The regulation of reproductive neuroendocrine function by insulin and insulin-like growth factor-1 (IGF-1)

Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions*

Jones, J. I. W., & Clemmons, D. R. (1995) · Endocrine Reviews · doi:10.1210/edrv-16-1-3 · Cited by 4,488

Signal transduction by the JNK group of MAP kinases

Davis, R. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00116-1 · Cited by 4,237

The MAPK signaling cascade

Seger, R., & Krebs, E. G. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.9.7601337 · Cited by 3,631

A central role for JNK in obesity and insulin resistance

Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359

Role of leptin in the neuroendocrine response to fasting

Ahima, R. S., Prabakaran, D., Mantzoros, C., Qu, D., Lowell, B., Maratos-Flier, E., & Flier, J. S. (1996) · Nature · doi:10.1038/382250a0 · Cited by 3,117

AP-1 as a regulator of cell life and death

Shaulian, E., & Karin, M. (2002) · Nature Cell Biology · doi:10.1038/ncb0502-e131 · Cited by 2,961

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

Liu, J.-P., Baker, J. C., Perkins, A. S., Robertson, E. J., & Efstratiadis, A. (1993) · Cell · doi:10.1016/s0092-8674(05)80084-4 · Cited by 2,854

The GPR54 Gene as a Regulator of Puberty

Seminara, S. B., Messager, S., Chatzidaki, E. E., Thresher, R. R., Acierno, J. S., Shagoury, J. K., Bo-Abbas, Y., Kuohung, W., Schwinof, K. M., Hendrick, A. G., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa035322 · Cited by 2,557

Role of insulin-like growth factors in embryonic and postnatal growth

Baker, J., Liu, J.-P., Robertson, E. J., & Efstratiadis, A. (1993) · Cell · doi:10.1016/s0092-8674(05)80085-6 · Cited by 2,463

Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54

de Roux, N., Genin, E., Carel, J.-C., Matsuda, F., Chaussain, J.-L., & Milgrom, E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1834399100 · Cited by 2,431 · cited 1×

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes.

Guilherme, A., Virbasius, J. V., Puri, V., & Czech, M. P. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2391 · Cited by 2,292

Glycoprotein Hormones: Structure and Function

Pierce, J. G., & Parsons, T. F. (1981) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.50.070181.002341 · Cited by 2,288

Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

Brüning, J. C., Gautam, D., Burks, D. J., Gillette, J., Schubert, M., Orban, P. C., Klein, R., Krone, W., Müller-Wieland, D., & Kahn, C. R. (2000) · Science · doi:10.1126/science.289.5487.2122 · Cited by 2,235

The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-coupled Receptor GPR54

Kotani, M., Detheux, M., Vandenbogaerde, A., Communi, D., Vanderwinden, J.-M., Le Poul, E., Brézillon, S., Tyldesley, R., Suarez-Huerta, N., Vandeput, F., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104847200 · Cited by 1,546

Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor

Ohtaki, T., Shintani, Y., Honda, S., Matsumoto, H., Hori, A., Kanehashi, K., Terao, Y., Kumano, S., Takatsu, Y., Masuda, Y., et al. (2001) · Nature · doi:10.1038/35079135 · Cited by 1,447

Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54

Messager, S., Chatzidaki, E. E., Ma, D., Hendrick, A. G., Zahn, D., Dixon, J., Thresher, R. R., Malinge, I., Lomet, D., Carlton, M. B. L., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409330102 · Cited by 1,242

Insulin receptors are widely distributed in the central nervous system of the rat

Havránková, J., Roth, J., & Brownstein, M. (1978) · Nature · doi:10.1038/272827a0 · Cited by 1,116

Origin of luteinizing hormone-releasing hormone neurons

Schwanzel-Fukuda, M., & Pfaff, D. W. (1989) · Nature · doi:10.1038/338161a0 · Cited by 1,116

Regulation of Kiss1 gene expression in the brain of the female mouse

Smith, J. T., Cunningham, M. J., Rissman, E. F., Clifton, D. K., & Steiner, R. A. (2005) · Endocrinology · doi:10.1210/en.2005-0488 · Cited by 1,102

Activation of Gonadotropin-Releasing Hormone Neurons by Kisspeptin as a Neuroendocrine Switch for the Onset of Puberty

Han, S.-K., Gottsch, M. L., Lee, K. J., Popa, S. M., Smith, J. T., Jakawich, S. K., Clifton, D. K., Steiner, R. A., & Herbison, A. E. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3328-05.2005 · Cited by 1,036

Immortalization of hypothalamic GnRH by genetically targeted tumorigenesis

Mellon, P. L., Windle, J. J., Goldsmith, P. C., Padula, C. A., Roberts, J. L., & Weiner, R. I. (1990) · Neuron · doi:10.1016/0896-6273(90)90028-e · Cited by 960

Kisspeptin Activation of Gonadotropin Releasing Hormone Neurons and Regulation of KiSS-1 mRNA in the Male Rat

Irwig, M. S., Fraley, G. S., Smith, J. T., Acohido, B. V., Popa, S. M., Cunningham, M. J., Gottsch, M. L., Clifton, D. K., & Steiner, R. A. (2004) · Neuroendocrinology · doi:10.1159/000083140 · Cited by 930

Insulin-like growth factors and their binding proteins

Sara, V. R., & Hall, K. E. (1990) · Physiological Reviews · doi:10.1152/physrev.1990.70.3.591 · Cited by 923

AXOR12, a Novel Human G Protein-coupled Receptor, Activated by the Peptide KiSS-1

Muir, A. I., Chamberlain, L., Elshourbagy, N. A., Michalovich, D., Moore, D. J., Calamari, A., Szekeres, P. G., Sarau, H. M., Chambers, J. K., Murdock, P. R., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102743200 · Cited by 906

Increased hypothalamic GPR54 signaling: A potential mechanism for initiation of puberty in primates

Shahab, M., Mastronardi, C. A., Seminara, S. B., Crowley, W. F., Ojeda, S. R., & Plant, T. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409822102 · Cited by 888

Postnatal Development of Kisspeptin Neurons in Mouse Hypothalamus; Sexual Dimorphism and Projections to Gonadotropin-Releasing Hormone Neurons

Clarkson, J., & Herbison, A. E. (2006) · Endocrinology · doi:10.1210/en.2006-0787 · Cited by 875

Early onset of reproductive function in normal female mice treated with leptin

Chehab, F. F., Mounzih, K., Lu, R., & Lim, M. E. (1997) · Science · doi:10.1126/science.275.5296.88 · Cited by 822

A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis

Gendt, K. D., Swinnen, J. V., Saunders, P. T. K., Schoonjans, L., Dewerchin, M. A., Devos, A., Tan, K. A. L., Atanassova, N. N., Claessens, F., Lécureuil, C., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308114100 · Cited by 805

Gonadotropin-Releasing Hormone Receptors

Millar, R. P., Lu, Z.-L., Pawson, A. J., Flanagan, C. A., Morgan, K., & Maudsley, S. R. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0002 · Cited by 791

Leptin accelerates the onset of puberty in normal female mice.

