Impact of ectopic fat on brain structure and cognitive function: A systematic review and meta-analysis from observational studies
Abstract
Ectopic fat, defined as a specific organ or compartment with the accumulation of fat tissue surrounding organs, is highly associated with obesity which has been identified as a risk factor for cognitive impairment and dementia. However, the relationship between ectopic fat and changes in brain structure or cognition is yet to be elucidated. Here, we investigated the effects of ectopic fat on brain structure and cognitive function via systemic review and meta-analysis. A total of 21 studies were included from electronic databases up to July 9, 2022. We found ectopic fat was associated with decreased total brain volumeand increased lateral ventricle volume. In addition, ectopic was associated with decreased cognitive scores and negatively correlated with cognitive function. More specifically, dementia development were correlated with increased levels of visceral fat. Overall, our data suggested that increased ectopic fat was associated with prominent structural changes in the brain and cognitive decline, an effect driven mainly by increases in visceral fat, while subcutaneous fat may be protective. Our results suggest that patients with increased visceral fat are at risk of developing cognitive impairment and, therefore, represent a subset of population in whom appropriate and timely preventive measures could be implemented.
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Adiposity is associated with reduced cognitive function.
“Recent evidence has demonstrated an association between adiposity and reduced cognitive function”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [577]
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Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193 · see citing works
- Authors
- Song, Z.-H., Liu, J., Wang, X.-F., Simó, R., Zhang, C., & Zhou, J.-B.
- Affiliations
- Xinjiang Medical University (CN)
- Universitat Autònoma de Barcelona (ES)
- Beijing Tongren Hospital (CN)
- Corresponding author
- Zhang, Chao
- Venue
- Frontiers in Neuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2023-07
- Volume
- 70
- Pages
- 101082
- ISSN
- 0091-3022 (ISSN-L)
- OpenAlex
- W4383105275
- Cited by
- 14
- References
- 80
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 8
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Frontiers in Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (82270866)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- ectopic fat, visceral fat, subcutaneous adipose tissue, brain structure, cognitive function, cognitive impairment, dementia, total brain volume, lateral ventricle volume, obesity, neurodegeneration
- MeSH terms
- Adipose Tissue, Brain, Cognition, Dementia, Humans, Cognitive Dysfunction
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