Cited by 769Stress Responses and CortisolHormonal and reproductive studiesAdrenal Hormones and Disorders

The DOI matches its Crossref record; 365 of the 365 references it cites were found in a registry or an index.

Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS)

Open access

Maninger, Nicole, Wolkowitz, Owen M., Reus, Victor I., Epel, Elissa S., Mellon, Synthia H.·2009·Frontiers in Neuroendocrinology

DOI 10.1016/j.yfrne.2008.11.002PMC PMC2725024

Open this paper in CoChat — free account

Abstract

DHEA and DHEAS are steroids synthesized in human adrenals, but their function is unclear. In addition to adrenal synthesis, evidence also indicates that DHEA and DHEAS are synthesized in the brain, further suggesting a role of these hormones in brain function and development. Despite intensifying research into the biology of DHEA and DHEAS, many questions concerning their mechanisms of action and their potential involvement in neuropsychiatric illnesses remain unanswered. We review and distill the preclinical and clinical data on DHEA and DHEAS, focusing on (i) biological actions and putative mechanisms of action, (ii) differences in endogenous circulating concentrations in normal subjects and patients with neuropsychiatric diseases, and (iii) the therapeutic potential of DHEA in treating these conditions. Biological actions of DHEA and DHEAS include neuroprotection, neurite growth, and antagonistic effects on oxidants and glucocorticoids. Accumulating data suggest abnormal DHEA and/or DHEAS concentrations in several neuropsychiatric conditions. The evidence that DHEA and DHEAS may be fruitful targets for pharmacotherapy in some conditions is reviewed.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.yfrne.2008.11.002

