The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Human papillomavirus type 16 E7 oncoprotein inhibits the anaphase promoting complex/cyclosome activity by dysregulating EMI1 expression in mitosis
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“the E7-induced re-entry into cell cycle leading to aberrant proliferation, together with deregulation of Scrib and Par polarity complexes by HPV-E6 in the expanding population of infected cells in the mid-epithelial layer, potentially leads to enhanced symmetrical cell division”
From The Not-So-Good, the Bad and the Ugly: HPV E5, E6 and E7 Oncoproteins in the Orchestration of Carcinogenesis (2021) · cites this paper as [288]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Duda, D. M., Borg, L. A., Scott, D. C., Hunt, H. W., Hammel, M., & Schulman, B. A. (2008) · Cell · doi:10.1016/j.cell.2008.07.022 · Cited by 767
White, E. A., Sowa, M. E., Tan, M. J. A., Jeudy, S., Hayes, S. D., Santha, S., Münger, K., Harper, J. W., & Howley, P. M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116776109 · Cited by 198
Self-citation
Research works printed but not linked: 64
- Balczon, 2001, Overexpression of cyclin A in human HeLa cells induces detachment of kinetochores and spindle pole/centrosome overproduction, Chromosoma, 110, 381, 10.1007/s004120100157 · DOI
- Ban, 2007, The END network couples spindle pole assembly to inhibition of the anaphase-promoting complex/cyclosome in early mitosis, Dev. cell, 13, 29, 10.1016/j.devcel.2007.04.017 · DOI
- Bellanger, 2005, High-risk but not low-risk HPV E2 proteins bind to the APC activators Cdh1 and Cdc20 and cause genomic instability, Cell Cycle, 4, 1608, 10.4161/cc.4.11.2123 · DOI
- Boyer, 1996, E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway, Cancer Res., 56, 4620
- Carter, 2006, A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers, Nat. Genet., 38, 1043, 10.1038/ng1861 · DOI
- Di Fiore, 2007, Emi1 is needed to couple DNA replication with mitosis but does not regulate activation of the mitotic APC/C, J. Cell Biol., 177, 425, 10.1083/jcb.200611166 · DOI
- Duensing, 2000, The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle, Proc. Natl. Acad. Sci. USA, 97, 10002, 10.1073/pnas.170093297 · DOI · Paper page
- Duensing, 2002, The human papillomavirus type 16 E6 and E7 oncoproteins independently induce numerical and structural chromosome instability, Cancer Res., 62, 7075
- Engelbert, 2008, The ubiquitin ligase APC(Cdh1) is required to maintain genome integrity in primary human cells, Oncogene, 27, 907, 10.1038/sj.onc.1210703 · DOI
- Fehr, 2013, Control the host cell cycle: viral regulation of the anaphase-promoting complex, J. Virol., 87, 8818, 10.1128/JVI.00088-13 · DOI
- Frye, 2013, Electron microscopy structure of human APC/C-EMI1 reveals multimodal mechanism of E3 ligase shutdown, Nat. Struct. Mol. Biol., 10.1038/nsmb.2593 · DOI
- Garcia-Higuera, 2008, Genomic stability and tumour suppression by the APC/C cofactor Cdh1, Nat. Cell Biol., 10, 802, 10.1038/ncb1742 · DOI
- Gonzalez, 2001, Degradation of the retinoblastoma tumor suppressor by the human papillo- mavirus type 16 E7 oncoprotein is important for functional inactivation and is separable from proteasomal degradation of E7, J. Virol., 75, 7583, 10.1128/JVI.75.16.7583-7591.2001 · DOI · Paper page
- Guardavaccaro, 2003, Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo, Dev. Cell, 4, 799, 10.1016/S1534-5807(03)00154-0 · DOI
- Hansen, 2004, Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1, Mol. Biol. Cell, 15, 5623, 10.1091/mbc.e04-07-0598 · DOI
- Hayward, 2004, The centrosomal kinase Nek2 displays elevated levels of protein expression in human breast cancer, Cancer Res., 64, 7370, 10.1158/0008-5472.CAN-04-0960 · DOI
- Heilman, 2005, The anaphase promoting complex: a critical target for viral proteins and anti-cancer drugs, Cell Cycle, 4, 560, 10.4161/cc.4.4.1606 · DOI
- Hsu, 2002, E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1), Nat. Cell Biol., 4, 358, 10.1038/ncb785 · DOI