Ahima, R. S., Dushay, J. R., Flier, S. N., Prabakaran, D., & Flier, J. S. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119172 · Cited by 760

The Molecular Control of Corpus Luteum Formation, Function, and Regression

Stocco, C. O., Telleria, C. M., & Gibori, G. (2007) · Endocrine Reviews · doi:10.1210/er.2006-0022 · Cited by 756

Evidence that cells expressing luteinizing hormone-releasing hormone mRNA in the mouse are derived from progenitor cells in the olfactory placode.

Wray, S., Grant, P. G., & Gainer, H. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.20.8132 · Cited by 722

Differential Regulation of KiSS-1 mRNA Expression by Sex Steroids in the Brain of the Male Mouse

Smith, J. T., Lemko, H. M. D., Stoll, E. A., Gottsch, M. L., Braun, R. E., Eacker, S. M., Clifton, D. K., & Steiner, R. A. (2005) · Endocrinology · doi:10.1210/en.2005-0323 · Cited by 717

Effects of an Igf1 Gene Null Mutation on Mouse Reproduction

Baker, J., Hardy, M. P., Zhou, J., Bondy, C., Lupu, F., Bellvé, A. R., & Efstratiadis, A. (1996) · Molecular Endocrinology · doi:10.1210/mend.10.7.8813730 · Cited by 674

The Mitogenic and Myogenic Actions of Insulin-like Growth Factors Utilize Distinct Signaling Pathways

Coolican, S. A., Samuel, D. S., Ewton, D. Z., McWade, F. J., & Florini, J. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.10.6653 · Cited by 646

Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1

Nakae, J., Biggs, W., Kitamura, T., Cavenee, W. K., Wright, C. V. E., Arden, K. C., & Accili, D. (2002) · Nature Genetics · doi:10.1038/ng890 · Cited by 617

Widespread recombinase expression using FLPeR (Flipper) mice

Farley, F. W., Soriano, P. M., Steffen, L. S., & Dymecki, S. M. (2000) · genesis · doi:10.1002/1526-968x(200011/12)28:3/4 · Cited by 602

Definition of Estrogen Receptor Pathway Critical for Estrogen Positive Feedback to Gonadotropin-Releasing Hormone Neurons and Fertility

Wintermantel, T. M., Campbell, R. E., Porteous, R. W., Bock, D., Gröne, H., Todman, M. G., Korach, K. S., Greiner, E. F., Pérez, C. A., Schütz, G., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.023 · Cited by 598

Changes in Hypothalamic KiSS-1 System and Restoration of Pubertal Activation of the Reproductive Axis by Kisspeptin in Undernutrition

Castellano, J. M., Navarro, V. M., Fernández-Fernández, R., Nogueiras, R., Tovar, S. A., Roa, J., Vazquez, M. J., Vigo, E., Casanueva, F. F., Aguilar, E., et al. (2005) · Endocrinology · doi:10.1210/en.2005-0337 · Cited by 564

Distinct and Overlapping Functions of Insulin and IGF-I Receptors

Nakae, J., Kido, Y., & Accili, D. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.6.0452 · Cited by 562

KiSS‐1 Neurones Are Direct Targets for Leptin in the ob/ob Mouse

Smith, J. T., Acohido, B. V., Clifton, D. K., & Steiner, R. A. (2006) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2006.01417.x · Cited by 559

A Deletion Truncating the Gonadotropin-Releasing Hormone Gene Is Responsible for Hypogonadism in the hpg Mouse

Mason, A. J., Hayflick, J. S., Zoeller, R. T., Young, W. S., PHILLIPS, H. S., Nikolics, K., & Seeburg, P. H. (1986) · Science · doi:10.1126/science.3024317 · Cited by 534

Leptin Is a Metabolic Gate for the Onset of Puberty in the Female Rat

Cheung, C. C., Thornton, J. E., Kuijper, J. L., Weigle, D. S., Clifton, D. K., & Steiner, R. A. (1997) · Endocrinology · doi:10.1210/endo.138.2.5054 · Cited by 534

Peripheral administration of metastin induces marked gonadotropin release and ovulation in the rat

Matsui, H., Takatsu, Y., Kumano, S., Matsumoto, H., & Ohtaki, T. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.05.185 · Cited by 520

Signaling Mechanisms That Regulate Glucose Transport

Czech, M., & Corvera, S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.4.1865 · Cited by 519

Cell Lines of the Pituitary Gonadotrope Lineage Derived by Targeted Oncogenesis in Transgenic Mice

Windle, J. J., Weiner, R. I., & Mellon, P. L. (1990) · Molecular Endocrinology · doi:10.1210/mend-4-4-597 · Cited by 497

Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain.

Baura, G. D., Foster, D. M., Porte, D., Kahn, S. E., Bergman, R. N., Cobelli, C., & Schwartz, M. W. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116773 · Cited by 489

Leptin Treatment Rescues the Sterility of Genetically Obese ob/ob Males*

Mounzih, K., Lu, R., & Chehab, F. F. (1997) · Endocrinology · doi:10.1210/en.138.3.1190 · Cited by 482

Advanced vaginal opening and precocious activation of the reproductive axis by KiSS‐1 peptide, the endogenous ligand of GPR54

Navarro, V. M., Fernández‐Fernández, R., Castellano, J. M., Roa, J., Mayen, A., Barreiro, M. L., Gaytán, F., Aguilar, E., Pinilla, L., Diéguez, C., et al. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.072298 · Cited by 473

The role of the insulin-like growth factors in the central nervous system

D’Ercole, A. J., Ye, P., Calikoglu, A. S., & Gutierrez-Ospina, G. (1996) · Molecular Neurobiology · doi:10.1007/bf02740625 · Cited by 447

Olfactory Inputs to Hypothalamic Neurons Controlling Reproduction and Fertility

Yoon, H., Enquist, L. W., & Dulac, C. G. (2005) · Cell · doi:10.1016/j.cell.2005.08.039 · Cited by 435

Codon‐improved Cre recombinase (iCre) expression in the mouse

Shimshek, D. R., Kim, J., Hübner, M., Spergel, D. J., Buchholz, F., Casanova, E., Stewart, A. F., SEEBURG, P. H., & Sprengel, R. (2002) · genesis · doi:10.1002/gene.10023 · Cited by 398

Effect of obesity on total and free insulin-like growth factor (IGF)-1, and their relationship to IGF-binding protein (BP)-1, IGFBP-2, IGFBP-3, insulin, and growth hormone

Nam, S., Lee, E. J., Kim, K., Cha, B., Song, Y., Lim, S., Lee, H., & Kb, H. (1997) · International Journal of Obesity · doi:10.1038/sj.ijo.0800412 · Cited by 385

Leptin Indirectly Regulates Gonadotropin-Releasing Hormone Neuronal Function

Quennell, J. H., Mulligan, A. C., Tups, A., Liu, X., Phipps, S. J., Kemp, C. J., Herbison, A. E., Grattan, D. R., & Anderson, G. M. (2009) · Endocrinology · doi:10.1210/en.2008-1693 · Cited by 385

Cloning and functional expression of a mouse gonadotropin-releasing hormone receptor

Tsutsumi, M. (1992) · Molecular Endocrinology · doi:10.1210/me.6.7.1163 · Cited by 383

Estrogen receptor β

Lewandowski, S. A., Kalita, K. B., & Kaczmarek, L. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03015-6 · Cited by 378

