Poly(ADP-ribose) polymerases in double-strand break repair: Focus on PARP1, PARP2 and PARP3

The DNA-damage response in human biology and disease

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Poly(ADP-ribose): novel functions for an old molecule

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New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs

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ATM Signaling Facilitates Repair of DNA Double-Strand Breaks Associated with Heterochromatin

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PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways

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DNA Double-Strand Break Repair: All's Well that Ends Well

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Involvement of Poly(ADP-ribose) Polymerase-1 and XRCC1/DNA Ligase III in an Alternative Route for DNA Double-strand Breaks Rejoining

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Mechanism of homologous recombination: mediators and helicases take on regulatory functions

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Structural Basis for DNA Damage–Dependent Poly(ADP-ribosyl)ation by Human PARP-1

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PARP1-dependent Kinetics of Recruitment of MRE11 and NBS1 Proteins to Multiple DNA Damage Sites

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IgH class switching and translocations use a robust non-classical end-joining pathway

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PARP is activated at stalled forks to mediate Mre11‐dependent replication restart and recombination

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Topoisomerase I poisoning results in PARP-mediated replication fork reversal

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The diverse roles and clinical relevance of PARPs in DNA damage repair: Current state of the art

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Is Non-Homologous End-Joining Really an Inherently Error-Prone Process?

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Proteome-wide identification of poly(ADP-ribose) binding proteins and poly(ADP-ribose)-associated protein complexes

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Recruitment of DNA methyltransferase I to DNA repair sites

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Mre11-Dependent Degradation of Stalled DNA Replication Forks Is Prevented by BRCA2 and PARP1

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Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1

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PARP-3 and APLF Function Together to Accelerate Nonhomologous End-Joining

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Function of BRCA1 in the DNA Damage Response Is Mediated by ADP-Ribosylation

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Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination

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Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression

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Parp‐1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells

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The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks

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PARP-2 and PARP-3 are selectively activated by 5′ phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1

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Stimulation of the DNA-dependent Protein Kinase by Poly(ADP-Ribose) Polymerase

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Ablation of PARP-1 does not interfere with the repair of DNA double-strand breaks, but compromises the reactivation of stalled replication forks

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Crystal Structures of Poly(ADP-ribose) Polymerase-1 (PARP-1) Zinc Fingers Bound to DNA

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The alternative end-joining pathway for repair of DNA double-strand breaks requires PARP1 but is not dependent upon microhomologies

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Parp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/c-myc translocations during immunoglobulin class switch recombination

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HP1α recruitment to DNA damage by p150CAF-1 promotes homologous recombination repair

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Chromosome Translocation, B Cell Lymphoma, and Activation-Induced Cytidine Deaminase

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Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis

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Poly(ADP-ribose) Polymerase and Ku Autoantigen Form a Complex and Synergistically Bind to Matrix Attachment Sequences

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The DNA-Binding Domain of Human PARP-1 Interacts with DNA Single-Strand Breaks as a Monomer through Its Second Zinc Finger

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Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects

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Toward specific functions of poly(ADP-ribose) polymerase-2

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Role for DNA repair factor XRCC4 in immunoglobulin class switch recombination

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Modulation of DNMT1 activity by ADP-ribose polymers

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The expanding field of poly(ADP‐ribosyl)ation reactions

Hakmé, A., Wong, H., Dantzer, F., & Schreiber, V. (2008) · EMBO Reports · doi:10.1038/embor.2008.191 · Cited by 148 · see citing works

CCCTC-binding Factor Activates PARP-1 Affecting DNA Methylation Machinery

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PARP‐2 deficiency affects the survival of CD4+CD8+ double‐positive thymocytes

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BAL1 and Its Partner E3 Ligase, BBAP, Link Poly(ADP-Ribose) Activation, Ubiquitylation, and Double-Strand DNA Repair Independent of ATM, MDC1, and RNF8

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Rapid and transient recruitment of DNMT1 to DNA double-strand breaks is mediated by its interaction with multiple components of the DNA damage response machinery

