Cited by 83Hypothalamic control of reproductive hormonesGrowth Hormone and Insulin-like Growth FactorsRegulation of Appetite and Obesity

The DOI matches its Crossref record; 310 of the 310 references it cites were found in a registry or an index.

The regulation of reproductive neuroendocrine function by insulin and insulin-like growth factor-1 (IGF-1)

Open access

Wolfe, Andrew, Divall, Sara, Wu, Sheng·2014·Frontiers in Neuroendocrinology

DOI 10.1016/j.yfrne.2014.05.007PMC PMC4175134

Open this paper in CoChat — free account

Abstract

The mammalian reproductive hormone axis regulates gonadal steroid hormone levels and gonadal function essential for reproduction. The neuroendocrine control of the axis integrates signals from a wide array of inputs. The regulatory pathways important for mediating these inputs have been the subject of numerous studies. One class of proteins that have been shown to mediate metabolic and growth signals to the CNS includes Insulin and IGF-1. These proteins are structurally related and can exert endocrine and growth factor like action via related receptor tyrosine kinases. The role that insulin and IGF-1 play in controlling the hypothalamus and pituitary and their role in regulating puberty and nutritional control of reproduction has been studied extensively. This review summarizes the in vitro and in vivo models that have been used to study these neuroendocrine structures and the influence of these growth factors on neuroendocrine control of reproduction.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.yfrne.2014.05.007

Cites

310 of 310 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Items 201–310 of 310

