The DOI matches its Crossref record; 221 of the 222 references it cites were found in a registry or an index.
Comparing vasopressin and oxytocin fiber and receptor density patterns in the social behavior neural network: Implications for cross-system signaling
Open accessAbstract
Vasopressin (AVP) and oxytocin (OXT) regulate social behavior by binding to their canonical receptors, the vasopressin V1a receptor (V1aR) and oxytocin receptor (OTR), respectively. Recent studies suggest that these neuropeptides may also signal via each other's receptors. The extent to which such cross-system signaling occurs likely depends on anatomical overlap between AVP/OXT fibers and V1aR/OTR expression. By comparing AVP/OXT fiber densities with V1aR/OTR binding densities throughout the rat social behavior neural network (SBNN), we propose the potential for cross-system signaling in four regions: the medial amygdala (MeA), bed nucleus of the stria terminalis (BNSTp), medial preoptic area, and periaqueductal grey. We also discuss possible implications of corresponding sex (higher in males versus females) and age (higher in adults versus juveniles) differences in AVP fiber and OTR binding densities in the MeA and BNSTp. Overall, this review reveals the need to unravel the consequences of potential cross-system signaling between AVP and OXT systems in the SBNN for the regulation of social behavior.
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“The behavioral effects of AVP are mediated primarily by V1aR (or Avpr1a) and V1bR (16,37,38,49,68), while AVP acts on V2 to regulate fluid homeostasis in the kidney (69).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [37]
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Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities
Rigney, N., de Vries, G. J., Petrulis, A., & Young, L. J. (2022) · Endocrinology · doi:10.1210/endocr/bqac111 · Cited by 191
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Links between the neurobiology of oxytocin and human musicality
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Plasencia, G., Luedicke, J., Pournajafi‐Nazarloo, H., Carter, C. S., & Ebner, N. C. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104419 · Cited by 87
Metadata
- Authors
- Smith, C. J. W., DiBenedictis, B. T., & Veenema, A. H.
- Affiliations
- Boston College (US)
- Corresponding author
- Smith, Caroline J.W.
- Venue
- Frontiers in Neuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2019-04
- Volume
- 53
- Pages
- 100737
- ISSN
- 0091-3022 (ISSN-L)
- PMC
- PMC7469073
- OpenAlex
- W2911777171
- Cited by
- 59
- References
- 222
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 9 · 2020: 19 · 2019: 3
- FWCI
- 1.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Frontiers in Neuroendocrinology (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (R01MH102456)
- National Science Foundation (IOS1253385)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- vasopressin, oxytocin, vasopressin V1a receptor, oxytocin receptor, receptor binding density, medial amygdala, bed nucleus of the stria terminalis, medial preoptic area, periaqueductal gray, sex differences, age differences, rats
- MeSH terms
- Animals, Humans, Nerve Net, Oxytocin, Social Behavior, Vasopressins, Receptors, Vasopressin, Receptors, Oxytocin
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