Clinical trial of blood-brain barrier disruption by pulsed ultrasound

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Ultrasound Technologies for Imaging and Modulating Neural Activity

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Getting Drugs Across Biological Barriers

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MR-guided focused ultrasound enhances delivery of trastuzumab to Her2-positive brain metastases

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A Historical Review of Brain Drug Delivery

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Investigating the optimum size of nanoparticles for their delivery into the brain assisted by focused ultrasound-induced blood–brain barrier opening

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Clinical and experimental insight into pathophysiology, comorbidity and therapy of absence seizures

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Neuronavigation-guided focused ultrasound for transcranial blood-brain barrier opening and immunostimulation in brain tumors

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Localized delivery of curcumin into brain with polysorbate 80-modified cerasomes by ultrasound-targeted microbubble destruction for improved Parkinson's disease therapy

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Ultrasound-mediated Delivery of Paclitaxel for Glioma: A Comparative Study of Distribution, Toxicity, and Efficacy of Albumin-bound Versus Cremophor Formulations

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Localized blood–brain barrier opening in infiltrating gliomas with MRI-guided acoustic emissions–controlled focused ultrasound

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Using Evans Blue Dye to Determine Blood‐Brain Barrier Integrity in Rodents

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Theranostic Strategy of Focused Ultrasound Induced Blood-Brain Barrier Opening for CNS Disease Treatment

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Therapeutic approaches targeting Apolipoprotein E function in Alzheimer’s disease

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MR-guided focused ultrasound liquid biopsy enriches circulating biomarkers in patients with brain tumors

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Novel Focused Ultrasound Gene Therapy Approach Noninvasively Restores Dopaminergic Neuron Function in a Rat Parkinson’s Disease Model

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Ultrasound-mediated blood–brain barrier opening: An effective drug delivery system for theranostics of brain diseases

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Overview of Current Drug Delivery Methods Across the Blood–Brain Barrier for the Treatment of Primary Brain Tumors

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Safety and efficacy of focused ultrasound induced blood-brain barrier opening, an integrative review of animal and human studies

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Ultrasonically Propelled Micro‐ and Nanorobots

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Ultrasound-responsive droplets for therapy: A review

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Repeated blood–brain barrier opening with a nine-emitter implantable ultrasound device in combination with carboplatin in recurrent glioblastoma: a phase I/II clinical trial

Carpentier, A. C., Stupp, R., Sonabend, A. M., Dufour, H., Chinot, O. L., Mathon, B., Ducray, F., Guyotat, J., Baize, N., Meneï, P., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45818-7 · Cited by 150 · see citing works

Opening of the Blood–Brain Barrier Using Low-Intensity Pulsed Ultrasound Enhances Responses to Immunotherapy in Preclinical Glioma Models

Sabbagh, A., Beccaria, K., Ling, X., Marisetty, A., Ott, M., Caruso, H. G., Barton, E. A., Kong, L.-Y., Fang, D., Latha, K., et al. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-3760 · Cited by 147 · see citing works

Systemic Delivery of Monoclonal Antibodies to the Central Nervous System for Brain Tumor Therapy

Han, L., Liu, C., Qi, H., Zhou, J., Wen, J., Wu, D., Xu, D., Qin, M., Ren, J., Wang, Q., et al. (2019) · Advanced Materials · doi:10.1002/adma.201805697 · Cited by 145 · see citing works

Applications of focused ultrasound-mediated blood-brain barrier opening

Gorick, C. M., Breza, V. R., Nowak, K. M., Cheng, V. W. T., Fisher, D. G., Debski, A. C., Hoch, M. R., Demir, Z. E. F., Tran, N. M., Schwartz, M. R., et al. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114583 · Cited by 144 · see citing works

Enhancing glioblastoma treatment using cisplatin-gold-nanoparticle conjugates and targeted delivery with magnetic resonance-guided focused ultrasound