Mechanisms mediating multiple physiological responses to gonadotropin-releasing hormone
Stanislaus, D., Pinter, J. H., Janovick, J. A., & Conn, P. M. (1998) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(98)00126-9 · Cited by 67
The Maturation of Estradiol-Negative Feedback in Female Rats: Evidence that the Resetting of the Hypothalamic “Gonadostat” Does Not Precede the First Preovulatory Surge of Gonadotropins*
Andrews, W. W., Advis, J. P., & Ojeda, S. R. (1981) · Endocrinology · doi:10.1210/endo-109-6-2022 · Cited by 67
Cholera toxin and pertussis toxin provoke differential effects on luteinizing hormone release, inositol phosphate production, and gonadotropin-releasing hormone (GnRH) receptor binding in the gonadotrope: evidence for multiple guanyl nucleotide binding proteins in GnRH action.
Hawes, B. E., Barnes, S., & Conn, P. M. (1993) · Endocrinology · doi:10.1210/endo.132.5.8386608 · Cited by 67
Insulin-Like Growth Factor-I Effects on Gonadotropin-Releasing Hormone Biosynthesis in GT1-7 Cells
Longo, K. M., Sun, Y., & Gore, A. C. (1998) · Endocrinology · doi:10.1210/endo.139.3.5852 · Cited by 66
Redundancy in Kiss1 Expression Safeguards Reproduction in the Mouse
Popa, S. M., Moriyama, R., Caligioni, C. S., Yang, J. J., Cho, C. M., Concepcion, T. L., Oakley, A. E., Lee, I. H., Sanz, E., Amieux, P. S., et al. (2013) · Endocrinology · doi:10.1210/en.2013-1222 · Cited by 66
The complete nucleotide sequence of the human gonadotropin-releasing hormone gene
Hayflick, J. S., Adelman, J. P., & Seeburg, P. H. (1989) · Nucleic Acids Research · doi:10.1093/nar/17.15.6403 · Cited by 66
Structural Basis for the Lower Affinity of the Insulin-like Growth Factors for the Insulin Receptor
Gauguin, L., Klaproth, B., Sajid, W., Andersen, A. S., McNeil, K. A., Forbes, B. E., & MEYTS, P. D. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m709220200 · Cited by 65
Acute inflammation reduces kisspeptin immunoreactivity at the arcuate nucleus and decreases responsiveness to kisspeptin independently of its anorectic effects
Castellano, J. M., Bentsen, A. H., Romero, M., Pineda, R., Ruíz-Pino, F., García-Galiano, D., Sanchez-Garrido, M. A., Pinilla, L., Mikkelsen, J. D., & Tena‐Sempere, M. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00081.2010 · Cited by 65
Reproductive tissues maintain insulin sensitivity in diet-induced obesity
Wu, S., Divall, S., Wondisford, F., & Wolfe, A. (2012) · Diabetes · doi:10.2337/db11-0956 · Cited by 65
Self-citation
GPR54 and Kisspeptins
Colledge, W. H. (2008) · Springer eBooks · doi:10.1007/400_2007_050 · Cited by 64
Use of a Gonadotropin-Releasing Hormone Antagonist as a Physiologic Probe in Polycystic Ovary Syndrome: Assessment of Neuroendocrine and Androgen Dynamics
Hayes, F. J., Taylor, A. E., Martin, K. A., & Hall, J. E. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.7.4925 · Cited by 63
Neuropeptide Y stimulates luteinizing hormone-releasing hormone release from superfused hypothalamic GT1-7 cells
Besecke, L. M., Wolfe, A., Pierce, M. E., Takahashi, J. S., & Levine, J. E. (1994) · Endocrinology · doi:10.1210/endo.135.4.7925125 · Cited by 62
Self-citation
Knockdown of GABAA Receptor Signaling in GnRH Neurons Has Minimal Effects upon Fertility
Lee, K., Porteous, R. W., Campbell, R. E., Lüscher, B., & Herbison, A. E. (2010) · Endocrinology · doi:10.1210/en.2010-0314 · Cited by 62
Gonadal and nongonadal mechanisms contribute to the prepubertal hiatus in gonadotropin secretion in the female rhesus monkey (Macaca mulatta)
Pohl, C. R., deRidder, C. M., & Plant, T. M. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.7.7608261 · Cited by 62
Decrease in Hypothalamic Kiss1 and Kiss1r Expression: A Potential Mechanism for Fasting-induced Suppression of the HPG Axis in the Adult Male Rhesus Monkey ( Macaca mulatta )
Wahab, F., Ullah, F., Chan, Y.-M., et al. (2010) · Hormone and Metabolic Research · doi:10.1055/s-0030-1269852 · Cited by 61
Liver-specific Knockdown of JNK1 Up-regulates Proliferator-activated Receptor γ Coactivator 1β and Increases Plasma Triglyceride despite Reduced Glucose and Insulin Levels in Diet-induced Obese Mice
Yang, R., Wilcox, D. M., Haasch, D. L., Jung, P. M., Nguyen, P., Voorbach, M. J., Doktor, S. Z., Brodjian, S. J., Bush, E. N., Lin, E. P.-Y., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700790200 · Cited by 61
Impaired Reproductive Behavior by Lack of GluR-B Containing AMPA Receptors But Not of NMDA Receptors in Hypothalamic and Septal Neurons
Shimshek, D. R., Bus, T., Grinevich, V., Single, F. N., Mack, V., Sprengel, R., Spergel, D. J., & Seeburg, P. H. (2005) · Molecular Endocrinology · doi:10.1210/me.2005-0262 · Cited by 61
