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Retinal nerve fiber layer thinning in Parkinson disease
Open accessAbstract
Retinal dopamine loss in Parkinson disease (PD) is reflected by visual neurophysiological dysfunction. We measured the thickness of the circumpapillary retinal nerve fiber layer (RNFL) in PD patients using optical coherence tomography. The thickness in the inferior quadrant of PD patients (147 +/- 20 microns) was significantly thinner than that of controls (173 +/- 12 microns; p=0.002), while the inferotemporal area was the thinnest (146 +/- 24 vs. 191 +/- 21 microns; p=0.0003). The results show significant loss of RNFL thickness in PD at specific sites.
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“As mentioned above, PD is a motor disorder associated with degeneration of dopaminergic neurons in the substantia nigra (Inzelberg et al., 2004).”
From The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma. (2017) · cites this paper as Inzelberg et al., 2004
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Visual tests predict dementia risk in Parkinson disease
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“Retinal structural changes are seen in PD, but early studies of retinal nerve fiber layer (RNFL) thinning in PD were not replicated.(9) The location of dopaminergic amacrine cells in the inner plexiform layer (IPL)(10) in nonhuman studies, and postmortem findings of phosphorylated alpha-synuclein in the IPL, suggest t…”
BackgroundEsteve-Rudd, J., Fernández‐Sánchez, L., Lax, P., de Juan, E., Martín‐Nieto, J., & Cuenca, N. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.06.009 · Cited by 52
“Also, PD patients and animal models show a thinning of this and/or other layers of the inner retina (Hajee et al., 2009; Inzelberg et al., 2004).”
Visual System Involvement in Patients with Newly Diagnosed Parkinson Disease
Arrigo, A., Calamuneri, A., Milardi, D., Mormina, E., Rania, L., Postorino, E. I., Marino, S., Lorenzo, G. D., Anastasi, G., Ghilardi, M. F., et al. (2017) · Radiology · doi:10.1148/radiol.2017161732 · Cited by 52
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Alzheimer's Disease and Glaucoma: Imaging the Biomarkers of Neurodegenerative Disease
Valenti, D. A. (2010) · International Journal of Alzheimer s Disease · doi:10.4061/2010/793931 · Cited by 50
“The older OCT technology has also been reported to identify deficits in the nerve fiber layer of those with Parkinson’s disease compared to age-matched controls [68–70].”
Moschos, M. M., & Chatziralli, I. (2017) · Seminars in Ophthalmology · doi:10.1080/08820538.2017.1307423 · Cited by 50
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ResultRetina Thickness as a Marker of Neurodegeneration in Prodromal Lewy Body Disease
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Zou, J., Liu, K., Li, F., Xu, Y., Shen, L., & Xu, H. (2020) · Quantitative Imaging in Medicine and Surgery · doi:10.21037/qims-20-460 · Cited by 50
“Optical coherence tomography (OCT) has been used for more than 10 years to detect and quantify changes in the retina in PD (7).”
MethodOptical Coherence Tomography in Patients with Alzheimer’s Disease: What Can It Tell Us?
Song, A., Johnson, N., Ayala, A. M., & Thompson, A. C. (2021) · Eye and Brain · doi:10.2147/eb.s235238 · Cited by 50
Visual field analysis in patients with Parkinson's disease
Yenice, Ö., Önal, S., Midi, İ., Özcan, E., Temel, A., & Günal, D. İ. (2007) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2007.07.018 · Cited by 50
“In this study, the authors noted a significant reduction in RNFL in the inferotemporal quadrant of patients with PD when compared with controls [24].”
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Diederich, N. J., Pieri, V., Hipp, G., Rufra, O., Blyth, S., & Vaillant, M. (2010) · Movement Disorders · doi:10.1002/mds.22963 · Cited by 48
“The motor Unified Parkinson’s Disease Rating Score (mUPDRS) and the daily medication dosages were determined in the patients with PD.”
BackgroundInfluentialMiri, S., Glazman, S., Mylin, L. H., & Bodis-Wollner, I. G. (2015) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2015.09.015 · Cited by 47
“Visualizing retinal structures using a newly advanced noninvasive technology, optical coherence tomography (OCT), revealed thinning of the retinal nerve fiber layer (RNFL) andmacula [13,14] in PD.”
