The DOI matches its Crossref record; 222 of the 222 references it cites were found in a registry or an index.
The adrenal peripheral clock: Glucocorticoid and the circadian timing system
Abstract
The mammalian circadian timing system is organized in a hierarchy, with the master clock residing in the suprachiasmatic nucleus (SCN) of the hypothalamus and subsidiary peripheral clocks in other brain regions as well as peripheral tissues. Since the local oscillators in most cells contain a similar molecular makeup to that in the central pacemaker, determining the role of the peripheral clocks in the regulation of rhythmic physiology and behavior is an important issue. Glucocorticoids (GCs) are a class of multi-functional adrenal steroid hormones, which exhibit a robust circadian rhythm, with a peak linked with the onset of the daily activity phase. It has long been believed that the production and secretion of GC is primarily governed through the hypothalamus-pituitary-adrenal (HPA) neuroendocrine axis in mammals. Growing evidence, however, strongly supports the notion that the periodicity of GC involves the integrated activity of multiple regulatory mechanisms related to circadian timing system along with the classical HPA neuroendocrine regulation. The adrenal-intrinsic oscillator as well as the central pacemaker plays a pivotal role in its rhythmicity. GC influences numerous biological processes, such as metabolic, cardiovascular, immune and even higher brain functions, and also acts as a resetting signal for the ubiquitous peripheral clocks, suggesting its importance in harmonizing circadian physiology and behavior. In this review, we will therefore focus on the recent advances in our understanding of the circadian regulation of adrenal GC and its functional relevance.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“the circadian system regulates glucocorticoid secretion from the adrenal glands, such that concentrations tend to peak in the morning just before awakening and decrease throughout the day in diurnal animals, including humans52,53.”
From Circadian rhythm disruption and mental health (2020) · cites this paper as [52]
Citations
Cites
Items 201–222 of 222
Gerhold, L. M., Rosewell, K. L., & Wise, P. M. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3598-04.2005 · Cited by 61
Stratakis, C. A. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.11.010 · Cited by 59
Core body temperature is normal in chronic fatigue syndrome
Hamilos, D. L., Nutter, D., Gershtenson, J., Redmond, D. P., Diclementi, J. D., Schmaling, K. B., Make, B. J., & Jones, J. F. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)83214-3 · Cited by 57
Differential hormonal regulation of tryptophan hydroxylase-2 mRNA in the murine dorsal raphe nucleus
Clark, J. A., Pai, L.-Y., Flick, R. B., & Rohrer, S. P. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.013 · Cited by 56
Singh, V. B., Onaivi, E. S., Phan, T.-H., & Boadle‐Biber, M. C. (1990) · Brain Research · doi:10.1016/0006-8993(90)90656-v · Cited by 51
Spiga, F., Liu, Y., Aguilera, G., & Lightman, S. L. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02096.x · Cited by 50
De novo synthesis of corticosteroids in hamster adrenal glands
Lehoux, J., & Lefèbvre, A. (1980) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(80)90310-6 · Cited by 48
Aldosterone and cardiovascular disease
Carey, R. M. (2010) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3283390fa4 · Cited by 48
Ciocca, D., Maurel, D., & Bosler, O. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00287.2001 · Cited by 47
Expression and Regulation of Adenylyl Cyclase Isoforms in the Human Adrenal Gland
Côté, M., Guillon, G., PAYET, M. D., & Gallo‐Payet, N. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.9.7837 · Cited by 43
Liu, J., Malkani, G., Shi, X., Meyer, M., Cunningham-Runddles, S., Ma, X., & Sun, Z. S. (2007) · Cited by 39
Pilorz, V., Steinlechner, S., & Oster, H. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.08.010 · Cited by 33
Location, location, location: important for jet-lagged circadian loops
Harrington, M. E. (2010) · Journal of Clinical Investigation · doi:10.1172/jci43632 · Cited by 33
Involvement of CLOCK:BMAL1 heterodimer in serum-responsive mPer1 induction
