Tissue/planar cell polarity in vertebrates: new insights and new questions
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This review focuses on the tissue/planar cell polarity (PCP) pathway and its role in generating spatial patterns in vertebrates. Current evidence suggests that PCP integrates both global and local signals to orient diverse structures with respect to the body axes. Interestingly, the system acts on both subcellular structures, such as hair bundles in auditory and vestibular sensory neurons, and multicellular structures, such as hair follicles. Recent work has shown that intriguing connections exist between the PCP-based orienting system and left-right asymmetry, as well as between the oriented cell movements required for neural tube closure and tubulogenesis. Studies in mice, frogs and zebrafish have revealed that similarities, as well as differences, exist between PCP in Drosophila and vertebrates.
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In vertebrates, planar cell polarity organization underlies the organization and orientation of stereocilia in the sensory epithelium of the inner ear, the organization of hair follicles, and the morphology and migratory behavior of dorsal mesodermal cells undergoing gastrulation.
“In vertebrates, this organization has been shown to underlie the organization and orientation of stereo- cilia in the sensory epithelium of the inner ear, the organization of hair follicles, and the morphology and migratory behavior of dorsal mesodermal cells undergoing gastrulation.61”
From Wnt signal transduction pathways (2008) · cites this paper as [61]
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Multicellular dynamics during epithelial elongation
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Qu, Y., Huang, Y., Feng, J., Álvarez-Bolado, G., Grove, E. A., Yang, Y., Tissir, F., Zhou, L., & Goffinet, A. M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1402105111 · Cited by 83 · see citing works
Yang, W., Garrett, L. J., Feng, D., Elliott, G., Liu, X., Wang, N., Wong, Y. M., Choi, N. T., Yang, Y., & Gao, B. (2017) · Cell Research · doi:10.1038/cr.2017.127 · Cited by 83 · see citing works
The Tangled Web of Non-Canonical Wnt Signalling in Neural Migration
Clark, C., Nourse, C. C., & Cooper, H. M. (2012) · Neurosignals · doi:10.1159/000332153 · Cited by 81 · see citing works
Takagishi, M., Sawada, M., Ohata, S., Asai, N., Enomoto, A., Takahashi, K., Weng, L., Ushida, K., Ara, H., Matsui, S., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.06.089 · Cited by 81 · see citing works
Wang, G., Cadwallader, A. B., Jang, D. S., Tsang, M., Yost, H. J., & Amack, J. D. (2010) · Development · doi:10.1242/dev.052985 · Cited by 80 · see citing works
Strutt, D. I., & Warrington, S. J. (2008) · Development · doi:10.1242/dev.025205 · Cited by 80 · see citing works
The Dishevelled Protein Family
Mlodzik, M. (2016) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2015.11.027 · Cited by 78 · see citing works
- Authors
- Wang, Y., & Nathans, J.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2007-02-15
- Volume
- 134
- Issue
- 4
- Pages
- 647-658
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1998166790
- Cited by
- 442
- References
- 121
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 4 · 2023: 7 · 2022: 10 · 2021: 16 · 2020: 19 · 2019: 9 · 2018: 9 · 2017: 27 · 2016: 26 · 2015: 23 · 2014: 30 · 2013: 35 · 2012: 34
- FWCI
- 3.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Development (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Keywords
- planar cell polarity, tissue polarity, vertebrate development, left-right asymmetry, neural tube closure, tubulogenesis, cell migration, spatial patterning
- MeSH terms
- Animals, Drosophila, Vertebrates, Signal Transduction, Cell Polarity, Body Patterning, Organogenesis
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