BackgroundNew strategies for neuroprotection in glaucoma, a disease that affects the central nervous system
Nucci, C., Russo, R., Martucci, A., Giannini, C., Garaci, F. G., Floris, R., Bagetta, G., & Morrone, L. A. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.04.030 · Cited by 47
“significantly reduced RNFL thickness in patients with PD (Inzelberg et al., 2004; Altinta,ş et al., 2008; Eraslan et al., 2015).”
Potential role of retina as a biomarker for progression of Parkinson's disease.
Tian, T., Zhu, X., & Liu, Y.-H. (2011) · PubMed Central · doi:10.3980/j.issn.2222-3959.2011.04.21 · Cited by 46
Retinal biomarkers provide “insight” into cortical pharmacology and disease
Nguyen, C. T. O., Hui, F., Charng, J., Velaedan, S., van Koeverden, A. K., Lim, J. K. H., He, Z., Wong, V. H. Y., Vingrys, A. J., Bui, B. V., et al. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.02.009 · Cited by 47
Retinal changes in Parkinson's disease and glaucoma
Matlach, J., Wagner, M., Malzahn, U., Schmidtmann, I. M., Steigerwald, F., Musacchio, T., Volkmann, J., Grehn, F. J., Göbel, W., & Klebe, S. (2018) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2018.06.016 · Cited by 46
“in 2004 finding a reduced pRNFL thickness with a Time-Domain OCT device [10].”
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Şen, A., Tuğcu, B., Coşkun, Ç., Ekinci, C., & Nacaroğlu, Ş. A. (2013) · European Journal of Ophthalmology · doi:10.5301/ejo.5000338 · Cited by 46
Optical coherence tomography as a potential readout in clinical trials
Greenberg, B. M., & Frohman, E. M. (2010) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756285610368890 · Cited by 45
“When PD patients were studied with OCT, selective thinning of the RNFL in the inferotemporal region was noted [Inzelberg et al. 2004].”
BackgroundEraslan, M., Çerman, E., Çekıç, O., Balci, S. Y., Dericioğlu, V., ŞAHİN, Ö., Süer, D., CHABOU, B., & Elmaci, E. N. T. (2015) · TURKISH JOURNAL OF MEDICAL SCIENCES · doi:10.3906/sag-1406-145 · Cited by 44
The Retina in Multiple System Atrophy: Systematic Review and Meta-Analysis
Mendoza‐Santiesteban, C. E., Gabilondo, I., Palma, J., Norcliffe‐Kaufmann, L., & Kaufmann, H. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00206 · Cited by 44
“Initial reports showed atrophy of the peripapillary retinal nerve fiber layer (RNFL), especially in its temporal and temporal–inferior sectors (26, 27).”
BackgroundOphthalmic manifestations of inherited neurodegenerative disorders
Kersten, H. M., Roxburgh, R. H., & Danesh-Meyer, H. V. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.79 · Cited by 43
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“The results of this study differ in part from previously reported data demonstrating an RNFL thinning and TMV reduction in patients with compared to healthy controls, in particular those of Inzelberg et al. (2004).”
ResultUçak, T., Alagöz, A. N., Çakır, B. K., Çelik, E., Bozkurt, E., & Alagöz, G. (2016) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2016.07.004 · Cited by 42
“Inzelberg et al[4] found out RNFL thickness”
BackgroundInfluentialA rat model of Parkinsonism shows depletion of dopamine in the retina
Biehlmaier, O., Alam, M., & Schmidt, W. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2006.08.001 · Cited by 42
“Furthermore, morphological evidence shows significant nerve fiber layer thinning in PD patients (Inzelberg et al., 2004), as well as significant reductions in both the thickness and cell numbers of the retinal ganglion cell layer in mice with rotenone injected eyes (Zhang et al.”
Progressive retinal structure abnormalities in multiple system atrophy
Mendoza‐Santiesteban, C. E., Palma, J., Martinez, J. M., Norcliffe‐Kaufmann, L., Hedges, T. R., & Kaufmann, H. (2015) · Movement Disorders · doi:10.1002/mds.26360 · Cited by 41
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Lateral geniculate atrophy in Parkinson's with visual hallucination: A trans‐synaptic degeneration?
