Intestinal tube formation in Caenorhabditis elegans requires vang-1 and egl-15 signaling

Hoffmann, Michael; Segbert, Christoph; Helbig, Gisela; Bossinger, Olaf

doi:10.1016/j.ydbio.2009.12.002

Cited by 38Developmental Biology and Gene RegulationWnt/β-catenin signaling in development and cancerHippo pathway signaling and YAP/TAZ

Intestinal tube formation in Caenorhabditis elegans requires vang-1 and egl-15 signaling

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Hoffmann, Michael, Segbert, Christoph, Helbig, Gisela, Bossinger, Olaf·2010·Developmental Biology

DOI 10.1016/j.ydbio.2009.12.002

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Abstract

Understanding how epithelial organs form during morphogenesis is a major problem in developmental biology. In the present paper, we provide a detailed analysis of vang-1, the only homolog of the planar cell polarity protein Strabismus/Van Gogh in Caenorhabditis elegans. We demonstrate that during organogenesis of the intestine, (i) VANG-1 specifically interacts with PDZ 2 domain of DLG-1 (Discs large) and becomes phosphorylated by the kinase domain of the FGF-like receptor tyrosine kinase EGL-15; (ii) VANG-1 is predominantly restrained to the cell cortex but relocates to the apical junction; and (iii) in vang-1 embryos epithelial cells of the intestine are not correctly arranged along the anterior-posterior axis. To investigate what determines the disposition of the VANG-1 protein, either truncated protein forms were expressed in the intestine or RNAi was used to remove the functions of gene products previously shown to be involved in apical junction formation. Removal of the VANG-1 PDZ binding motif "-ESAV" and depletion of dlg-1 or let-413 gene functions interferes with the localization of VANG-1. In addition, egl-15 embryos show a premature relocation of VANG-1 to the apical junction, causing defects that resemble those observed in mutant vang-1 embryos and after intestine-specific overexpression of full-length vang-1. Finally, the localization of VANG-1 depends on DSH-2, a homolog of the planar cell polarity protein Dishevelled and depletion phenocopies vang-1 and egl-15 phenotypes in the embryonic intestine.

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Functional connections exist between the C. elegans Scribble relative LET-413 and the Vang homologue Vang-1.
“Functional connections also exist between the C. elegans Scribble relative LET-413 and the Vang homologue Vang-1 (Hoffmann et al., 2010).”
From Scribble: A master scaffold in polarity, adhesion, synaptogenesis, and proliferation (2019) · cites this paper as Hoffmann et al., 2010

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Authors: Hoffmann, M., Segbert, C., Helbig, G., & Bossinger, O.
Affiliations: Heinrich Heine University Düsseldorf (DE)
RWTH Aachen University (DE)
Corresponding author: Bossinger, Olaf
ORCID: Hoffmann, Michael
Venue: Developmental Biology
Publisher: Elsevier BV
Published: 2010-03
Volume: 339
Issue: 2
Pages: 268-279
ISSN: 0012-1606 (ISSN-L)
DOI: 10.1016/j.ydbio.2009.12.002
OpenAlex: W2003727659
Cited by: 38
References: 71
Citations by year: 2026: 2 · 2024: 1 · 2023: 2 · 2022: 1 · 2019: 5 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 2 · 2012: 8
FWCI: 1.60
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1234 d)
Locations: Developmental Biology (publishedVersion)
PubMed (publishedVersion)
RWTH Publications (RWTH Aachen) (submittedVersion)
Funders: Boehringer Ingelheim Fonds
Deutsche Forschungsgemeinschaft
National Institutes of Health
National Center for Research Resources
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
Keywords: planar cell polarity, egl-15, DLG1, PDZ domain, protein phosphorylation, apical junctions, anterior-posterior axis, epithelial morphogenesis, Caenorhabditis elegans intestine
MeSH terms: Dishevelled Proteins, Alleles, Animals, Embryo, Nonmammalian, Intestinal Mucosa, Intestines, Phosphoproteins, Signal Transduction, Cell Polarity, Caenorhabditis elegans, Receptors, Fibroblast Growth Factor, Cell Cycle Proteins, Body Patterning, Caenorhabditis elegans Proteins

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Intestinal tube formation in Caenorhabditis elegans requires vang-1 and egl-15 signaling

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