Evolution of clinical, haematological and biochemical findings in young dogs naturally infected by vector-borne pathogens
Abstract
Longitudinal studies evaluating the evolution of clinical, haematological, biochemical findings in young dogs exposed for the first time to multiple vector-borne pathogens have not been reported. With the objective of assessing the evolution of clinical, haematological and biochemical findings, these parameters were serially monitored in naturally infected dogs throughout a 1-year follow-up period. Young dogs, infected by vector-borne pathogens based on cytology or polymerase chain reaction, were examined clinically and blood samples were obtained at seven different follow-up time points. Dogs were randomized to group A (17 dogs treated with a spot-on formulation of imidacloprid 10% and permethrin 50%) or to group B (17 dogs untreated). In addition, 10 4-month-old beagles were enrolled in each group and used as sentinel dogs. At baseline, Anaplasma platys was the most frequently detected pathogen, followed by Babesia vogeli, Bartonella spp., Ehrlichia canis and Hepatozoon canis. Co-infections with A. platys and B. vogeli, followed by E. canis and B. vogeli, A. platys and H. canis and A. platys and Bartonella spp. were also diagnosed. In dogs from group B, abnormal clinical signs were recorded at different time points throughout the study. No abnormal clinical signs were recorded in group A dogs. Thrombocytopenia was the most frequent haematological alteration recorded in A. platys-infected dogs, B. vogeli-infected dogs and in dogs co-infected with A. platys and B. vogeli or A. platys and Bartonella spp. Lymphocytosis was frequently detected among dogs infected with B. vogeli or co-infected with A. platys and B. vogeli. Beagles were often infected with a single pathogen rather than with multiple canine vector-borne pathogens. There was a significant association (p<0.01) between tick infestation and A. platys or B. vogeli, as single infections, and A. platys and B. vogeli or A. platys and Bartonella spp. co-infections. This study emphasizes the clinical difficulties associated with assigning a specific clinical sign or haematological abnormality to a particular canine vector-borne disease.
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In Italy, Bartonella spp. is endemic especially in the South, where human seropositivity to cat scratch disease has been unveiled.
“In Italy, Bartonella spp. is endemic especially in the South [165,166], where human seropositivity to cat scratch disease has been unveiled [167].”
From Fleas infesting pets in the era of emerging extra-intestinal nematodes (2013) · cites this paper as [166]
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- Authors
- de Caprariis, D., Dantas-Torres, F., Capelli, G., Mencke, N., Stanneck, D., Breitschwerdt, E. B., & Otranto, D.
- Affiliations
- Istituto Zooprofilattico Sperimentale delle Venezie (IT)
- Bayer (Germany) (DE)
- North Carolina State University (US)
- University of Bari Aldo Moro (IT)
- Corresponding author
- Otranto, Domenico
- Venue
- Veterinary Microbiology
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 149
- Issue
- 1-2
- Pages
- 206-212
- ISSN
- 0378-1135 (ISSN-L)
- OpenAlex
- W1965016527
- Cited by
- 73
- References
- 31
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 5 · 2022: 9 · 2021: 5 · 2020: 5 · 2019: 1 · 2018: 3 · 2017: 6 · 2016: 6 · 2015: 6 · 2014: 7 · 2013: 12 · 2012: 5
- FWCI
- 4.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Veterinary Microbiology (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
- Funders
- Bayer
- Bayer Animal Health
- Topics
- Life Sciences › Immunology and Microbiology › Parasitology › Vector-borne infectious diseases
- Life Sciences › Immunology and Microbiology › Parasitology › Bartonella species infections research
- Health Sciences › Veterinary › Small Animals › Brucella: diagnosis, epidemiology, treatment
- Keywords
- canine vector-borne diseases, Anaplasma platys, Babesia vogeli, Bartonella, Ehrlichia canis, Hepatozoon canis, co-infection, tick infestation, thrombocytopenia, lymphocytosis, hematological abnormalities, biochemical abnormalities, clinical signs, long-term monitoring
- MeSH terms
- Neonicotinoids, Anaplasma, Animals, Babesia, Bartonella, Coccidia, Disease Vectors, Dog Diseases, Dogs, Siphonaptera, Imidazoles, Longitudinal Studies, Male, Nitro Compounds, Protozoan Infections, Animal, Thrombocytopenia, Ticks, Polymerase Chain Reaction, Gram-Negative Bacterial Infections, Permethrin, Ehrlichia canis
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