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Cited by 30Neuroendocrine regulation and behaviorNeurotransmitter Receptor Influence on BehaviorAnimal Vocal Communication and Behavior

Estrogenic regulation of dopaminergic neurons in the opportunistically breeding zebra finch

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Kabelik, David, Schrock, Sara E., Ayres, Lauren C., Goodson, James L.·2011·General and Comparative Endocrinology
DOI 10.1016/j.ygcen.2011.04.026PMC PMC3130106
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Abstract

Steroid-induced changes in dopaminergic activity underlie many correlations between gonadal hormones and social behaviors. However, the effects of steroid hormones on the various behaviorally relevant dopamine cell groups remain unclear, and ecologically relevant species differences remain virtually unexplored. We examined the effects of estradiol (E2) manipulations on dopamine (DA) neurons of male and female zebra finches (Taeniopygia guttata), focusing on numbers of tyrosine hydroxylase-immunoreactive (TH-ir) cells in the A8-A15 cell groups, and on TH colocalization with Fos, conducted in the early A.M., in order to quantify basal transcriptional activity. TH is the rate-limiting enzyme for catecholamine synthesis, and specifically DA in the A8-A15 cell groups. In contrast to other examined birds and mammals, reducing E2 levels with the aromatase-inhibitor Letrozole failed to alter TH-ir neuron numbers within the ventral tegmental area (VTA; A10), while increasing neuron numbers in the central gray (CG; A11) and caudal midbrain A8 populations. Consistent with findings in other birds, but not mammals, we also found no effects of E2 manipulations (Letrozole or Letrozole plus E2 replacement) on TH-Fos colocalization in any location. In accordance with previous observations in both mammals and birds, E2 treatment decreased the number of TH-ir neurons in the A12 population of the tuberal hypothalamus, a cell group that inhibits the release of prolactin. In general, males and females exhibited similar TH-ir neuron numbers, although males exhibited significantly more TH-ir neurons in the A11 CG population than did females. These results suggest partial variability in E2 regulation of DA across species.

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  • Because AVP/OT and the dopaminergic pathways they feed into are heavily influenced by sex steroids across the lifespan, their sexually dimorphic ontogeny and function may be particularly vulnerable to endocrine disruption.

    “Because AVP/OT and the dopaminergic pathways they feed into are heavily influenced by sex steroids across the lifespan (50–59), it is highly plausible that their sexually dimorphic ontogeny and function may be particularly vulnerable to endocrine disruption.”

    From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [54]

    The Introduction reports that sex steroids regulate dopamine activity and synthesis, including effects during specific developmental periods. It does not establish that AVP/OT feeds into those pathways or that both systems are heavily influenced by sex steroids across the lifespan. The proposed vulnerability to endocrine disruption is the citing authors’ inference, not a finding attributed to this source. (LLM, conf=0.84)

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Research works printed but not linked: 4

  1. [10]Balthazart J Foidart A Baillien M Harada N Ball GF Anatomical relationships between aromatase and tyrosine hydroxylase in the quail brain: double-label immunocytochemical studies J Comp Neurol 1998 391 214 26 9518270
  2. [65]Reiner A Medina L Veenman CL Structural and functional evolution of the basal ganglia in vertebrates Brain Res Brain Res Rev 1998 28 235 85 9858740
  3. [69]Saigusa T Takada K Baker SC Kumar R Stephenson JD Dopamine efflux in the rat nucleus accumbens evoked by dopamine receptor stimulation in the entorhinal cortex is modulated by oestradiol and progesterone Synapse 1997 25 37 43 8987146
  4. [79]Tramontin AD Smith GT Breuner CW Brenowitz EA Seasonal plasticity and sexual dimorphism in the avian song control system: stereological measurement of neuron density and number J Comp Neurol 1998 396 186 92 9634141

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Authors
Kabelik, D., Schrock, S. E., Ayres, L. C., & Goodson, J. L.
Affiliations
Indiana University Bloomington (US)
Corresponding author
Kabelik, David
ORCID
Kabelik, David
Venue
General and Comparative Endocrinology
Publisher
Elsevier BV
Published
2011-08
Volume
173
Issue
1
Pages
96-104
ISSN
0016-6480 (ISSN-L)
DOI
10.1016/j.ygcen.2011.04.026
PMC
PMC3130106
OpenAlex
W1995091013
Cited by
30
References
90
Citations by year
2022: 2 · 2021: 2 · 2020: 5 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 4 · 2014: 4 · 2013: 5 · 2012: 2
FWCI
4.80
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • General and Comparative Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Mental Health (R01MH062656)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Developmental Biology › Animal Vocal Communication and Behavior
Keywords
estrogen, estradiol, dopaminergic neurons, zebra finch, tyrosine hydroxylase, aromatase inhibition, letrozole, ventral tegmental area, periaqueductal gray, tuberal hypothalamus, FOS, gonadal hormones, sex differences, species differences, prolactin
MeSH terms
Letrozole, Animals, Estradiol, Female, Immunohistochemistry, Male, Nitriles, Triazoles, Tyrosine 3-Monooxygenase, Finches, Aromatase Inhibitors, Dopaminergic Neurons

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