Leptin’s effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons

Donato, J., Cravo, R. M., Frazão, R., Gautron, L., Scott, M. M., Lachey, J. L., de Castro, I. A., Margatho, L. O., Lee, S., Lee, C., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci45106 · Cited by 367

Reduction of Plasma Immunoreactive Somatomedin C during Fasting in Humans*

Clemmons, D. R., Klibanski, A., Underwood, L. E., McArthur, J. W., Ridgway, E. C., Beitins, I. Z., & Wyk, J. J. V. (1981) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-53-6-1247 · Cited by 364

A Pulsatile Gonadotropin-Releasing Hormone Stimulus is Required to Increase Transcription of the Gonadotropin Subunit Genes: Evidence for Differential Regulation of Transcription by Pulse Frequency In Vivo*

HAISENLEDER, D. J., DALKIN, A. C., ORTOLANO, G. A., MARSHALL, J. C., & SHUPNIK, M. A. (1991) · Endocrinology · doi:10.1210/endo-128-1-509 · Cited by 355

Discrete Lesions Reveal Functional Heterogeneity of Suprachiasmatic Structures in Regulation of Gonadotropin Secretion in the Female Rat

Wiegand, S. J., & Terasawa, E. (2008) · Neuroendocrinology · doi:10.1159/000123335 · Cited by 354

Isolation of the gene and hypothalamic cDNA for the common precursor of gonadotropin-releasing hormone and prolactin release-inhibiting factor in human and rat.

Adelman, J. P., Mason, A. J., Hayflick, J. S., et al. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.1.179 · Cited by 354

Characterization of Kiss1 neurons using transgenic mouse models

Cravo, R. M., Margatho, L. O., Osborne-Lawrence, S., Donato, J., Atkin, S., Bookout, A. L., Rovinsky, S., Frazão, R., Lee, C. E., Gautron, L., et al. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2010.11.022 · Cited by 353

Glucocorticoids, stress, and fertility.

Whirledge, S., & Cidlowski, J. A. (2010) · PubMed · Cited by 347

Timing and completion of puberty in female mice depend on estrogen receptor α-signaling in kisspeptin neurons

Mayer, C., Acosta‐Martínez, M., Dubois, S. L., Wolfe, A., Radovick, S., Boehm, U., & Levine, J. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012406108 · Cited by 344

Neuroendocrine Aberrations in Women With Functional Hypothalamic Amenorrhea*

BERGA, S. L., MORTOLA, J. F., GIRTON, L., SUH, B., LAUGHLIN, G., PHAM, P., & YEN, S. S. C. (1989) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-68-2-301 · Cited by 337

Targeted disruption of luteinizing hormone β-subunit leads to hypogonadism, defects in gonadal steroidogenesis, and infertility

Ma, X., Dong, Y., Matzuk, M. M., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404743101 · Cited by 335

A Daily Signal for the LH Surge in the Rat

Legan, S. J., & Karsch, F. J. (1975) · Endocrinology · doi:10.1210/endo-96-1-57 · Cited by 333

Laser-Captured Single Digoxigenin-Labeled Neurons of Gonadotropin-Releasing Hormone Types Reveal a Novel G Protein-Coupled Receptor (Gpr54) during Maturation in Cichlid Fish

Parhar, I. S., Ogawa, S., & Sakuma, Y. (2004) · Endocrinology · doi:10.1210/en.2004-0395 · Cited by 324

High molecular weight insulin-like growth factor binding protein complex

Baxter, R. C., Martin, J. L., & Beniac, V. A. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)80143-0 · Cited by 321

The Insulin-Like Growth Factor-I Receptor

MEYTS, P. D., Wallach, B. J., Christoffersen, C. T., Ursø, B., nskov, K. G. O., Latus, L.-J., Yakushiji, F., Ilondo, M. M., & Shymko, R. M. (2008) · Hormone Research · doi:10.1159/000184188 · Cited by 320

Epigenetic control of female puberty

Lomniczi, A., Loche, A., Castellano, J. M., Rønnekleiv, O. K., Bosch, M. A., Kaidar, G., Knoll, J. G., Wright, H., Pfeifer, G. P., & Ojeda, S. R. (2013) · Nature Neuroscience · doi:10.1038/nn.3319 · Cited by 318

Effects of KiSS-1 Peptide, the Natural Ligand of GPR54, on Follicle-Stimulating Hormone Secretion in the Rat

Navarro, V. M., Castellano, J. M., Fernández-Fernández, R., Tovar, S. A., Roa, J., Mayen, A., Barreiro, M. L., Casanueva, F. F., Aguilar, E., Diéguez, C., et al. (2005) · Endocrinology · doi:10.1210/en.2004-1353 · Cited by 317

Insulin-like growth factor I of peripheral origin acts centrally to accelerate the initiation of female puberty

Hiney, J. K., Srivastava, V. K., Nyberg, C. L., Ojeda, S. R., & Dees, W. L. (1996) · Endocrinology · doi:10.1210/endo.137.9.8756538 · Cited by 304

Neuroendocrinology of nutritional infertility

Wade, G. N., & Jones, J. E. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00475.2004 · Cited by 303

Neurochemical architecture of the human striatum

Holt, D. J., Graybiel, A. M., & Saper, C. B. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970721)384:1 · Cited by 297

Immortalization of pituitary cells at discrete stages of development by directed oncogenesis in transgenic mice

Alarid, E. T., Windle, J. J., Whyte, D. B., & Mellon, P. L. (1996) · Development · doi:10.1242/dev.122.10.3319 · Cited by 297

Leptin Deficiency and Diet-Induced Obesity Reduce Hypothalamic Kisspeptin Expression in Mice

Quennell, J. H., Howell, C. S., Roa, J., Augustine, R. A., Grattan, D. R., & Anderson, G. M. (2011) · Endocrinology · doi:10.1210/en.2010-1100 · Cited by 291

Activation of Protein Kinase C (α, β, and ζ) by Insulin in 3T3/L1 Cells

Bandyopadhyay, G. K., Standaert, M. L., Zhao, L., Yu, B., Avignon, A., Galloway, L. C., Karnam, P., Moscat, J., & Farese, R. V. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.4.2551 · Cited by 288

An increase in kisspeptin-54 release occurs with the pubertal increase in luteinizing hormone-releasing hormone-1 release in the stalk-median eminence of female rhesus monkeys in vivo

Keen, K. L., Wegner, F. H., Bloom, S. R., Ghatei, M. A., & Terasawa, E. (2008) · Endocrinology · doi:10.1210/en.2008-0231 · Cited by 273

Depolarising and Hyperpolarising Actions of GABAA Receptor Activation on Gonadotrophin-Releasing Hormone Neurones: Towards an Emerging Consensus

Herbison, A. E., & Moenter, S. M. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02145.x · Cited by 272

Adipokines: implications for female fertility and obesity

Mitchell, M., Armstrong, D. T., Robker, R. L., & Norman, R. J. (2005) · Reproduction · doi:10.1530/rep.1.00521 · Cited by 262

Insulin-like Growth Factor I Receptor β-Subunit Heterogeneity

Moxham, C., Duronio, V., & Jacobs, S. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)51620-3 · Cited by 261

Expression of Hypothalamic KiSS-1 System and Rescue of Defective Gonadotropic Responses by Kisspeptin in Streptozotocin-Induced Diabetic Male Rats

