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Seizure detection, seizure prediction, and closed-loop warning systems in epilepsy
Open accessAbstract
Nearly one-third of patients with epilepsy continue to have seizures despite optimal medication management. Systems employed to detect seizures may have the potential to improve outcomes in these patients by allowing more tailored therapies and might, additionally, have a role in accident and SUDEP prevention. Automated seizure detection and prediction require algorithms which employ feature computation and subsequent classification. Over the last few decades, methods have been developed to detect seizures utilizing scalp and intracranial EEG, electrocardiography, accelerometry and motion sensors, electrodermal activity, and audio/video captures. To date, it is unclear which combination of detection technologies yields the best results, and approaches may ultimately need to be individualized. This review presents an overview of seizure detection and related prediction methods and discusses their potential uses in closed-loop warning systems in epilepsy.
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“There is also a growing interest in using wearable devices to detect seizures in epilepsy [2].”
From Wearable sensors for clinical applications in epilepsy, Parkinson’s disease, and stroke: A mixed-methods systematic review (2018) · cites this paper as [2]
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Rubboli, G., Beniczky, S., Claus, S. P., Canevini, M. P., Kahane, P., Stefan, H., Boas, W. V. E., Velis, D. N., Reus, E., Gil‐Nagel, A., et al. (2015) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2015.02.004 · Cited by 54
Alkawadri, R. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00191 · Cited by 53
Epileptic seizure onset detection based on EEG and ECG data fusion
Qaraqe, M., Ismail, M., Serpedin, E., & Haneef, Z. (2016) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2016.02.039 · Cited by 52
An Automatic Prediction of Epileptic Seizures Using Cloud Computing and Wireless Sensor Networks
Sareen, S., Sood, S. K., & Gupta, S. K. (2016) · Journal of Medical Systems · doi:10.1007/s10916-016-0579-1 · Cited by 52
Behnam, M., & Pourghassem, H. (2016) · Computer Methods and Programs in Biomedicine · doi:10.1016/j.cmpb.2016.04.014 · Cited by 51
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Akbarian, B., & Erfanian, A. (2020) · Biomedical Signal Processing and Control · doi:10.1016/j.bspc.2020.101878 · Cited by 50
Seizure Forecasting and the Preictal State in Canine Epilepsy
Varatharajah, Y., Iyer, R. K., Berry, B. M., Worrell, G. A., & Brinkmann, B. H. (2016) · International Journal of Neural Systems · doi:10.1142/s0129065716500465 · Cited by 51
Deep Architectures for Automated Seizure Detection in Scalp EEGsPreprint
Golmohammadi, M., Ziyabari, S., Shah, V., de Diego, S. L., Obeid, I., & Picone, J. (2017) · arXiv (Cornell University) · doi:10.48550/arxiv.1712.09776 · Cited by 51
Shorter latency of real-time epileptic seizure detection via probabilistic prediction
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Time Series Classification by Sequence Learning in All-Subsequence Space
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Deep Architectures for Spatio-Temporal Modeling: Automated Seizure Detection in Scalp EEGs
Golmohammadi, M., Ziyabari, S., Shah, V., Obeid, I., & Picone, J. (2018) · International Conference on Machine Learning and Applications · doi:10.1109/icmla.2018.00118 · Cited by 47
Susam, B. T., Riek, N. T., Akçakaya, M., Xu, X., de Sa, V. R., Nezamfar, H., Díaz, D., Craig, K. D., Goodwin, M. S., & Huang, J. S. (2021) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2021.3096137 · Cited by 47
Early seizure detection for closed loop direct neurostimulation devices in epilepsy
Dümpelmann, M. (2019) · Journal of Neural Engineering · doi:10.1088/1741-2552/ab094a · Cited by 47
A review on the pattern detection methods for epilepsy seizure detection from EEG signals
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Capturing time-varying brain dynamics
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Metadata
- Authors
- Ramgopal, S., Thome-Souza, S., Jackson, M., Kadish, N. E., Sánchez Fernández, I., Klehm, J., Bosl, W., Reinsberger, C., Schachter, S., & Loddenkemper, T.
- Affiliations
- Boston Children's Hospital (US)
- University of San Francisco (US)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Corresponding author
- Loddenkemper, Tobias
- ORCID
- Venue
- Epilepsy & Behavior
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 37
- Pages
- 291-307
- ISSN
- 1525-5050 (ISSN-L)
- OpenAlex
- W2133082272
- Cited by
- 469
- References
- 151
- Citations by year
- 2026: 18 · 2025: 19 · 2024: 30 · 2023: 17 · 2022: 25 · 2021: 55 · 2020: 53 · 2019: 52 · 2018: 72 · 2017: 50 · 2016: 43 · 2015: 32 · 2014: 2
- FWCI
- 23.57
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Epilepsy & Behavior (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- USF Scholarship Repository (University of San Francisco) (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Physical Sciences › Computer Science › Artificial Intelligence › Seismology and Earthquake Studies
- Keywords
- epilepsy, seizure detection, seizure prediction, automated seizure detection, intracranial EEG, scalp EEG, accelerometry, electrodermal activity, SUDEP prevention, accident prevention, feature extraction, machine learning classifiers
- MeSH terms
- Adolescent, Algorithms, Child, Child, Preschool, Electrocardiography, Electroencephalography, Epilepsy, Humans, Markov Chains, Motion, Predictive Value of Tests, Scalp, Seizures, Sensitivity and Specificity
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