Cited by 59Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on Behavior

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Comparing vasopressin and oxytocin fiber and receptor density patterns in the social behavior neural network: Implications for cross-system signaling

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Smith, Caroline J.W., DiBenedictis, Brett T., Veenema, Alexa H.·2019·Frontiers in Neuroendocrinology

DOI 10.1016/j.yfrne.2019.02.001PMC PMC7469073

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Abstract

Vasopressin (AVP) and oxytocin (OXT) regulate social behavior by binding to their canonical receptors, the vasopressin V1a receptor (V1aR) and oxytocin receptor (OTR), respectively. Recent studies suggest that these neuropeptides may also signal via each other's receptors. The extent to which such cross-system signaling occurs likely depends on anatomical overlap between AVP/OXT fibers and V1aR/OTR expression. By comparing AVP/OXT fiber densities with V1aR/OTR binding densities throughout the rat social behavior neural network (SBNN), we propose the potential for cross-system signaling in four regions: the medial amygdala (MeA), bed nucleus of the stria terminalis (BNSTp), medial preoptic area, and periaqueductal grey. We also discuss possible implications of corresponding sex (higher in males versus females) and age (higher in adults versus juveniles) differences in AVP fiber and OTR binding densities in the MeA and BNSTp. Overall, this review reveals the need to unravel the consequences of potential cross-system signaling between AVP and OXT systems in the SBNN for the regulation of social behavior.

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Preface
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Copyright Page
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Abbreviations Used for Major Brain Regions
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.002.0007
Dedication
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Authors: Smith, C. J. W., DiBenedictis, B. T., & Veenema, A. H.
Affiliations: Boston College (US)
Corresponding author: Smith, Caroline J.W.
ORCID: Smith, Caroline J.W.
DiBenedictis, Brett T.
Veenema, Alexa H.
Venue: Frontiers in Neuroendocrinology
Publisher: Elsevier BV
Published: 2019-04
Volume: 53
Pages: 100737
ISSN: 0091-3022 (ISSN-L)
DOI: 10.1016/j.yfrne.2019.02.001
PMC: PMC7469073
OpenAlex: W2911777171
Cited by: 59
References: 222
Citations by year: 2026: 5 · 2025: 10 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 9 · 2020: 19 · 2019: 3
FWCI: 1.43
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (am, 419 d)
Locations: Frontiers in Neuroendocrinology (acceptedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (R01MH102456)
National Science Foundation (IOS1253385)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: vasopressin, oxytocin, vasopressin V1a receptor, oxytocin receptor, receptor binding density, medial amygdala, bed nucleus of the stria terminalis, medial preoptic area, periaqueductal gray, sex differences, age differences, rats
MeSH terms: Animals, Humans, Nerve Net, Oxytocin, Social Behavior, Vasopressins, Receptors, Vasopressin, Receptors, Oxytocin

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Comparing vasopressin and oxytocin fiber and receptor density patterns in the social behavior neural network: Implications for cross-system signaling

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