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PARP‐3 associates with polycomb group bodies and with components of the DNA damage repair machinery

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Generation of a nicking enzyme that stimulates site-specific gene conversion from the I-AniI LAGLIDADG homing endonuclease

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PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways

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Interactive effects of inhibitors of poly(ADP-ribose) polymerase and DNA-dependent protein kinase on cellular responses to DNA damage

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The expanding field of poly(ADP‐ribosyl)ation reactions. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

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Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repair

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Visualization of a DNA-PK/PARP1 complex

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DNA repair genes are selectively mutated in diffuse large B cell lymphomas

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Novel method for site-specific induction of oxidative DNA damage reveals differences in recruitment of repair proteins to heterochromatin and euchromatin

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The role of poly(ADP-ribosyl)ation in epigenetic events

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PARG is dispensable for recovery from transient replicative stress but required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress

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New readers and interpretations of poly(ADP-ribosyl)ation

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Double strand break (DSB) repair in heterochromatin and heterochromatin proteins in DSB repair

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Histone H1 functions as a stimulatory factor in backup pathways of NHEJ

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Mobilization and recruitment of HP1β: A bimodal response to DNA breakage

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DNMT1 deficiency triggers mismatch repair defects in human cells through depletion of repair protein levels in a process involving the DNA damage response

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Competition between PARP-1 and Ku70 control the decision between high-fidelity and mutagenic DNA repair

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DNA Nicks Promote Efficient and Safe Targeted Gene Correction

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The PARP3- and ATM-dependent phosphorylation of APLF facilitates DNA double-strand break repair

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The histone subcode: poly(ADP‐ribose) polymerase‐1 (Parp‐1) and Parp‐2 control cell differentiation by regulating the transcriptional intermediary factor TIF1β and the heterochromatin protein HPlα

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The expanding role of PARP s in the establishment and maintenance of heterochromatin

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The absence of Ku but not defects in classical non-homologous end-joining is required to trigger PARP1-dependent end-joining

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Loss of poly(ADP-ribose) polymerase-2 leads to rapid development of spontaneous T-cell lymphomas in p53-deficient mice

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Does Poly(ADP-ribosyl)ation Regulate the DNA Methylation Pattern?

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Poly(ADP‐ribose) polymerase‐1 (Parp‐1)‐deficient mice demonstrate abnormal antibody responses

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PARP-3, a DNA-dependent PARP with emerging roles in double-strand break repair and mitotic progression

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Differential Requirement for H2AX and 53BP1 in Organismal Development and Genome Maintenance in the Absence of Poly(ADP)ribosyl Polymerase 1

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PARP1 and DNA-PKcs synergize to suppress p53 mutation and telomere fusions during T-lineage lymphomagenesis

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NAD+ metabolism and its roles in cellular processes during ageing

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PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes

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Degradation of proteins by PROTACs and other strategies

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From “Cellular” RNA to “Smart” RNA: Multiple Roles of RNA in Genome Stability and Beyond

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Nicotinamide phosphoribosyltransferase in smooth muscle cells maintains genome integrity, resists aortic medial degeneration, and is suppressed in human thoracic aortic aneurysm disease

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Targeting the DNA Damage Response and DNA Repair Pathways to Enhance Radiosensitivity in Colorectal Cancer

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PARP Inhibitors Display Differential Efficacy in Models of BRCA Mutant High-Grade Serous Ovarian Cancer

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Investigation of the relative biological effectiveness and uniform isobiological killing effects of irradiation with a clinical carbon SOBP beam on DNA repair deficient CHO cells

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PARP1 Is Required for ATM-Mediated p53 Activation and p53-Mediated Gene Expression after Ionizing Radiation

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Unsprung traps keep PARP inhibitors effective

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ADP-ribose contributions to genome stability and PARP enzyme trapping on sites of DNA damage; paradigm shifts for a coming-of-age modification

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A Review on Poly (ADP-ribose) Polymerase (PARP) - An Enzyme that Share the ability to Catalyze the Transfer of ADP-Ribose to Target Proteins

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