Ectopic fat and insulin resistance
Abstract
Ectopic fat is defined by the deposition of triglycerides within cells of non-adipose tissue that normally contain only small amounts of fat. Over the past decade, magnetic resonance spectroscopy has been used extensively for noninvasive quantification of intramyocellular, intrahepatocellular, and more recently myocardial and pancreatic lipids. In liver and muscle, triglyceride content usually correlates with whole-body and tissue-specific insulin sensitivity. However, fat mass and oxidative capacity influence this relationship, indicating that ectopic lipid content is not the only factor that explains insulin resistance. Ectopic lipids may rather serve as biomarkers of the balance between metabolic supply and demand in different states of insulin sensitivity. Consequently, ectopic lipid concentrations, particularly in the liver, decrease with lifestyle- or drug-induced improvement of insulin sensitivity.
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Dysregulation of fatty acid metabolism has a central role in the development of insulin resistance in skeletal muscle.
“Dysregulation of fatty acid metabolism plays a pivotal role in the pathogenesis of insulin resistance in skeletal muscle.”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [11]
Increased intramyocellular fat content and fatty acid metabolites have a pivotal role in the development of skeletal muscle insulin resistance.
“an increased intramyocellar fat content and fatty acid metabolites have been shown to play a pivotal role in the development of insulin resistance in skeletal muscle [11–15].”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [11]
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(2020) · American Academy of PediatricsItasca, IL eBooks · doi:10.1542/9781610024181-33
Andrade, L. J. D. O., de Brito, L. F. M., de Oliveira, G. C. M., de Oliveira, L. C. M., Bittencourt, A. M. V., Baptista, G. M., Silva, C. P., & de Oliveira, L. M. (2023) · medRxiv · doi:10.1101/2023.12.20.23300240
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- Authors
- Lettner, A., & Roden, M.
- Affiliations
- Hanusch Hospital (AT)
- Corresponding author
- Roden, Michael
- ORCID
- Roden, Michael
- Venue
- Current Diabetes Reports
- Published
- 2008-06
- Volume
- 8
- Issue
- 3
- Pages
- 185-191
- ISSN
- 1534-4827 (ISSN-L)
- 1539-0829
- OpenAlex
- W2151826036
- Cited by
- 106
- References
- 51
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 4 · 2023: 8 · 2022: 5 · 2021: 3 · 2020: 5 · 2019: 10 · 2018: 8 · 2017: 4 · 2016: 4 · 2015: 2 · 2014: 13 · 2013: 11 · 2012: 10
- FWCI
- 0.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Diabetes Reports (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- ectopic fat, insulin resistance, intramyocellular lipid, myocardial lipids, magnetic resonance spectroscopy, insulin sensitivity, oxidative capacity, fat mass, biomarkers, lifestyle intervention
- MeSH terms
- Animals, Choristoma, Humans, Insulin, Insulin Resistance, Obesity, Pancreas, Triglycerides
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