Cites

365 of 365 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A molecular and cellular theory of depression
Duman, R. S. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830190015002 · Cited by 2,129
Cortisol levels during human aging predict hippocampal atrophy and memory deficits
Lupien, S. J., de Leon, M., de Santi, S., Convit, A., Tarshish, C., Nair, N. P. V., Thakur, M., McEwen, B. S., Hauger, R. L., & Meaney, M. J. (1998) · Nature Neuroscience · doi:10.1038/271 · Cited by 1,653
Textbook of Rheumatology
Kelley, W. N. (1985) · Virtual Defense Library (Ministerio de Defensa) · Cited by 1,641
Protection and damage from acute and chronic stress: allostasis and allostatic overload and relevance to the pathophysiology of psychiatric disorders
MCEWEN, B. S. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1314.001 · Cited by 1,638
Psychobiological mechanisms of resilience and vulnerability: implications for successful adaptation to extreme stress
Charney, D. S. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.2.195 · Cited by 1,605
Allostatic load as a marker of cumulative biological risk: MacArthur studies of successful aging
Seeman, T. E., McEwen, B. S., Rowe, J. W., & Singer, B. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081072698 · Cited by 1,385 · cited 2×
“[146,279].”
Background
Mechanisms and consequences of activation of protein kinase B/Akt
Downward, J. (1998) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(98)80149-x · Cited by 1,304
Neurosteroids: Endogenous bimodal modulators of the GABAA receptor mechanism of action and physiological significance
Majewska, M. D. (1992) · Progress in Neurobiology · doi:10.1016/0301-0082(92)90025-a · Cited by 1,089
Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age.
Morales, A. J., Nolan, J. J., Nelson, J. C., & Yen, S. S. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.78.6.7515387 · Cited by 841
Neurosteroids: biosynthesis and function of these novel neuromodulators
Compagnone, N. A., & Mellon, S. H. (2000) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1999.0188 · Cited by 820
Self-citation
The possibility of neurotoxicity in the hippocampus in major depression: a primer on neuron death
Sapolsky, R. M. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00971-9 · Cited by 699
Intracrinology
Labrie, F. (1991) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(91)90116-a · Cited by 685
Developmental and Functional Biology of the Primate Fetal Adrenal Cortex*
Mesiano, S. A., & Jaffe, R. B. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.3.0304 · Cited by 676
Characterization and measurement of dehydroepiandrosterone sulfate in rat brain
Corpéchot, C., Robel, P., Axelson, M., Sjövall, J., & Baulieu, E. E. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.8.4704 · Cited by 656
Adult male rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017α and P450 aromatase localized in neurons
Hojo, Y., Hattori, T.-A., Enami, T., Furukawa, A., Suzuki, K., Ishii, H.-T., Mukai, H., Morrison, J. H., Janssen, W. G. M., Kominami, S., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2630225100 · Cited by 644
Dehydroepiandrosterone Replacement in Women with Adrenal Insufficiency
Arlt, W., Callies, F., van Vlijmen, J. C., Koehler, I., Reincke, M., Bidlingmaier, M., Huebler, D., Oettel, M., Ernst, M., Schulte, H. M., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909303411401 · Cited by 644
Untitled work
(1997) · PubMed · Cited by 643
Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives
Rupprecht, R., & Holsboer, F. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01399-5 · Cited by 640
NEUROSTEROIDS: A NOVEL FUNCTION OF THE BRAIN
Baulieu, E. E. (1998) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(98)00071-7 · Cited by 631
Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: contribution of the DHEAge Study to a sociobiomedical issue.
Baulieu, E.-E., Thomas, G., Legrain, S., Lahlou, N., Roger, M., Debuire, B., Faucounau, V., Girard, L., Hervy, M.-P., Latour, F., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.8.4279 · Cited by 577
DHEA in elderly women and DHEA or testosterone in elderly men.
Nair, K. S., Rizza, R. A., O'Brien, P., Dhatariya, K., Short, K. R., Nehra, A., Vittone, J. L., Klee, G. G., Basu, A., Basu, R., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa054629 · Cited by 566
Peroxisome Proliferator-activated Receptor α Activation Modulates Cellular Redox Status, Represses Nuclear Factor-κB Signaling, and Reduces Inflammatory Cytokine Production in Aging
Poynter, M. E., & Daynes, R. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.49.32833 · Cited by 556
Neurosteroids: biochemistry and clinical significance
Mellon, S. H., & Griffin, L. D. (2002) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(01)00503-3 · Cited by 538
Self-citation
DHEA and DHEA‐S: A Review
Kroboth, P. D., Salek, F. S., Pittenger, A. L., Fabian, T. J., & Frye, R. F. (1999) · The Journal of Clinical Pharmacology · doi:10.1177/00912709922007903 · Cited by 530
High, usual and impaired functioning in community-dwelling older men and women: Findings from the MacArthur Foundation Research Network on successful aging
Berkman, L. F., Seeman, T. E., Albert, M., Blazer, D. G., Kahn, R. L., Mohs, R. C., Finch, C. E., Schneider, E. L., Cotman, C. W., McClearn, G. E., et al. (1993) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(93)90112-e · Cited by 499
Sulfonation and molecular action
Strott, C. A. (2002) · Endocrine Reviews · doi:10.1210/er.2001-0040 · Cited by 487
Allostatic load as a predictor of functional decline
Karlamangla, A. S., Singer, B. H., McEwen, B. S., Rowe, J. W., & Seeman, T. E. (2002) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(02)00399-2 · Cited by 483
Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age [published erratum appears in J Clin Endocrinol Metab 1995 Sep;80(9):2799]
Morales, A. J. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.78.6.1360 · Cited by 458
The Textbook of Rheumatology.
Deighton, C., & PERKINS, P. (1997) · Annals of the Rheumatic Diseases · doi:10.1136/ard.56.11.639b · Cited by 456
Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicity
Kimonides, V. G., Khatibi, N. H., Svendsen, C. N., Sofroniew, M. V., & Herbert, J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.4.1852 · Cited by 438 · cited 6×
“A comparison of these two studies suggest that the actual timing of the ‘‘pretreatment” is important since pretreatment occurred 24 h prior to NMDA administration in the study by Kurata and colleagues [159] and 6 h prior to NMDA administration in the study by Kimonides and colleagues [149].”
BackgroundMethodResultInfluential
Neurosteroids, via sigma receptors, modulate the [3H]norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampus.
Monnet, F. P., Mahé, V, Robel, P., & Baulieu, E. E. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.9.3774 · Cited by 429
Neuroactive steroids: mechanisms of action and neuropsychopharmacological properties
Rupprecht, R. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00064-1 · Cited by 427
Double-blind treatment of major depression with dehydroepiandrosterone.
Wolkowitz, O. M., Reus, V. I., Keebler, A., Nelson, N., Friedland, M., Brizendine, L., & Roberts, E. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.4.646 · Cited by 411
Improvement in Mood and Fatigue after Dehydroepiandrosterone Replacement in Addison’s Disease in a Randomized, Double Blind Trial
Hunt, P. J., Gurnell, E. M., Huppert, F. A., Richards, C., Prevost, A. T., Wass, J. A. H., Herbert, J., & Chatterjee, V. K. K. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.12.7022 · Cited by 386 · cited 1×
“tive function, with three months of DHEA treatment [131].”
Background
Pregnenolone and its sulfate ester in the rat brain
Corpéchot, C., Synguelakis, M., Talha, S., Axelson, M., Sjövall, J., Vihko, R., Baulieu, E.-E., & Robel, P. (1983) · Brain Research · doi:10.1016/0006-8993(83)90797-7 · Cited by 385 · cited 2×
“after adrenalectomy and gonadectomy of rats [68,69].”
Background
Sulfated and unsulfated steroids modulate γ-aminobutyric acidA receptor function through distinct sites
Park-Chung, M., Malayev, A., Purdy, R. H., Gibbs, T. T., & Farb, D. H. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01381-5 · Cited by 356