Lee, J., Yoon, E. J., Lee, W. W., Kim, Y. K., Lee, J., & Jeon, B. (2016) · Movement Disorders · doi:10.1002/mds.26533 · Cited by 40
Ridder, A. J., Müller, M. L. T. M., Kotagal, V., Frey, K. A., Albin, R. L., & Bohnen, N. I. (2016) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2016.10.006 · Cited by 40
Progressive Changes in the Retinal Structure of Patients with Parkinson’s Disease
Ma, L., Xu, L., Mao, C., Fu, Y., Ji, X., Shen, Y., Chen, J., Yang, Y., & Liu, C. (2018) · Journal of Parkinson s Disease · doi:10.3233/jpd-171184 · Cited by 40
“To our knowledge, RNFL thinning in PD was first demonstrated in 2004 [9], and additional investigations have confirmed this finding, although with varying results [7, 10, 12–16].”
ResultThe contribution of optical coherence tomography in neurodegenerative diseases
Simão, L. M. (2013) · Current Opinion in Ophthalmology · doi:10.1097/icu.0000000000000000 · Cited by 39
“[35] found that the thinning of RNFL, particu-”
BackgroundEvoked potential changes in patients with Parkinson's disease
Liu, C., Zhang, Y., Tang, W., Wang, B., Wang, B., & He, S. (2017) · Brain and Behavior · doi:10.1002/brb3.703 · Cited by 37
Bayhan, H. A., Bayhan, S. A., Tanık, N., & Gürdal, C. (2014) · Current Eye Research · doi:10.3109/02713683.2014.894080 · Cited by 37
“Previous OCT studies mostly concentrated on retinal nerve fiber layer thickness, thereby provided an estimation of retinal ganglion cell nerve fiber integrity.(6,8,20) Inzelberg et al.”
BackgroundResultInfluentialOptical coherence tomography findings in Parkinson's disease
Türkoğlu, Ş. A., Umit, D., Öğün, M. N., Ulaş, F., Keleş, A., Nefise, O. Y., & Serpil, Y. (2017) · The Kaohsiung Journal of Medical Sciences · doi:10.1016/j.kjms.2017.11.006 · Cited by 36
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Premotor Symptoms and Early Diagnosis of Parkinson's Disease
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Angiographic and structural imaging using high axial resolution fiber-based visible-light OCT
Pi, S., Camino, A., Zhang, M., Cepurna, W. O., Liu, G., Huang, D., Morrison, J., & Jia, Y. (2017) · Biomedical Optics Express · doi:10.1364/boe.8.004595 · Cited by 33
Retinal imaging biomarkers of neurodegenerative diseases
Christinaki, E., Kulenovic, H., Hadoux, X., Baldassini, N., Eijgen, J. V., Groef, L. D., Stalmans, I., & van Wijngaarden, P. (2021) · Clinical and Experimental Optometry · doi:10.1080/08164622.2021.1984179 · Cited by 35
“dysfunction, and mitochondrial optic neuropathies typically first affect the temporal quadrant of the optic nerve.(107) In”
BackgroundRetinal Degeneration: A Window to Understand the Origin and Progression of Parkinson’s Disease?
Zhang, Y., Zhang, X., Yue, Y., & Tian, T. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.799526 · Cited by 32
Laudate, T. M., Neargarder, S. A., & Cronin‐Golomb, A. (2013) · Behavioral Neuroscience · doi:10.1037/a0031618 · Cited by 32
“A prior study of RNFL thickness in PD (not distinguished by side of onset) reported a reduction in the inferior retinal quadrant compared with a control group (Inzelberg et al., 2004).”
Uludağ, G. (2014) · Medical Science Monitor · doi:10.12659/msm.890756 · Cited by 32
“In the literature there are some studies investigating the neuroaxonal degeneration by using OCT in schizophrenia, Parkinson disease, and Alzheimer disease [12–14].”
