The DOI matches its Crossref record; 365 of the 365 references it cites were found in a registry or an index.
Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS)
Open accessAbstract
DHEA and DHEAS are steroids synthesized in human adrenals, but their function is unclear. In addition to adrenal synthesis, evidence also indicates that DHEA and DHEAS are synthesized in the brain, further suggesting a role of these hormones in brain function and development. Despite intensifying research into the biology of DHEA and DHEAS, many questions concerning their mechanisms of action and their potential involvement in neuropsychiatric illnesses remain unanswered. We review and distill the preclinical and clinical data on DHEA and DHEAS, focusing on (i) biological actions and putative mechanisms of action, (ii) differences in endogenous circulating concentrations in normal subjects and patients with neuropsychiatric diseases, and (iii) the therapeutic potential of DHEA in treating these conditions. Biological actions of DHEA and DHEAS include neuroprotection, neurite growth, and antagonistic effects on oxidants and glucocorticoids. Accumulating data suggest abnormal DHEA and/or DHEAS concentrations in several neuropsychiatric conditions. The evidence that DHEA and DHEAS may be fruitful targets for pharmacotherapy in some conditions is reviewed.
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“As opposed to cortisol, a catabolic hormone, DHEA has anabolic and antiglucocorticoid effects (Kalimi et al., 1994; Maninger et al., 2009).”
From Effect of oxytocin on craving and stress response in marijuana-dependent individuals: A pilot study (2013) · cites this paper as Maninger et al., 2009
In the citing paper
“animal models have shown that DHEA reduces the adverse effects of cortisol on the central nervous system (81)”
From The Impact of Stress and Major Depressive Disorder on Hippocampal and Medial Prefrontal Cortex Morphology (2019) · cites this paper as [81]
In the citing paper
“Interestingly, one previous study has shown high serum levels of dehydroepiandrosterone-sulphate (DHEA-S), a hormone with anti-glucocorticoid action, in patients with first-episode psychosis (Strous et al., 2004), while lower levels of DHEA have been described late in the course of chronic illness (Maninger et al., 2009).”
From Abnormal cortisol levels during the day and cortisol awakening response in first-episode psychosis: The role of stress and of antipsychotic treatment (2010) · cites this paper as Maninger et al., 2009
In the citing paper
“The DHEA-to-cortisol ratio has been described as more informative than either DHEA or cortisol absolute concentrations in particular regarding the possible effect of these hormones on cognitive function (Maninger et al., 2009).”
From Abnormal cortisol levels during the day and cortisol awakening response in first-episode psychosis: The role of stress and of antipsychotic treatment (2010) · cites this paper as Maninger et al., 2009
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Self-citation
Research works printed but not linked: 1
- O.M. Wolkowitz, V.I. Reus, N. Maninger, S.H. Mellon, Dehydroepiandrosterone in the treatment of neuropsychiatric conditions. in: D. Mischoulon, J.F. Rosenbaum (Eds.), Natural Medications for Psychiatric Disorders: Considering the Alternatives, Second Edition, Lippincott Williams & Wilkins, Philadelphia, PA, 2008, pp. 84–104.
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Belleau, E. L., Treadway, M. T., & Pizzagalli, D. A. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.09.031 · Cited by 550
The neurobiology of depression and antidepressant action
Willner, P., Scheel-Krüger, J., & Belzung, C. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.12.007 · Cited by 519
HPA axis and aging in depression: Systematic review and meta-analysis
Belvederi Murri, M., Pariante, C., Mondelli, V., Masotti, M., Atti, A. R., Mellacqua, Z., Antonioli, M., Ghio, L., Menchetti, M., Zanetidou, S., et al. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.12.004 · Cited by 367
Depression gets old fast: do stress and depression accelerate cell aging?
Wolkowitz, O. M., Epel, E. S., Reus, V. I., & Mellon, S. H. (2010) · Depression and Anxiety · doi:10.1002/da.20686 · Cited by 298
Self-citationHypothalamic-pituitary-adrenal axis dysfunction in chronic fatigue syndrome
Papadopoulos, A. S., & Cleare, A. J. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.153 · Cited by 280
Metadata
- Authors
- Maninger, N., Wolkowitz, O. M., Reus, V. I., Epel, E. S., & Mellon, S. H.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Mellon, Synthia H.
- Venue
- Frontiers in Neuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 30
- Issue
- 1
- Pages
- 65-91
- ISSN
- 0091-3022 (ISSN-L)
- PMC
- PMC2725024
- OpenAlex
- W2042430625
- Cited by
- 769
- References
- 365
- Citations by year
- 2026: 38 · 2025: 45 · 2024: 36 · 2023: 45 · 2022: 39 · 2021: 47 · 2020: 70 · 2019: 41 · 2018: 59 · 2017: 45 · 2016: 51 · 2015: 34 · 2014: 47 · 2013: 47 · 2012: 49
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Frontiers in Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (T32 MH09391)
- National Institute of Neurological Disorders and Stroke (NS 049462, U01NS049462)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- dehydroepiandrosterone, DHEA sulfate, neuropsychiatric disorders, neuroprotection, neurite outgrowth, glucocorticoid antagonism, oxidative stress, adrenal steroids
- MeSH terms
- Adult, Aged, Aging, Animals, Antioxidants, Brain, Dehydroepiandrosterone, Dementia, Depression, Female, Humans, Male, Middle Aged, Schizophrenia, Stress Disorders, Post-Traumatic, Neuroprotective Agents, Dehydroepiandrosterone Sulfate, Hypoxia-Ischemia, Brain
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