Low Serum Levels of Free and Total Insulin-Like Growth Factor I (IGF-I) in Patients with Anorexia Nervosa Are Not Associated with Increased IGF-Binding Protein-3 Proteolysis
Støving, R. K., Flyvbjerg, A., Frystyk, J., Fisker, S., Hangaard, J., Hansen‐Nord, M., & Hagen, C. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.4.5622 · Cited by 58
Interactions of insulin-like growth factor-I, insulin and estradiol with GnRH-stimulated luteinizing hormone release from female rat gonadotrophs
Xia, Y., Weiss, J., Polack, S., Diedrich, K., & Ortmann, O. (2001) · European Journal of Endocrinology · doi:10.1530/eje.0.1440073 · Cited by 58
Phylogeny of the insulin‐like growth factors (IGFS) and receptors: A molecular approach
LeRoith, D., Kavsan, V. M., Koval, A. P., et al. (1993) · Molecular Reproduction and Development · doi:10.1002/mrd.1080350403 · Cited by 56
Central metabolic messengers and the effects of nutrition on gonadotrophin secretion in sheep
Miller, D. W., Blache, D., Boukhliq, R., et al. (1998) · Reproduction · doi:10.1530/jrf.0.1120347 · Cited by 54
Cell-specific Expression of the Human Gonadotropin-releasing Hormone Gene in Transgenic Animals
Wolfe, A., Wray, S., Westphal, H., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.33.20018 · Cited by 54
Self-citation
Decreased availability of metabolic fuels induces anestrus in golden hamsters
Schneider, J. E., & Wade, G. N. (1990) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1990.258.3.r750 · Cited by 54
Deletion of Otx2 in GnRH Neurons Results in a Mouse Model of Hypogonadotropic Hypogonadism
Diaczok, D., DiVall, S. A., Matsuo, I., Wondisford, F. E., Wolfe, A., & Radovick, S. (2011) · Molecular Endocrinology · doi:10.1210/me.2010-0271 · Cited by 53
Self-citation
Insulin-Like Growth Factor Binding Protein-6 Transgenic Mice: Postnatal Growth, Brain Development, and Reproduction Abnormalities
Bienvenu, G., Seurin, D., Grellier, P., Froment, P., Baudrimont, M., Monget, P., Bouc, Y. L., & Babajko, S. (2004) · Endocrinology · doi:10.1210/en.2003-1196 · Cited by 53
Suppression of luteinizing hormone secretion during short-term fasting in male rhesus monkeys: the role of metabolic versus stress signals
Schreihofer, D. A., Parfitt, D. B., & Cameron, J. L. (1993) · Endocrinology · doi:10.1210/endo.132.5.8477641 · Cited by 52
Increased expression of hypothalamic leptin receptor and adiponectin accompany resistance to dietary-induced obesity and infertility in female C57BL/6J mice
Tortoriello, D. V., McMinn, J. E., & Chua, S. C. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803392 · Cited by 51
Effects of glucose and related substrates on the recovery of the electrical activity of gonadotropin-releasing hormone pulse generator which is decreased by insulin-induced hypoglycemia in the estrogen-primed ovariectomized rat
He, D., Funabashi, T., Sano, A., Uemura, T., MINAGUCHI, H., & Kimura, F. (1999) · Brain Research · doi:10.1016/s0006-8993(98)01358-4 · Cited by 49
Jak2 Is Necessary for Neuroendocrine Control of Female Reproduction
Wu, S., DiVall, S. A., Hoffman, G. E., Le, W. W., Wagner, K., & Wolfe, A. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2974-10.2011 · Cited by 49
Self-citation
Hypoglycemia, But Not Insulin, Acutely Decreases LH and T Secretion in Men
Oltmanns, K. M., Fruehwald‐Schultes, B., Kern, W., Jan Born, A., Fehm, H. L., & Peters, A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.10.7892 · Cited by 49
Effect of Centrally Administered Insulin on Gonadotropin-Releasing Hormone Neuron Activity and Luteinizing Hormone Surge in the Diabetic Female Rat
Kovacs, P. L., Parlow, A. F., & Karkanias, G. B. (2002) · Neuroendocrinology · doi:10.1159/000067585 · Cited by 48
Regulation of gonadotropin-releasing hormone neurons by glucose
Roland, A. V., & Moenter, S. M. (2011) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2011.07.001 · Cited by 48
Regulation of Gonadal and Somatotropic Axis by Chronic Intraventricular Infusion of Insulin-Like Growth Factor 1 Antibody at the Initiation of Puberty in Male Rats
Pazos, F., Sánchez‐Franco, F., Balsa, J. A., López‐Fernández, J., Escalada, J., & Cacicedo, L. (1999) · Neuroendocrinology · doi:10.1159/000054443 · Cited by 48
Transgenics Identify Distal 5'- and 3'-Sequences Specifying Gonadotropin-Releasing Hormone Expression in Adult Mice
Pape, J., Skynner, M. J., Allen, N. D., & Herbison, A. E. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.12.0380 · Cited by 47
Identification of a Discrete Promoter Region of the Human GnRH Gene That Is Sufficient for Directing Neuron-Specific Expression: A Role for POU Homeodomain Transcription Factors
Wolfe, A., Kim, H. H., Tobet, S. A., et al. (2002) · Molecular Endocrinology · doi:10.1210/mend.16.3.0780 · Cited by 46
Self-citation