Castellano, J. M., Navarro, V. M., Fernández-Fernández, R., Roa, J., Vigo, E., Pineda, R., Diéguez, C., Aguilar, E., Pinilla, L., & Tena‐Sempere, M. (2006) · Diabetes · doi:10.2337/db05-1584 · Cited by 250

Nutritional and Endocrine-Metabolic Aberrations in Women with Functional Hypothalamic Amenorrhea

Laughlin, G. A., Dominguez, C. E., & Yen, S. S. C. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.1.4502 · Cited by 245

Targeting genes for self-excision in the germ linePreprint

Bunting, M., Bernstein, K. E., Greer, J. M., Capecchi, M. R., & Thomas, K. R. (1999) · Genes & Development · doi:10.1101/gad.13.12.1524 · Cited by 234

Kisspeptin, Neurokinin B, and Dynorphin Act in the Arcuate Nucleus to Control Activity of the GnRH Pulse Generator in Ewes

Goodman, R. L., Hileman, S. M., Nestor, C. C., Porter, K. L., Connors, J. M., Hardy, S. L., Millar, R. P., Cernea, M., Coolen, L. M., & Lehman, M. N. (2013) · Endocrinology · doi:10.1210/en.2013-1331 · Cited by 234

Effects of Discrete Lesions of Preoptic and Suprachiasmatic Structures in the Female Rat

Wiegand, S. J., Terasawa, E., Bridson, W. E., & Goy, R. W. (2008) · Neuroendocrinology · doi:10.1159/000123066 · Cited by 227

Insulin-Like Growth Factor I: A Possible Metabolic Signal Involved in the Regulation of Female Puberty

Hiney, J. K., Ojeda, S. R., & Dees, L. (2008) · Neuroendocrinology · doi:10.1159/000125924 · Cited by 219

Effects of Ghrelin upon Gonadotropin-Releasing Hormone and Gonadotropin Secretion in Adult Female Rats: In vivo and in vitro Studies

Fernández-Fernández, R., Tena‐Sempere, M., Navarro, V. M., Barreiro, M. L., Castellano, J. M., Aguilar, E., & Pinilla, L. (2005) · Neuroendocrinology · doi:10.1159/000092753 · Cited by 217

Environmental Control of Kisspeptin: Implications for Seasonal Reproduction

Greives, T. J., Mason, A. O., Scotti, M. L., Levine, J., Ketterson, E. D., Kriegsfeld, L. J., & Demas, G. E. (2006) · Endocrinology · doi:10.1210/en.2006-1249 · Cited by 216

Estrogen Receptor β Mediates Rapid Estrogen Actions on Gonadotropin-Releasing Hormone NeuronsIn Vivo

Ábrahám, I. M., Han, S., Todman, M. G., Korach, K. S., & Herbison, A. E. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05771.2003 · Cited by 215

Leptin Regulation of Agrp and Npy mRNA in the Rat Hypothalamus

Körner, J., Savontaus, E., Chua, S. C., Leibel, R. L., & Wardlaw, S. L. (2001) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2001.00716.x · Cited by 213

Female reproductive maturation in the absence of kisspeptin/GPR54 signaling

Mayer, C., & Boehm, U. (2011) · Nature Neuroscience · doi:10.1038/nn.2818 · Cited by 213

Migratory arrest of gonadotropin-releasing hormone neurons in transgenic mice.

Radovick, S., Wray, S., Lee, E., Nicols, D. K., Nakayama, Y., Weintraub, B. D., Westphal, H., Cutler, G. B., & Wondisford, F. E. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.8.3402 · Cited by 210

Expanding the Mind: Insulin-Like Growth Factor I and Brain Development

D’Ercole, A. J., & Ye, P. (2008) · Endocrinology · doi:10.1210/en.2008-0920 · Cited by 208

Dependence of fertility on kisspeptin–Gpr54 signaling at the GnRH neuron

Kirilov, M., Clarkson, J., Liu, X., Roa, J., Campos, P., Porteous, R. W., Schütz, G., & Herbison, A. E. (2013) · Nature Communications · doi:10.1038/ncomms3492 · Cited by 206

Somatomedins in adolescence: a cross-sectional study of the effect of puberty on plasma insulin-like growth factor I and II levels

LUNA, A. M., WILSON, D. M., WIBBELSMAN, C. J., BROWN, R. C., NAGASHIMA, R. J., HINTZ, R. L., & ROSENFELD, R. G. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-57-2-268 · Cited by 204

Characterization of insulin/IGF hybrid receptors: contributions of the insulin receptor L2 and Fn1 domains and the alternatively spliced exon 11 sequence to ligand binding and receptor activation

Benyoucef, S., Surinya, K. H., Hadaschik, D., & Siddle, K. (2007) · Biochemical Journal · doi:10.1042/bj20061709 · Cited by 203

Hyperinsulinemia and Decreased Insulin-Like Growth Factor-Binding Protein-1 Are Common Features in Prepubertal and Pubertal Girls with a History of Premature Pubarche1

Ibáñez, L., Potau, N., Zampolli, M., RiquÉ, S., Saenger, P., & Carrascosa, A. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.7.4084 · Cited by 199

Immunological relationships between receptors for insulin and insulin-like growth factor I. Evidence for structural heterogeneity of insulin-like growth factor I receptors involving hybrids with insulin receptors

Soos, M. A., & Siddle, K. (1989) · Biochemical Journal · doi:10.1042/bj2630553 · Cited by 198

Dietary-Induced Obesity and Hypothalamic Infertility in Female DBA/2J Mice

Tortoriello, D. V., McMinn, J. E., & Chua, S. C. (2003) · Endocrinology · doi:10.1210/en.2003-1406 · Cited by 195

LHRH immunopositive cells and their projections to the median eminence and organum vasculosum of the lamina terminalis

King, J. C., Tobet, S. A., Snavely, F. L., & Arimura, A. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902090307 · Cited by 195

Neurobiological mechanisms of puberty in higher primates

Plant, T. M. (2004) · Human Reproduction Update · doi:10.1093/humupd/dmh001 · Cited by 188

Nutritional and Endocrine-Metabolic Aberrations in Women with Functional Hypothalamic Amenorrhea

Laughlin, G. A. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.1.25 · Cited by 187

Insulin Binding Sites Localized to Nerve Terminals in Rat Median Eminence and Arcuate Nucleus

van Houten, M., Posner, B. I., Kopriwa, B. M., & Brawer, J. R. (1980) · Science · doi:10.1126/science.6986652 · Cited by 185

Insulin-like growth factor-binding protein 5 ( Igfbp5 ) compromises survival, growth, muscle development, and fertility in mice

Salih, D. A. M., Tripathi, G., Holding, C., Szestak, T., Gonzalez, M. I., Carter, E. J., Cobb, L. J., Eisemann, J. H., & Pell, J. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400230101 · Cited by 184

Obesity-Induced Infertility and Hyperandrogenism Are Corrected by Deletion of the Insulin Receptor in the Ovarian Theca Cell

Wu, S., DiVall, S. A., Nwaopara, A., Radovick, S., Wondisford, F. E., Ko, C. J., & Wolfe, A. (2013) · Diabetes · doi:10.2337/db13-1514 · Cited by 178