- Huh, 2007, Human papillomavirus type 16 E7 oncoprotein associates with the cullin 2 ubiquitin ligase complex, which contributes to degradation of the retinoblastoma tumor suppressor, J. Virol., 81, 9737, 10.1128/JVI.00881-07 · DOI · Paper page
- Jackman, 2003, Active cyclin B1-Cdk1 first appears on centrosomes in prophase, Nat. Cell Biol., 5, 143, 10.1038/ncb918 · DOI
- Jeganathan, 2005, The Rae1-Nup98 complex prevents aneuploidy by inhibiting securin degradation, Nature, 438, 1036, 10.1038/nature04221 · DOI
- Kitagawa, 1999, An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin, EMBO J., 18, 2401, 10.1093/emboj/18.9.2401 · DOI
- Klingelhutz, 2012, Cellular transformation by human papillomaviruses: lessons learned by comparing high- and low-risk viruses, Virology, 424, 77, 10.1016/j.virol.2011.12.018 · DOI
- Kraft, 2003, Mitotic regulation of the human anaphase-promoting complex by phosphorylation, EMBO J., 22, 6598, 10.1093/emboj/cdg627 · DOI
- Lehman, 2007, Oncogenic regulators and substrates of the anaphase promoting complex/cyclosome are frequently overexpressed in malignant tumors, Am. J. Pathol., 170, 1793, 10.2353/ajpath.2007.060767 · DOI
- Lehman, 2006, Overexpression of the anaphase promoting complex/cyclosome inhibitor Emi1 leads to tetraploidy and genomic instability of p53-deficient cells, Cell Cycle, 5, 1569, 10.4161/cc.5.14.2925 · DOI
- Lenart, 2007, The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1, Curr. Biol.: CB, 17, 304, 10.1016/j.cub.2006.12.046 · DOI
- Lipkowitz, 2011, RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis, Nat. Rev. Cancer, 11, 629, 10.1038/nrc3120 · DOI
- Margottin-Goguet, 2003, Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase, Dev. Cell, 4, 813, 10.1016/S1534-5807(03)00153-9 · DOI
- McLaughlin-Drubin, 2008, Human papillomavirus type 16 E7 oncoprotein associates with E2F6, J. Virol., 82, 8695, 10.1128/JVI.00579-08 · DOI · Paper page
- McLaughlin-Drubin, 2012, Cancer associated human papillomaviruses, Curr. Opinion Virol., 2, 459, 10.1016/j.coviro.2012.05.004 · DOI
- McLaughlin-Drubin, 2009, The human papillomavirus E7 oncoprotein, Virology, 384, 335, 10.1016/j.virol.2008.10.006 · DOI
- McLaughlin-Drubin, 2009, Oncogenic activities of human papillomaviruses, Virus Res., 143, 195, 10.1016/j.virusres.2009.06.008 · DOI
- Meraldi, 2002, Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53−/− cells, EMBO J., 21, 483, 10.1093/emboj/21.4.483 · DOI
- Miller, 2006, Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor, Genes Dev., 20, 2410, 10.1101/gad.1454006 · DOI
- Mo, 2012, How viruses affect the cell cycle through manipulation of the APC/C, Trends Microbiol., 10.1016/j.tim.2012.05.007 · DOI
- Moody, 2010, Human papillomavirus oncoproteins: pathways to transformation, Nat. Rev. Cancer, 10, 550, 10.1038/nrc2886 · DOI
- Moshe, 2011, Regulation of the action of early mitotic inhibitor 1 on the anaphase-promoting complex/cyclosome by cyclin-dependent kinases, J. Biol. Chem., 286, 16647, 10.1074/jbc.M111.223339 · DOI
- Moshe, 2004, Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome, Proc.Natl. Acad. Sci. USA, 101, 7937, 10.1073/pnas.0402442101 · DOI
- Mundt, 1997, On the regulation and function of human polo-like kinase 1 (PLK1): effects of overexpression on cell cycle progression, Biochem. Biophys. Res. Commun., 239, 377, 10.1006/bbrc.1997.7378 · DOI
- Munger, 2004, Mechanisms of human papillomavirus-induced oncogenesis, J. Virol., 78, 11451, 10.1128/JVI.78.21.11451-11460.2004 · DOI · Paper page
- Musacchio, 2007, The spindle-assembly checkpoint in space and time, Nat. Rev. Mol. Cell Biol., 8, 379, 10.1038/nrm2163 · DOI · Paper page
- Nakayama, 2005, Regulation of the cell cycle by SCF-type ubiquitin ligases, Semin. Cell Dev. Biol., 16, 323, 10.1016/j.semcdb.2005.02.010 · DOI
- Nakayama, 2006, Ubiquitin ligases: cell-cycle control and cancer, Nat. Rev. Cancer, 6, 369, 10.1038/nrc1881 · DOI
- Nguyen, 2007, Human papillomavirus type 16 E7 oncoprotein associates with the centrosomal component gamma-tubulin, J. Virol., 81, 13533, 10.1128/JVI.01669-07 · DOI · Paper page