BackgroundCombining Optical Coherence Tomography and Fundus Photography to Improve Glaucoma Screening
Watanabe, T., Hiratsuka, Y., Kita, Y., Tamura, H., Kawasaki, R., Yokoyama, T., Kawashima, M., Nakano, T., & Yamada, M. (2022) · Diagnostics · doi:10.3390/diagnostics12051100 · Cited by 31
Optical coherence tomography (OCT) study in Argentinean Huntington’s disease patients
Gatto, E. M., Parisi, V. L., Persi, G. G., Rey, E. F., Cesarini, M., Etcheverry, J. L., Rivera, P., & Squitieri, F. (2018) · International Journal of Neuroscience · doi:10.1080/00207454.2018.1489807 · Cited by 31
“disease (PD) [4], Alzheimer disease (AD) [5] and other”
BackgroundLiu, R., Wang, Y., Xia, Q., Xu, T., Han, T., Cai, S., Luo, S.-L., Wu, R., & Shao, Y. (2021) · Quantitative Imaging in Medicine and Surgery · doi:10.21037/qims-21-359 · Cited by 31
Ophthalmology Issues in Schizophrenia
Gracitelli, C. P. B., Abe, R. Y., Diniz‐Filho, A., de Lima, F. B. V., Paranhos, A., & Medeiros, F. A. (2015) · Current Psychiatry Reports · doi:10.1007/s11920-015-0569-x · Cited by 32
Evaluation of Retinal Changes in Progressive Supranuclear Palsy and Parkinson Disease
Sevim, D. G., Ünlü, M., Gültekin, M., Karaca, Ç., Mirza, M., & Mirza, G. E. (2017) · Journal of Neuro-Ophthalmology · doi:10.1097/wno.0000000000000591 · Cited by 30
Kurtulmuş, A., Elbay, A., Yıldız, F. B. P., Kılıçarslan, T., Ozdemir, M. H., & Kırpınar, İ. (2020) · Schizophrenia Research · doi:10.1016/j.schres.2019.12.034 · Cited by 30
Retinal ganglion cell/inner plexiform layer thickness in patients with Parkinson’s disease
Živković, M., Dayanır, V., Stamenović, J., Ljubisavljević, S., Pražić, A., Zlatanović, M., Zlatanović, G., Jakšić, V., Radenković, M., & Jovanović, S. (2017) · Folia Neuropathologica · doi:10.5114/fn.2017.68584 · Cited by 29
The role of Optical Coherence Tomography in Parkinsonism: A critical review
Mailankody, P., Lenka, A., & Pal, P. K. (2019) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2019.06.009 · Cited by 31
Yang, Z.-J., Wei, J., Mao, C., Zhang, J., Chen, J., Ji, X., Liu, J., Shen, Y., Xiong, K., Huang, J., et al. (2016) · Sleep And Breathing · doi:10.1007/s11325-016-1366-4 · Cited by 28
“A significant decrease in RNFL thickness during PD was first reported in 2004 [16].”
BackgroundOptical coherence tomography findings in patients of parkinson's disease: An Indian perspective
Sengupta, P., Dutta, K., Ghosh, S., Mukherjee, A., Pal, S., & Basu, D. (2018) · Annals of Indian Academy of Neurology · doi:10.4103/aian.aian_152_18 · Cited by 27
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Tabashum, T., Zaffer, A., Yousefzai, R., Colletta, K., Jost, M. B., Park, Y., Chawla, J. P. S., Gaynes, B. I., Albert, M. V., & Xiao, T. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.645293 · Cited by 26
Optical coherence tomography in neurodegenerative disorders
Cunha, L. P., Pires, L. A., Cruzeiro, M. M., Almeida, A. L. M., MARTINS, L. C., Martins, P. N., Shigaeff, N., & Vale, T. C. (2022) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x-anp-2021-0134 · Cited by 29
Stemplewitz, B., Keserü, M., Bittersohl, D., Buhmann, C., Skevas, C., Richard, G. W., & Hassenstein, A. (2015) · Acta Ophthalmologica · doi:10.1111/aos.12764 · Cited by 26
“(Inzelberg et al. 2004) were the first to describe the thinning of”
BackgroundMethodInfluentialLiu, S.-W., Chen, S., Ren, J., Li, B.-J., & Qin, B. (2017) · Neuropeptides · doi:10.1016/j.npep.2017.11.007 · Cited by 24
Slower saccadic reading in Parkinson’s disease
Jehangir, N., Yu, C., Song, J., Shariati, A., Binder, S. W., Beyer, J., Santini, V. E., Poston, K. L., & Liao, Y. J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0191005 · Cited by 26
Türkyılmaz, K., Öner, V., Türkyılmaz, A. K., Kırbaş, A., Kırbaş, S., & Gediz, B. Ş. (2013) · Current Eye Research · doi:10.3109/02713683.2012.758291 · Cited by 25
Deng, Y., Chuanhong, J., Wang, J., Liu, Z., Li, Y., & Hou, X. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.957700 · Cited by 25
“Decreased dopamine secretion and degeneration of retinal dopaminergic neurons are directly related to visual impairment and retinal nerve changes in PD patients (39).”