Accelerated 24-hour luteinizing hormone pulsatile activity in adolescent girls with ovarian hyperandrogenism: relevance to the developmental phase of polycystic ovarian syndrome

Apter, D. L., Bützow, T. L., Laughlin, G. A., & YEN, S. S. C. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.1.8027216 · Cited by 177

Divergent roles of growth factors in the GnRH regulation of puberty in mice

DiVall, S. A., Williams, T. R., Carver, S. E., Koch, L., Brüning, J. C., Kahn, C. R., Wondisford, F. E., Radovick, S., & Wolfe, A. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41069 · Cited by 176

Women with functional hypothalamic amenorrhea but not other forms of anovulation display amplified cortisol concentrations

Berga, S. L., Daniels, T. L., & Giles, D. E. (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)81434-3 · Cited by 173

Kisspeptins: Bridging energy homeostasis and reproduction

Castellano, J. M., Overgaard, A., Mikkelsen, J. D., & Tena‐Sempere, M. (2010) · Brain Research · doi:10.1016/j.brainres.2010.08.057 · Cited by 168

Postnatal Morphological Changes in Rat LHRH Neurons Correlated with Sexual Maturation

Wray, S., & Hoffman, G. E. (2008) · Neuroendocrinology · doi:10.1159/000124516 · Cited by 168

Localization of 125I-insulin binding sites in the rat hypothalamus by quantitative autoradiography

Woods, S. C., Porte, D., Dorsa, D. M., Figlewicz, D. P., & Baskin, D. G. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90430-1 · Cited by 168

Control of preovulatory follicular estrogen biosynthesis in the human ovary

HILLIER, S. G., REICHERT, L. E., & VAN HALL, E. V. (1981) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-52-5-847 · Cited by 163

Availability of Metabolic Fuels Controls Estrous Cyclicity of Syrian Hamsters

Schneider, J. E., & Wade, G. N. (1989) · Science · doi:10.1126/science.2734610 · Cited by 161

Diminished Growth and Enhanced Glucose Metabolism in Triple Knockout Mice Containing Mutations of Insulin-Like Growth Factor Binding Protein-3, -4, and -5

Ning, Y., Schuller, A. G., Bradshaw, S. L., Rotwein, P. S., Ludwig, T. E., Frystyk, J., & Pintar, J. E. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0196 · Cited by 161

Mechanisms for Pulsatile Regulation of the Gonadotropin Subunit Genes by GNRH11

Ferris, H. A., & Shupnik, M. A. (2006) · Biology of Reproduction · doi:10.1095/biolreprod.105.049049 · Cited by 158

Insulin regulation of hepatic gluconeogenesis through phosphorylation of CREB-binding protein

Zhou, X., Shibusawa, N., Naik, K., Porras, D., Temple, K. A., Ou, H., Kaihara, K. A., Roe, M. W., Brady, M., & Wondisford, F. E. (2004) · Nature Medicine · doi:10.1038/nm1050 · Cited by 157

Rescue of Obesity-Induced Infertility in Female Mice due to a Pituitary-Specific Knockout of the Insulin Receptor

Brothers, K. J., Wu, S., DiVall, S. A., Messmer, M., Kahn, C. R., Miller, R. S., Radovick, S., Wondisford, F. E., & Wolfe, A. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.06.010 · Cited by 157

Deficits in Female Reproductive Function in GH-R-KO Mice; Role of IGF-I

Danilovich, N., Wernsing, D. R., Coschigano, K. T., Kopchick, J. J., & Bartke, A. (1999) · Endocrinology · doi:10.1210/endo.140.6.6992 · Cited by 156

Epigenetic regulation of Kiss1 gene expression mediating estrogen-positive feedback action in the mouse brain

Tomikawa, J., Uenoyama, Y., Ozawa, M., Fukanuma, T., Takase, K., Goto, T., Abe, H., Ieda, N., Minabe, S., Deura, C., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114245109 · Cited by 155

Circulating Luteinizing Hormone Pulse Frequency in Women with Polycystic Ovary Syndrome *

Kazer, R. R., Kessel, B., & Yen, S. S. C. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-65-2-233 · Cited by 154

Adiponectin Activates Adenosine Monophosphate-Activated Protein Kinase and Decreases Luteinizing Hormone Secretion in LβT2 Gonadotropes

Lu, M. M., Tang, Q., Olefsky, J. M., Mellon, P. L., & Webster, N. J. G. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0330 · Cited by 154

Insulin-Like Growth Factor I

Kooijman, R., Sarre, S., Michotte, Y. M., & Keyser, J. D. (2009) · Stroke · doi:10.1161/strokeaha.108.528356 · Cited by 152

Pituitary cell lines and their endocrine applications

Ooi, G. T., Tawadros, N., & Escalona, R. M. (2004) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2004.07.018 · Cited by 152

Phenotypic Manifestations of Insulin-Like Growth Factor-Binding Protein-3 Overexpression in Transgenic Mice

Modric, T., Silha, J. V., Shi, Z., Gui, Y., Suwanichkul, A., Durham, S. K., Powell, D. R., & Murphy, L. J. (2001) · Endocrinology · doi:10.1210/endo.142.5.8165 · Cited by 150

Postnatal Remodeling of Dendritic Structure and Spine Density in Gonadotropin-Releasing Hormone Neurons

Cottrell, E. C., Campbell, R. E., Han, S.-K., & Herbison, A. E. (2006) · Endocrinology · doi:10.1210/en.2006-0296 · Cited by 150

Solution structure of human insulin-like growth factor 1: a nuclear magnetic resonance and restrained molecular dynamics study

Cooke, R. M., Harvey, T. S., & Campbell, I. D. (1991) · Biochemistry · doi:10.1021/bi00236a022 · Cited by 143

Control of GnRH neuronal activity by metabolic factors: The role of leptin and insulin

Gamba, M., & Pralong, F. P. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.04.023 · Cited by 142

Molecular Properties of Kiss1 Neurons in the Arcuate Nucleus of the Mouse

Gottsch, M. L., Popa, S. M., Lawhorn, J. K., Qiu, J., Tonsfeldt, K. J., Bosch, M. A., Kelly, M. J., Rønnekleiv, O. K., Sanz, E., McKnight, G. S., et al. (2011) · Endocrinology · doi:10.1210/en.2011-1521 · Cited by 141

The ligand specificities of the insulin receptor and the insulin-like growth factor I receptor reside in different regions of a common binding site.

