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Cited by 33Circadian rhythm and melatoninHypothalamic control of reproductive hormonesEstrogen and related hormone effects

Age and oestrus cycle-related changes in glucocorticoid excretion and wheel-running activity in female mice carrying mutations in the circadian clock genes per1 and per2

Pilorz, Violetta, Steinlechner, Stephan, Oster, Henrik·2009·Physiology & Behavior
DOI 10.1016/j.physbeh.2008.08.010
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Abstract

In mammals, numerous physiological and behavioural functions are controlled by an endogenous circadian clock located in the suprachiasmatic nuclei (SCN). Within the SCN neurons, clock genes such as Per1 and Per2 interact in a molecular clockwork regulating the expression of hundreds of output genes. Through the timed release of humoral and neuronal signals, the rhythmicity of numerous biological processes, including reproductive behaviour, the oestrus cycle and endocrine parameters is controlled by the SCN. Mutations in Per genes in mice affect a wide array of physiological functions. Interestingly, most of these studies use only male animals, thus neglecting potential gender-specificities in clock function. In an attempt to broaden this perspective we have investigated the impact of Per1 and Per2 mutations on both glucocorticoid (GC) metabolite excretion and locomotor activity in relation to age and oestrus cycle stage of female mice. We show that the Per2 mutation dampens daily GC rhythms in young adult females. While locomotor activity does not vary along the different oestrus stages in Per2 mutant females, oestrus effects on GC excretion and locomotor activity are largely comparable between Per1 mutants and wild-type animals. 20 month-old, acyclic Per1 and wild-type females show reduced GC levels when compared to young adults while aged Per2 mutants retain their normal GC rhythmicity. Correlating with this, onsets of locomotor activity do not change with age in Per2 mutant females. Together, our data highlight specific roles for Per1 and Per2 in both the regulation of locomotor activity and endocrine functions in the female organism.

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  • CORT levels change across the estrous cycle, in addition to circadian and ultradian fluctuations, with maximum levels around the diestrus and proestrus phase.

    “For example, evidence shows that in addition to exhibiting circadian and ultradian fluctuations, CORT levels also change across the estrous cycle, with maximum levels around the diestrus and proestrus phase (Carey et al., 1995; Atkinson and Waddell, 1997; Pilorz et al., 2009).”

    From Dynamic Hormone Control of Stress and Fertility (2020) · cites this paper as Pilorz et al., 2009

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Authors
Pilorz, V., Steinlechner, S., & Oster, H.
Affiliations
  • University of Veterinary Medicine Hannover, Foundation (DE)
  • Max Planck Society (DE)
Corresponding author
Pilorz, Violetta
ORCID
Venue
Physiology & Behavior
Publisher
Elsevier BV
Published
2009-01
Volume
96
Issue
1
Pages
57-63
ISSN
0031-9384 (ISSN-L)
DOI
10.1016/j.physbeh.2008.08.010
OpenAlex
W1976740833
Cited by
33
References
65
Citations by year
2026: 1 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 7 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 1 · 2015: 2 · 2014: 1 · 2013: 2 · 2012: 2
FWCI
0.89
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Physiology & Behavior (publishedVersion)
  • PubMed (publishedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords
Per1, Per2, clock genes, wheel running, locomotor activity, estrous cycle, aging, female mice, suprachiasmatic nucleus, circadian rhythm, reproductive behavior, hormonal regulation
MeSH terms
Aging, Analysis of Variance, Animals, Female, Glucocorticoids, Mice, Inbred C57BL, Mice, Transgenic, Motor Activity, Mutation, Nuclear Proteins, Transcription Factors, Statistics, Nonparametric, Cell Cycle Proteins, Estrous Cycle, Intracellular Signaling Peptides and Proteins, Mice, Period Circadian Proteins

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