Prevalence of high-risk human papillomavirus infection in women with ovarian endometriosis
Abstract
AIM: In this study, we aimed to determine the prevalence of human papillomavirus (HPV) in ovarian endometriosis and ovarian tissue from women without endometriosis. Understanding the pathogenesis of the disease could help us design preventative strategies as well as novel and appropriate treatment approaches in this regard. METHODS: In this cross-sectional study, formalin-fixed and paraffin-embedded tissue sections from 50 and 49 ovaries with and without endometriosis, respectively, were evaluated for the presence of high-risk HPV using the polymerase chain reaction technique. Prevalence of HPV infection and other related characteristics of the studied population were compared. RESULTS: = 3.16). Mean age and parity were not significantly different in subjects with and without HPV infection in the two studied groups (P = 0.7 and P = 0.06 for age in case and control groups, respectively; and P = 0.32 and P = 0.09 for parity in case and control groups, respectively). CONCLUSION: The results of our study indicated a higher rate of high-risk HPV infection among patients with endometriosis. The findings could provide us baseline information for future studies regarding the pathogenesis of endometriosis and the role of viral infection and their possible impact on future cancer development in this group of patients.
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Endometriosis is associated with vaginal and pelvic infection and with an important metabolome in the uterine and peritoneal cavities.
“In addition, we recently realized the association of endometriosis with vaginal and pelvic infection (78, 136, 138) and the presence of an important metabolome in the uterine and peritoneal cavities.”
From Pathogenesis of endometriosis: The genetic/epigenetic theory (2019) · cites this paper as [138]
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- Authors
- Heidarpour, M., Derakhshan, M., Derakhshan‐Horeh, M., Kheirollahi, M., & Dashti, S.
- Affiliations
- Isfahan University of Medical Sciences (IR)
- Tehran University of Medical Sciences (IR)
- Corresponding author
- Derakhshan, Maryam
- Venue
- Journal of obstetrics and gynaecology research
- Publisher
- Wiley
- Published
- 2016-12-08
- Volume
- 43
- Issue
- 1
- Pages
- 135-139
- ISSN
- 1341-8076 (ISSN-L)
- 1447-0756
- OpenAlex
- W2560719619
- Cited by
- 49
- References
- 26
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 4 · 2023: 11 · 2022: 3 · 2021: 5 · 2020: 6 · 2019: 11 · 2018: 1
- FWCI
- 5.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of obstetrics and gynaecology research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
- Keywords
- high-risk HPV, endometrioma, HPV prevalence, ovarian tissue, endometriosis pathogenesis, viral infection, parity, endometriosis-associated cancer risk
- MeSH terms
- Adult, Cross-Sectional Studies, DNA, Viral, Endometriosis, Female, Humans, Middle Aged, Prevalence, Papillomaviridae, Papillomavirus Infections
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