Kjeldsen, T., Andersen, A. S., Wiberg, F. C., Rasmussen, J. S., Schäffer, L., Balschmidt, P., Møller, K. B., & Møller, N. P. H. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.10.4404 · Cited by 138

Cognitive and psychiatric correlates of functional hypothalamic amenorrhea: a controlled comparison

Giles, D. E., & Berga, S. L. (1993) · Fertility and Sterility · doi:10.1016/s0015-0282(16)56165-2 · Cited by 136

Hormonal Regulation of Cytochrome P450 Enzymes, Cholesterol Side-Chain Cleavage and 17α-Hydroxylase/C17 – 20 Lyase in Leydig Cells1

Payne, A. H. (1990) · Biology of Reproduction · doi:10.1095/biolreprod42.3.399 · Cited by 133

Promoter Transgenics Reveal Multiple Gonadotropin-Releasing Hormone-I-Expressing Cell Populations of Different Embryological Origin in Mouse Brain

Skynner, M. J., Slater, R., Sim, J. A., Allen, N. D., & Herbison, A. E. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-14-05955.1999 · Cited by 130

Gonadotropin-Releasing Hormone Neurons Extend Complex Highly Branched Dendritic Trees Outside the Blood-Brain Barrier

Herde, M. K., Geist, K., Campbell, R. E., & Herbison, A. E. (2011) · Endocrinology · doi:10.1210/en.2011-1228 · Cited by 127

Suppression of luteinizing hormone pulses by restriction of glucose availability is mediated by sensors in the brain stem

Murahashi, K., Bucholtz, D. C., Nagatani, S., Tsukahara, S., Tsukamura, H., Foster, D. L., & Maeda, K. (1996) · Endocrinology · doi:10.1210/endo.137.4.8625886 · Cited by 125

Gonadotropin-Releasing Hormone-Expressing Neurons Immortalized Conditionally Are Activated by Insulin: Implication of the Mitogen-Activated Protein Kinase Pathway

Salvi, R., Castillo, E., Voirol, M., Glauser, M., Rey, J.-P., Gaillard, R. C., Vollenweider, P., & Pralong, F. P. (2005) · Endocrinology · doi:10.1210/en.2005-0728 · Cited by 125

Kisspepeptin-GPR54 signaling in the neuroendocrine reproductive axis

Gottsch, M. L., Clifton, D. K., & Steiner, R. A. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.04.030 · Cited by 123

Insulin, insulin-like growth factor I (IGF-I) and IGF-II enhance basal and gonadotrophin-releasing hormone-stimulated luteinizing hormone release from rat anterior pituitary cells in vitro

Soldani, R., Cagnacci, A., & Yen, S. S. C. (1994) · European Journal of Endocrinology · doi:10.1530/eje.0.1310641 · Cited by 122

Immunocytochemical Detection of Insulin in Rat Hypothalamus and Its Possible Uptake from Cerebrospinal Fluid*

Baskin, D. G., Woods, S. C., West, D. B., van Houten, M., Posner, B. I., Dorsa, D. M., & Porte, D. (1983) · Endocrinology · doi:10.1210/endo-113-5-1818 · Cited by 122

Disrupted Kisspeptin Signaling in GnRH Neurons Leads to Hypogonadotrophic Hypogonadism

Novaira, H. J., Sonko, M. L., Hoffman, G. E., Koo, Y., Ko, C. J., Wolfe, A., & Radovick, S. (2014) · Molecular Endocrinology · doi:10.1210/me.2013-1319 · Cited by 118

Isolation and Characterization of the Human Gonadotropin-Releasing Hormone Gene in the Hypothalamus and Placenta

Radovick, S., Wondisford, F. E., Nakayama, Y., Yamada, M., Cutler, G. B., & Weintraub, B. D. (1990) · Molecular Endocrinology · doi:10.1210/mend-4-3-476 · Cited by 117

LbetaT2 gonadotroph cells secrete follicle stimulating hormone (FSH) in response to active A

Graham, K. E. R., Nusser, K. D., & Low, M. J. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.162r001 · Cited by 116

Gonadotropin-Releasing Hormone Receptor Couples to Multiple G Proteins in Rat Gonadotrophs and in GGH3 Cells: Evidence from Palmitoylation and Overexpression of G proteins1

Stanislaus, D., Ponder, S., Ji, T. H., & Conn, P. M. (1998) · Biology of Reproduction · doi:10.1095/biolreprod59.3.579 · Cited by 116

Delayed Puberty but Normal Fertility in Mice With Selective Deletion of Insulin Receptors From Kiss1 Cells

Qiu, X., Dowling, A. R., Marino, J. S., Faulkner, L. D., Bryant, B., Brüning, J. C., Elias, C. F., & Hill, J. W. (2013) · Endocrinology · doi:10.1210/en.2012-2056 · Cited by 114

Gonadotropin-Releasing Hormone Neurons Express K ATP Channels That Are Regulated by Estrogen and Responsive to Glucose and Metabolic Inhibition

Zhang, C., Bosch, M. A., Levine, J. E., Rønnekleiv, O. K., & Kelly, M. J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1657-07.2007 · Cited by 114 · cited 1×

The pubertal timing controversy in the USA, and a review of possible causative factors for the advance in timing of onset of puberty

Slyper, A. H. (2006) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2006.02539.x · Cited by 113

Pituitary gonadotropin-releasing hormone (GnRH) receptor: Structure, distribution and regulation of expression

Rispoli, L. A., & Nett, T. M. (2005) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2005.05.004 · Cited by 112

Functional Characterization of Genetically Labeled Gonadotropes

Wen, S., Schwarz, J. R., Niculescu, D., Dinu, C., Bauer, C. K., Hirdes, W., & Boehm, U. (2008) · Endocrinology · doi:10.1210/en.2007-1502 · Cited by 112

Growth, puberty, and final height in children with Type 1 diabetes

Elamin, A., Hussein, O., & Tuvemo, T. (2006) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2005.07.001 · Cited by 109

Circulating Concentrations of Nocturnal Leptin, Growth Hormone, and Insulin-Like Growth Factor-I Increase before the Onset of Puberty in Agonadal Male Monkeys: Potential Signals for the Initiation of Puberty

Suter, K. J., Pohl, C. R., & Wilson, M. E. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.2.6371 · Cited by 109

Leptin effects on pulsatile gonadotropin releasing hormone secretion from the adult rat hypothalamus and interaction with cocaine and amphetamine regulated transcript peptide and neuropeptide Y

Parent, A., Lebrethon, M. C., Gérard, A., Vandersmissen, E., & Bourguignon, J. P. (2000) · Regulatory Peptides · doi:10.1016/s0167-0115(00)00144-0 · Cited by 107

Assembly of insulin/insulin-like growth factor-1 hybrid receptors in vitro

Treadway, J. L., Morrison, B. D., Goldfine, I. D., et al. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)88201-5 · Cited by 103

Changes in the circulating IGF system during short-term fasting and refeeding in rats

Frystyk, J., Delhanty, P. J. D., Skjærbæk, C., et al. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.2.e245 · Cited by 102

Fasting Reduces KiSS‐1 Expression in the Anteroventral Periventricular Nucleus (AVPV): Effects of Fasting on the Expression of KiSS‐1 and Neuropeptide Y in the AVPV or Arcuate Nucleus of Female Rats

Κalamatianos, T., Grimshaw, S. E., Poorun, R., Hahn, J. D., & Coen, C. W. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01757.x · Cited by 101

Shift in Kiss1 Cell Activity Requires Estrogen Receptor α

Frazão, R., Cravo, R. M., Donato, J., Ratra, D. V., Clegg, D. J., Elmquist, J. K., Zigman, J. M., Williams, K. W., & Elias, C. F. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1610-12.2013 · Cited by 101

Kisspeptin and GnRH Pulse Generation

Okamura, H., Tsukamura, H., Ohkura, S., Uenoyama, Y., Wakabayashi, Y., & Maeda, K. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-6199-9_14 · Cited by 101

The Rat Gonadotropin-Releasing Hormone: SH Locus: Structure and Hypothalamic Expression

Bond, C. T., Hayflick, J. S., SEEBURG, P. H., & Adelman, J. P. (1989) · Molecular Endocrinology · doi:10.1210/mend-3-8-1257 · Cited by 99

Insulin-Like Growth Factor-I Activates KiSS-1 Gene Expression in the Brain of the Prepubertal Female Rat

Hiney, J. K., Srivastava, V. K., Pine, M. D., & Dees, W. L. (2008) · Endocrinology · doi:10.1210/en.2008-0954 · Cited by 99

Impaired Estrogen Feedback and Infertility in Female Mice with Pituitary-Specific Deletion of Estrogen Receptor Alpha (ESR1)1

Singh, S. P., Wolfe, A., Ng, Y., DiVall, S. A., Buggs, C., Levine, J. E., Wondisford, F. E., & Radovick, S. (2009) · Biology of Reproduction · doi:10.1095/biolreprod.108.075259 · Cited by 99

Insulin-like growth factor binding protein-3: biochemistry and physiology.

