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Cited by 572

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Pax-7 up-regulation inhibits myogenesis and cell cycle progression in satellite cells: a potential mechanism for self-renewal

Open access
Olguin, Hugo C., Olwin, Bradley B.·2004·Developmental Biology
DOI 10.1016/j.ydbio.2004.08.015
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Abstract

Satellite cells are myogenic precursors responsible for skeletal muscle regeneration. Satellite cells are absent in the Pax-7-/- mouse, suggesting that this transcription factor is crucial for satellite cell specification [Seale, P., Sabourin, L.A., Girgis-Gabardo, A., Mansouri, A., Gruss, P., Rudnicki, M.A., 2000. Pax7 is required for the specification of myogenic satellite cells. Cell 102, 777-786]. Analysis of Pax-7 expression in activated satellite cells unexpectedly revealed substantial heterogeneity within individual clones. Further analyses show that Pax-7 and myogenin expression are mutually exclusive during differentiation, where Pax-7 appears to be up-regulated in cells that escape differentiation and exit the cell cycle, suggesting a regulatory relationship between these two transcription factors. Indeed, overexpression of Pax-7 down-regulates MyoD, prevents myogenin induction, and blocks MyoD-induced myogenic conversion of 10T1/2 cells. Overexpression of Pax-7 also promotes cell cycle exit even in proliferation conditions. Together, these results suggest that Pax-7 may play a crucial role in allowing activated satellite cells to reacquire a quiescent, undifferentiated state. These data support the concept that satellite cell self-renewal may be a primary mechanism for replenishment of the satellite cell compartment during skeletal muscle regeneration.

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Research works printed but not linked: 24

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Metadata

Authors
Olguin, H. C., & Olwin, B. B.
Venue
Developmental Biology
Publisher
Elsevier BV
Published
2004-11
Volume
275
Issue
2
Pages
375-388
ISSN
0012-1606 (ISSN-L)
DOI
10.1016/j.ydbio.2004.08.015
OpenAlex
W1987030748
Cited by
572
References
2
FWCI
5.90
Type
journal article
Language
en
Open access
bronze
Licence
Funders
  • Muscular Dystrophy Association
  • National Institutes of Health (AR39467)

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CoChat. (2026). Citation check: Pax-7 up-regulation inhibits myogenesis and cell cycle progression in satellite cells: a potential mechanism for self-renewal. https://app.cochat.ai/papers/10.1016/j.ydbio.2004.08.015
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Olguin, H. C., & Olwin, B. B. (2004). Pax-7 up-regulation inhibits myogenesis and cell cycle progression in satellite cells: a potential mechanism for self-renewal. Developmental Biology. https://doi.org/10.1016/j.ydbio.2004.08.015

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