The DOI matches its Crossref record; 222 of the 222 references it cites were found in a registry or an index.
The adrenal peripheral clock: Glucocorticoid and the circadian timing system
Abstract
The mammalian circadian timing system is organized in a hierarchy, with the master clock residing in the suprachiasmatic nucleus (SCN) of the hypothalamus and subsidiary peripheral clocks in other brain regions as well as peripheral tissues. Since the local oscillators in most cells contain a similar molecular makeup to that in the central pacemaker, determining the role of the peripheral clocks in the regulation of rhythmic physiology and behavior is an important issue. Glucocorticoids (GCs) are a class of multi-functional adrenal steroid hormones, which exhibit a robust circadian rhythm, with a peak linked with the onset of the daily activity phase. It has long been believed that the production and secretion of GC is primarily governed through the hypothalamus-pituitary-adrenal (HPA) neuroendocrine axis in mammals. Growing evidence, however, strongly supports the notion that the periodicity of GC involves the integrated activity of multiple regulatory mechanisms related to circadian timing system along with the classical HPA neuroendocrine regulation. The adrenal-intrinsic oscillator as well as the central pacemaker plays a pivotal role in its rhythmicity. GC influences numerous biological processes, such as metabolic, cardiovascular, immune and even higher brain functions, and also acts as a resetting signal for the ubiquitous peripheral clocks, suggesting its importance in harmonizing circadian physiology and behavior. In this review, we will therefore focus on the recent advances in our understanding of the circadian regulation of adrenal GC and its functional relevance.
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“the circadian system regulates glucocorticoid secretion from the adrenal glands, such that concentrations tend to peak in the morning just before awakening and decrease throughout the day in diurnal animals, including humans52,53.”
From Circadian rhythm disruption and mental health (2020) · cites this paper as [52]
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Cites
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Transcriptional regulation by the phosphorylation-dependent factor CREB
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Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses
Vandenberg, L. N., Colborn, T., Hayes, T. B., Heindel, J. J., Jacobs, D. R., Lee, D.-H., Shioda, T., Soto, A. M., vom Saal, F. S., Welshons, W. V., et al. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1050 · Cited by 3,209
“There are additional reasons why natural hormones are active at low doses: 4) hormones have a strong affinity for their receptors (relative to affinity for other receptors) because many hormones are secreted from a single gland or site in the body but must have effects throughout the body in multiple tissues and 5) bl…”
Circadian rhythm disruption and mental health
Walker, W. H., Walton, J. C., DeVries, A. C., & Nelson, R. J. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0694-0 · Cited by 1,030
The Functional and Clinical Significance of the 24-Hour Rhythm of Circulating Glucocorticoids
Oster, H., Challet, E., Ott, V., Arvat, E., de Kloet, E. R., Dijk, D.-J., Lightman, S., Vgontzas, A., & Van Cauter, E. (2017) · Endocrine Reviews · doi:10.1210/er.2015-1080 · Cited by 548
How might circadian rhythms control mood? Let me count the ways
McClung, C. A. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.02.019 · Cited by 507
“Glucocorticoids have a strong circadian rhythm in expression and peak in expression just prior to the onset of awakening (8).”
BackgroundTiming of light exposure affects mood and brain circuits
Bedrosian, T. A., & Nelson, R. J. (2017) · Translational Psychiatry · doi:10.1038/tp.2016.262 · Cited by 356
Metadata
- Authors
- Son, G. H., Chung, S., & Kim, K.
- Affiliations
- Seoul National University (KR)
- Corresponding author
- Kim, Kyungjin
- Venue
- Frontiers in Neuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 32
- Issue
- 4
- Pages
- 451-465
- ISSN
- 0091-3022 (ISSN-L)
- OpenAlex
- W1971407944
- Cited by
- 136
- References
- 221
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 9 · 2023: 6 · 2022: 6 · 2021: 8 · 2020: 7 · 2019: 8 · 2018: 10 · 2017: 16 · 2016: 8 · 2015: 12 · 2014: 12 · 2013: 12 · 2012: 13
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Frontiers in Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- glucocorticoids, circadian system, peripheral clocks, adrenal gland, suprachiasmatic nucleus, hypothalamic-pituitary-adrenal axis, circadian rhythm, glucocorticoid secretion, clock resetting, circadian physiology
- MeSH terms
- Adrenal Glands, Animals, Biological Clocks, Glucocorticoids, Humans, Models, Biological, Signal Transduction, Neuroendocrine Cells, Circadian Clocks
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