Effects of gonadectomy and hormone replacement on a spontaneous novel object recognition task in adult male rats
Open accessAbstract
Recent studies in adult male rats have shown that gonadal hormones influence performance on certain working memory and other types of cognitive tasks that are sensitive to lesions of the medial and/or orbital prefrontal cortices. This study asked whether gonadal hormone modulation of prefrontal cortical function in males also extends to the perirhinal division of the rat prefrontal cortex. Specifically, sham-operated control, gonadectomized, and gonadectomized rats supplemented with testosterone propionate or estradiol were tested on a spontaneous novel object recognition task, a paradigm where performance has been shown to be impaired by perirhinal cortical lesions. Using analyses of variance, regression analyses and post-hoc testing to evaluate group differences, it was found that during both the sample and test trials of the task all four groups spent similar absolute and proportional amounts of time ambulating, rearing, stationary, and exploring the two objects present. All groups also explored each of the two identical objects present during sample trials equally. However, during the test trials, only the control and gonadectomized rats given testosterone showed the expected increase in exploration of the novel objects presented, whereas the gonadectomized and gonadectomized, estradiol-supplemental groups continued to explore the novel and familiar objects equally. That regression analyses also identified significant correlations between low bulbospongiosus muscle weight…
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Previous studies have shown that only intact and GDX male rats substituted with testosterone display object memory, in contrast to GDX males treated with oil or estradiol.
“Previous studies have shown that only intact and GDX male rats substituted with testosterone display object memory, in contrast to GDX males treated with oil or estradiol [32].”
From Effects of sex and gonadectomy on social investigation and social recognition in mice (2015) · cites this paper as [32]
Cites
A new one-trial test for neurobiological studies of memory in rats. 1: behavioral data
Ennaceur, A., & Delacour, J. (1988) · Behavioural Brain Research · doi:10.1016/0166-4328(88)90157-x · Cited by 3,223 · see citing works
Ennaceur, A., Neave, N., & Aggleton, J. P. (1997) · Experimental Brain Research · doi:10.1007/pl00005603 · Cited by 670 · see citing works
Berman, K. F., Schmidt, P. J., Rubinow, D. R., Danaceau, M. A., Van Horn, J. D., Esposito, G., Ostrem, J. L., & Weinberger, D. R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.16.8836 · Cited by 318 · see citing works
Frye, C. A., & Walf, A. A. (2004) · Behavioral Neuroscience · doi:10.1037/0735-7044.118.2.306 · Cited by 172 · cited 3× · see citing works
“, 1981, 1986; Swanson, 1966), between ovariectomized and hormonally replaced female rats (Frye and Walf, 2004; Heinsbroek et al., 1988; Palermo-Neto and Dorce, 1990), and among gonadectomized and hormone-replaced adult male rats (Adler et al.”
Reinforcing aspects of androgens
Wood, R. I. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.08.012 · Cited by 121 · see citing works
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Impacts of stress and sex hormones on dopamine neurotransmission in the adolescent brain
Sinclair, D., Purves-Tyson, T. D., Allen, K. M., & Weickert, C. S. (2014) · Psychopharmacology · doi:10.1007/s00213-013-3415-z · Cited by 191 · see citing works
Sex differences in hippocampal function
Koss, W. A., & Frick, K. M. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.23864 · Cited by 156 · see citing works
Maras, P. M., Molet, J., Chen, Y., Rice, C., Ji, S. G., Solodkin, A., & Baram, T. Z. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.12 · Cited by 118 · see citing works
Sobolewski, M., Conrad, K., Allen, J. L., Weston, H., Martin, K., Lawrence, B. P., & Cory-Slechta, D. A. (2014) · NeuroToxicology · doi:10.1016/j.neuro.2014.09.008 · Cited by 91 · see citing works
Effects of sex and gonadectomy on social investigation and social recognition in mice
Karlsson, S. A., Haziri, K., Hansson, E., Kettunen, P., & Westberg, L. (2015) · BMC Neuroscience · doi:10.1186/s12868-015-0221-z · Cited by 72 · see citing works
“Previous studies have shown that only intact and GDX male rats substituted with testosterone display object memory, in contrast to GDX males treated with oil or estradiol [32].”
ResultTozzi, A., Bellingacci, L., & Pettorossi, V. E. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.572511 · Cited by 36 · see citing works
“Accordingly, the consolidation of hippocampal memory might be facilitated within minutes after treatments with estrogenic and androgenic neurosteroids or with agonists of their receptors, enhancing the performance on hippocampal memory tasks, as reported in experiments performed with rats and mice (Luine et al., 2003;…”
Result
- Authors
- Aubele, T., Kaufman, R., Montalmant, F., & Kritzer, M. F.
- Affiliations
- Stony Brook University (US)
- Corresponding author
- Aubele, T.
- ORCID
- Kritzer, M.F.
- Venue
- Hormones and Behavior
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 54
- Issue
- 2
- Pages
- 244-252
- ISSN
- 0018-506X (ISSN-L)
- PMC
- PMC2517217
- OpenAlex
- W2084467300
- Cited by
- 115
- References
- 5
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 9 · 2023: 6 · 2022: 9 · 2021: 3 · 2020: 12 · 2019: 6 · 2018: 6 · 2017: 6 · 2016: 11 · 2015: 9 · 2014: 12 · 2013: 2 · 2012: 4
- FWCI
- 2.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Hormones and Behavior (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS041966)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- gonadectomy, hormone replacement therapy, testosterone propionate, estradiol, novel object recognition, perirhinal cortex, prefrontal cortex, androgen sensitivity, working memory, object recognition memory, adult male rats
- MeSH terms
- Acclimatization, Age Factors, Animals, Behavior, Animal, Exploratory Behavior, Male, Orchiectomy, Pattern Recognition, Visual, Task Performance and Analysis, Rats, Sprague-Dawley, Gonadal Hormones, Rats
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