Developmental Changes in Serum Levels of Free and Total Insulin-Like Growth Factor I (IGF-I), IGF-Binding Protein-1 and -3, and the Acid-Labile Subunit in Rats**This work was supported by grants from the Danish Health Research Council (Grants 9602012 and 9700592), the Aarhus University-Novo Nordisk Center for Research in Growth and Regeneration (Danish Health Research Council Grant 9600822), the Institute of Experimental Clinical Research, University of Aarhus, the Novo Foundation, the Nordic Insulin Foundation, and the National Health and Medical Research Council of Australia (to R.C.B.).
Frystyk, J., Grønbæk, H., Skjærbæk, C., et al. (1998) · Endocrinology · doi:10.1210/endo.139.10.6273 · Cited by 46
Insulin receptors in the pituitary gland: morphological evidence for influence on opioid peptide-synthesizing cells
Unger, J. W., & Lange, W. (1997) · Cell and Tissue Research · doi:10.1007/s004410050833 · Cited by 45
Neuroendocrine Effects of Cytokines in the Rat
RIVIER, C. L. (1993) · Reviews in the Neurosciences · doi:10.1515/revneuro.1993.4.3.223 · Cited by 45
The Luteinizing Hormone-releasing Hormone Inhibits the Anti-apoptotic Activity of Insulin-like Growth Factor-1 in Pituitary αT3 Cells by Protein Kinase Cα-mediated Negative Regulation of Akt
Rose, A., Froment, P., Perrot, V., Quon, M. J., LeRoith, D., & Dupont, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404571200 · Cited by 45
Reproductive Abnormalities in Human Insulin-Like Growth Factor-Binding Protein-1 Transgenic Male Mice
Froment, P., Staub, C., Hembert, S., Pisselet, C., Magistrini, M., Delaleu, B., Seurin, D., Levine, J. E., Johnson, L. W., Binoux, M., et al. (2004) · Endocrinology · doi:10.1210/en.2003-0956 · Cited by 44
Developmental Changes in Hypothalamic Insulin-Like Growth Factor-1: Relationship to Gonadotropin-Releasing Hormone Neurons
Daftary, S. S., & Gore, A. C. (2003) · Endocrinology · doi:10.1210/en.2002-221025 · Cited by 44
Genetic Mechanisms Mediating Kisspeptin Regulation of GnRH gene Expression
Novaira, H. J., Fadoju, D., Diaczok, D., & Radovick, S. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2438-12.2012 · Cited by 43
Granulosa-thecal cell interaction in ovarian steroidogenesis
Ryan, K. J. (1979) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(79)90014-1 · Cited by 43
Multiple transcription start sites for the GnRH gene in rhesus and cynomolgus monkeys: a non-human primate model for studying GnRH gene regulation
Dong, K.-W., Duval, P., Zeng, Z., et al. (1996) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(95)03737-3 · Cited by 42
Multiple Factors Interacting at the GATA Sites of the Gonadotropin-Releasing Hormone Neuron-Specific Enhancer Regulate Gene Expression
Lawson, M. A., Buhain, A. R., Jovenal, J. C., & Mellon, P. L. (1998) · Molecular Endocrinology · doi:10.1210/mend.12.3.0082 · Cited by 41
The area postrema mediates insulin hypoglycaemia-induced suppression of pulsatile LH secretion in the female rat
Cates, P. S., & O'Byrne, K. T. (2000) · Brain Research · doi:10.1016/s0006-8993(99)02301-x · Cited by 41
Interrelationships between dietary restriction, the IGF‐I axis, and expression of vascular endothelial growth factor by prostate adenocarcinoma in rats
Powolny, A. A., Wang, S., Carlton, P. S., et al. (2007) · Molecular Carcinogenesis · doi:10.1002/mc.20403 · Cited by 41
Characterization of iNOS+ Neutrophil-like ring cell in tumor-bearing mice
Virtuoso, L. P., Harden, J. L., Sotomayor, P. C., Sigurdson, W. J., Yoshimura, F., Egilmez, N. K., Minev, B., & Kilinc, M. O. (2012) · Journal of Translational Medicine · doi:10.1186/1479-5876-10-152 · Cited by 41
A neuron-specific enhancer targets expression of the gonadotropin- releasing hormone gene to hypothalamic neurosecretory neurons
Whyte, D. B. (1995) · Molecular Endocrinology · doi:10.1210/me.9.4.467 · Cited by 41
Insulin-like growth factor I enhances gonadotropin-releasing hormone-stimulated luteinizing hormone release from bovine anterior pituitary cells
HASHIZUME, T., Kumahara, A., Fujino, M., & Okada, K. (2002) · Animal Reproduction Science · doi:10.1016/s0378-4320(01)00190-7 · Cited by 40
The Insulin-Like Growth Factor System in the GT1-7 GnRH Neuronal Cell Line
Anderson, R. A., Zwain, I. H., Arroyo, A., Mellon, P. L., & Yen, S. S. C. (1999) · Neuroendocrinology · doi:10.1159/000054496 · Cited by 40
Sensitivity to stress-induced reproductive dysfunction is associated with a selective but not a generalized increase in activity of the adrenal axis
Herod, S. M., Dettmer, A. M., Novak, M. A., Meyer, J. S., & Cameron, J. L. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00223.2010 · Cited by 40
Appositions between cocaine and amphetamine-related transcript- and gonadotropin releasing hormone-immunoreactive neurons in the hypothalamus of the Siberian hamster
