peng, Y. B., Peters, M. L., Fuchs, P. N., & Turk, D. C. (2007) · Psychological Bulletin · doi:10.1037/0033-2909.133.4.581 · Cited by 3,392
Theoretical perspectives on the relation between catastrophizing and pain
Sullivan, M. J. L., Thorn, B., Haythornthwaite, J. A., Keefe, F., Martin, M., Bradley, L. A., & Lefebvre, J. C. (2001) · The Clinical Journal of Pain · doi:10.1097/00002508-200103000-00008 · Cited by 2,472
The Cerebral Signature for Pain Perception and Its Modulation
Tracey, I., & Mantyh, P. W. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.012 · Cited by 1,843
Pain catastrophizing and neural responses to pain among persons with fibromyalgia
Gracely, R. H. (2004) · Brain · doi:10.1093/brain/awh098 · Cited by 892
Smeets, R. J. E. M., Vlaeyen, J. W. S., Kester, A. D. M., & Knottnerus, J. A. (2006) · The Journal of Pain · doi:10.1016/j.jpain.2005.10.011 · Cited by 629
Pain and Stress in a Systems Perspective: Reciprocal Neural, Endocrine, and Immune Interactions
Chapman, C. R., Tuckett, R. P., & Song, C. W. (2008) · The Journal of Pain · doi:10.1016/j.jpain.2007.09.006 · Cited by 541
Catastrophizing and pain in arthritis, fibromyalgia, and other rheumatic diseases
Edwards, R. R., Bingham, C. O., Bathon, J. M., & Haythornthwaite, J. A. (2006) · Arthritis Care & Research · doi:10.1002/art.21865 · Cited by 511
Cortical responses to pain in healthy individuals depends on pain catastrophizing
Seminowicz, D. A., & Davis, K. D. (2006) · Pain · doi:10.1016/j.pain.2005.11.008 · Cited by 407
McBeth, J., Silman, A. J., Gupta, A., Chiu, Y. H., Ray, D. W., Morriss, R. K., Dickens, C. M., King, Y., & Macfarlane, G. J. (2006) · Arthritis & Rheumatism · doi:10.1002/art.22336 · Cited by 233
Affleck, G. G., Tennen, H. A., URROWS, S. T., & Higgins, P. S. (1992) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.60.1.119 · Cited by 231
Cited by
Sorted by citations
Pain, catastrophizing, and depression in the rheumatic diseases
Edwards, R. R., Cahalan, C., Mensing, G., Smith, M., & Haythornthwaite, J. A. (2011) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2011.2 · Cited by 596
Self-citationAndersen, K. G., & Kehlet, H. (2011) · The Journal of Pain · doi:10.1016/j.jpain.2010.12.005 · Cited by 523
Fersum, K. V., O’Sullivan, P., Skouen, J. S., Smith, A. J., & Kvåle, A. (2012) · European Journal of Pain · doi:10.1002/j.1532-2149.2012.00252.x · Cited by 490
Psychological processing in chronic pain: a neural systems approach
Simons, L. E., Elman, I., & Borsook, D. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.12.006 · Cited by 359
Wiese‐Bjornstal, D. M. (2010) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/j.1600-0838.2010.01195.x · Cited by 346
Metadata
- Authors
- Campbell, C. M., & Edwards, R. R.
- Affiliations
- Johns Hopkins University (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Edwards, Robert R.
- Venue
- Translational research
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 153
- Issue
- 3
- Pages
- 97-101
- ISSN
- 1878-1810 (ISSN-L)
- 1931-5244
- PMC
- PMC2738609
- OpenAlex
- W2057603114
- Cited by
- 175
- References
- 42
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 7 · 2023: 13 · 2022: 6 · 2021: 8 · 2020: 9 · 2019: 9 · 2018: 9 · 2017: 11 · 2016: 11 · 2015: 12 · 2014: 14 · 2013: 13 · 2012: 11
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Translational research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (7k23ar051315-05)
- National Institute of Neurological Disorders and Stroke (F32NS063624)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (K23-AR051315)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
- Keywords
- pain catastrophizing, mind-body problem, biopsychosocial model, pain coping, pain perception, rumination, helplessness
- MeSH terms
- Anxiety, Humans, Inflammation, Nervous System Physiological Phenomena, Pain, Psychophysiology, Thinking
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