Serum Dehydroepiandrosterone (DHEA) and DHEA Sulfate Are Negatively Correlated with Serum Interleukin-6 (IL-6), and DHEA Inhibits IL-6 Secretion from Mononuclear Cells in Man in Vitro: Possible Link between Endocrinosenescence and Immunosenescence
Straub, R. H., Konecná, L., Hrach, S., Rothe, G., Kreutz, M. P., Schölmerich, J., Falk, W., & Lang, B. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.6.4876 · Cited by 351
Endogenous sex hormones in men aged 40-80 years
Muller, M., den Tonkelaar, I., Thijssen, J., Grobbee, D., & van der Schouw, Y. (2003) · European Journal of Endocrinology · doi:10.1530/eje.0.1490583 · Cited by 346
Neurosteroid quantification in human brain regions: comparison between Alzheimer’s and nondemented patients
Weill-Engerer, S., David, J.-P., Sazdovitch, V., Liere, P., Eychenne, B., Pianos, A., Schumacher, M., Delacourte, A., Baulieu, E.-E., & Akwa, Y. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020878 · Cited by 333
Anti-glucocorticoid effects of dehydroepiandrosterone (DHEA).
Kalimi, M., Shafagoj, Y., Loria, R., Padgett, D., & Regelson, W. (1994) · Molecular and Cellular Biochemistry · doi:10.1007/bf00925945 · Cited by 328
Dehydroepiandrosterone: a potential signalling molecule for neocortical organization during development
Compagnone, N. A., & Mellon, S. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4678 · Cited by 327
Self-citation
Molecular Mechanism of Suppression of Testicular Steroidogenesis by Proinflammatory Cytokine Tumor Necrosis Factor Alpha
Hong, C. Y., Park, J. H., Ahn, R. S., Im, S., Choi, H., Soh, J., Mellon, S. H., & Lee, K. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.7.2593-2604.2004 · Cited by 322
Self-citation
Adrenarche: a survey of rodents, domestic animals and primates
CUTLER, G. B., GLENN, M., BUSH, M., HODGEN, G. D., GRAHAM, C. E., & LORIAUX, D. L. (1978) · Endocrinology · doi:10.1210/endo-103-6-2112 · Cited by 321
Dehydroepiandrosterone (DHEA) treatment of depression
Wolkowitz, O. M., Reus, V. I., Roberts, E., Manfredi, F., Chan, T., Raum, W. J., Ormiston, S., Johnson, R. C., Canick, J., Brizendine, L., et al. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00043-1 · Cited by 314
Self-citation
Biosynthesis and action of neurosteroids
Mellon, S. H., Griffin, L. D., & Compagnone, N. A. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00109-6 · Cited by 305
Self-citation
Relationships Among Plasma Dehydroepiandrosterone Sulfate and CortisolLevels, Symptoms of Dissociation, and Objective Performance in Humans Exposedto Acute Stress
Morgan, C. A., Southwick, S., Hazlett, G., Rasmusson, A., Hoyt, G., Zimolo, Z., & Charney, D. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.8.819 · Cited by 304
Potentiation of neuronal NMDA response induced by dehydroepiandrosterone and its suppression by progesterone: effects mediated via sigma receptors
Bergeron, R., de Montigny, C., & Debonnel, G. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-03-01193.1996 · Cited by 299
Dehydroepiandrosterone (DHEA) stimulates neurogenesis in the hippocampus of the rat, promotes survival of newly formed neurons and prevents corticosterone-induced suppression
Karishma, K. K., & Herbert, J. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02099.x · Cited by 297
The Role of Cytochrome P450 17α-Hydroxylase and 3β-Hydroxysteroid Dehydrogenase in the Integration of Gonadal and Adrenal Steroidogenesis via the Δ5 and Δ4 Pathways of Steroidogenesis in Mammals
Conley, A. J., & Bird, I. M. (1997) · Biology of Reproduction · doi:10.1095/biolreprod56.4.789 · Cited by 296
Effect of 12-month dehydroepiandrosterone replacement therapy on bone, vagina and endometrium in postmenopausal women.
Labrie, F., Diamond, P., Cusan, L., Gomez, J.-L., Bélanger, A., & Candas, B. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.10.4306 · Cited by 292
Relationships of dehydroepiandrosterone sulfate in the elderly with functional, psychological, and mental status, and short-term mortality: A French community-based study
Berr, C., Lafont, S., Debuire, B., Dartigues, J., & Baulieu, É.-É. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.23.13410 · Cited by 292
Evidence for Adrenocortical Adaptation to Severe Illness*
Parker, L. N., Levin, E. R., & Lifrak, E. T. (1985) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-60-5-947 · Cited by 289
Actions of dehydroepiandrosterone and its sulfate in the central nervous system: effects on cognition and emotion in animals and humans
Wolf, O. T., & Kirschbaum, C. (1999) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00021-1 · Cited by 288
Decreased Cerebrospinal Fluid Allopregnanolone Levels in Women with Posttraumatic Stress Disorder
Rasmusson, A. M., Pinna, G., Paliwal, P., Weisman, D., Gottschalk, C. H., Charney, D. S., Krystal, J. H., & Guidotti, A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.026 · Cited by 287
Dehydroepiandrosterone Activates Endothelial Cell Nitric-oxide Synthase by a Specific Plasma Membrane Receptor Coupled to Gαi2,3
Liu, D., & Dillon, J. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200491200 · Cited by 285
Adrenal secretion during major depression in 8- to 16-year-olds, I. Altered diurnal rhythms in salivary cortisol and dehydroepiandrosterone (DHEA) at presentation
Goodyer, I. M., Herbert, J., ALTHAM, P. M. E., Pearson, J., SECHER, S. M., & Shiers, H. M. (1996) · Psychological Medicine · doi:10.1017/s0033291700034644 · Cited by 284
Steroid Hormones and Excitability in the Mammalian Brain
Joëls, M. (1997) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1996.0144 · Cited by 284
Serum levels of insulin-like growth factor-I (IGF-I) and dehydroepiandrosterone sulfate (DHEA-S), and their relationships with serum interleukin-6, in the geriatric syndrome of frailty
Leng, S. X., Cappola, A. R., Andersen, R. E., Blackman, M. R., Koenig, K., Blair, M., & Walston, J. D. (2004) · Aging Clinical and Experimental Research · doi:10.1007/bf03324545 · Cited by 270
Developing an Agenda for Translational Studies of Resilience and Vulnerability Following Trauma Exposure
YEHUDA, R., FLORY, J. D., SOUTHWICK, S., & CHARNEY, D. S. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1364.028 · Cited by 266
Adrenal glands of mouse and rat do not synthesize androgens
van Weerden, W. M., Bierings, H. G., Van Steenbrugge, G. J., De Jong, F. H., & Schröder, F. H. (1992) · Life Sciences · doi:10.1016/0024-3205(92)90204-3 · Cited by 260
Dehydroepiandrosterone (DHEA) protects hippocampal cells from oxidative stress-induced damage
Bastianetto, S., Ramassamy, C., Poirier, J., & Quirion, R. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00002-9 · Cited by 257
Neurosteroid Synthesis by Cytochrome P450-Containing Systems Localized in the Rat Brain Hippocampal Neurons: N-Methyl-D-Aspartate and Calcium-Dependent Synthesis
Kimoto, T., Tsurugizawa, T., Ohta, Y., Makino, J., Tamura, H.-O., Hojo, Y., Takata, N., & Kawato, S. (2001) · Endocrinology · doi:10.1210/endo.142.8.8327 · Cited by 256
Dehydroepiandrosterone Monotherapy in Midlife-Onset Major and Minor Depression
Schmidt, P. J., Daly, R. C., Bloch, M., SMITH, M. J., Danaceau, M. A., Clair, L. S. S., Murphy, J. H., Haq, N., & Rubinow, D. R. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.2.154 · Cited by 256
Effects of a Two-Week Physiological Dehydroepiandrosterone Substitution on Cognitive Performance and Well-Being in Healthy Elderly Women and Men
Wolf, O. T., Neumann, O., Hellhammer, D. H., Geiben, A. C., Strasburger, C. J., Dressendörfer, R. A., Pirke, K., & Kirschbaum, C. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.7.4056 · Cited by 250
Oxidative damage and protection by antioxidants in the frontal cortex of Alzheimer’s disease is related to the apolipoprotein E genotype
Ramassamy, C., Averill‐Bates, D. A., Beffert, U., Bastianetto, S., Théroux, L., Lussier‐Cacan, S., Cohn, J. S., Christen, Y., Davignon, J., Quirion, R., et al. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00102-1 · Cited by 244
The Biological Actions of Dehydroepiandrosterone Involves Multiple Receptors
Webb, S. J., Geoghegan, T. E., Prough, R. A., & Miller, K. K. M. (2006) · Drug Metabolism Reviews · doi:10.1080/03602530600569877 · Cited by 235
Endogenous Levels of Dehydroepiandrosterone Sulfate, but Not Other Sex Hormones, Are Associated with Depressed Mood in Older Women: The Rancho Bernardo Study
