Cited by 442Developmental Biology and Gene RegulationGenetic and Kidney Cyst DiseasesCellular Mechanics and Interactions

Tissue/planar cell polarity in vertebrates: new insights and new questions

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Wang, Yanshu, Nathans, Jeremy·2007·Development

Abstract

This review focuses on the tissue/planar cell polarity (PCP) pathway and its role in generating spatial patterns in vertebrates. Current evidence suggests that PCP integrates both global and local signals to orient diverse structures with respect to the body axes. Interestingly, the system acts on both subcellular structures, such as hair bundles in auditory and vestibular sensory neurons, and multicellular structures, such as hair follicles. Recent work has shown that intriguing connections exist between the PCP-based orienting system and left-right asymmetry, as well as between the oriented cell movements required for neural tube closure and tubulogenesis. Studies in mice, frogs and zebrafish have revealed that similarities, as well as differences, exist between PCP in Drosophila and vertebrates.

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  • In vertebrates, planar cell polarity organization underlies the organization and orientation of stereocilia in the sensory epithelium of the inner ear, the organization of hair follicles, and the morphology and migratory behavior of dorsal mesodermal cells undergoing gastrulation.

    “In vertebrates, this organization has been shown to underlie the organization and orientation of stereo- cilia in the sensory epithelium of the inner ear, the organization of hair follicles, and the morphology and migratory behavior of dorsal mesodermal cells undergoing gastrulation.61”

    From Wnt signal transduction pathways (2008) · cites this paper as [61]

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Authors
Wang, Y., & Nathans, J.
Affiliations
Howard Hughes Medical Institute (US)
Venue
Development
Published
2007-02-15
Volume
134
Issue
4
Pages
647-658
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
OpenAlex
W1998166790
Cited by
442
References
121
Citations by year
2026: 4 · 2025: 4 · 2024: 4 · 2023: 7 · 2022: 10 · 2021: 16 · 2020: 19 · 2019: 9 · 2018: 9 · 2017: 27 · 2016: 26 · 2015: 23 · 2014: 30 · 2013: 35 · 2012: 34
FWCI
3.51
Type
journal article
Language
en
Open access
Locations
  • Development (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Keywords
planar cell polarity, tissue polarity, vertebrate development, left-right asymmetry, neural tube closure, tubulogenesis, cell migration, spatial patterning
MeSH terms
Animals, Drosophila, Vertebrates, Signal Transduction, Cell Polarity, Body Patterning, Organogenesis

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