- Nguyen, 2009, Human papillomavirus E7 protein deregulates mitosis via an association with nuclear mitotic apparatus protein 1, J. Virol., 83, 1700, 10.1128/JVI.01971-08 · DOI · Paper page
- Oh, 2004, The papillomavirus E7 oncoprotein is ubiquitinated by UbcH7 and Cullin 1- and Skp2-containing E3 ligase, J. Virol., 78, 5338, 10.1128/JVI.78.10.5338-5346.2004 · DOI
- Peters, 2006, The anaphase promoting complex/cyclosome: a machine designed to destroy, Nat. Rev. Mol. Cell Biol., 7, 644, 10.1038/nrm1988 · DOI · Paper page
- Piboonniyom, 2003, Abrogation of the retinoblastoma tumor suppressor checkpoint during keratinocyte immortalization is not sufficient for induction of centrosome-mediated genomic instability, Cancer Res., 63, 476
- Pines, 2011, Cubism and the cell cycle: the many faces of the APC/C. Nature reviews, Mol. Cell Biol., 12, 427
- Podust, 2000, A Nedd8 conjugation pathway is essential for proteolytic targeting of p27Kip1 by ubiquitination, Proc. Natl. Acad. Sci. USA, 97, 4579, 10.1073/pnas.090465597 · DOI
- Read, 2000, Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha, Mol. Cell. Biol., 20, 2326, 10.1128/MCB.20.7.2326-2333.2000 · DOI · Paper page
- Reimann, 2001, Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex, Cell, 105, 645, 10.1016/S0092-8674(01)00361-0 · DOI
- Reimann, 2001, Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins, Genes Dev., 15, 3278, 10.1101/gad.945701 · DOI
- Scheffner, 1993, The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53, Cell, 75, 495, 10.1016/0092-8674(93)90384-3 · DOI · Paper page
- Song, 2004, The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex, Nat. Cell Biol., 6, 129, 10.1038/ncb1091 · DOI
- Soucy, 2009, An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer, Nature, 458, 732, 10.1038/nature07884 · DOI · Paper page
- Spardy, 2009, Human papillomavirus 16 E7 oncoprotein attenuates DNA damage checkpoint control by increasing the proteolytic turnover of claspin, Cancer Res., 69, 7022, 10.1158/0008-5472.CAN-09-0925 · DOI · Paper page
- Suijkerbuijk, 2008, Preventing aneuploidy: the contribution of mitotic checkpoint proteins, Biochim. Biophys. Acta, 1786, 24
- van Vugt, 2004, Polo-like kinase-1 is required for bipolar spindle formation but is dispensable for anaphase promoting complex/Cdc20 activation and initiation of cytokinesis, J.Biol. Chem., 279, 36841, 10.1074/jbc.M313681200 · DOI
- Wang, 2013, Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex, Nat. Cell Biol., 10.1038/ncb2755 · DOI
- Watanabe, 2005, Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways, Proc. Natl. Acad. Sci. USA, 102, 11663, 10.1073/pnas.0500410102 · DOI
- Winkler, 1984, Koilocytotic lesions of the cervix. The relationship of mitotic abnormalities to the presence of papillomavirus antigens and nuclear DNA content, Cancer, 53, 1081, 10.1002/1097-0142(19840301)53:5<1081::AID-CNCR2820530511>3.0.CO;2-L · DOI
- Yu, 2012, Human papillomavirus type 16 E7 oncoprotein engages but does not abrogate the mitotic spindle assembly checkpoint, Virology, 432, 120, 10.1016/j.virol.2012.06.006 · DOI · Paper page
Cited by
Basukala, O., & Banks, L. (2021) · Viruses · doi:10.3390/v13101892 · Cited by 137
Metadata
- Authors
- Yu, Y., & Munger, K.
- Venue
- Virology
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 446
- Issue
- 1-2
- Pages
- 251-259
- ISSN
- 0042-6822
- PMC
- PMC3799973
- Cited by
- 15
- References
- 2
- Language
- en
- Licence
- Funders
- PHS (R01 CA066980, R01 CA081135)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Human papillomavirus type 16 E7 oncoprotein inhibits the anaphase promoting complex/cyclosome activity by dysregulating EMI1 expression in mitosis. https://app.cochat.ai/papers/10.1016/j.virol.2013.08.013
- The paper
- Yu, Y., & Munger, K. (2013). Human papillomavirus type 16 E7 oncoprotein inhibits the anaphase promoting complex/cyclosome activity by dysregulating EMI1 expression in mitosis. Virology. https://doi.org/10.1016/j.virol.2013.08.013