Barrett-Connor, E. L., von Mühlen, D. G., Laughlin, G. A., & Kripke, A. (1999) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1999.tb01590.x · Cited by 231
Cortisol, dehydroepiandrosterone (DHEA), and DHEA sulfate in the cerebrospinal fluid of man: relation to blood levels and the effects of age
Guazzo, E., Kirkpatrick, P. J., Goodyer, I. M., Shiers, H. M., & Herbert, J. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.11.8923843 · Cited by 228
Dehydroepiandrosterone and its sulfate enhance memory retention in mice.
Flood, J. F., Smith, G. E., & Roberts, E. (1988) · Brain Research · doi:10.1016/0006-8993(88)91129-8 · Cited by 227 · cited 1×
“dose-dependent inverted U-shaped effects on memory retention in mice given T-maze footshock avoidance training, with the lowest doses of DHEA or DHEAS showing no significant effect on memory, intermediate doses improving memory retention, and the highest doses showing no effect [94].”
Background
Pregnancy, the postpartum, and steroid hormones: effects on cognition and mood
Buckwalter, J. G., Stanczyk, F. Z., McCleary, C. A., Bluestein, B. W., Buckwalter, D. K., Rankin, K. P., Chang, L., & Goodwin, T. M. (1999) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(98)00044-4 · Cited by 227
Steroid hormones, the menopause, sexuality and well-being of women
Cawood, E. H. H., & Bancroft, J. (1996) · Psychological Medicine · doi:10.1017/s0033291700035261 · Cited by 225
Two Prevalent CYP17 Mutations and Genotype-Phenotype Correlations in 24 Brazilian Patients with 17-Hydroxylase Deficiency
Costa-Santos, M., Kater, C. E., & Auchus, R. J. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031021 · Cited by 224
Handbook of health psychology and aging
Aldwin, C. M., Park, C. L., & Spiro, A. (2007) · Cited by 218
Dehydroepiandrosterone antagonizes the neurotoxic effects of corticosterone and translocation of stress-activated protein kinase 3 in hippocampal primary cultures
Kimonides, V. G., Spillantini, M. G., Sofroniew, M. V., Fawcett, J. W., & Herbert, J. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00347-9 · Cited by 218
Elevation of the Cortisol-Dehydroepiandrosterone Ratio in Drug-Free Depressed Patients
Young, A. H., Gallagher, P., & Porter, R. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.7.1237 · Cited by 210
THE SECRETION OF DEHYDROEPIANDROSTERONE AND DEHYDROEPIANDROSTERONE SULPHATE IN MAN
Nieschlag, E., Loriaux, D. L., Ruder, H. J., Zucker, I., Kirschner, M. A., & LIPSETT, M. B. (1973) · Journal of Endocrinology · doi:10.1677/joe.0.0570123 · Cited by 209
Altered salivary dehydroepiandrosterone levels in major depression in adults
Michael, A., Jenaway, A., Paykel, E. S., & Herbert, J. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00955-0 · Cited by 207
Treatment of Depression With Antiglucocorticoid Drugs
Wolkowitz, O. M., & Reus, V. I. (1999) · Psychosomatic Medicine · doi:10.1097/00006842-199909000-00011 · Cited by 205
Self-citation
Steroidogenic enzyme P450c17 is expressed in the embryonic central nervous system
Compagnone, N. A., Bulfone, A., Rubenstein, J. L., & Mellon, S. H. (1995) · Endocrinology · doi:10.1210/endo.136.11.7588260 · Cited by 201
Self-citation
Dehydroepiandrosterone Augmentation in the Management of Negative, Depressive, and Anxiety Symptoms in Schizophrenia
Strous, R. D., Maayan, R., Lapidus, R., Stryjer, R., Lustig, M., Kotler, M., & Weizman, A. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.2.133 · Cited by 201
GASTRIN SEGRETION IN THE PANCREAS?
Lagios, M. (1970) · The Lancet · doi:10.1016/s0140-6736(70)91374-7 · Cited by 200
Sex Differences in Endocrine and Psychological Responses to Psychosocial Stress in Healthy Elderly Subjects and the Impact of a 2-Week Dehydroepiandrosterone Treatment1
Kudielka, B. M., Hellhammer, J., Hellhammer, D. H., Wolf, O. T., Pirke, K., Váradi, E., Pilz, J., & Kirschbaum, C. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.5.4758 · Cited by 196
A Prospective Study on Cortisol, Dehydroepiandrosterone Sulfate, and Cognitive Function in the Elderly
Kalmijn, S., Launer, L. J., Stolk, R. P., de Jong, F. H., Pols, H. A. P., Albert Hofman, D., Breteler, M. M. B., & Lamberts, S. W. J. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.10.5164 · Cited by 196
ANTIGLUCOCORTICOID ACTIONS OF DEHYDROEPIANDROSTERONE AND LOW CONCENTRATIONS IN ALZHEIMER'S DISEASE
Svec, F., & Lopez‐S, A. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91940-5 · Cited by 192
Adrenal steroid secretion and major depression in 8- to 16-year-olds, III. Influence of cortisol/DHEA ratio at presentation on subsequent rates of disappointing life events and persistent major depression
Goodyer, I. M., HERBERT, J., & ALTHAM, P. M. E. (1998) · Psychological Medicine · doi:10.1017/s0033291797006314 · Cited by 191
Changes in cortisol and dehydroepiandrosterone in women victims of physical and psychological intimate partner violence
Pico-Alfonso, M. A., Garcia-Linares, M. I., Celda-Navarro, N., Herbert, J., & Martı́nez, M. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.06.001 · Cited by 184
Control of adrenal androgen secretion.
Parker, L. N., & Odell, W. (1980) · Endocrine reviews · doi:10.1210/edrv-1-4-392 · Cited by 184
Sex steroids and 5-en-3β-hydroxysteroids in specific regions of the human brain and cranial nerves
Lanthier, A., & Patwardhan, V. V. (1986) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(86)90259-1 · Cited by 182
Dehydroepiandrosterone treatment of midlife dysthymia∗∗See accompanying Editorial, in this issue.
Bloch, M., Schmidt, P. J., Danaceau, M. A., Adams, L. F., & Rubinow, D. R. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00066-9 · Cited by 179
Androgen biosynthesis from cholesterol to DHEA
Miller, W. L. (2002) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(02)00363-5 · Cited by 179
The Effect of Deydroepiandrosterone Supplementation to Symptomatic Perimenopausal Women on Serum Endocrine Profiles, Lipid Parameters, and Health-Related Quality of Life
Barnhart, K. T., Freeman, E. W., Grisso, J. A., Rader, D. J., Sammel, M. D., Kapoor, S. C., & Nestler, J. E. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.11.6153 · Cited by 178
The Rise in Adrenal Androgen Biosynthesis: Adrenarche
Havelock, J. C., Auchus, R. J., & Rainey, W. E. (2004) · Seminars in Reproductive Medicine · doi:10.1055/s-2004-861550 · Cited by 178
Dehydroepiandrosterone Protects Hippocampal Neurons Against Neurotoxin‐Induced Cell Death: Mechanism of Action2
Cardounel, A. J., Regelson, W., & Kalimi, M. (1999) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.1999.d01-124.x · Cited by 177
The 17, 20-Lyase Activity of Cytochrome P450c17 from Human Fetal Testis Favors the Δ5Steroidogenic Pathway
Flück, C. E., Miller, W. L., & Auchus, R. J. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030143 · Cited by 173
Salivary cortisol and DHEA: association with measures of cognition and well-being in normal older men, and effects of three months of DHEA supplementation.
van Niekerk, J. K., Huppert, F. A., & Herbert, J. (2001) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(01)00014-2 · Cited by 171
Neuroactive Steroids are Altered in Schizophrenia and Bipolar Disorder: Relevance to Pathophysiology and Therapeutics
Marx, C. E., Stevens, R. D., Shampine, L. J., Uzunova, V., Trost, W. T., Butterfield, M. I., Massing, M. W., Hamer, R. M., Morrow, A. L., & Lieberman, J. A. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300952 · Cited by 170
Dehydroepiandrosterone and allopregnanolone protect sympathoadrenal medulla cells against apoptosis via antiapoptotic Bcl-2 proteins
Charalampopoulos, I., Tsatsanis, C., Dermitzaki, E., Alexaki, V. I., Castanas, E., Margioris, A. N., & Gravanis, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306631101 · Cited by 166
Dehydroepiandrosterone and its sulfated derivative reduce neuronal death and enhance astrocytic differentiation in brain cell cultures
Bologa, L., Sharma, J., & Roberts, E. R. (1987) · Journal of Neuroscience Research · doi:10.1002/jnr.490170305 · Cited by 166
Changes in cortisol and DHEA plasma levels after psychotherapy for PTSD
Olff, M., de Vries, G.-J., Güzelcan, Y., Assies, J., & Gersons, B. P. R. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.04.001 · Cited by 159
An open study of dehydroepiandrosterone in systemic lupus erythematosus
van Vollenhoven, R., Engleman, E. G., & McGuire, J. L. (1994) · Arthritis & Rheumatism · doi:10.1002/art.1780370906 · Cited by 157