Leslie, R. A., Sanders, S., Anderson, S., Schuhler, S., Horan, T. L., & Ebling, F. J. P. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02291-1 · Cited by 39
Insulin augments GnRH-stimulated LHβ gene expression by Egr-1
Buggs, C., Weinberg, F. D., Kim, E., Wolfe, A., Radovick, S., & Wondisford, F. E. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.02.001 · Cited by 39
Self-citation
Membrane Localization of 3-Phosphoinositide-dependent Protein Kinase-1 Stimulates Activities of Akt and Atypical Protein Kinase C but Does Not Stimulate Glucose Transport and Glycogen Synthesis in 3T3-L1 Adipocytes
Egawa, K., Maegawa, H., Shi, K., Nakamura, T., Obata, T., Yoshizaki, T., Morino, K., Shimizu, S., Nishio, Y., Suzuki, E., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203132200 · Cited by 39
FOXO1 Transcription Factor Inhibits Luteinizing Hormone β Gene Expression in Pituitary Gonadotrope Cells
Arriola, D. J., Mayo, S. L., Skarra, D. V., Benson, C. A., & Thackray, V. G. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.362103 · Cited by 37
Reproductive Abnormalities in Human IGF Binding Protein-1 Transgenic Female Mice
Froment, P., Seurin, D., Hembert, S., Levine, J. E., Pisselet, C., Monniaux, D., Binoux, M., & Monget, P. (2002) · Endocrinology · doi:10.1210/endo.143.5.8815 · Cited by 36
Treatment with a CRH-R1 antagonist prevents stress-induced suppression of the central neural drive to the reproductive axis in female macaques
Herod, S. M., Pohl, C. R., & Cameron, J. L. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00224.2010 · Cited by 36
Structure of the distal human gonadotropin releasing hormone (hGnrh) gene promoter and functional analysis in Gt1-7 neuronal cells
Kepa, J. K. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.18.3614 · Cited by 36
Insulin augments gonadotropin-releasing hormone induction of translation in LβT2 cells
Navratil, A. M., Song, H., Hernandez, J. B., Cherrington, B. D., Santos, S. J., Low, J. M., Minh‐Ha, T., & Lawson, M. A. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.07.014 · Cited by 36
Glucosamine Induces Resistance to Insulin-Like Growth Factor I (IGF-I) and Insulin in Hep G2 Cell Cultures: Biological Significance of IGF-I/Insulin Hybrid Receptors
Sakai, K., & Clemmons, D. R. (2003) · Endocrinology · doi:10.1210/en.2002-221133 · Cited by 35
Cholecystokinin Directly Inhibits Neuronal Activity of Primary Gonadotropin-Releasing Hormone Cells through Cholecystokinin-1 Receptor
Giacobini, P., & Wray, S. (2006) · Endocrinology · doi:10.1210/en.2006-0758 · Cited by 35
Gonadotropin-releasing hormone immunoreactivity in the adult and fetal human olfactory system.
Kim, K., Patel, L., Tobet, S., King, J. C., Rubin, B. S., & Stopa, E. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01271-8 · Cited by 34
Use of a Gonadotropin-Releasing Hormone Antagonist as a Physiologic Probe in Polycystic Ovary Syndrome: Assessment of Neuroendocrine and Androgen Dynamics
Hayes, F. J. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.7.2343 · Cited by 34
Egr-1 binds the GnRH promoter to mediate the increase in gene expression by insulin
DiVall, S. A., Radovick, S., & Wolfe, A. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.02.007 · Cited by 32
Self-citation
Pitx2 deletion in pituitary gonadotropes is compatible with gonadal development, puberty, and fertility
Charles, M. A., Mortensen, A. H., Potok, M. A., & Camper, S. A. (2008) · genesis · doi:10.1002/dvg.20398 · Cited by 32
Microwave oven-based technique for immunofluorescent staining of paraffin-embedded tissues
Long, D. J., & Buggs, C. (2007) · Journal of Molecular Histology · doi:10.1007/s10735-007-9093-6 · Cited by 31
Promoter Sequences Targeting Tissue-specific Gene Expression of Hypothalamic and Ovarian Gonadotropin-releasing Hormone in Vivo
Kim, H. H., Wolfe, A., Smith, G. R., Tobet, S. A., & Radovick, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110535200 · Cited by 31
Self-citation
Rostral medial preoptic area lesions' influence on female estrous processes and LHRH distribution
Popolow, H. B., King, J. C., & Gerall, A. A. (1981) · Physiology & Behavior · doi:10.1016/0031-9384(81)90053-6 · Cited by 31
Stress sensitive female macaques have decreased fifth Ewing variant (Fev) and serotonin-related gene expression that is not reversed by citalopram
Lima, F. B., Centeno, M. L., Costa, M. E., Reddy, A. P., Cameron, J. L., & Bethea, C. L. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.08.010 · Cited by 31
Autocrine regulation of calcium influx and gonadotropin-releasing hormone secretion in hypothalamic neurons
Goor, F. V., Krsmanović, L. Z., Catt, K. J., & Stojilković, S. S. (2000) · Biochemistry and Cell Biology · doi:10.1139/bcb-78-3-359 · Cited by 31