Coluccia, D., Figueiredo, C. A., Wu, M., Riemenschneider, A. N., Diaz, R. J., Luck, A. J., Smith, C. A., Das, S., Ackerley, C. A., O’Reilly, M. A., et al. (2018) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2018.01.021 · Cited by 141 · see citing works

Central nervous system delivery of molecules across the blood-brain barrier

Gosselet, F., Loiola, R. A., Roig, A., Rosell, A., & Culot, M. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2020.104952 · Cited by 141 · see citing works

Exploiting the mechanical effects of ultrasound for noninvasive therapy

O’Reilly, M. A. (2024) · Science · doi:10.1126/science.adp7206 · Cited by 140 · see citing works

Endothelial Unc5B controls blood-brain barrier integrity

Boyé, K., Geraldo, L. H., Furtado, J., Pibouin-Fragner, L., Poulet, M., Kim, D., Nelson, B., Xu, Y., Jacob, L., Maïssa, N., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28785-9 · Cited by 139 · see citing works

Technology Roadmap of Micro/Nanorobots

Ju, X., Chen, C., Oral, Ç. M., Sevim, S., Golestanian, R., Sun, M., Bouzari, N., Lin, X., Urso, M., Nam, J. S., et al. (2025) · ACS Nano · doi:10.1021/acsnano.5c03911 · Cited by 139 · see citing works

Acute effects of focused ultrasound-induced increases in blood-brain barrier permeability on rat microvascular transcriptome

McMahon, D., Bendayan, R., & Hynynen, K. (2017) · Scientific Reports · doi:10.1038/srep45657 · Cited by 138 · see citing works

A Clinical System for Non-invasive Blood–Brain Barrier Opening Using a Neuronavigation-Guided Single-Element Focused Ultrasound Transducer

Pouliopoulos, A. N., Wu, S.-Y., Burgess, M. T., Karakatsani, M. E., Kamimura, H. A. S., & Konofagou, E. E. (2019) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2019.09.010 · Cited by 137 · see citing works

Tight junction modulation at the blood-brain barrier: Current and future perspectives

Hashimoto, Y., & Campbell, M. (2020) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2020.183298 · Cited by 136 · see citing works

Ultrasound-responsive microbubbles and nanodroplets: A pathway to targeted drug delivery

Shakya, G., Cattaneo, M., Guerriero, G., Prasanna, A., Fiorini, S., & Supponen, O. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.115178 · Cited by 135 · see citing works

<p>Overcoming the Blood–Brain Barrier: Successes and Challenges in Developing Nanoparticle-Mediated Drug Delivery Systems for the Treatment of Brain Tumours</p>

Ferraris, C., Cavalli, R., Panciani, P. P., & Battaglia, L. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s231479 · Cited by 131 · see citing works

Three-dimensional transcranial microbubble imaging for guiding volumetric ultrasound-mediated blood-brain barrier opening

Jones, R. M., Deng, L., Leung, K., McMahon, D., O’Reilly, M. A., & Hynynen, K. (2018) · Theranostics · doi:10.7150/thno.24911 · Cited by 128 · see citing works

Acoustically targeted chemogenetics for the non-invasive control of neural circuits

Szablowski, J. O., Lee‐Gosselin, A., Lue, B., Malounda, D., & Shapiro, M. G. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0258-2 · Cited by 127 · see citing works

Acoustic feedback enables safe and reliable carboplatin delivery across the blood-brain barrier with a clinical focused ultrasound system and improves survival in a rat glioma model

McDannold, N. J., Zhang, Y., Supko, J. G., Power, C., Sun, T., Peng, C., Vykhodtseva, N. I., Golby, A. J., & Reardon, D. A. (2019) · Theranostics · doi:10.7150/thno.35892 · Cited by 127 · see citing works

High fried food consumption impacts anxiety and depression due to lipid metabolism disturbance and neuroinflammation

Wang, A., Wan, X., Zhuang, P., Wei, J., Yang, A., Liu, X., Tian, Y., Zhu, L., Huang, Y., Yao, J., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2221097120 · Cited by 126 · see citing works