BackgroundApplication of an OCT data-based mathematical model of the foveal pit in Parkinson disease
Ding, Y., Spund, B., Glazman, S., Shrier, E. M., Miri, S., Selesnick, I., & Bodis-Wollner, I. G. (2014) · Journal of Neural Transmission · doi:10.1007/s00702-014-1214-2 · Cited by 25
“2013) and PD (Inzelberg et al. 2004).”
Harper, D. J., Augustin, M., Lichtenegger, A., Gesperger, J., Himmel, T., Muck, M., Merkle, C. W., Eugui, P., Kummer, S., Wöehrer, A., et al. (2020) · Neurophotonics · doi:10.1117/1.nph.7.1.015006 · Cited by 25
Anoop, B. N., Pavan, R., Girish, G. N., Kothari, A. R., & Rajan, J. (2020) · Journal of Applied Biomedicine · doi:10.1016/j.bbe.2020.07.010 · Cited by 23
Stemplewitz, B., Kromer, R., Vettorazzi, E., Hidding, U., Фрингс, А., & Buhmann, C. (2017) · Scientific Reports · doi:10.1038/s41598-017-05575-8 · Cited by 23
“5A): (1) temporal quadrant, (2) superior temporal quadrant, (3) superior quadrant, (4) superior nasal quadrant, (5) nasal quadrant, (6) inferior nasal quadrant, (7) inferior quadrant, and (8) inferior temporal quadrant.”
Tak, A. Z. A., Şengül, Y., & Karadağ, A. S. (2017) · Acta Neurologica Belgica · doi:10.1007/s13760-017-0852-1 · Cited by 23
Retinal nerve fiber layer structure abnormalities in patients with Neuro-Behcet's disease
Uçar, D., Uygunoğlu, U., Dikkaya, F., Yıldırım, Y., Elgin, C. Y., Saip, S., Sıva, A., & Özyazgan, Y. (2015) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-015-3040-0 · Cited by 22
Meta-Analysis of Visual Evoked Potential and Parkinson’s Disease
He, S., Liu, C.-Y., Chen, L.-D., Ye, Z.-N., Zhang, Y.-P., Tang, W.-G., Wang, B.-D., & Gao, X. (2018) · Parkinson s Disease · doi:10.1155/2018/3201308 · Cited by 22
“Someone also found structural damage in the retina by using optical coherence tomography which revealed thinning of the retinal nerve ber layer and macula [29] in PD.”
BackgroundGümüş, A., & Öner, V. (2014) · Cutaneous and Ocular Toxicology · doi:10.3109/15569527.2014.954715 · Cited by 22
Chang, Z., Xie, F., Li, H., Yuan, F., Zeng, L., Shi, L., Zhu, S., Lu, X., Wei, X., & Wang, Q. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.832768 · Cited by 21
“One OCT study found thinner RNFL thickness of the inferior quadrant of PD cases than that of healthy subjects, with the inferotemporal area being the thinnest region (Inzelberg et al., 2004).”
BackgroundRetinal nerve fibre layer loss in hereditary spastic paraplegias is restricted to complex phenotypes
Wiethoff, S., Zhour, A., Schöls, L. J., & Fischer, M. D. (2012) · BMC Neurology · doi:10.1186/1471-2377-12-143 · Cited by 21
“(PD), one study showed the RNFL to be significantly reduced in the (inferior-) temporal sector [10], other studies revealed statistically significant decrease of global RNFL [17] or reduced inner retinal thickness (RNFL, ganglion cell and inner plexiform layer) in both inferior and superior macular fields [16], while…”
Wang, D., Li, Y., Zhou, Y., Jin, C., Zhao, Q., Wang, A., Wu, S., Wei, W. B., Zhao, X., & Jonas, J. B. (2017) · PLoS ONE · doi:10.1371/journal.pone.0177277 · Cited by 21
Lo, C., Vuong, L. N., & Micieli, J. A. (2021) · Taiwan Journal of Ophthalmology · doi:10.4103/tjo.tjo_76_20 · Cited by 24
“[113] OCT changes consistent with nonspecific neurodegeneration such as RNFL and macular thinning have long been described in patients with PD.[114] Recent work has focused on looking at OCT changes seen in those with rapid eye movement sleep behavior disorders (RBD) as a surrogate for prodromal PD and have seen RNFL…”
BackgroundÖzkasap, S., Türkyılmaz, K., Dereci, S., Öner, V., Calapoğlu, T., Cüre, M. C., & Durmuş, M. (2013) · Child s Nervous System · doi:10.1007/s00381-013-2138-0 · Cited by 21
Decreased retinal sensitivity and loss of retinal nerve fibers in multiple system atrophy
Fischer, M. D., Synofzik, M., Kernstock, C., Dietzsch, J., Heidlauf, R., Schicks, J., Srulijes, K., Wiethoff, S., Menn, O., Berg, D., et al. (2012) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-012-2118-1 · Cited by 21
“In idiopathic Parkinson’s disease (PD), the RNFLT in the (inferior-)temporal sector was significantly reduced in one study [7], while another study additionally demonstrated significant changes of the nasal region and foveal thickness [8].”
