The DOI matches its Crossref record; 222 of the 222 references it cites were found in a registry or an index.
The adrenal peripheral clock: Glucocorticoid and the circadian timing system
Abstract
The mammalian circadian timing system is organized in a hierarchy, with the master clock residing in the suprachiasmatic nucleus (SCN) of the hypothalamus and subsidiary peripheral clocks in other brain regions as well as peripheral tissues. Since the local oscillators in most cells contain a similar molecular makeup to that in the central pacemaker, determining the role of the peripheral clocks in the regulation of rhythmic physiology and behavior is an important issue. Glucocorticoids (GCs) are a class of multi-functional adrenal steroid hormones, which exhibit a robust circadian rhythm, with a peak linked with the onset of the daily activity phase. It has long been believed that the production and secretion of GC is primarily governed through the hypothalamus-pituitary-adrenal (HPA) neuroendocrine axis in mammals. Growing evidence, however, strongly supports the notion that the periodicity of GC involves the integrated activity of multiple regulatory mechanisms related to circadian timing system along with the classical HPA neuroendocrine regulation. The adrenal-intrinsic oscillator as well as the central pacemaker plays a pivotal role in its rhythmicity. GC influences numerous biological processes, such as metabolic, cardiovascular, immune and even higher brain functions, and also acts as a resetting signal for the ubiquitous peripheral clocks, suggesting its importance in harmonizing circadian physiology and behavior. In this review, we will therefore focus on the recent advances in our understanding of the circadian regulation of adrenal GC and its functional relevance.
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“the circadian system regulates glucocorticoid secretion from the adrenal glands, such that concentrations tend to peak in the morning just before awakening and decrease throughout the day in diurnal animals, including humans52,53.”
From Circadian rhythm disruption and mental health (2020) · cites this paper as [52]
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Cites
Sapolsky, R. M., Romero, L. M., & Munck, A. U. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.1.0389 · Cited by 7,541
Sapolsky, R. M. (2000) · Endocrine Reviews · doi:10.1210/er.21.1.55 · Cited by 7,533
Transcriptional regulation by the phosphorylation-dependent factor CREB
Mayr, B., & Montminy, M. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35085068 · Cited by 2,587
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice
Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., et al. (2005) · Science · doi:10.1126/science.1108750 · Cited by 2,485
Dibner, C., Schibler, U., & Albrecht, U. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135821 · Cited by 2,421
Damiola, F., Le Minh, N., Preitner, N., Kornmann, B., Fleury-Olela, F., & Schibler, U. (2000) · Genes & Development · doi:10.1101/gad.183500 · Cited by 2,394
Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock
Panda, S., Antoch, M. P., Miller, B. H., Su, A. I., Schook, A. C., Straume, M., Schultz, P. G., Kay, S. A., Takahashi, J. S., & Hogenesch, J. B. (2002) · Cell · doi:10.1016/s0092-8674(02)00722-5 · Cited by 2,310
Preitner, N., Damiola, F., Luis-Lopez-Molina, Zakany, J., Duboule, D., Albrecht, U., & Schibler, U. (2002) · Cell · doi:10.1016/s0092-8674(02)00825-5 · Cited by 2,198
Loss of a circadian adrenal corticosterone rhythm following suprachiasmatic lesions in the rat
Moore, R. Y., & Eichler, V. B. (1972) · Brain Research · doi:10.1016/0006-8993(72)90054-6 · Cited by 2,135
Stephan, F. K., & Zucker, I. (1972) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.69.6.1583 · Cited by 2,039
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Items 101–133 of 133
Circadian Rhythms in Mood Disorders
McClung, C. A. (2015) · Wiley eBooks · doi:10.1002/9781118467831.ch17 · Cited by 4
Relevance of Circadian Rhythm in Cancer
DiTacchio, L., DiTacchio, K. A., & Panda, S. (2015) · Energy balance and cancer · doi:10.1007/978-3-319-16733-6_1 · Cited by 3
“peripheral clocks [69–71].”
Basic Circadian Timing and Sleep-Wake Regulation
Cuesta, M., Boudreau, P., & Boivin, D. B. (2017) · Springer eBooks · doi:10.1007/978-1-4939-6578-6_6 · Cited by 4
Salivary Cortisol as a Measure of Acute Stress and Diurnal Adrenal Activity in Bottlenose Dolphins
Charlton, B., Lanyon, J. M., Madden, C., Phillips, W., & Keeley, T. (2025) · Marine Mammal Science · doi:10.1111/mms.70044 · Cited by 2
“Circadian rhythms of GCs, including cortisol, are common in mammals (Honma 2018; Son et al. 2011).”
Cicha, E., Blatkiewicz, M., Jopek, K., Szyszka, M., Malendowicz, P. W., Olechnowicz, A., Malendowicz, L. K., & Ruciński, M. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48020135 · Cited by 2
“The adrenal peripheral clock regulates temporal patterns of steroidogenic gene expression and responsiveness to ACTH [78,79].”
Short daylight photoperiod alleviated alarm substance-stimulated fear response of zebrafish
Tan, M., Xie, C., Tu, X., Li, Y., Chen, Q.-L., Shen, Y., & Liu, Z. (2023) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2023.114274 · Cited by 3
Circadian Synchronization of Cognitive Functions
Anzulovich, A. C. (2015) · Springer eBooks · doi:10.1007/978-3-319-17103-6_11 · Cited by 2
Possible protective effects of the Bmal1 gene and melatonin on the prognosis of apical periodontitis
Küçük, M., Aksoy, U., & Şehirli, A. Ö. (2022) · Medical Hypotheses · doi:10.1016/j.mehy.2022.110806 · Cited by 2
Mechanism and maladies of the circadian clock synchronization in human and mammals
Huang, H., & Fu, S. (2017) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/n972016-00862
Tecot, S. R., Ossello, G., Smith, P. G., Rakotonirina, L. H. F., Telo, A., Victor Rasendry, N., Emile Rakotonirina, T., & Peñaherrera‐Aguirre, M. (2023) · American Journal of Primatology · doi:10.1002/ajp.23521 · Cited by 1
“Age (Gust, 2000), health (reviewed in Miller et al., 2007 and Son et al., 2011), and social status (Cross & Rogers, 2004) may have additional effects on diurnal patterns of glucocorticoid secretion.”
