Cited by 256Vitamin D Research StudiesNeurological Disease Mechanisms and TreatmentsVitamin K Research Studies

Vitamin D as a neurosteroid affecting the developing and adult brain

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Groves, Natalie J., McGrath, John J., Burne, Thomas H.J.·2014·Annual Review of Nutrition

Abstract

Vitamin D deficiency is prevalent throughout the world, and growing evidence supports a requirement for optimal vitamin D levels for the healthy developing and adult brain. Vitamin D has important roles in proliferation and differentiation, calcium signaling within the brain, and neurotrophic and neuroprotective actions; it may also alter neurotransmission and synaptic plasticity. Recent experimental studies highlight the impact that vitamin D deficiency has on brain function in health and disease. In addition, results from recent animal studies suggest that vitamin D deficiency during adulthood may exacerbate underlying brain disorders and/or worsen recovery from brain stressors. An increasing number of epidemiological studies indicate that vitamin D deficiency is associated with a wide range of neuropsychiatric disorders and neurodegenerative diseases. Vitamin D supplementation is readily available and affordable, and this review highlights the need for further research.

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Crossref · 10.1146/annurev-nutr-071813-105557

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  • Depending on the timing of exposure to low vitamin D status, different brain areas might be affected and the consequence might be different neurodevelopment and cognitive outcomes in infants.

    “These findings suggest that depending on the timing of the exposure to low vitamin D status, different brain areas might be affected and the consequence might be different neurodevelopment and cognitive outcomes in infants [105].”

    From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [105]

  • Mounting evidence suggests that low vitamin D status is involved in the aetiology of the abnormalities associated with ASD.

    “Mounting evidence suggests that low vitamin D status is involved in the aetiology of the mentioned abnormalities [105].”

    From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [105]

  • Neurotrophins are involved in the development, maintenance, survival, and synapsis of neurons.

    “Neurotrophins are involved in the development, maintenance, survival and synapsis of neurons [105].”

    From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [105]

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Authors
Groves, N. J., McGrath, J. J., & Burne, T. H. J.
Affiliations
The University of Queensland (AU)
Venue
Annual Review of Nutrition
Published
2014-07-17
Volume
34
Issue
1
Pages
117-141
ISSN
  • 0199-9885 (ISSN-L)
  • 1545-4312
OpenAlex
W2101714022
Cited by
256
References
211
Citations by year
2026: 22 · 2025: 23 · 2024: 15 · 2023: 28 · 2022: 28 · 2021: 20 · 2020: 26 · 2019: 22 · 2018: 21 · 2017: 23 · 2016: 12 · 2015: 13 · 2014: 3
FWCI
2.40
Type
journal article
Language
en
Open access
Locations
  • Annual Review of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Medical Research Council
  • National Health and Medical Research Council (1070081)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
  • Health Sciences › Nursing › Nutrition and Dietetics › Vitamin K Research Studies
Keywords
vitamin D, neurosteroids, vitamin D deficiency, brain development, neuroprotection, calcium signaling, neurotrophic factors, synaptic plasticity, neurotransmission, neuropsychiatric disorders, neurodegenerative diseases, vitamin D supplementation
MeSH terms
Animals, Mental Disorders, Brain, Humans, Models, Biological, Neurons, Vitamin D, Vitamin D Deficiency, Neurotransmitter Agents, Neuroprotective Agents, Dietary Supplements, Neurodegenerative Diseases, Neurogenesis

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