Efficient Blood-Brain Barrier Opening in Primates with Neuronavigation-Guided Ultrasound and Real-Time Acoustic Mapping

Wu, S.-Y., Aurup, C., Sánchez, C. S., Grondin, J., Zheng, W., Kamimura, H. A. S., Ferrera, V. P., & Konofagou, E. E. (2018) · Scientific Reports · doi:10.1038/s41598-018-25904-9 · Cited by 125 · see citing works

Ultrasound and microbubbles to beat barriers in tumors: Improving delivery of nanomedicine

Snipstad, S., Vikedal, K., Maardalen, M., Kurbatskaya, A., Sulheim, E., & Davies, C. D. L. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113847 · Cited by 120 · see citing works

Glioblastoma: Current Status, Emerging Targets, and Recent Advances

Thakur, A., Faujdar, C., Sharma, R., Sharma, S., Malik, B., Nepali, K., & Liou, J. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c01946 · Cited by 120 · see citing works

Sonopermeation to improve drug delivery to tumors: from fundamental understanding to clinical translation

Snipstad, S., Sulheim, E., Davies, C. D. L., MOONEN, C. T. W., Storm, G., Kiessling, F. M., Schmid, R., & Lammers, T. (2018) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2018.1547279 · Cited by 119 · see citing works

Therapeutic oxygen delivery by perfluorocarbon-based colloids

Krafft, M. P., & Riess, J. G. (2021) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2021.102407 · Cited by 119 · see citing works

Newly Diagnosed Glioblastoma: A Review on Clinical Management.

Lukas, R. V., Wainwright, D. A., Ladomersky, E., Sachdev, S., Sonabend, A. M., & Stupp, R. (2019) · PubMed · Cited by 117 · see citing works

A Review of Phospholipid Encapsulated Ultrasound Contrast Agent Microbubble Physics

Helfield, B. L. (2018) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2018.09.020 · Cited by 115 · see citing works

Physical triggering strategies for drug delivery

Sun, T., Dasgupta, A., Zhao, Z., Nurunnabi, M., & Mitragotri, S. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.010 · Cited by 115 · see citing works

Ultrasound-mediated delivery of doxorubicin to the brain results in immune modulation and improved responses to PD-1 blockade in gliomas

Arrieta, V. A., Gould, A., Kim, K.-S., Habashy, K. J., Dmello, C., Vazquez-Cervantes, G. I., Palacín-Aliana, I., McManus, G., Amidei, C., Gomez, C., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48326-w · Cited by 115 · see citing works

Single-cell analysis reveals effective siRNA delivery in brain tumors with microbubble-enhanced ultrasound and cationic nanoparticles

Guo, Y., Lee, H., Fang, Z., Velalopoulou, A. P., Kim, J., Thomas, M. B., Liu, J., Abramowitz, R. G., Kim, Y., Coskun, A. F., et al. (2021) · Science Advances · doi:10.1126/sciadv.abf7390 · Cited by 114 · see citing works

Ultrasound-Responsive Carriers for Therapeutic Applications

Chandan, R., Mehta, S., & Banerjee, R. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.9b01979 · Cited by 113 · see citing works

Focused Ultrasound and Microbubbles-Mediated Drug Delivery to Brain Tumor

Wu, S., Tsai, C., Huang, Y., & Hynynen, K. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics13010015 · Cited by 113 · see citing works

Towards controlled drug delivery in brain tumors with microbubble-enhanced focused ultrasound

Schoen, S. J., Kilinc, M. S., Lee, H., Guo, Y., Degertekin, F. L., Woodworth, G. F., & Arvanitis, C. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.114043 · Cited by 113 · see citing works

Ultrasound in tumor immunotherapy: Current status and future developments

Ho, Y.-J., Li, J.-P., Fan, C., Liu, H.-L., & Yeh, C. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.04.023 · Cited by 110 · see citing works