Jl, M., & Rc, B. (1992) · PubMed · Cited by 99

The role of intracerebral insulin in the effect of nutrition on gonadotrophin secretion in mature male sheep

Miller, D. W., Blache, D., & Martin, G. B. (1995) · Journal of Endocrinology · doi:10.1677/joe.0.1470321 · Cited by 94

Ghrelin and Reproduction: Ghrelin as Novel Regulator of the Gonadotropic Axis

Tena‐Sempere, M. (2007) · Vitamins and hormones · doi:10.1016/s0083-6729(06)77012-1 · Cited by 93

Changes in Content of Cytochrome P45017α, Cytochrome P450scc, and 3-Hydroxy-3-Methylglutaryl CoA Reductase in Developing Rat Ovarian Fotlicles and Corpora Lutea: Correlation with Theca Cell Steroidogenesis1

Hedin, L., Rodgers, R. J., Simpson, E. R., & Richards, J. S. (1987) · Biology of Reproduction · doi:10.1095/biolreprod37.1.211 · Cited by 93

ERK Signaling in the Pituitary Is Required for Female But Not Male Fertility

Bliss, S. P., Miller, A., Navratil, A. M., Xie, J., McDonough, S. P., Fisher, P. J., Landreth, G. E., & Roberson, M. S. (2009) · Molecular Endocrinology · doi:10.1210/me.2009-0030 · Cited by 91

Developmental Changes in the Luteinizing Hormone Secretory Pattern in Peripubertal Female Rhesus Monkeys: Comparisons between Gonadally Intact and Ovariectomized Animals*

Terasawa, E., Bridson, W. E., Nass, T. E., Noonan, J. J., & Dierschke, D. J. (1984) · Endocrinology · doi:10.1210/endo-115-6-2233 · Cited by 90

Cocaine and Amphetamine‐Regulated‐Transcript Peptide Mediation of Leptin Stimulatory Effect on the Rat Gonadotropin‐Releasing Hormone Pulse Generator In Vitro

Lebrethon, Vandersmissen, Gérard, Parent, & Bourguignon (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00497.x · Cited by 89

Anatomy of the pituitary insulin-like growth factor system.

Bach, M. A., & Bondy, C. A. (1992) · Endocrinology · doi:10.1210/endo.131.6.1280202 · Cited by 89

Gonadotropin-releasing hormone immunoreactive neurons with access to fenestrated capillaries in mouse brain.

Jennes, L., & Stumpf, W. (1986) · Neuroscience · doi:10.1016/0306-4522(86)90162-4 · Cited by 89

Developmental Changes in Neuroendocrine Regulation of Gonadotropin Secretion in Gonadal Dysgenesis

ROSS, J. L., Loriaux, D. L., & Cutler, G. B. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-57-2-288 · Cited by 88

CREB Binding Protein Recruitment to the Transcription Complex Requires Growth Factor–Dependent Phosphorylation of Its GF Box

Zanger, K., Radovick, S., & Wondisford, F. E. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00202-7 · Cited by 85

Central Action of Insulin Regulates Pulsatile Luteinizing Hormone Secretion in the Diabetic Sheep Model1

Tanaka, T., Nagatani, S., Bucholtz, D. C., Ohkura, S., Tsukamura, H., Maeda, K.-I., & Foster, D. L. (2000) · Biology of Reproduction · doi:10.1095/biolreprod62.5.1256 · Cited by 85

Hormonal response to overfeeding

Forbes, G. B., Brown, M. R., Welle, S. L., & Underwood, L. E. (1989) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/49.4.608 · Cited by 85

A neuron-specific enhancer targets expression of the gonadotropin-releasing hormone gene to hypothalamic neurosecretory neurons.

Whyte, D. B., Lawson, M. A., Belsham, D. D., et al. (1995) · Molecular Endocrinology · doi:10.1210/mend.9.4.7659090 · Cited by 84

Electrophysiological and Morphological Evidence for Synchronized GnRH Pulse Generator Activity Among Kisspeptin/Neurokinin B/Dynorphin A (KNDy) Neurons in Goats

Wakabayashi, Y., Yamamura, T., Sakamoto, K., Mori, Y., & OKAMURA, H. (2012) · Journal of Reproduction and Development · doi:10.1262/jrd.2012-136 · Cited by 84

Regulation of Gonadotropin-Releasing Hormone (GnRH) Gene Expression by Insulin-Like Growth Factor I in a Cultured GnRH-Expressing Neuronal Cell Line

Zhen, S., Zakaria, M., Wolfe, A., & Radovick, S. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.8.9956 · Cited by 83

Metabolic influences on neuroendocrine regulation of reproduction

Navarro, V. M., & Kaiser, U. B. (2013) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e32836318ce · Cited by 83

Functional Interactions between Estrogen and Insulin-Like Growth Factor-I in the Regulation of α1B-Adrenoceptors and Female Reproductive Function

Quesada, A., & Etgen, A. M. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-06-02401.2002 · Cited by 80

Androgen Biosynthesis in Developing Ovarian Follicles Evidence that Luteinizing Hormone Regulates Thecal 17α-Hydroxylase and C17–2o-Lyase Activities*

Bogovich, K., & Richards, J. S. (1982) · Endocrinology · doi:10.1210/endo-111-4-1201 · Cited by 80

Central Infusion of Agouti-Related Peptide Suppresses Pulsatile Luteinizing Hormone Release in the Ovariectomized Rhesus Monkey

Vulliémoz, N. R., Xiao, E., Xia‐Zhang, L., Wardlaw, S. L., & Ferin, M. (2004) · Endocrinology · doi:10.1210/en.2004-1093 · Cited by 80

Ancient Divergence of Insulin and Insulin-Like Growth Factor

McRory, J. E., & Sherwood, N. M. (1997) · DNA and Cell Biology · doi:10.1089/dna.1997.16.939 · Cited by 80

Ion channel properties and episodic activity in isolated immortalized gonadotropin-releasing hormone (GnRH) neurons

Bosma, M. (1993) · The Journal of Membrane Biology · doi:10.1007/bf00241492 · Cited by 79

Pubertal Endocrinology of the Baboon: Elevated Somatomedin-C/Insulin-Like Growth Factor I at Puberty

Copeland, K. C., Kuehl, T. J., & Castracane, V. D. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-55-6-1198 · Cited by 79

Insulin Regulation of GnRH Gene Expression through MAP Kinase Signaling Pathways

Kim, H. H., DiVall, S. A., Deneau, R. M., & Wolfe, A. (2005) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2005.07.002 · Cited by 78