BackgroundYou, J. W., Nam, Y., Yu, R., & Ryu, V. (2024) · Mood and Emotion · doi:10.35986/me.2024.22.1.10 · Cited by 1
Chronic stress shifts the phase of adrenal clock gene rhythms
Karsten, C. A. (2012) · University of Minnesota Digital Conservancy (University of Minnesota)
Reinhardt, É. L. (2013) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.6.2013.tde-12042013-113122
Hupalo, S. (2012) · University of Minnesota Digital Conservancy (University of Minnesota)
Kallur, S. D. (2012) · OakTrust (Texas A&M University Libraries)
Analysis of Circadian Properties and Clock Regulation of Glioma and Breast Cancer Stem Cells
Sharma, V. P. (2014) · OhioLink ETD Center (Ohio Library and Information Network)
Circadian Timing of Curcumin Efficacy and Nuclear Transport Properties of Cancer Cells
Sarma, A. (2015) · ScholarWorks@BGSU (Bowling Green State University)
Durant, A. C. (2015) · YorkSpace (York University)
Light-At-Night and Mood: Examining The Role Of Sex In C57Bl/6 Mice
Cleary-Gaffney, M. (2015) · Maynooth University ePrints and eTheses Archive (Maynooth University)
Hippocampal neuroplasticity and neurogenesis in major depressive disorder: a high field MRI study
Huang, Y. (2012) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3qm0k
Circadian rhythms and physiological processes
Tsuchiya, Y., Sasawaki, Y., & Yagita, K. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-822963-7.00292-9 · Cited by 1
Psychiatric Disturbances of Attention
Cohen, R. A. (2013) · Springer eBooks · doi:10.1007/978-0-387-72639-7_17
Foster, T. R., Dadzie, K. A., Dunn, S., & Bupp, M. G. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.24.595677
“In nocturnal animals like mice, blood GC levels peak at the start of the dark phase and fall during the light phase [12,15,16,18].”
InfluentialRomero, M. D. M., Martín‐González, M. Z., Aragonès, G., Muguerza, B., Remesar, X., Arola‐Arnal, A., & Fernández–Löpez, J. (2024) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202400323
Circadian rhythm and body health: A review of the literatur
Vaghefi, S. S. E., Afshar, R. M., Shahsavari, F., Mousavi, F., Vaghefi, S. H. E., Nosratabadi, S. J., Khaksari, M., Soltani, Z., Asadikaram, G., Meymandi, M. S., et al. (2024) · Physiology and Pharmacology · doi:10.61186/phypha.28.3.237
Spulber, S. D., Bose, R., Elberling, F., Conti, M., & Ceccatelli, S. (2025) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2025.1620800
Embryonic Circadian Rhythm Establishment, Homeostasis, and Dysfunction During Organogenesis
Chen, S.-L., Zhou, H., Li, Y.-M., & Zheng, Y.-W. (2025) · Stem Cells International · doi:10.1155/sci/9621027
“Various studies have also explored the regulatory roles of different circadian genes in the gastrointestinal and adrenal systems [9, 10].”
Alnasser, S. M. (2026) · Stem Cell Research & Therapy · doi:10.1186/s13287-026-04979-6
“The SCN acts as the master pacemaker, transmitting timing signals through neural and endocrine pathways, including glucocorticoids, catecholamines and melatonin to align peripheral stem cell clocks with organismal physiology [73–75].”
The role of chromatin remodelers in dopaminoceptive neurons
Zayed, A. (2019) · theses.fr (ABES) · doi:10.70675/f1d09c9dz29c5z44e4zae26z358715db672e
The role of the circadian transcription factor KLF10 in liver physiology
Ruberto, A. A. (2019) · theses.fr (ABES) · doi:10.70675/cb3492c2z5778z48e3za7d7zf17279fd718b
Sexual dimorphism in the adrenal cortex: implications for stress responsiveness
Siatra, P., Bornstein, S. R., & Steenblock, C. (2026) · European Journal of Endocrinology · doi:10.1093/ejendo/lvag104
Metadata
- Authors
- Son, G. H., Chung, S., & Kim, K.
- Affiliations
- Seoul National University (KR)
- Corresponding author
- Kim, Kyungjin
- Venue
- Frontiers in Neuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 32
- Issue
- 4
- Pages
- 451-465
- ISSN
- 0091-3022 (ISSN-L)
- OpenAlex
- W1971407944
- Cited by
- 136
- References
- 221
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 9 · 2023: 6 · 2022: 6 · 2021: 8 · 2020: 7 · 2019: 8 · 2018: 10 · 2017: 16 · 2016: 8 · 2015: 12 · 2014: 12 · 2013: 12 · 2012: 13
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Frontiers in Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- glucocorticoids, circadian system, peripheral clocks, adrenal gland, suprachiasmatic nucleus, hypothalamic-pituitary-adrenal axis, circadian rhythm, glucocorticoid secretion, clock resetting, circadian physiology
- MeSH terms
- Adrenal Glands, Animals, Biological Clocks, Glucocorticoids, Humans, Models, Biological, Signal Transduction, Neuroendocrine Cells, Circadian Clocks
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