ResultOcular findings in patients with attention deficit and hyperactivity
ULUCAN, P. B., Ceylan, O. M., Dönmez, Y. E., & Özcan, Ö. (2020) · International Ophthalmology · doi:10.1007/s10792-020-01497-z · Cited by 20
Asefzadeh, B., & Ninyo, K. (2008) · Optometry · doi:10.1016/j.optm.2007.08.021 · Cited by 19
Retinal vessel diameter obtained by optical coherence tomography is spared in Parkinson’s disease
Sevim, D. G., Ünlü, M., Sönmez, S., Gültekin, M., Karaca, Ç., & Öner, A. (2018) · International Ophthalmology · doi:10.1007/s10792-018-0873-7 · Cited by 19
Dias‐Santos, A., Ferreira, J., Pinheiro, S., Cunha, J. P., Alves, M., Papoila, A. L., Moraes‐Fontes, M. F., & Proença, R. D. (2020) · International Journal of Retina and Vitreous · doi:10.1186/s40942-020-00219-y · Cited by 18
Ayık, B., Kaya, H., Taşdelen, R., & Sevimli, N. (2022) · Psychiatry Research · doi:10.1016/j.psychres.2022.114606 · Cited by 17
Optical coherence tomography as a biomarker in multiple sclerosis
Fjeldstad, A. S., Carlson, N. G., & ROSE, J. W. (2012) · Expert Opinion on Medical Diagnostics · doi:10.1517/17530059.2012.719496 · Cited by 17
“One study revealed a decreased thickness of the RNFL in the temporal quadrant [56], whereas the thickness in the inferior quadrant was significantly thinner than that of controls and the temporal inferior area reported as the thinnest [57].”
BackgroundOptical coherence tomography of patients with Parkinson’s disease and progressive supranuclear palsy
Alkabie, S., Lange, A. P., Manogaran, P., Stoessl, A. J., Costello, F., & Barton, J. J. S. (2019) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2019.105635 · Cited by 18
Association Between Retinal Microanatomy in Preterm Infants and 9-Month Visual Acuity
Seely, K. R., Mangalesh, S., Shen, L. L., McGeehan, B., Ying, G., Sarin, N., Vajzovic, L. M., Prakalapakorn, S. G., Freedman, S. F., Toth, C. A., et al. (2022) · JAMA Ophthalmology · doi:10.1001/jamaophthalmol.2022.1643 · Cited by 16
Póveda, S., Arellano, X., Bernal-Pacheco, Ó., & López, A. V. (2024) · Frontiers in Neuroimaging · doi:10.3389/fnimg.2024.1340754 · Cited by 16
Retinal Optical Coherence Tomography in Neurodegenerative Diseases (Review)
Svetozarskiy, S. N., & Kopishinskaya, S. V. (2015) · Современные технологии в медицине · doi:10.17691/stm2015.7.1.14 · Cited by 15
Mukherjee, C., Alfahad, Q., & Elsherbiny, S. (2019) · Therapeutic Advances in Ophthalmology · doi:10.1177/2515841419831155 · Cited by 16
Imaging in Neuro-ophthalmology
Costello, F., & Scott, J. N. (2019) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000000783 · Cited by 20
Changes of Retina Are Not Involved in the Genesis of Visual Hallucinations in Parkinson’s Disease
Kopal, A., Mejzlíková, E., Preiningerova, J. L., Brebera, D., Ulmanová, O., Ehler, E., & Roth, J. (2015) · Parkinson s Disease · doi:10.1155/2015/709191 · Cited by 15
Optical coherence tomography in the investigation of systemic neurologic disease
Srinivasan, S., & Efron, N. (2018) · Clinical and Experimental Optometry · doi:10.1111/cxo.12858 · Cited by 15
Serfőző, C., Barta, A. G., Horváth, E., Sumánszki, C., Csákány, B., Resch, M., Nagy, Z. Z., & Reismann, P. (2020) · Molecular Genetics and Metabolism Reports · doi:10.1016/j.ymgmr.2020.100649 · Cited by 14
“suggested that DA depletion causes dysfunctions and impoverished dopaminergic input to a subset of ganglion cells and contributes to abnormal production of glutamate and atrophy of these selected fibers [69].”