Clinical correlates of DHEA associated with post‐traumatic stress disorder
Yehuda, R., Brand, S. R., Golier, J. A., & Yang, R. ‐. (2006) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2006.00801.x · Cited by 155
The relationship of dehydroepiandrosterone sulfate (DHEAS) to endocrine- metabolic parameters and functional status in the oldest-old. Results from an Italian study on healthy free-living over-ninety-year-olds
Ravaglia, G., Forti, P., Maioli, F., Boschi, F., Bernardi, M., Pratelli, L., Pizzoferrato, A., & Gasbarrini, G. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.3.8772596 · Cited by 153
Pineal and pituitary-adrenocortical function in physiological aging and in senile dementia
Ferrari, E., Arcaini, A., Gornati, R., Pelanconi, L., Cravello, L., Fioravanti, M., Solerte, S. B., & Magri, F. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00160-1 · Cited by 153
Neuroactive steroids: molecular mechanisms of action and implications for neuropsychopharmacology
Rupprecht, R., di Michele, F., Hermann, B., Ströhle, A., Lancel, M., Romeo, E., & Holsboer, F. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00123-0 · Cited by 152
Mitotic and neurogenic effects of dehydroepiandrosterone (DHEA) on human neural stem cell cultures derived from the fetal cortex
Suzuki, M., Wright, L. S., Marwah, P., Lardy, H. A., & Svendsen, C. N. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307325101 · Cited by 152 · cited 3×
“neural stem cells derived from fetal cortex [305].”
BackgroundInfluential
Stress Hormone-Related Psychopathology: Pathophysiological and Treatment Implications
Wolkowitz, O. M., Epel, E. S., & Reus, V. I. (2001) · The World Journal of Biological Psychiatry · doi:10.3109/15622970109026799 · Cited by 151
Self-citation
The Actions of Exogenous Dehydroepiandrosterone in Experimental Animals and Humans
Švec, F., & Porter, J. R. (1998) · Experimental Biology and Medicine · doi:10.3181/00379727-218-44285 · Cited by 149
Increased Diurnal Plasma Concentrations of Dehydroepiandrosterone in Depressed Patients
Heuser, I., Deuschle, M., Luppa, P. B., Schweiger, U., Standhardt, H., & Weber, B. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.9.5081 · Cited by 148
Dehydroepiandrosterone and dehydroepiandrosterone sulfate as neuroactive neurosteroids.
Baulieu, É.-É., & Röbel, P. (1996) · PubMed · Cited by 148
Hippocampal cytochrome P450s synthesize brain neurosteroids which are paracrine neuromodulators of synaptic signal transduction.
Shibuya, K., Takata, N., Hojo, Y., Furukawa, A., Yasumatsu, N., Kimoto, T., Enami, T., Suzuki, K., Tanabe, N., Ishii, H., et al. (2003) · Biochimica et Biophysica Acta · doi:10.1016/s0304-4165(02)00489-0 · Cited by 147
Psychoendocrine antecedents of persistent first-episode major depression in adolescents: a community-based longitudinal enquiry
GOODYER, I. M., HERBERT, J., & TAMPLIN, A. (2003) · Psychological Medicine · doi:10.1017/s0033291702007286 · Cited by 146
Adrenal Androgens and Intracrinology
Labrie, F. (2004) · Seminars in Reproductive Medicine · doi:10.1055/s-2004-861547 · Cited by 145
The Neuroendocrinology of Posttraumatic Stress Disorder: New Directions
Rasmusson, A. M., Vythilingam, M., & Morgan, C. A. (2003) · CNS Spectrums · doi:10.1017/s1092852900008841 · Cited by 144
Replacement of dehydroepiandrosterone in adrenal failure: no benefit for subjective health status and sexuality in a 9-month, randomized, parallel group clinical trial.
Løvås, K., Gebre-Medhin, G., Trovik, T. S., Fougner, K. J., Uhlving, S., Nedrebø, B. G., Myking, O. L., Kämpe, O., & Husebye, E. S. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020769 · Cited by 144
Blood—Brain Barrier Is Involved in the Efflux Transport of a Neuroactive Steroid, Dehydroepiandrosterone Sulfate, via Organic Anion Transporting Polypeptide 2
Asaba, H., Hosoya, K., Takanaga, H., Ohtsuki, S., Tamura, E., Takizawa, T., & Terasaki, T. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0751907.x · Cited by 144
Peroxisome proliferator-activated receptor alpha required for gene induction by dehydroepiandrosterone-3 beta-sulfate.
Peters, J., Zhou, Y., Ram, P. A., Lee, S. S., Gonzalez, F. J., & Waxman, D. J. (1996) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09162-x · Cited by 144
Developmental and Functional Biology of the Primate Fetal Adrenal Cortex
Mesiano, S. A. (1997) · Endocrine Reviews · doi:10.1210/er.18.3.378 · Cited by 144
Serum dehydroepiandrosterone sulfate in Alzheimer's disease and in multi-infarct dementia
Näsman, B., Olsson, T., Bäckström, T. C., Eriksson, S., Grankvist, K., Viitanen, M. H., & Bucht, G. (1991) · Biological Psychiatry · doi:10.1016/0006-3223(91)90013-c · Cited by 143
REDUCED PLASMA DEHYDROEPIANDROSTERONE CONCENTRATIONS IN ALZHEIMER'S DISEASE
Sunderland, T., Merril, C. R., Harrington, M. G., Lawlor, B., Molchan, S., Martínez, R. A., & Murphy, D. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90700-9 · Cited by 143
Neuro(active)steroids actions at the neuromodulatory sigma1 (σ1) receptor: Biochemical and physiological evidences, consequences in neuroprotection
Maurice, T., Gregoire, C. J., & Espallergues, J. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.07.009 · Cited by 141
Neurosteroids in rat brain: extraction, isolation and analysis by nanoscale liquid chromatography-electrospray mass spectrometry
Liu, S., Sjövall, J., & Griffiths, W. J. (2003) · Analytical Chemistry · doi:10.1021/ac0346297 · Cited by 141
An Increased Capacity for Adrenal DHEA Release is Associated with Decreased Avoidance and Negative Mood Symptoms in Women with PTSD
Rasmusson, A. M., Vasek, J., Lipschitz, D. S., Vojvoda, D., Mustone, M. E., Shi, Q., Gudmundsen, G. R., Morgan, C. A., Wolfe, J., & Charney, D. S. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300432 · Cited by 141
Psychoendocrinological Assessment of the Menstrual Cycle: The Relationship Between Hormones, Sexuality, and Mood
van Goozen, S. H. M., Wiegant, V. M., Endert, E., Helmond, F. A., & van de Poll, N. E. (1997) · Archives of Sexual Behavior · doi:10.1023/a:1024587217927 · Cited by 140
Sigma (σ1) receptor mediated antidepressant-like effects of neurosteroids in the Porsolt forced swim test
Reddy, D. S., Kaur, G., & Kulkarni, S. K. (1998) · Neuroreport · doi:10.1097/00001756-199809140-00028 · Cited by 140
Dehydroepiandrosterone is an anxiolytic in mice mice on the plus maze
Melchior, C. L., & Ritzmann, R. F. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90140-6 · Cited by 140
Elevation of the cortisol/dehydroepiandrosterone ratio in schizophrenia patients
Ritsner, M. S., Maayan, R., Gibel, A., Strous, R. D., Modai, I., & Weizman, A. (2003) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2003.09.003 · Cited by 140
A Prospective Study of Dehydroepiandrosterone Sulfate and Cognitive Function in an Older Population: The Rancho Bernardo Study
Barrett-Connor, E. L., & Edelstein, S. L. (1994) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1994.tb07491.x · Cited by 137
Simultaneous radioimmunoassay of progesterone, androst-4-enedione, pregnenolone, dehydroepiandrosterone and 17-hydroxyprogesterone in specific regions of human brain
Lacroix, C., Fiet, J., Benais, J.-P., GUEUX, B., Boneté, R., Villette, J., Gourmel, B., & DREUX, C. (1987) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(87)91025-9 · Cited by 133
Neuroactive steroids modulate HPA axis activity and cerebral brain-derived neurotrophic factor (BDNF) protein levels in adult male rats
Naert, G., Maurice, T., Tapia‐Arancibia, L., & Givalois, L. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.09.002 · Cited by 131
Plasma cortisol-dehydroepiandrosterone (DHEA) ratios in schizophrenia and bipolar disorder
GALLAGHER, P., WATSON, S., SMITH, M., YOUNG, A., & FERRIER, I. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2006.11.020 · Cited by 129
Elevated circulatory level of GABAA – antagonistic neurosteroids in patients with combat-related post-traumatic stress disorder
Спивак, Б., Maayan, R., Kotler, M., Mester, R., Gil‐Ad, I., Shtaif, B., & Weizman, A. (2000) · Psychological Medicine · doi:10.1017/s0033291799002731 · Cited by 129
Age, hormones, and cognitive functioning among middle-aged and elderly men: cross-sectional evidence from the Massachusetts Male Aging Study.
Fonda, S. J., Bertrand, R., O'Donnell, A., Longcope, C., & McKinlay, J. B. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.3.385 · Cited by 129