Focused Ultrasound Immunotherapy for Central Nervous System Pathologies: Challenges and Opportunities

Curley, C. T., Sheybani, N., Bullock, T. N. J., & Price, R. J. (2017) · Theranostics · doi:10.7150/thno.21225 · Cited by 109 · see citing works

Ultrasound technology and biomaterials for precise drug therapy

Zhao, Z., Saiding, Q., Cai, Z., Cai, M., & Cai, M. (2023) · Materials Today · doi:10.1016/j.mattod.2022.12.004 · Cited by 108 · see citing works

Blood–Brain Barrier Modulation to Improve Glioma Drug Delivery

Luo, H., & Shusta, E. V. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12111085 · Cited by 105 · see citing works

Understanding the activity of antibody–drug conjugates in primary and secondary brain tumours

Mair, M. J., Bartsch, R., Rhun, É. L., Berghoff, A. S., Brastianos, P. K., Cortés, J., Gan, H. K., Lin, N., Lassman, A. B., Wen, P. Y., et al. (2023) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-023-00756-z · Cited by 104 · see citing works

From concept to early clinical trials: 30 years of microbubble-based ultrasound-mediated drug delivery research

Bouakaz, A., & Escoffre, J. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115199 · Cited by 104 · see citing works

Focused Ultrasound‐Augmented Delivery of Biodegradable Multifunctional Nanoplatforms for Imaging‐Guided Brain Tumor Treatment

Wu, M., Chen, W., Chen, Y., Zhang, H., Liu, C., Deng, Z., Sheng, Z., Chen, J., Liu, X., Yan, F., et al. (2018) · Advanced Science · doi:10.1002/advs.201700474 · Cited by 103 · see citing works

Engineered nanomaterials that exploit blood-brain barrier dysfunction for delivery to the brain

Wu, J. R., Hernández, Y. M., Miyasaki, K. F., & Kwon, E. J. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114820 · Cited by 103 · see citing works

Safety and Feasibility of Repeated and Transient Blood–Brain Barrier Disruption by Pulsed Ultrasound in Patients with Recurrent Glioblastoma

Idbaïh, A., Canney, M. S., Belin, L., Desseaux, C., Vignot, A., Bouchoux, G., Asquier, N., Law-Ye, B., Leclercq, D., Bissery, A., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-3643 · Cited by 367 · see citing works

Temporary disruption of the blood-brain barrier using an implantable ultrasound system for recurrent glioblastoma patients under IV carboplatin chemotherapy: initial phase 1/2a clinical trial observations

Carpentier, A. C., Canney, M. S., Vignot, A., Horodyckid, C., Goldwirt, L., Leclercq, D., Delattre, J., Chapelon, J., & Idbaïh, A. (2015) · Journal of Therapeutic Ultrasound · doi:10.1186/2050-5736-3-s1-o14 · Cited by 11 · see citing works

A phase I/IIa study to evaluate the safety and efficacy of blood-brain barrier (BBB) opening with the SonoCloud-9 implantable ultrasound device in recurrent glioblastoma patients receiving IV carboplatin.

Idbaïh, A., Ducray, F., Stupp, R., Baize, N., Chinot, O. L., Groot, J. F. D., Guyotat, J., Sonabend, A. M., Meneï, P., Dufour, H., et al. (2021) · Journal of Clinical Oncology · doi:10.1200/jco.2021.39.15_suppl.2049 · Cited by 11 · see citing works

News in brief

(2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)30136-3

OS07.3.A Phase 1/2 clinical trial of blood-brain barrier opening with the SonoCloud-9 implantable ultrasound device in recurrent glioblastoma patients receiving IV carboplatin

Idbaïh, A., Sonabend, A. M., Stupp, R., Chinot, O. L., Dufour, H., Ducray, F., Meneï, P., de Groot, J., Desseaux, C., & Carpentier, A. C. (2022) · Neuro-Oncology · doi:10.1093/neuonc/noac174.048 · Cited by 2 · see citing works