Effects of citalopram on serotonin and CRF systems in the midbrain of primates with differences in stress sensitivity
Bethea, C. L., Lima, F. B., Centeno, M. L., Weissheimer, K. V., Senashova, O., Reddy, A. P., & Cameron, J. L. (2011) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2011.05.010 · Cited by 30
Hypothalamic Insulin-Like Growth Factor-I Receptors Are Necessary for Hormone-Dependent Luteinizing Hormone Surges: Implications for Female Reproductive Aging
Todd, B. J., Merhi, Z. O., Shu, J., Etgen, A. M., & Neal-Perry, G. S. (2010) · Endocrinology · doi:10.1210/en.2009-1009 · Cited by 30
Influence of Stage of the Estrous Cycle on Insulin-Like Growth Factor-I Modulation of Luteinizing Hormone Secretion in the Gilt1
Whitley, N. C. C., Barb, C. R., Utley, R. V., Popwell, J. M., Kraeling, R. R., & Rampacek, G. B. (1995) · Biology of Reproduction · doi:10.1095/biolreprod53.6.1359 · Cited by 30
Modes of Action of GnRH and GnRH Analogs
(1992) · Springer eBooks · doi:10.1007/978-1-4612-2916-2 · Cited by 29
Effects of long-term treatment with α-glucosidase inhibitor on the peripheral nerve function and structure in Goto-Kakizaki rats: a genetic model for Type 2 diabetes
Wada, R., Koyama, M., Mizukami, H., Odaka, H., Ikeda, H., & Yagihashi, S. (1999) · Diabetes/Metabolism Research and Reviews · doi:10.1002/(sici)1520-7560(199909/10)15:5 · Cited by 29
In VivoIdentification of a 107-Base Pair Promoter Element Mediating Neuron-Specific Expression of Mouse Gonadotropin-Releasing Hormone
Kim, H. H., Wolfe, A., Cohen, R., Eames, S. C., Johnson, A. L., Wieland, C. N., & Radovick, S. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0216 · Cited by 28
Self-citation
Insulin enhances the transcription of luteinizing hormone-β gene
Dorn, C., Mouillet, J., Yan, X., Ou, Q., & Sadovsky, Y. (2004) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2004.01.054 · Cited by 27
Insulin-Related Materials in the Nervous System of Vertebrates and Non-Vertebrates: Possible Extrapancreatic Production
LeRoith, D., Adamo, M. L., Shemer, J., et al. (1988) · Hormone and Metabolic Research · doi:10.1055/s-2007-1010850 · Cited by 27
Hypothalamic expression of serotonin 1A, 2A and 2C receptor and GAD67 mRNA in female cynomolgus monkeys with different sensitivity to stress
Centeno, M. L., Sanchez, R. L., Cameron, J. L., & Bethea, C. L. (2007) · Brain Research · doi:10.1016/j.brainres.2007.01.056 · Cited by 27
Hypothalamic Gonadotrophin‐Releasing Hormone Expression in Female Monkeys with Different Sensitivity to Stress
Centeno, M. ‐., Sanchez, R. L., Cameron, J. L., & Bethea, C. L. (2007) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2007.01566.x · Cited by 27
Autocrine regulation of calcium influx and gonadotropin-releasing hormone secretion in hypothalamic neurons
Goor, F. V., Krsmanović, L. Z., Catt, K. J., et al. (2000) · Biochemistry and Cell Biology · doi:10.1139/o00-058 · Cited by 27
Differential Effects of Hypothalamic IGF-I on Gonadotropin Releasing Hormone Neuronal Activation During Steroid-Induced LH Surges in Young and Middle-Aged Female Rats
Sun, Y., Todd, B. J., Thornton, K. M., Etgen, A. M., & Neal-Perry, G. S. (2011) · Endocrinology · doi:10.1210/en.2011-1051 · Cited by 26
CREB Binding Protein (CBP) Activation Is Required for Luteinizing Hormone Beta Expression and Normal Fertility in Mice
Miller, R. S., Wolfe, A., He, L., Radovick, S., & Wondisford, F. E. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00394-12 · Cited by 26
Self-citation
Mating Induces Gonadotropin-Releasing Hormone Neuronal Activation in Anosmic Female Ferrets1
Bakker, J., Kelliher, K. R., & Baum, M. J. (2001) · Biology of Reproduction · doi:10.1095/biolreprod64.4.1100 · Cited by 26
Suppression of Luteinizing Hormone Secretion during Food Restriction in Male Rhesus Monkeys (Macaca mulatta): Failure of Naloxone to Restore Normal Pulsatility
Helmreich, D. L., & Cameron, J. L. (2008) · Neuroendocrinology · doi:10.1159/000126263 · Cited by 25
Administration of fatty acids and gonadotrophin secretion in the mature ram
Boukhliq, R., & Martin, G. B. (1997) · Animal Reproduction Science · doi:10.1016/s0378-4320(97)00065-1 · Cited by 25
Hypothalamic IGF-I Gene Therapy Prolongs Estrous Cyclicity and Protects Ovarian Structure in Middle-Aged Female Rats
Rodríguez, S. S., Schwerdt, J. I., Barbeito, C. G., et al. (2013) · Endocrinology · doi:10.1210/en.2013-1069 · Cited by 21
Arrest of pulsatile luteinizing hormone (LH) secretion during insulin-induced hypoglycemia (IIH): Improvement by intrahypothalamic perfusion with glucose
Rodríguez, M., Arias, P., Refojo, D., et al. (2009) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0029-1212109 · Cited by 20