BackgroundKaya, H., Ayık, B., Taşdelen, R., Sevimli, N., & Ertekin, E. (2022) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2022.103089 · Cited by 14
Nonmotor Symptoms of Parkinson's Disease
Rektorová, I., Aarsland, D., Chaudhuri, К. R., & Strafella, A. P. (2011) · Parkinson s Disease · doi:10.4061/2011/351461 · Cited by 13
“4 years [63].”
BackgroundRetinal and choroidal alterations in patients with anorexia nervosa without vision loss
Moschos, M. M., Moustafa, G., Gonidakis, F., & Papageorgiou, C. (2015) · International Journal of Eating Disorders · doi:10.1002/eat.22471 · Cited by 13
Flash Electroretinography Parameters and Parkinson’s Disease
Netser, R., Demmin, D. L., Dobkin, R. D., Goldstein, A., Roché, M. W., Zernik, A. N., & Silverstein, S. M. (2020) · Journal of Parkinson s Disease · doi:10.3233/jpd-191830 · Cited by 13
Retinal Nerve Fiber Layer and Macular Thickness in Parkinson's Disease Patients
Hamid, M. R. A., Hitam, W. H. W., & Halim, S. A. (2021) · Cureus · doi:10.7759/cureus.16224 · Cited by 13
“This is fairly consistent with several other studies [3,9,10].”
BackgroundResultInfluentialThe macular inner plexiform layer thickness as an early diagnostic indicator for Parkinson’s disease
Wang, X., Jiao, B., Jia, X., Wang, Y., Liu, H., Zhu, X., Hao, X., Zhu, Y., Xu, B., Zhang, S., et al. (2022) · npj Parkinson s Disease · doi:10.1038/s41531-022-00325-8 · Cited by 13
“ESS – 6 (2, 12) – 5 (2, 9) 7 (3, 12) 8 (3, 15) 0.”
First-Visit Diagnosis of Preperimetric Glaucoma
Ophir, A. (2010) · The Open Ophthalmology Journal · doi:10.2174/1874364101004010022 · Cited by 13
“Quantitative comparison at that initial stage with our own normative database revealed thinning of the RNFL below its lower border in the two typical RNFL-loss glaucomatous locations by 37% (from 150 to 94 μm; Fig.”
ResultZiemssen, T., & Ziemssen, F. (2013) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2013.09.022 · Cited by 13
Are All Retinal Nerve Fiber Layer Defects on Optic Coherence Tomography Glaucomatous?
Güngör, S. G., & Akman, A. (2017) · Turkish Journal of Ophthalmology · doi:10.4274/tjo.86461 · Cited by 13
Metadata
- Authors
- Inzelberg, R., Ramirez, J. A., Nisipeanu, P., & Ophir, A.
- Affiliations
- Technion – Israel Institute of Technology (IL)
- Hillel Yaffe Medical Center (IL)
- Corresponding author
- Ophir, Avinoam
- ORCID
- Inzelberg, Rivka
- Venue
- Vision Research
- Publisher
- Elsevier BV
- Published
- 2004-11
- Volume
- 44
- Issue
- 24
- Pages
- 2793-2797
- ISSN
- 0042-6989 (ISSN-L)
- OpenAlex
- W1974244012
- Cited by
- 343
- References
- 17
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 15 · 2023: 13 · 2022: 25 · 2021: 15 · 2020: 30 · 2019: 20 · 2018: 21 · 2017: 26 · 2016: 21 · 2015: 27 · 2014: 23 · 2013: 21 · 2012: 22
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Vision Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Health, State of Israel
- Topics
- Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Ophthalmology › Drug-Induced Ocular Toxicity
- Keywords
- Parkinson's disease, retinal nerve fiber layer, retinal nerve fiber layer thickness, optic nerve head, retinal neurodegeneration
- MeSH terms
- Adult, Aged, Female, Humans, Male, Middle Aged, Nerve Fibers, Parkinson Disease, Retina, Tomography, Optical Coherence
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