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Developmental experiences and the oxytocin receptor system
Open accessAbstract
The long-term effects of developmental experiences on social behavior, and the neuropeptide systems such as oxytocin which subserve the behavior, are still little understood. In this article, we review various types of early experience, including normal development, knockout models, pharmacological exposures, and early social experiences. We consider the processes by which experience can affect oxytocin receptor binding, and what is known about the directionality of experience effects on oxytocin receptors. Finally, we attempt to synthesize the literature into a predictive model as to the direction of early experience effects on oxytocin receptor binding potential, and whether these changes have functional significance. These predictions are relevant to current human health practice, given proposals to use chronic intranasal oxytocin to treat developmental disorders including autism and schizophrenia. This article is part of a Special Issue entitled Oxytocin, Vasopressin, and Social Behavior.
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“Developmental treatments can have particular ramifications to receptor binding and up- or down-regulation of peptide production (38,54,74,75).”
From Chronic intranasal oxytocin causes long-term impairments in partner preference formation in male prairie voles (2013) · cites this paper as [75]
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Metadata
- Authors
- Bales, K. L., & Perkeybile, A. M.
- Affiliations
- University of California, Davis (US)
- Corresponding author
- Bales, Karen L.
- ORCID
- Bales, Karen L.
- Venue
- Hormones and Behavior
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 61
- Issue
- 3
- Pages
- 313-319
- ISSN
- 0018-506X (ISSN-L)
- OpenAlex
- W1964035308
- Cited by
- 142
- References
- 92
- Citations by year
- 2026: 6 · 2025: 2 · 2024: 2 · 2023: 6 · 2022: 12 · 2021: 8 · 2020: 21 · 2019: 5 · 2018: 8 · 2017: 16 · 2016: 15 · 2015: 12 · 2014: 12 · 2013: 14 · 2012: 3
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- green
- escholarship.org
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Hormones and Behavior (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- oxytocin receptor, developmental experiences, early social experience, receptor binding potential, knockout models, social behavior, autism spectrum disorder, schizophrenia, intranasal oxytocin, developmental disorders, neuropeptide systems
- MeSH terms
- Animals, Child, Child Development, Child, Preschool, Humans, Social Behavior, Receptors, Vasopressin, Receptors, Oxytocin, Mice, Knockout, Mice
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