The Gonadotropin-Releasing Hormone Cell-Specific Element Is Required for Normal Puberty and Estrous Cyclicity
Novaira, H. J., Yates, M. M., Diaczok, D., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5419-10.2011 · Cited by 19
Ultrastructural immunolocalization of IGF-1 and insulin receptors in rat pituitary culture: evidence of a functional interaction between gonadotroph and lactotroph cells
Gutiérrez, S., Mukdsi, J. H., Aoki, A., Torres, A. I., Soler, A. P., & Orgnero, E. M. (2006) · Cell and Tissue Research · doi:10.1007/s00441-006-0283-4 · Cited by 19
Generation of Immortal Cell Lines from the Adult Pituitary: Role of cAMP on Differentiation of SOX2-Expressing Progenitor Cells to Mature Gonadotropes
Kim, G. L., Wang, X., Chalmers, J. A., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027799 · Cited by 17
The involvement of phosphatidylinositol 3-kinase in gonadotropin-releasing hormone-induced gonadotropin α- and FSHβ-subunit genes expression in clonal gonadotroph LβT2 cells☆
Mutiara, S., Kanasaki, H., Harada, T., et al. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.12.001 · Cited by 17
Fasting-induced suppression of LH secretion does not require activation of ATP-sensitive potassium channels
Huang, W., Acosta‐Martínez, M., Horton, T. H., & Levine, J. E. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90615.2008 · Cited by 17
The developmental biology of the GnRH neurons
Crowley, W. F. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.06.023 · Cited by 16
Indirect assessment of pulsatile gonadotropin-releasing hormone release in agonadal prepubertal rhesus monkeys (Macaca mulatta)
Suter, K. J., Pohl, C. R., & Plant, T. M. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1600035 · Cited by 16
Insulin-like growth factor I (IGF I)
Souberbielle, J. (2006) · EMC - Biologie Médicale · doi:10.1016/s2211-9698(06)76084-8 · Cited by 15
Modulation of circulating IGF-I and IGFBP-3 levels by hormonal regulators of energy homeostasis in obese children
Woelfle, J., Harz, K., & Roth, C. L. (2007) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2006-957350 · Cited by 14
Male-biased effects of gonadotropin-releasing hormone neuron-specific deletion of the phosphoinositide 3-kinase regulatory subunit p85alpha on the reproductive axis.
Acosta-Martínez, M., Luo, J., Elias, C., Wolfe, A., & Levine, J. (2009) · Endocrinology · doi:10.1210/en.2008-1753 · Cited by 13
Self-citation
GnRH Subgroups: A Microarchitecture
King, J. C., & Rubin, B. S. (1992) · Springer eBooks · doi:10.1007/978-1-4612-2916-2_11 · Cited by 11
Gonadotropin-Releasing Hormone
Jennes, L., & Conn, P. M. (2002) · Elsevier eBooks · doi:10.1016/b978-012532104-4/50063-9 · Cited by 10
Insulin Resistance and Pubertal Changes
Wilson, P. W. F., & Umpierrez, G. E. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0873 · Cited by 9
Estrogen receptor alpha (ERα) and insulin‐like growth factor I receptor (IGF‐IR) cross‐talk in the gonadotropic αT3‐1 cell line
Eertmans, F., Dhooge, W., Wever, O. D., et al. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21053 · Cited by 9
The Effect of Citalopram on Midbrain CRF Receptors 1 and 2 in a Primate Model of Stress-Induced Amenorrhea
Senashova, O., Reddy, A. P., Cameron, J. L., & Bethea, C. L. (2012) · Reproductive Sciences · doi:10.1177/1933719111430992 · Cited by 8
The lack of effect of insulin on luteinizing hormone pulsatility in healthy male volunteers provides evidence of a sexual dimorphism in the metabolic regulation of reproductive hormones
Pesant, M.-H., Dwyer, A. A., Marques-Vidal, P. M., Schneiter, P., Giusti, V., Tappy, L., & Pralong, F. P. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.030189 · Cited by 7
Interactions of Insulin-like Growth Factors and Estradiol in Rat Pituitary Gonadotrophs
Weiss, J.-M., Chi, M., Polack, S., Diedrich, K., & Ortmann, O. (2003) · Growth Factors · doi:10.1080/08977190310001605760 · Cited by 6
Extracellular Signal-Regulated Kinase 1 and 2 Are Not Required for GnRH Neuron Development and Normal Female Reproductive Axis Function in Mice
Wierman, M. E., Xu, M., Pierce, A., Bliesner, B., Bliss, S. P., & Roberson, M. S. (2012) · Neuroendocrinology · doi:10.1159/000331389 · Cited by 6
Insulin-induced hypoglycemia does not impair the surge of luteinizing hormone secretion in the proestrous rat
Kawaguchi, M., Funabashi, T., & Kimura, F. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00783-6 · Cited by 6
Short-term effects of IGF-I and estradiol on LH secretion from female rat gonadotrophs
Weiss, J.-M., Xia, Y., Polack, S., Diedrich, K., & Ortmann, O. (2006) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2006.09.004 · Cited by 4
Untitled work
(2000) · doi:10.1002/1520-7560(2000)9999:9999

