Cited by 1,059Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyNeuroscience and Neuropharmacology Research

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Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication

Landgraf, Rainer, Neumann, Inga D.·2004·Frontiers in Neuroendocrinology

DOI 10.1016/j.yfrne.2004.05.001

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Abstract

As exemplified particularly with vasopressin and oxytocin, release of neuropeptides within the brain occurs from dendrites, somata, and axons of neurosecretory neurons; mechanisms include activation of intracellular Ca2+ stores, changed strength of synaptic input and altered interaction between transcription factors and gene promoters. Upon demand, both diffuse spread of neuropeptides in the extracellular fluid following dendritic release and focal release from axonal terminals may contribute to regionally and temporally varying combinations of neuromodulator and neurotransmitter actions, thus providing a theoretically unlimited variability in interneuronal signaling. Thus, instead of favoring volume or synaptic transmission following central neuropeptide release, a more dynamic concept is presented with multiple and variable modes of release and communication. This concept considers neuropeptides in the extracellular fluid of the brain rather than those in the cerebrospinal fluid or plasma as primary signals, triggering a variety of receptor-mediated effects, including those underlying behavioral and neuroendocrine regulation and psychopathology.

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Authors: Landgraf, R., & Neumann, I. D.
Affiliations: Max Planck Society (DE)
University of Regensburg (DE)
Corresponding author: Landgraf, Rainer
ORCID: Neumann, Inga D.
Venue: Frontiers in Neuroendocrinology
Publisher: Elsevier BV
Published: 2004-09
Volume: 25
Issue: 3-4
Pages: 150-176
ISSN: 0091-3022 (ISSN-L)
DOI: 10.1016/j.yfrne.2004.05.001
OpenAlex: W1996368170
Cited by: 1,059
References: 295
Citations by year: 2026: 24 · 2025: 25 · 2024: 38 · 2023: 38 · 2022: 48 · 2021: 52 · 2020: 61 · 2019: 47 · 2018: 54 · 2017: 59 · 2016: 60 · 2015: 54 · 2014: 61 · 2013: 66 · 2012: 61
FWCI: 43.49
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Frontiers in Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
Max Planck Institute for Plasma Physics (submittedVersion)
University of Regensburg Publication Server (University of Regensburg) (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: vasopressin, oxytocin, neuropeptide release, dendritic release, neurosecretory cells, intracellular calcium stores, synaptic input, transcription factors, neuromodulation, neuroendocrine regulation, psychopathology
MeSH terms: Animals, Brain, Cell Communication, Humans, Nerve Net, Neurons, Oxytocin, Vasopressins, Feedback, Physiological

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Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication

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