Dehydroepiandrosterone (DHEA)–the Multifunctional Steroid
Regelson, W., & Kalimi, M. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb56860.x · Cited by 126
Associations between sex steroid hormone levels and depressive symptoms in elderly men and women: Results from the Health ABC study
Morsink, L., Vogelzangs, N., Nicklas, B. J., Beekman, A. T. F., Satterfield, S., Rubin, S. M., Yaffe, K. S., Simonsick, E. M., Newman, A. B., Kritchevsky, S. B., et al. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.06.009 · Cited by 125
Regulation of [3H]dopamine release from rat striatal slices by sigma receptor ligands.
Gonzalez‐Alvear, G. M., & Werling, L. L. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22758-6 · Cited by 122
Local Neurosteroid Production in the Hippocampus: Influence on Synaptic Plasticity of Memory
Mukai, H., Tsurugizawa, T., Ogiue-Ikeda, M., Murakami, G., Hojo, Y., Ishii, H., Kimoto, T., & Kawato, S. (2007) · Neuroendocrinology · doi:10.1159/000097747 · Cited by 120
Neuropsychiatric Function and Dehydroepiandrosterone Sulfate in Elderly Women: A Prospective Study
Yaffe, K. S., Ettinger, B. B., Pressman, A. R., Seeley, D. G., Whooley, M. A., Schaefer, C. A., & Cummings, S. R. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00303-x · Cited by 120
Hippocampal synthesis of estrogens and androgens which are paracrine modulators of synaptic plasticity: synaptocrinology.
Mukai, H., Takata, N., Ishii, H., Tanabe, N., Hojo, Y., Furukawa, A., Kimoto, T., & Kawato, S. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.09.010 · Cited by 119
Dehydroepiandrosterone 7-hydroxylase cyp7b: predominant expression in primate hippocampus and reduced expression in alzheimer's disease☆
Yau, J. L. W., Rasmuson, S., Andrew, R., Graham, M., Noble, J., Olsson, T., Fuchs, E., Lathe, R., & Seckl, J. R. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00438-x · Cited by 118
The regional brain distribution of the neurosteroids pregnenolone and pregnenolone sulfate following intravenous infusion
Wang, M., Wahlström, G., & Bäckström, T. C. (1997) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(97)00041-1 · Cited by 118
Novel lipoidal derivatives of pregnenolone and dehydroepiandrosterone and absence of their sulfated counterparts in rodent brain
Liere, P., Pianos, A., Eychenne, B., Cambourg, A., Liu, S., Griffiths, W., Schumacher, M., Sjövall, J., & Baulieu, E.-E. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m400244-jlr200 · Cited by 118
Dehydroepiandrosterone, Dehydroepiandrosterone Sulfate and Related Steroids: Their Role in Inflammatory, Allergic and Immunological Disorders
Dillon, J. S. (2005) · Current Drug Targets - Inflammation & Allergy · doi:10.2174/1568010054022079 · Cited by 116
OPPOSING EFFECTS OF DHEA REPLACEMENT IN ELDERLY SUBJECTS ON DECLARATIVE MEMORY AND ATTENTION AFTER EXPOSURE TO A LABORATORY STRESSOR
Wolf, O. T., Kudielka, B. M., Hellhammer, D. H., Hellhammer, J., & Kirschbaum, C. (1998) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(98)00032-8 · Cited by 116
Anti-stress effects of dehydroepiandrosterone
Hu, Y. P., Cardounel, A. J., Gursoy, E. C., Anderson, P. W., & Kalimi, M. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00385-8 · Cited by 116
Serum Dehydroepiandrosterone (DHEA) and DHEA-Sulfate (DHEA-S) in Alzheimer's Disease and in Cerebrovascular Dementia.
Yanase, T., Fukahori, M., Taniguchi, S., Nishi, Y., Sakai, Y., Takayanagi, R., Haji, M., & Nawata, H. (1996) · Endocrine Journal · doi:10.1507/endocrj.43.119 · Cited by 115
Dehydroepiandrosterone Decreases Serum Tumor Necrosis Factor- and Restores Insulin Sensitivity: Independent Effect from Secondary Weight Reduction in Genetically Obese Zucker Fatty Rats
Kimura, M., Tanaka, S., Yamada, Y., Kiuchi, Y., Yamakawa, T., & Sekihara, H. (1998) · Endocrinology · doi:10.1210/endo.139.7.6118 · Cited by 115
Dehydroepiandrosterone Sulfate Is Neuroprotective in a Reversible Spinal Cord Ischemia Model
Lapchak, P. A., Chapman, D. F., Nunez, S., & Zivin, J. A. (2000) · Stroke · doi:10.1161/01.str.31.8.1953 · Cited by 115
Neurosteroid secretion in panic disorder
Brambilla, F., Biggio, G., Pisu, M. G., Bellodi, L., Perna, G., Bogdanovich-Djukic, V., Purdy, R. H., & Serra, M. (2003) · Psychiatry Research · doi:10.1016/s0165-1781(03)00077-5 · Cited by 113
Immunoreactive cytochrome P-45017α in rat and guineapig gonads, adrenal glands and brain
Le Goascogne, C., Sananés, N., Gouézou, M., Takemori, S., Kominami, S., Baulieu, E. E., & Robel, P. (1991) · Reproduction · doi:10.1530/jrf.0.0930609 · Cited by 113
Dehydroepiandrosterone metabolism
Longcope, C. (1996) · Journal of Endocrinology · doi:10.1677/joe.0.150s125 · Cited by 113
Adrenal Androgens and the Immune System
Chen, C. C. G., & Parker, C. R. (2004) · Seminars in Reproductive Medicine · doi:10.1055/s-2004-861553 · Cited by 111
The modulation by neurosteroids of the scopolamine-induced learning impairment in mice involves an interaction with sigma1 (σ1) receptors
Urani, A., Privat, A., & Maurice, T. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00469-7 · Cited by 111
Serum gonadal steroid hormones in young schizophrenic patients
Oades, R. D., & Schepker, R. (1994) · Psychoneuroendocrinology · doi:10.1016/0306-4530(94)90017-5 · Cited by 111
Basal plasma hormone levels in depressed perimenopausal women
Schmidt, P. J., Murphy, J. H., Haq, N., Danaceau, M. A., & Clair, L. S. S. (2002) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00004-5 · Cited by 110
Stress and dementia: the role of the hypothalamic-pituitary-adrenal axis
Magri, F., Cravello, L., Barili, L., Sarra, S., Cinchetti, W., Salmoiraghi, F., Micale, G., & Ferrari, E. (2006) · Aging Clinical and Experimental Research · doi:10.1007/bf03327435 · Cited by 110
Relationship of dehydroepiandrosterone and cortisol in disease
Hechter, O., Grossman, A., & Chatterton, R. T. (1997) · Medical Hypotheses · doi:10.1016/s0306-9877(97)90258-9 · Cited by 110
Metabolic effects of 12-month percutaneous dehydroepiandrosterone replacement therapy in postmenopausal women
Diamond, P., Cusan, L., Gomez, J.-L., BÉLANGER, A., & Labrie, F. (1996) · Journal of Endocrinology · doi:10.1677/joe.0.150s043 · Cited by 109
Dehydroepiandrosterone Sulfate Levels Are Associated with More Favorable Cognitive Function in Women
Davis, S. R., Shah, S. M., McKenzie, D. P., Kulkarni, J., Davison, S. L., & Bell, R. J. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2128 · Cited by 109
Dehydroepiandrosterone and ageing
Arlt, W. (2004) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2004.02.006 · Cited by 108
Pregnenolone sulfate in the brain: A controversial neurosteroid
Schumacher, M., Lière, P., Akwa, Y., Rajkowski, K. M., Griffiths, W. J., Bodin, K., Sjövall, J., & Baulieu, É.-É. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.08.022 · Cited by 108
Anticonvulsant Activity of Androsterone and Etiocholanolone
Kaminski, R. M., Marini, H. R., Kim, W., & Rogawski, M. A. (2005) · Epilepsia · doi:10.1111/j.1528-1167.2005.00705.x · Cited by 108
Immune and Hormonal Changes following Intense Military Training
Gomez-Mérino, D., Chennaoui, M., Burnat, P., Drogou, C., & Guézennec, C. Y. (2003) · Military Medicine · doi:10.1093/milmed/168.12.1034 · Cited by 107
The relevance of neurosteroids to clinical psychiatry: From the laboratory to the bedside
Strous, R. D., Maayan, R., & Weizman, A. (2005) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2005.09.005 · Cited by 103
Dehydroepiandrosterone sulfate and longevity: New clues for an old friend
Yen, S. S. C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161278698 · Cited by 102
β-Estradiol, Dehydroepiandrosterone, and Dehydroepiandrosterone Sulfate Protect against N-Methyl-d-aspartate-Induced Neurotoxicity in Rat Hippocampal Neurons by Different Mechanisms
Kurata, K., Takebayashi, M., Morinobu, S., & Yamawaki, S. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.067629 · Cited by 102
DHEA treatment of Alzheimer’s disease
Wolkowitz, O. M., Kramer, J. H., Reus, V. I., Costa, M. L., Yaffe, K. S., Walton, P., Raskind, M. A., Peskind, E. R., NEWHOUSE, P. A., Sack, D. A., et al. (2003) · Neurology · doi:10.1212/01.wnl.0000052994.54660.58 · Cited by 101
Self-citation
Placebo-controlled trial of dehydroepiandrosterone (DHEA) for treatment of nonmajor depression in patients with HIV/AIDS.