Jung, H., Choe, Y., Kim, H., Park, N., Son, G. H., Khang, I., & Kim, K. (2003) · Neuroreport · doi:10.1097/00001756-200301200-00003 · Cited by 30
Self-citationDecreased Delta-Sleep and Plasma Delta-Sleep-Inducing Peptide in Patients with Cushing Syndrome
Friedman, T. C., Garcı́a-Borreguero, D., Hardwick, D., Akuete, C. N., Doppman, J. L., Dorn, L. D., Barker, C. N., Yanovski, J. A., & Chrousos, G. P. (2008) · Neuroendocrinology · doi:10.1159/000126806 · Cited by 29
Torres‐Farfan, C., Valenzuela, F. J., Ebensperger, R., Méndez, N., Campino, C., Richter, H. G., Valenzuela, G. J., & Serón‐Ferré, M. (2007) · American Journal of Primatology · doi:10.1002/ajp.20461 · Cited by 28
A new focus on interoceptive properties of adrenal medulla
Mravec, B. (2005) · Autonomic Neuroscience · doi:10.1016/j.autneu.2005.04.005 · Cited by 24
Joëls, M., & van Riel, E. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1314.046 · Cited by 23
Mahoney, C. E., Brewer, D. N., Costello, M. K., Brewer, J. M., & Bittman, E. L. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00746.2009 · Cited by 20
PERsuading nuclear receptors to dance the circadian rhythm
Ripperger, J. A., Schmutz, I., & Albrecht, U. (2010) · Cell Cycle · doi:10.4161/cc.9.13.12075 · Cited by 19
Management of patients with glucocorticoid deficiency
Crown, A. L., & Lightman, S. L. (2005) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0051 · Cited by 14
Phase response profile of hamster adrenal organ cultures treated with acth and exogenous steroid
Andrews, R. V. (1980) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(80)90276-5 · Cited by 7
Cited by
Sorted by citations
Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses
Vandenberg, L. N., Colborn, T., Hayes, T. B., Heindel, J. J., Jacobs, D. R., Lee, D.-H., Shioda, T., Soto, A. M., vom Saal, F. S., Welshons, W. V., et al. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1050 · Cited by 3,209
“There are additional reasons why natural hormones are active at low doses: 4) hormones have a strong affinity for their receptors (relative to affinity for other receptors) because many hormones are secreted from a single gland or site in the body but must have effects throughout the body in multiple tissues and 5) bl…”
Circadian rhythm disruption and mental health
Walker, W. H., Walton, J. C., DeVries, A. C., & Nelson, R. J. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0694-0 · Cited by 1,030
The Functional and Clinical Significance of the 24-Hour Rhythm of Circulating Glucocorticoids
Oster, H., Challet, E., Ott, V., Arvat, E., de Kloet, E. R., Dijk, D.-J., Lightman, S., Vgontzas, A., & Van Cauter, E. (2017) · Endocrine Reviews · doi:10.1210/er.2015-1080 · Cited by 548
How might circadian rhythms control mood? Let me count the ways
McClung, C. A. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.02.019 · Cited by 507
“Glucocorticoids have a strong circadian rhythm in expression and peak in expression just prior to the onset of awakening (8).”
BackgroundTiming of light exposure affects mood and brain circuits
Bedrosian, T. A., & Nelson, R. J. (2017) · Translational Psychiatry · doi:10.1038/tp.2016.262 · Cited by 356
Metadata
- Authors
- Son, G. H., Chung, S., & Kim, K.
- Affiliations
- Seoul National University (KR)
- Corresponding author
- Kim, Kyungjin
- Venue
- Frontiers in Neuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 32
- Issue
- 4
- Pages
- 451-465
- ISSN
- 0091-3022 (ISSN-L)
- OpenAlex
- W1971407944
- Cited by
- 136
- References
- 221
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 9 · 2023: 6 · 2022: 6 · 2021: 8 · 2020: 7 · 2019: 8 · 2018: 10 · 2017: 16 · 2016: 8 · 2015: 12 · 2014: 12 · 2013: 12 · 2012: 13
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Frontiers in Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- glucocorticoids, circadian system, peripheral clocks, adrenal gland, suprachiasmatic nucleus, hypothalamic-pituitary-adrenal axis, circadian rhythm, glucocorticoid secretion, clock resetting, circadian physiology
- MeSH terms
- Adrenal Glands, Animals, Biological Clocks, Glucocorticoids, Humans, Models, Biological, Signal Transduction, Neuroendocrine Cells, Circadian Clocks
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
