The DOI matches its Crossref record; 295 of the 295 references it cites were found in a registry or an index.
Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication
Abstract
As exemplified particularly with vasopressin and oxytocin, release of neuropeptides within the brain occurs from dendrites, somata, and axons of neurosecretory neurons; mechanisms include activation of intracellular Ca2+ stores, changed strength of synaptic input and altered interaction between transcription factors and gene promoters. Upon demand, both diffuse spread of neuropeptides in the extracellular fluid following dendritic release and focal release from axonal terminals may contribute to regionally and temporally varying combinations of neuromodulator and neurotransmitter actions, thus providing a theoretically unlimited variability in interneuronal signaling. Thus, instead of favoring volume or synaptic transmission following central neuropeptide release, a more dynamic concept is presented with multiple and variable modes of release and communication. This concept considers neuropeptides in the extracellular fluid of the brain rather than those in the cerebrospinal fluid or plasma as primary signals, triggering a variety of receptor-mediated effects, including those underlying behavioral and neuroendocrine regulation and psychopathology.
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In the citing paper
“effects of a single neuropharmacological challenge might differ considerably from endogenous OT mechanisms”
From Sex-specific effects of intranasal oxytocin on autonomic nervous system and emotional responses to couple conflict (2013) · cites this paper as Landgraf and Neumann, 2004
In the citing paper
“These regions are the primary producers of OXT, which is released into both the blood and the brain in response to reproductive stimuli (e.g. birth, suckling, sex) as well as social interaction and stressors (Landgraf and Neumann, 2004).”
From Convergence of oxytocin and dopamine signalling in neuronal circuits: Insights into the neurobiology of social interactions across species (2024) · cites this paper as Landgraf and Neumann, 2004
In the citing paper
“A more global form of OT and AVP release can occur when these neuropeptides are released from non-synaptic regions of neurons (e.g., dendrites) (Figure 6) [108; 109; 110].”
From Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery (2018) · cites this paper as [109]
In the citing paper
“Both published case studies 67 and anecdotal evidence 68 suggest off-label prescriptions of oxytocin are already a common practice by treating clinicians, despite concerns about pediatric use outside of a clinical trial setting.69”
From Beyond the hype and hope: critical considerations for intranasal oxytocin research in autism spectrum disorder (2017) · cites this paper as [69]
Citations
Cites
Vale, W., Spiess, J., RIVIER, C. L., & Rivier, J. (1982) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198205000-00013 · Cited by 3,904
Neurocircuitry of stress: central control of the hypothalamo–pituitary–adrenocortical axis
Herman, J. P., & Cullinan, W. E. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10069-2 · Cited by 2,270
Herman, J. P., Figueiredo, H., Mueller, N. K., Ulrich-Lai, Y., Ostrander, M. M., Choi, D. C., & Cullinan, W. E. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2003.07.001 · Cited by 1,586
The role of corticotropin-releasing factor in depression and anxiety disorders
Arborelius, L., Owens, M., Plotsky, P., & Nemeroff, C. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1600001 · Cited by 1,378
Chemical Signals in Vertebrates
Müller‐Schwarze, D., & Mozell, M. M. (1977) · Springer eBooks · doi:10.1007/978-1-4684-2364-8 · Cited by 1,151
Social amnesia in mice lacking the oxytocin gene
Ferguson, J. N., Young, L. J., Hearn, E. F., Matzuk, M. M., Insel, T. R., & Winslow, J. T. (2000) · Nature Genetics · doi:10.1038/77040 · Cited by 1,130
Candidate-gene approaches for studying complex genetic traits: practical considerations
Tabor, H. K., Risch, N. J., & Myers, R. M. (2002) · Nature Reviews Genetics · doi:10.1038/nrg796 · Cited by 1,076
The neurobiology and control of anxious states
Millan, M. J. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00087-x · Cited by 978
Extracellular space structure revealed by diffusion analysis
Nicholson, C., & Syková, E. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01261-2 · Cited by 914
NEURAL CONTROL OF THE PITUITARY GLAND
Harris, G. W. (1948) · Physiological Reviews · doi:10.1152/physrev.1948.28.2.139 · Cited by 903
Cited by
Sorted by citations
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690
Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3044 · Cited by 1,688
Joëls, M., & Baram, T. Z. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2632 · Cited by 1,521
Oxytocin improves “mind-reading” in humans
Domes, G., Heinrichs, M., Michel, A., Berger, C., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.015 · Cited by 1,298
Oxytocin shapes the neural circuitry of trust and trust adaptation in humans
Baumgartner, T., Heinrichs, M., Vonlanthen, A., Fischbacher, U., & Fehr, E. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.009 · Cited by 1,258
Metadata
- Authors
- Landgraf, R., & Neumann, I. D.
- Affiliations
- Max Planck Society (DE)
- University of Regensburg (DE)
- Corresponding author
- Landgraf, Rainer
- ORCID
- Neumann, Inga D.
- Venue
- Frontiers in Neuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2004-09
- Volume
- 25
- Issue
- 3-4
- Pages
- 150-176
- ISSN
- 0091-3022 (ISSN-L)
- OpenAlex
- W1996368170
- Cited by
- 1,059
- References
- 295
- Citations by year
- 2026: 24 · 2025: 25 · 2024: 38 · 2023: 38 · 2022: 48 · 2021: 52 · 2020: 61 · 2019: 47 · 2018: 54 · 2017: 59 · 2016: 60 · 2015: 54 · 2014: 61 · 2013: 66 · 2012: 61
- FWCI
- 43.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Frontiers in Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- University of Regensburg Publication Server (University of Regensburg) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- vasopressin, oxytocin, neuropeptide release, dendritic release, neurosecretory cells, intracellular calcium stores, synaptic input, transcription factors, neuromodulation, neuroendocrine regulation, psychopathology
- MeSH terms
- Animals, Brain, Cell Communication, Humans, Nerve Net, Neurons, Oxytocin, Vasopressins, Feedback, Physiological
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