Rabkin, J., McElhiney, M., Rabkin, R., McGrath, P., & Ferrando, S. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.1.59 · Cited by 101
Plasma Dehydroepiandrosterone Sulfate in Nursing Home Men
Rudman, D. R., Shetty, K. R., & Mattson, D. E. (1990) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1990.tb03540.x · Cited by 100
Neurosteroid 7-hydroxylation products in the brain
Morfin, R. F., & Stárka, L. (2001) · International review of neurobiology · doi:10.1016/s0074-7742(01)46059-4 · Cited by 99
Effects of DHEA administration on episodic memory, cortisol and mood in healthy young men: a double-blind, placebo-controlled study
Alhaj, H. A., Massey, A. E., & McAllister-Williams, H. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0136-y · Cited by 99
Dehydroepiandrosterone (DHEA) supplementation for cognitive function in healthy elderly people
Evans, J. G., Malouf, R. S., Huppert, F. A., & van Niekerk, J. K. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006221 · Cited by 99
Effect of Korean red ginseng on psychological functions in patients with severe climacteric syndromes
Tode, T., Kikuchi, Y., Hirata, J., et al. (1999) · International Journal of Gynecology & Obstetrics · doi:10.1016/s0020-7292(99)00168-x · Cited by 96
Neurosteroids: Cerebrospinal Fluid Levels for Alzheimer’s Disease and Vascular Dementia Diagnostics
Kim, S.-B., Hill, M., Kwak, Y. T., Hampl, R., Jo, D.-H., & Morfin, R. F. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030646 · Cited by 96
Enhanced plasma DHEAS, brain acetylcholine and memory mediated by steroid sulfatase inhibition
Rhodes, M. E., Li, P., Burke, A. M., & Johnson, D. A. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00867-6 · Cited by 95
Oxidative stress-mediated DHEA formation in Alzheimer's disease pathology
Brown, R. C. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00048-9 · Cited by 95
Dehydroepiandrosterone (DHEA) and its sulfated derivative (DHEAS) regulate apoptosis during neurogenesis by triggering the Akt signaling pathway in opposing ways
Zhang, L., Li, B. S., Ma, W., Barker, J. L., Chang, Y. H., Zhao, W., & Rubinow, D. R. (2002) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00315-1 · Cited by 95
Adrenal androgens and cortisol in major depression
Osran, H., Reist, C., Chen, C. C., Lifrak, E. T., Chicz-DeMet, A., & Parker, L. N. (1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.5.806 · Cited by 93
The Relation of Plasma Androgen Levels to Sexual Behaviors and Attitudes of Women1
Persky, H., Dreisbach, L., Miller, W. R., O’Brien, C. P., Khan, M. A., Lief, H. I., Charney, N., & Strauss, D. (1982) · Psychosomatic Medicine · doi:10.1097/00006842-198209000-00001 · Cited by 93
Increased circulatory dehydroepiandrosterone and dehydroepiandrosterone-sulphate in first-episode schizophrenia: relationship to gender, aggression and symptomatology
Strous, R. D., Maayan, R., Lapidus, R., Goredetsky, L., Zeldich, E., Kotler, M., & Weizman, A. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2004.03.005 · Cited by 92
Neuroactive steroids: their mechanism of action and their function in the stress response
Zinder, & Dar (1999) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.1999.00579.x · Cited by 90
Studies on neurosteroids XVII.
Higashi, T., Takido, N., & Shimada, K. (2004) · Steroids · doi:10.1016/j.steroids.2004.08.001 · Cited by 89
Dehydroepiandrosterone Sulphate (DHEAS) in the Oldest Old, Aged 85 and Overa
Birkenhäger‐Gillesse, E. G., Derksen, J. J. L., & Lagaay, A. M. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb56858.x · Cited by 89
Association of Dehydroepiandrosterone Sulfate, Body Composition, and Physical Fitness in Independent Community‐Dwelling Older Men and Women
Abbasi, A. A., Duthie, E. H., Sheldahl, L. M., Wilson, C. R., Sasse, E. A., Rudman, I. W., & Mattson, D. E. (1998) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1998.tb01036.x · Cited by 89
Enhancement of hippocampal acetylcholine release by the neurosteroid dehydroepiandrosterone sulfate: an in vivo microdialysis study
Rhodes, M. E., Li, P., Flood, J. F., et al. (1996) · Brain Research · doi:10.1016/0006-8993(96)00751-2 · Cited by 88
Dehydroepiandrosterone inhibits the amplification of glucocorticoid action in adipose tissue
Apostolova, G., Schweizer, R. A. S., Balázs, Z., Kostadinova, R. M., & Odermatt, A. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00442.2004 · Cited by 87
Overview of Dehydroepiandrosterone Biosynthesis
Auchus, R. J. (2004) · Seminars in Reproductive Medicine · doi:10.1055/s-2004-861545 · Cited by 87
Modulation of neurotransmitter systems by dehydroepiandrosterone and dehydroepiandrosterone sulfate: mechanism of action and relevance to psychiatric disorders.
Pérez-Neri, I., Montes, S., Ojeda-López, C., Ramírez-Bermúdez, J., & Ríos, C. (2008) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.12.001 · Cited by 87
Interactions of the Neurosteroid Dehydroepiandrosterone Sulfate with the GABAA Receptor Complex Reveals that it May Act via the Picrotoxin Site
Sousa, A. L., & Ticku, M. K. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36857-0 · Cited by 86
Dhea Replacement in Women with Adrenal Insufficiency—Pharmacokinetics, Bioconversion and Clinical Effects on Well-Being, Sexuality and Cognition
Arlt, W., Callies, F., & Allolio, B. (2000) · Endocrine Research · doi:10.3109/07435800009048561 · Cited by 85
Metabolism of free and sulfoconjugated DHEA in brain tissue in vivo and in vitro
Knapstein, P., David, A., Wu, C.-H., Archer, D. F., Flickinger, G. L., & Touchstone, J. C. (1968) · Steroids · doi:10.1016/s0039-128x(68)80102-3 · Cited by 84
Dehydroepiandrosterone sulfate (DHEAS) counteracts decremental effects of corticosterone on dentate gyrus LTP. implications for depression
Kaminska, M., Harris, J., Gijsbers, K., & Dubrovsky, B. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(00)00251-3 · Cited by 84
Differences in adrenal steroid profile in chronic fatigue syndrome, in depression and in health
Scott, L. V., Salahuddin, F. F., Cooney, J. M., Svec, F., & Dinan, T. G. (1999) · Journal of Affective Disorders · doi:10.1016/s0165-0327(98)00169-4 · Cited by 83
Dehydroepiandrosterone Modulates Nuclear Factor-κB Activation in Hippocampus of Diabetic Rats
Aragno, M., Mastrocola, R., Brignardello, E., Catalano, M. G., Robino, G., Manti, R., Parola, M., Danni, O., & Boccuzzi, G. (2002) · Endocrinology · doi:10.1210/en.2002-220182 · Cited by 83
Is There a Receptor for Dehydroepiandrosterone or Dehydroepiandrosterone Sulfate?
Widstrom, R. L., & Dillon, J. S. (2004) · Seminars in Reproductive Medicine · doi:10.1055/s-2004-861546 · Cited by 82
Dehydroepiandrosterone Sulfate and Allopregnanolone Directly Stimulate Catecholamine Production via Induction of Tyrosine Hydroxylase and Secretion by Affecting Actin Polymerization
Charalampopoulos, I., Dermitzaki, E., Vardouli, L., Tsatsanis, C., Stournaras, C., Margioris, A. N., & Gravanis, A. (2005) · Endocrinology · doi:10.1210/en.2005-0263 · Cited by 82
Neurosteroids in the Purkinje Cell: Biosynthesis, Mode of Action and Functional Significance
Tsutsui, K. (2008) · Molecular Neurobiology · doi:10.1007/s12035-008-8024-1 · Cited by 81
Analysis of clinical symptomatology, extrapyramidal symptoms and neurocognitive dysfunction following dehydroepiandrosterone (DHEA) administration in olanzapine treated schizophrenia patients: A randomized, double-blind placebo controlled trial
Strous, R. D., Stryjer, R., Maayan, R., Gal, G., Viglin, D., Katz, E., Eisner, D., & Weizman, A. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2006.11.002 · Cited by 80
Neuroactive Steroids and Suicidality in Posttraumatic Stress Disorder
Butterfield, M. I., Stechuchak, K. M., Connor, K. M., Davidson, J. R. T., Wang, C., MacKuen, C. L., Pearlstein, A. M., & Marx, C. E. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.2.380 · Cited by 80
Dehydroepiandrosterone 7α-hydroxylation in human tissues: Possible interference with type 1 11β-hydroxysteroid dehydrogenase-mediated processes
Hennebert, O., Chalbot, S., Alran, S., & Morfin, R. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2007.03.026 · Cited by 79
Modulation of GABA-Gated Chloride Ion Influx in the Brain by Dehydroepiandrosterone and Its Metabolites
Imamura, M., & Prasad, C. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8177 · Cited by 79