Pubertal Growth, Sexual Maturation, and Final Height in Children With IDDM: Effects of age at onset and metabolic control

Salerno, M., Argenziano, A., Maio, S. D., et al. (1997) · Diabetes Care · doi:10.2337/diacare.20.5.721 · Cited by 78

Ontogeny of somatomedin during development in the mouse

D’Ercole, A. J., & Underwood, L. E. (1980) · Developmental Biology · doi:10.1016/0012-1606(80)90071-8 · Cited by 75

Pulsatile LH secretion in streptozotocin-induced diabetes in the rat

Dong, Q., Lazarus, R. M., Wong, L. S., Vellios, M., & Handelsman, D. J. (1991) · Journal of Endocrinology · doi:10.1677/joe.0.1310049 · Cited by 75

Structure of the rat gonadotropin releasing hormone (rGnRH) gene promoter and functional analysis in hypothalamic cells

Kepa, J. K., Chun, W., Neeley, C. I., Raynolds, M. V., Gordon, D. F., Wood, W. M., & Wierman, M. E. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.6.1393 · Cited by 75

Effect of insulin-like growth factor 1 on gonadotropin release from the hypothalamus-pituitary axis in vitro

兼松, 豊., Irahara, M., Miyake, T., Shitsukawa, K., & Aono, T. (1991) · European Journal of Endocrinology · doi:10.1530/acta.0.1250227 · Cited by 75

Impaired Fertility and FSH Synthesis in Gonadotrope-Specific Foxl2 Knockout Mice

Tran, S., Zhou, X., Lafleur, C., Calderon, M. J., Ellsworth, B. S., Kimmins, S., Boehm, U., Treier, M., Boerboom, D., & Bernard, D. J. (2013) · Molecular Endocrinology · doi:10.1210/me.2012-1286 · Cited by 74

Pituitary Gonadotroph Estrogen Receptor-α Is Necessary for Fertility in Females

Gieske, M. C., Kim, H. J., Legan, S. J., Koo, Y., Krust, A., Chambon, P., & Ko, C. J. (2007) · Endocrinology · doi:10.1210/en.2007-1084 · Cited by 74

The Hypothalamic Insulin‐Like Growth Factor‐1 Receptor and Its Relationship to Gonadotropin‐Releasing Hormones Neurones During Postnatal Development

Daftary, S. S., & Gore, A. C. (2004) · Journal of Neuroendocrinology · doi:10.1111/j.0953-8194.2004.01149.x · Cited by 73

Alterations in Hypothalamic Insulin‐Like Growth Factor‐I and its Associations with Gonadotropin Releasing Hormone Neurones During Reproductive Development and Ageing

Miller, B. H., & Gore, A. C. (2001) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2001.00686.x · Cited by 72

Insulin modulation of luteinizing hormone secretion in normal female volunteers and lean polycystic ovary syndrome patients

Moret, M., Stettler, R., Rodieux, F., Gaillard, R. C., Waeber, G., Wirthner, D., Giusti, V., Tappy, L., & Pralong, F. P. (2009) · Neuroendocrinology · doi:10.1159/000160911 · Cited by 72

Modulation of anterior pituitary luteinizing hormone response to gonadotropin-releasing hormone by insulin-like growth factor I in vitro

Soldani, R., Cagnacci, A., Paoletti, A. M., Yen, S. S. C., & Melis, G. B. (1995) · Fertility and Sterility · doi:10.1016/s0015-0282(16)57804-2 · Cited by 72

Effects of Insulin-Like Growth Factors I and II and Insulin on the Immortalized Hypothalamic GTI-7 Cell Line

Olson, B. R., Scott, D. C., Wetsel, W. C., Elliot, S. J., Tomić, M., Stojilković, S. S., Nieman, L. K., & Wray, S. (2008) · Neuroendocrinology · doi:10.1159/000127000 · Cited by 70

Control of Gonadotropin Secretion in the Male during Puberty: A Decrease in Response to Steroid Inhibitory Feedback in the Absence of an Increase in Steroid-Independent Drive in the Sheep*

Olster, D. H., & Foster, D. L. (1986) · Endocrinology · doi:10.1210/endo-118-6-2225 · Cited by 70

Glucosensing by GnRH Neurons: Inhibition by Androgens and Involvement of AMP-Activated Protein Kinase

Roland, A. V., & Moenter, S. M. (2011) · Molecular Endocrinology · doi:10.1210/me.2010-0508 · Cited by 67

Reversal of fasting-induced suppression of luteinizing hormone (LH) secretion in male rhesus monkeys by intragastric nutrient infusion: evidence for rapid stimulation of LH by nutritional signals.

Schreihofer, D. A., Amico, J. A., & Cameron, J. L. (1993) · Endocrinology · doi:10.1210/endo.132.5.8477642 · Cited by 67

Evidence for Insulin Suppression of Baseline Luteinizing Hormone in Women with Polycystic Ovarian Syndrome and Normal Women

Lawson, M. A., Jain, S., Sun, S., Patel, K. S., Malcolm, P. J., & Chang, R. J. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2656 · Cited by 67

Pubertal development and regulation

Abreu, A. P., & Kaiser, U. B. (2016) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(15)00418-0 · Cited by 611

Developmental variations in environmental influences including endocrine disruptors on pubertal timing and neuroendocrine control: revision of human observations and mechanistic insight from rodents

Parent, A.-S., Franssen, D., Fudvoye, J., Gérard, A., & Bourguignon, J.-P. (2015) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.12.004 · Cited by 175

Development of the gonadotropin‐releasing hormone system

Duittoz, A. H., Forni, P. E., Giacobini, P., Golan, M., Mollard, P., Negrón, A. L., Radovick, S., & Wray, S. (2022) · Journal of Neuroendocrinology · doi:10.1111/jne.13087 · Cited by 50

Insulin-Like Growth Factor I (IGF-1) Ec/Mechano Growth Factor – A Splice Variant of IGF-1 within the Growth Plate

Schlegel, W., Raimann, A., Halbauer, D., Scharmer, D., Sagmeister, S., Wessner, B., Helmreich, M., Haeusler, G., & Egerbacher, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076133 · Cited by 24

Comparative effects of plateletderived growth factor‐BB and insulin‐like growth factor‐I, individually and in combination, on periodontal regeneration in Macaca fascicularis

Giannobile, W. V., Hernandez, R. A., Finkelman, R. D., et al. (1996) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.1996.tb00497.x · Cited by 225

Can insulin-like growth factor 1 (IGF-1), IGF-1 receptor connective tissue growth factor and Ki-67 labelling index have a prognostic role in pulmonary carcinoids?

Kanakis, G., Grimelius, L., Papaioannou, D., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.25203 · Cited by 4

The combination of platelet‐derived growth factor‐BB and insulin‐like growth factor‐I stimulates bone repair in adult Yucatan miniature pigs

Lynch, S. E., Trippel, S. B., Finkelman, R. D., et al. (1994) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.1994.20308.x · Cited by 22

Effects of Insulin-Like Growth Factor-1 on Proliferation of Human Corpus Cavernosal Smooth Muscle Cells

Kim, M., Park, K., Lee, H.-S., et al. (2003) · Korean Journal of Andrology