Vitamin D as a neurosteroid affecting the developing and adult brain
Open accessAbstract
Vitamin D deficiency is prevalent throughout the world, and growing evidence supports a requirement for optimal vitamin D levels for the healthy developing and adult brain. Vitamin D has important roles in proliferation and differentiation, calcium signaling within the brain, and neurotrophic and neuroprotective actions; it may also alter neurotransmission and synaptic plasticity. Recent experimental studies highlight the impact that vitamin D deficiency has on brain function in health and disease. In addition, results from recent animal studies suggest that vitamin D deficiency during adulthood may exacerbate underlying brain disorders and/or worsen recovery from brain stressors. An increasing number of epidemiological studies indicate that vitamin D deficiency is associated with a wide range of neuropsychiatric disorders and neurodegenerative diseases. Vitamin D supplementation is readily available and affordable, and this review highlights the need for further research.
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Depending on the timing of exposure to low vitamin D status, different brain areas might be affected and the consequence might be different neurodevelopment and cognitive outcomes in infants.
“These findings suggest that depending on the timing of the exposure to low vitamin D status, different brain areas might be affected and the consequence might be different neurodevelopment and cognitive outcomes in infants [105].”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [105]
Mounting evidence suggests that low vitamin D status is involved in the aetiology of the abnormalities associated with ASD.
“Mounting evidence suggests that low vitamin D status is involved in the aetiology of the mentioned abnormalities [105].”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [105]
Neurotrophins are involved in the development, maintenance, survival, and synapsis of neurons.
“Neurotrophins are involved in the development, maintenance, survival and synapsis of neurons [105].”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [105]
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Seasonality of birth in Epilepsy: A Southern Hemisphere study
Procopio, M., Marriott, P. K., & Davies, R. J. E. (2005) · Seizure · doi:10.1016/j.seizure.2005.10.001 · Cited by 36 · see citing works
Keilhoff, G., Grecksch, G., & Becker, A. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.04.010 · Cited by 34 · see citing works
Schizophrenia and vitamin D related genes could have been subject to latitude-driven adaptation
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Season of birth: aetiological implications for epilepsy
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Vitamin D Deficiency Impairs Spatial Learning in Adult Rats
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Vitamin D and Autism Spectrum Disorder: A Literature Review
Mazahery, H., Camargo, C., Conlon, C., Beck, K., Kruger, M., & Von Hurst, P. (2016) · Nutrients · doi:10.3390/nu8040236 · Cited by 110 · see citing works
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Biological pathways associated with vitamins in autism spectrum disorder
Gusso, D., Prauchner, G. R. K., Rieder, A. S., & Wyse, A. T. S. (2023) · Neurotoxicity Research · doi:10.1007/s12640-023-00674-z · Cited by 10 · see citing works
- Authors
- Groves, N. J., McGrath, J. J., & Burne, T. H. J.
- Affiliations
- The University of Queensland (AU)
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 2014-07-17
- Volume
- 34
- Issue
- 1
- Pages
- 117-141
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- OpenAlex
- W2101714022
- Cited by
- 256
- References
- 211
- Citations by year
- 2026: 22 · 2025: 23 · 2024: 15 · 2023: 28 · 2022: 28 · 2021: 20 · 2020: 26 · 2019: 22 · 2018: 21 · 2017: 23 · 2016: 12 · 2015: 13 · 2014: 3
- FWCI
- 2.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annual Review of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- National Health and Medical Research Council (1070081)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin K Research Studies
- Keywords
- vitamin D, neurosteroids, vitamin D deficiency, brain development, neuroprotection, calcium signaling, neurotrophic factors, synaptic plasticity, neurotransmission, neuropsychiatric disorders, neurodegenerative diseases, vitamin D supplementation
- MeSH terms
- Animals, Mental Disorders, Brain, Humans, Models, Biological, Neurons, Vitamin D, Vitamin D Deficiency, Neurotransmitter Agents, Neuroprotective Agents, Dietary Supplements, Neurodegenerative Diseases, Neurogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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