Research works printed but not linked: 1

O.M. Wolkowitz, V.I. Reus, N. Maninger, S.H. Mellon, Dehydroepiandrosterone in the treatment of neuropsychiatric conditions. in: D. Mischoulon, J.F. Rosenbaum (Eds.), Natural Medications for Psychiatric Disorders: Considering the Alternatives, Second Edition, Lippincott Williams & Wilkins, Philadelphia, PA, 2008, pp. 84–104.

Sorted by citations

The Impact of Stress and Major Depressive Disorder on Hippocampal and Medial Prefrontal Cortex Morphology
Belleau, E. L., Treadway, M. T., & Pizzagalli, D. A. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.09.031 · Cited by 550
The neurobiology of depression and antidepressant action
Willner, P., Scheel-Krüger, J., & Belzung, C. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.12.007 · Cited by 519
HPA axis and aging in depression: Systematic review and meta-analysis
Belvederi Murri, M., Pariante, C., Mondelli, V., Masotti, M., Atti, A. R., Mellacqua, Z., Antonioli, M., Ghio, L., Menchetti, M., Zanetidou, S., et al. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.12.004 · Cited by 367
Depression gets old fast: do stress and depression accelerate cell aging?
Wolkowitz, O. M., Epel, E. S., Reus, V. I., & Mellon, S. H. (2010) · Depression and Anxiety · doi:10.1002/da.20686 · Cited by 298
Self-citation
Hypothalamic-pituitary-adrenal axis dysfunction in chronic fatigue syndrome
Papadopoulos, A. S., & Cleare, A. J. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.153 · Cited by 280

See all 769

Authors: Maninger, N., Wolkowitz, O. M., Reus, V. I., Epel, E. S., & Mellon, S. H.
Affiliations: University of California, San Francisco (US)
Corresponding author: Mellon, Synthia H.
ORCID: Wolkowitz, Owen M.
Reus, Victor I.
Epel, Elissa S.
Mellon, Synthia H.
Venue: Frontiers in Neuroendocrinology
Publisher: Elsevier BV
Published: 2009-01
Volume: 30
Issue: 1
Pages: 65-91
ISSN: 0091-3022 (ISSN-L)
DOI: 10.1016/j.yfrne.2008.11.002
PMC: PMC2725024
OpenAlex: W2042430625
Cited by: 769
References: 365
Citations by year: 2026: 38 · 2025: 45 · 2024: 36 · 2023: 45 · 2022: 39 · 2021: 47 · 2020: 70 · 2019: 41 · 2018: 59 · 2017: 45 · 2016: 51 · 2015: 34 · 2014: 47 · 2013: 47 · 2012: 49
FWCI: 1.73
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Frontiers in Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (T32 MH09391)
National Institute of Neurological Disorders and Stroke (NS 049462, U01NS049462)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: dehydroepiandrosterone, DHEA sulfate, neuropsychiatric disorders, neuroprotection, neurite outgrowth, glucocorticoid antagonism, oxidative stress, adrenal steroids
MeSH terms: Adult, Aged, Aging, Animals, Antioxidants, Brain, Dehydroepiandrosterone, Dementia, Depression, Female, Humans, Male, Middle Aged, Schizophrenia, Stress Disorders, Post-Traumatic, Neuroprotective Agents, Dehydroepiandrosterone Sulfate, Hypoxia-Ischemia, Brain

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS)

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks