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Interaction between inflammation and angiogenesis during different stages of cervical carcinogenesis

Mazibrada, Jasenka, Rittà, Massimo, Mondini, Michele, De Andrea, Marco, Azzimonti, Barbara, Borgogna, Cinzia, Ciotti, Marco, Orlando, Augusto, Surico, Nicola, Chiusa, Luigi, Landolfo, Santo, Gariglio, Marisa·2008·Gynecologic Oncology
DOI 10.1016/j.ygyno.2007.08.095
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Abstract

Objective The primary aim of this study was to investigate the role of angiogenesis and inflammatory cell response in cervical carcinogenesis. Methods Formalin-fixed tissue specimens from 58 uterine cervical specimens (8 CIN1, 14 CIN2, 28 CIN3, and 8 SCC), representing the different stages of cervical carcinogenesis, were immunohistochemically analyzed. Normal cervical tissue specimens were also included as controls. The present study assessed the expression of CD31 and CD105 to evaluate microvessel density (MVD), the macrophage marker CD68 and the panleukocyte marker CD45. In addition, expression of iNOS (inducible Nitric Oxide Synthase) was also evaluated. Results MVD, measured by either CD31 or CD105, increased along the continuum from normal epithelium to squamous cell carcinoma, and a significant correlation between the CD105-MVD and the CD31-MVD was observed (r=0.8735; p Conclusions Our findings demonstrated a positive correlation between neovascularity and macrophage counts, whereas iNOS expression displayed an inverse relationship with macrophage density and tumor progression. Low iNOS expression may modify the function of tumor-infiltrating macrophages toward a malignant phenotype that promotes tumor progression rather than an anti-tumor response.

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Cited by

Metadata

Authors
Mazibrada, J., Rittà, M., Mondini, M., De Andrea, M., Azzimonti, B., Borgogna, C., Ciotti, M., Orlando, A., Surico, N., Chiusa, L., Landolfo, S., & Gariglio, M.
Venue
Gynecologic Oncology
Publisher
Elsevier BV
Published
2008-01
Volume
108
Issue
1
Pages
112-120
ISSN
0090-8258
DOI
10.1016/j.ygyno.2007.08.095
Cited by
94
References
1
Language
en
Update notices
erratum (2008-07-01)
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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