The DOI matches its Crossref record; 310 of the 310 references it cites were found in a registry or an index.
The regulation of reproductive neuroendocrine function by insulin and insulin-like growth factor-1 (IGF-1)
Open accessAbstract
The mammalian reproductive hormone axis regulates gonadal steroid hormone levels and gonadal function essential for reproduction. The neuroendocrine control of the axis integrates signals from a wide array of inputs. The regulatory pathways important for mediating these inputs have been the subject of numerous studies. One class of proteins that have been shown to mediate metabolic and growth signals to the CNS includes Insulin and IGF-1. These proteins are structurally related and can exert endocrine and growth factor like action via related receptor tyrosine kinases. The role that insulin and IGF-1 play in controlling the hypothalamus and pituitary and their role in regulating puberty and nutritional control of reproduction has been studied extensively. This review summarizes the in vitro and in vivo models that have been used to study these neuroendocrine structures and the influence of these growth factors on neuroendocrine control of reproduction.
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“IGF-1 is structurally homologous to insulin and findings suggest that it is also involved in GnRH regulation.108”
From Pubertal development and regulation (2016) · cites this paper as [108]
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Cites
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“Kisspeptin neurons and the kisspeptin receptor The description of a patient with idiopathic hypogonadotropic hypogonadism with a mutation in the KISS1R, and a mouse model with a deletion of the Kiss1R gene added a new member to the axis structure (Seminara et al. 2003, de Roux et al. 2003).”
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Pubertal development and regulation
Abreu, A. P., & Kaiser, U. B. (2016) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(15)00418-0 · Cited by 611
Parent, A.-S., Franssen, D., Fudvoye, J., Gérard, A., & Bourguignon, J.-P. (2015) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.12.004 · Cited by 175
Development of the gonadotropin‐releasing hormone system
Duittoz, A. H., Forni, P. E., Giacobini, P., Golan, M., Mollard, P., Negrón, A. L., Radovick, S., & Wray, S. (2022) · Journal of Neuroendocrinology · doi:10.1111/jne.13087 · Cited by 50
Metadata
- Authors
- Wolfe, A., Divall, S., & Wu, S.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Wolfe, Andrew
- Venue
- Frontiers in Neuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 35
- Issue
- 4
- Pages
- 558-572
- ISSN
- 0091-3022 (ISSN-L)
- PMC
- PMC4175134
- OpenAlex
- W2076110825
- Cited by
- 83
- References
- 310
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 5 · 2023: 2 · 2022: 5 · 2021: 13 · 2020: 7 · 2019: 7 · 2018: 7 · 2017: 9 · 2016: 8 · 2015: 3 · 2014: 2
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Frontiers in Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK079637)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD068777, K99HD068130, K08HD056139, R01HD044608, R00HD068130)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- insulin, insulin-like growth factor I, neuroendocrine regulation of reproduction, hypothalamus, pituitary gland, gonadotropin secretion, puberty, growth factor signaling, receptor tyrosine kinase, sex steroids
- MeSH terms
- Animals, Humans, Insulin, Insulin-Like Growth Factor I, Neurosecretory Systems, Pituitary Gland, Reproduction, Sexual Maturation
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