Arterial stiffness identification of the human carotid artery using the stress–strain relationship in vivo
Open accessAbstract
Arterial stiffness is well accepted as a reliable indicator of arterial disease. Increase in carotid arterial stiffness has been associated with carotid arterial disease, e.g., atherosclerotic plaque, thrombosis, stenosis, etc. Several methods for carotid arterial stiffness assessment have been proposed. In this study, in vivo noninvasive assessment using applanation tonometry and an ultrasound-based motion estimation technique was applied in seven healthy volunteers (age 28±3.6years old) to determine pressure and wall displacement in the left common carotid artery (CCA), respectively. The carotid pressure was obtained using a calibration method by assuming that the mean and diastolic blood pressures remained constant throughout the arterial tree. The regional carotid arterial wall displacement was estimated using a 1D cross-correlation technique on the ultrasound radio frequency (RF) signals acquired at a frame rate of 505-1010Hz. Young's moduli were estimated under two different assumptions: (i) a linear elastic two-parallel spring model and (ii) a two-dimensional, nonlinear, hyperelastic model. The circumferential stress (σ(θ)) and strain (ɛ(θ)) relationship was then established in humans in vivo. A slope change in the circumferential stress-strain curve was observed and defined as the transition point. The Young's moduli of the elastic lamellae (E(1)), elastin-collagen fibers (E(2)) and collagen fibers (E(3)) and the incremental Young's moduli before ( [Formula: see text] ) and after the transition point ( [Formula: see text] ) were determined from the first and second approach, respectively, to describe the contribution of the complex mechanical interaction of the different arterial wall constituents. The average moduli E(1), E(2) and E(3) from seven healthy volunteers were found to be equal to 0.15±0.04, 0.89±0.27 and 0.75±0.29MPa, respectively. The average moduli [Formula: see text] and [Formula: see text] of the intact wall (both the tunica adventitia and tunica media layers) were found to be equal to 0.16±0.04MPa and 0.90±0.25MPa, respectively. The average moduli [Formula: see text] and [Formula: see text] of the tunica adventitia were found to be equal to 0.18±0.05MPa and 0.84±0.22MPa, respectively. The average moduli [Formula: see text] and [Formula: see text] of the tunica media were found to be equal to 0.19±0.05MPa and 0.90±0.25MPa, respectively. The stiffness of the carotid artery increased with strain during the systolic phase. In conclusion, the feasibility of measuring the regional stress-strain relationship and stiffness of the normal human carotid artery was demonstrated noninvasively in vivo.
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Smaller peripheral vessels, such as the radial artery, exhibit similar mechanical behaviors to larger vessels like the aorta, carotid artery, and large coronary arteries.
“The mechanics of large vessels such as the aorta, carotid artery, and large coronary arteries has been studied extensively39–44 but several authors have noted that smaller peripheral vessels, such as the one under study here, exhibit similar mechanical behaviors to larger ones45,46.”
From Synthetic photoplethysmography (PPG) of the radial artery through parallelized Monte Carlo and its correlation to body mass index (BMI) (2021) · cites this paper as [46]
The radial artery has an inner diameter of 2.5 mm and a wall thickness of 0.2 mm.
“The radial artery has been reported to have 2.5 mm inner diameter and 0.2 wall thickness46–48.”
From Synthetic photoplethysmography (PPG) of the radial artery through parallelized Monte Carlo and its correlation to body mass index (BMI) (2021) · cites this paper as [46]
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- Authors
- Khamdaeng, T., Luo, J., Vappou, J., Terdtoon, P., & Konofagou, E. E.
- Affiliations
- Chiang Mai University (TH)
- Columbia University (US)
- Corresponding author
- Konofagou, E.E.
- Venue
- Ultrasonics
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 52
- Issue
- 3
- Pages
- 402-411
- ISSN
- 0041-624X (ISSN-L)
- PMC
- PMC4009743
- OpenAlex
- W2140732194
- Cited by
- 156
- References
- 50
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 11 · 2023: 8 · 2022: 10 · 2021: 14 · 2020: 13 · 2019: 11 · 2018: 14 · 2017: 7 · 2016: 14 · 2015: 15 · 2014: 12 · 2013: 6 · 2012: 2
- FWCI
- 4.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Ultrasonics (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL098830)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Physical Sciences › Engineering › Biomedical Engineering › Elasticity and Material Modeling
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Ultrasound Imaging and Elastography
- Keywords
- arterial stiffness, carotid artery, stress-strain behavior, Young's modulus, applanation tonometry, cross correlation function, hyperelastic material models, elastic lamellae, collagen fibers, adventitia, tunica media, hoop stress, wall displacement
- MeSH terms
- Adult, Carotid Arteries, Humans, Male, Manometry, Models, Theoretical, Stress, Mechanical, Ultrasonography, Tunica Media, Radio Frequency Identification Device, Vascular Stiffness
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