Cited by 769Stress Responses and CortisolHormonal and reproductive studiesAdrenal Hormones and Disorders

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Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS)

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Maninger, Nicole, Wolkowitz, Owen M., Reus, Victor I., Epel, Elissa S., Mellon, Synthia H.·2009·Frontiers in Neuroendocrinology

DOI 10.1016/j.yfrne.2008.11.002PMC PMC2725024

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Abstract

DHEA and DHEAS are steroids synthesized in human adrenals, but their function is unclear. In addition to adrenal synthesis, evidence also indicates that DHEA and DHEAS are synthesized in the brain, further suggesting a role of these hormones in brain function and development. Despite intensifying research into the biology of DHEA and DHEAS, many questions concerning their mechanisms of action and their potential involvement in neuropsychiatric illnesses remain unanswered. We review and distill the preclinical and clinical data on DHEA and DHEAS, focusing on (i) biological actions and putative mechanisms of action, (ii) differences in endogenous circulating concentrations in normal subjects and patients with neuropsychiatric diseases, and (iii) the therapeutic potential of DHEA in treating these conditions. Biological actions of DHEA and DHEAS include neuroprotection, neurite growth, and antagonistic effects on oxidants and glucocorticoids. Accumulating data suggest abnormal DHEA and/or DHEAS concentrations in several neuropsychiatric conditions. The evidence that DHEA and DHEAS may be fruitful targets for pharmacotherapy in some conditions is reviewed.

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O.M. Wolkowitz, V.I. Reus, N. Maninger, S.H. Mellon, Dehydroepiandrosterone in the treatment of neuropsychiatric conditions. in: D. Mischoulon, J.F. Rosenbaum (Eds.), Natural Medications for Psychiatric Disorders: Considering the Alternatives, Second Edition, Lippincott Williams & Wilkins, Philadelphia, PA, 2008, pp. 84–104.

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Authors: Maninger, N., Wolkowitz, O. M., Reus, V. I., Epel, E. S., & Mellon, S. H.
Affiliations: University of California, San Francisco (US)
Corresponding author: Mellon, Synthia H.
ORCID: Wolkowitz, Owen M.
Reus, Victor I.
Epel, Elissa S.
Mellon, Synthia H.
Venue: Frontiers in Neuroendocrinology
Publisher: Elsevier BV
Published: 2009-01
Volume: 30
Issue: 1
Pages: 65-91
ISSN: 0091-3022 (ISSN-L)
DOI: 10.1016/j.yfrne.2008.11.002
PMC: PMC2725024
OpenAlex: W2042430625
Cited by: 769
References: 365
Citations by year: 2026: 38 · 2025: 45 · 2024: 36 · 2023: 45 · 2022: 39 · 2021: 47 · 2020: 70 · 2019: 41 · 2018: 59 · 2017: 45 · 2016: 51 · 2015: 34 · 2014: 47 · 2013: 47 · 2012: 49
FWCI: 1.73
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Frontiers in Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (T32 MH09391)
National Institute of Neurological Disorders and Stroke (NS 049462, U01NS049462)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: dehydroepiandrosterone, DHEA sulfate, neuropsychiatric disorders, neuroprotection, neurite outgrowth, glucocorticoid antagonism, oxidative stress, adrenal steroids
MeSH terms: Adult, Aged, Aging, Animals, Antioxidants, Brain, Dehydroepiandrosterone, Dementia, Depression, Female, Humans, Male, Middle Aged, Schizophrenia, Stress Disorders, Post-Traumatic, Neuroprotective Agents, Dehydroepiandrosterone Sulfate, Hypoxia-Ischemia, Brain

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Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS)

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