Sorted by citations

Pubertal development and regulation
Abreu, A. P., & Kaiser, U. B. (2016) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(15)00418-0 · Cited by 611
Developmental variations in environmental influences including endocrine disruptors on pubertal timing and neuroendocrine control: revision of human observations and mechanistic insight from rodents
Parent, A.-S., Franssen, D., Fudvoye, J., Gérard, A., & Bourguignon, J.-P. (2015) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.12.004 · Cited by 175
Development of the gonadotropin‐releasing hormone system
Duittoz, A. H., Forni, P. E., Giacobini, P., Golan, M., Mollard, P., Negrón, A. L., Radovick, S., & Wray, S. (2022) · Journal of Neuroendocrinology · doi:10.1111/jne.13087 · Cited by 50

See all 83

Authors: Wolfe, A., Divall, S., & Wu, S.
Affiliations: Johns Hopkins University (US)
Corresponding author: Wolfe, Andrew
ORCID: Wolfe, Andrew
Divall, Sara
Wu, Sheng
Venue: Frontiers in Neuroendocrinology
Publisher: Elsevier BV
Published: 2014-10
Volume: 35
Issue: 4
Pages: 558-572
ISSN: 0091-3022 (ISSN-L)
DOI: 10.1016/j.yfrne.2014.05.007
PMC: PMC4175134
OpenAlex: W2076110825
Cited by: 83
References: 310
Citations by year: 2026: 7 · 2025: 8 · 2024: 5 · 2023: 2 · 2022: 5 · 2021: 13 · 2020: 7 · 2019: 7 · 2018: 7 · 2017: 9 · 2016: 8 · 2015: 3 · 2014: 2
FWCI: 1.15
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Frontiers in Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (P30DK079637)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD068777, K99HD068130, K08HD056139, R01HD044608, R00HD068130)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: insulin, insulin-like growth factor I, neuroendocrine regulation of reproduction, hypothalamus, pituitary gland, gonadotropin secretion, puberty, growth factor signaling, receptor tyrosine kinase, sex steroids
MeSH terms: Animals, Humans, Insulin, Insulin-Like Growth Factor I, Neurosecretory Systems, Pituitary Gland, Reproduction, Sexual Maturation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The regulation of reproductive neuroendocrine function by insulin and insulin-like growth factor-1 (IGF-1)

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks