Cited by 142Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyStress Responses and Cortisol

The DOI matches its Crossref record; 92 of the 92 references it cites were found in a registry or an index.

Developmental experiences and the oxytocin receptor system

Open access

Bales, Karen L., Perkeybile, Allison M.·2012·Hormones and Behavior

DOI 10.1016/j.yhbeh.2011.12.013

Open this paper in CoChat — free account

Abstract

The long-term effects of developmental experiences on social behavior, and the neuropeptide systems such as oxytocin which subserve the behavior, are still little understood. In this article, we review various types of early experience, including normal development, knockout models, pharmacological exposures, and early social experiences. We consider the processes by which experience can affect oxytocin receptor binding, and what is known about the directionality of experience effects on oxytocin receptors. Finally, we attempt to synthesize the literature into a predictive model as to the direction of early experience effects on oxytocin receptor binding potential, and whether these changes have functional significance. These predictions are relevant to current human health practice, given proposals to use chronic intranasal oxytocin to treat developmental disorders including autism and schizophrenia. This article is part of a Special Issue entitled Oxytocin, Vasopressin, and Social Behavior.

Integrity signals

Registry

Crossref · 10.1016/j.yhbeh.2011.12.013

Cites

92 of 92 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Maternal Care, Hippocampal Glucocorticoid Receptors, and Hypothalamic-Pituitary-Adrenal Responses to Stress
Liu, D., Diorio, J., Tannenbaum, B., Caldji, C., Francis, D., Freedman, A., Sharma, S., Pearson, D., Plotsky, P. M., & Meaney, M. J. (1997) · Science · doi:10.1126/science.277.5332.1659 · Cited by 3,170
The oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089
Nongenomic Transmission Across Generations of Maternal Behavior and Stress Responses in the Rat
Francis, D., Diorio, J., Liu, D., & Meaney, M. J. (1999) · Science · doi:10.1126/science.286.5442.1155 · Cited by 1,965
Maternal care during infancy regulates the development of neural systems mediating the expression of fearfulness in the rat
Caldji, C., Tannenbaum, B., Sharma, S., Francis, D., Plotsky, P. M., & Meaney, M. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5335 · Cited by 1,437
OXYTOCIN MAY MEDIATE THE BENEFITS OF POSITIVE SOCIAL INTERACTION AND EMOTIONS1The purpose of this paper is to describe the neuroendocrine mechanisms of positive social interactions.1
Uvnäs-Moberg, K. (1998) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(98)00056-0 · Cited by 966 · cited 1×
“We are also assuming that high levels of OT may be induced by either positive social stimuli, such as warmth, touch, and high levels of parenting (Uvnas-Moberg, 1998), as well as negative social stimuli such as separation from the attachment figure or other distressed relationships (Grippo et al.,…”
Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders.
Guastella, A. J., Einfeld, S. L., Gray, K. M., Rinehart, N. J., Tonge, B. J., Lambert, T. J., & Hickie, I. B. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.020 · Cited by 962
Oxytocin receptor distribution reflects social organization in monogamous and polygamous voles
Insel, T. R., & Shapiro, L. E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.5981 · Cited by 833
Oxytocin is required for nursing but is not essential for parturition or reproductive behavior.
Nishimori, K., Young, L. J., Guo, Q., Wang, Z., Insel, T. R., & Matzuk, M. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11699 · Cited by 734
Naturally occurring variations in maternal behavior in the rat are associated with differences in estrogen-inducible central oxytocin receptors
Champagne, F., Diorio, J., Sharma, S., & Meaney, M. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221224598 · Cited by 707
Regulation of transmembrane signaling by receptor phosphorylation
Sibley, D. R., Benovic, J., Caron, M. G., & Lefkowitz, R. J. (1987) · Cell · doi:10.1016/0092-8674(87)90700-8 · Cited by 672
Infantile Experience and Resistance to Physiological Stress
Levine, S. (1957) · Science · doi:10.1126/science.126.3270.405 · Cited by 659
Physiological substrates of mammalian monogamy: The prairie vole model
Sue Carter, C., Courtney Devries, A., & Getz, L. L. (1995) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(94)00070-h · Cited by 615
The effects of oxytocin and vasopressin on partner preferences in male and female prairie voles (Microtus ochrogaster)
Cho, M. M., DeVries, A. C., Williams, J. R., & Carter, C. S. (1999) · Behavioral Neuroscience · doi:10.1037/0735-7044.113.5.1071 · Cited by 529
Stress During Gestation Alters Postpartum Maternal Care and the Development of the Offspring in a Rodent Model
Champagne, F. A., & Meaney, M. J. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.016 · Cited by 510
Variations in maternal behaviour are associated with differences in oxytocin receptor levels in the rat
Francis, D. D., Champagne, F. C., & Meaney, M. J. (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00599.x · Cited by 496
Oxytocin Administered Centrally Facilitates Formation of a Partner Preference in Female Prairie Voles (Microtus ochrogaster)
Williams, J. R., Insel, T. R., Harbaugh, C. R., & Carter, C. S. (1994) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1994.tb00579.x · Cited by 483
Development of partner preferences in female prairie voles (Microtus ochrogaster): The role of social and sexual experience
WILLIAMS, J. (1992) · Hormones and Behavior · doi:10.1016/0018-506x(92)90004-f · Cited by 471
A trans-dimensional approach to the behavioral aspects of depression
Bessa, J. M. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.001.2009 · Cited by 469
Naturally Occurring Differences in Maternal Care are Associated with the Expression of Oxytocin and Vasopressin (V1a) Receptors: Gender Differences
Francis, D. D., Young, L. J., Meaney, M. J., & Insel, T. R. (2002) · Journal of Neuroendocrinology · doi:10.1046/j.0007-1331.2002.00776.x · Cited by 415
Oxytocin Receptors: Triggers for Parturition and Lactation?
Soloff, M. S., Alexandrová, M., & Fernström, M. J. (1979) · Science · doi:10.1126/science.221972 · Cited by 394
The neurobiology of pair bonding: Insights from a socially monogamous rodent
Young, K. A., Gobrogge, K. L., Liu, Y., & Wang, Z. (2011) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.07.006 · Cited by 389
Transgenerational effects of social environment on variations in maternal care and behavioral response to novelty
Champagne, F. A., & Meaney, M. J. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.6.1353 · Cited by 381
Oxytocin, vasopressin and sociality
CARTER, C., GRIPPO, A., POURNAJAFINAZARLOO, H., RUSCIO, M., & PORGES, S. (2008) · Progress in Brain Research · doi:10.1016/s0079-6123(08)00427-5 · Cited by 380
A randomized controlled trial of intranasal oxytocin as an adjunct to exposure therapy for social anxiety disorder
Guastella, A. J., Howard, A. L., Dadds, M. R., Mitchell, P., & Carson, D. S. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.01.005 · Cited by 366
Rearing effects on cerebrospinal fluid oxytocin concentration and social buffering in rhesus monkeys
Winslow, J. T., Noble, P. L., Lyons, C. K., Sterk, S. M., & Insel, T. R. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300128 · Cited by 345
Social isolation induces behavioral and neuroendocrine disturbances relevant to depression in female and male prairie voles
Grippo, A. J., Gerena, D., Huang, J., Kumar, N., Shah, M., Ughreja, R., & Sue Carter, C. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.07.004 · Cited by 336
Adjunctive intranasal oxytocin reduces symptoms in schizophrenia patients
Feifel, D., Macdonald, K., Nguyen, A., Cobb, P., Warlan, H., Galangue, B., Minassian, A., Becker, O., Cooper, J., Perry, W., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.04.039 · Cited by 308
The neurobiology of trust
ZAK, P. J., KURZBAN, R., & MATZNER, W. T. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1314.025 · Cited by 282
Opposite effects of maternal separation on intermale and maternal aggression in C57BL/6 mice: Link to hypothalamic vasopressin and oxytocin immunoreactivity
Veenema, A. H., Bredewold, R., & Neumann, I. D. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.02.008 · Cited by 263
Are plasma oxytocin in women and plasma vasopressin in men biomarkers of distressed pair-bond relationships?
Taylor, S. E., Saphire-Bernstein, S., & Seeman, T. E. (2010) · Psychological Science · doi:10.1177/0956797609356507 · Cited by 256
The impact of early life family structure on adult social attachment, alloparental behavior, and the neuropeptide systems regulating affiliative behaviors in the monogamous prairie vole (Microtus ochrogaster)
Ahern, T. H. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.017.2009 · Cited by 239
Oxytocin and Social Bondinga
CARTER, C. S., WILLIAMS, J. R., WITT, D. M., & INSEL, T. R. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb34356.x · Cited by 237
Appearance and transient expression of oxytocin receptors in fetal, infant, and peripubertal rat brain studied by autoradiography and electrophysiology
Tribollet, E., Charpak, S., Schmidt, A., Dubois-Dauphin, M., & Dreifuss, J. (1989) · The Journal of Neuroscience · doi:10.1523/jneurosci.09-05-01764.1989 · Cited by 228
Sex differences and developmental effects of oxytocin on aggression and social behavior in prairie voles (Microtus ochrogaster)
Bales, K. L., & Carter, C. S. (2003) · Hormones and Behavior · doi:10.1016/s0018-506x(03)00154-5 · Cited by 195
Oxytocin has dose-dependent developmental effects on pair-bonding and alloparental care in female prairie voles
Bales, K. L., van Westerhuyzen, J. A., Lewis-Reese, A. D., Grotte, N. D., Lanter, J. A., & Carter, C. S. (2007) · Hormones and Behavior · doi:10.1016/j.yhbeh.2007.05.004 · Cited by 192 · cited 11×
“As with OTR gene expression, OTR binding in the posterior cingulate (PCC) and some other areas is high at PND 10 and no longer present in adults (Shapiro and Insel, 1989), while binding in the bed nucleus of the stria terminalis appears later and is present in the adult.”
Influential
Social enrichment during postnatal development induces transgenerational effects on emotional and reproductive behavior in mice
Curley, J. P. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.025.2009 · Cited by 184
Maternal separation interferes with developmental changes in brain vasopressin and oxytocin receptor binding in male rats
Lukas, M., Bredewold, R., Neumann, I. D., & Veenema, A. H. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.06.020 · Cited by 183
Regional Changes in Brain Oxytocin Receptors Post‐Partum: Time‐Course and Relationship to Maternal Behaviour
Insel, T. R. (1990) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1990.tb00445.x · Cited by 164
Neurobiology of the Parental Brain
(2008) · Elsevier eBooks · doi:10.1016/b978-0-12-374285-8.x0001-7 · Cited by 161
Neonatal manipulations of oxytocin alter expression of oxytocin and vasopressin immunoreactive cells in the paraventricular nucleus of the hypothalamus in a gender-specific manner
Yamamoto, Y., Cushing, B. S., Kramer, K. M., Epperson, P. D., Hoffman, G. E., & Carter, C. S. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.02.028 · Cited by 155
Developmental exposure to oxytocin facilitates partner preferences in male prairie voles (Microtus ochrogaster)
Bales, K. L., & Carter, C. S. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.4.854 · Cited by 155
Neonatal oxytocin manipulations have long-lasting, sexually dimorphic effects on vasopressin receptors
Bales, K. L., Plotsky, P. M., Young, L. J., Lim, M. M., Grotte, N., Ferrer, E., & Carter, C. S. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.09.009 · Cited by 150
Oxytocin and vasopressin receptor distributions in a solitary and a social species of tuco‐tuco ( Ctenomys haigi and Ctenomys sociabilis )
Beery, A. K., Lacey, E. A., & Francis, D. D. (2008) · Journal of Comparative Neurology · doi:10.1002/cne.21638 · Cited by 144
Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome
Hall, S. S., Lightbody, A. A., McCarthy, B. E., Parker, K. J., & Reiss, A. L. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.020 · Cited by 143
Central vasopressin and oxytocin receptor distributions in two species of singing mice
Polly Campbell, A., Ophir, A. G., & Phelps, S. M. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.22116 · Cited by 133
Ontogeny of oxytocin receptors in rat forebrain: A quantitative study
Shapiro, L. E., & Insel, T. R. (1989) · Synapse · doi:10.1002/syn.890040312 · Cited by 131
Early appearance and transient expression of vasopressin receptors in the brain of rat fetus and infant. An autoradiographical and electrophysiological study
Tribollet, E., Goumaz, M., Raggenbass, M., Dubois‐Dauphin, M., & Dreifuss, J. J. (1991) · Developmental Brain Research · doi:10.1016/0165-3806(91)90232-8 · Cited by 124
Soman-induced seizures rapidly activate astrocytes and microglia in discrete brain regions
Zimmer, L. A., Ennis, M. J., & Shipley, M. T. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970224)378:4 · Cited by 124
Molecular neurobiology and pharmacology of the Vasopressin/Oxytocin receptor family
Burbach, J. P. H., Burbach, H., Adan, R. A. H., Lolait, S. J., van Leeuwen, F. W., Mezey, É., Palkovits, M., & Barberis, C. (1995) · Cellular and Molecular Neurobiology · doi:10.1007/bf02071318 · Cited by 118
Extraordinary diversity in vasopressin (V1a) receptor distributions among wild prairie voles (Microtus ochrogaster): Patterns of variation and covariation
Phelps, S. M., & Young, L. J. (2003) · Journal of Comparative Neurology · doi:10.1002/cne.10902 · Cited by 116
Species differences in central oxytocin receptor gene expression: Comparative analysis of promoter sequences
Young, L. J., Huot, B., Nilsen, R., Wang, Z., & Insel, T. R. (1996) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1996.05188.x · Cited by 110
Overexpression of Reelin Prevents the Manifestation of Behavioral Phenotypes Related to Schizophrenia and Bipolar Disorder
Teixeira, C. M., Martín, E. D., Sahún, I., Masachs, N., Pujadas, L., Corvelo, A., Bosch, C., Rossi, D. P., Martı́nez, A., Maldonado, R. J., et al. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.153 · Cited by 106
Paternal influence on female behavior: The role of Peg3 in exploration, olfaction, and neuroendocrine regulation of maternal behavior of female mice.
Champagne, F. A., Curley, J. P., Swaney, W. T., Hasen, N. S., & Keverne, E. B. (2009) · Behavioral Neuroscience · doi:10.1037/a0015060 · Cited by 104
Effects of neonatal handling on social memory, social interaction, and number of oxytocin and vasopressin neurons in rats
Todeschin, A. S., Duarte, E. C. W., Jacob, M., Aranda, B. C. C., Jacobs, S., Fernandes, M. D. C., Ribeiro, M. F. M., Sanvitto, G. L., & Lucion, A. B. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.03.006 · Cited by 103
Are behavioral effects of early experience mediated by oxytocin?
Bales, K. L., Boone, E., Epperson, P., Hoffman, G., & Carter, C. S. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00024 · Cited by 99
Early experience affects the traits of monogamy in a sexually dimorphic manner
Bales, K. L., Lewis‐Reese, A. D., Pfeifer, L. A., Kramer, K. M., & Carter, C. S. (2007) · Developmental Psychobiology · doi:10.1002/dev.20216 · Cited by 96
The meaning of weaning: Influence of the weaning period on behavioral development in mice
Curley, J. P., Jordan, E. R., Swaney, W. T., Izraelit, A., Kammel, S., & Champagne, F. A. (2009) · Developmental Neuroscience · doi:10.1159/000216543 · Cited by 92
A novel form of oxytocin in New World monkeys
Lee, A. G., Cool, D. R., Grunwald, W. C., Neal, D. E., Buckmaster, C. L., Cheng, M. Y., Hyde, S. A., Lyons, D. M., & Parker, K. J. (2011) · Biology Letters · doi:10.1098/rsbl.2011.0107 · Cited by 91
The impact of neonatal bisphenol-A exposure on sexually dimorphic hypothalamic nuclei in the female rat
Adewale, H. B., Todd, K. L., Mickens, J. A., & Patisaul, H. B. (2011) · NeuroToxicology · doi:10.1016/j.neuro.2010.07.008 · Cited by 86
Oxytocin Receptor Distribution Reflects Social Organization in Monogamous and Polygamous Voles
SHAPIRO, L. E., & INSEL, T. R. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb34380.x · Cited by 84
EFFECTS OF MATERNAL FACTORS UPON GROWTH AND BEHAVIOR OF THE RAT1
Denenberg, V. H., Ottinger, D. R., & Stephens, M. W. (1962) · Child Development · doi:10.1111/j.1467-8624.1962.tb05988.x · Cited by 80
Oxytocin receptors in brain cortical regions are reduced in haploinsufficient (+/−) reeler mice
Liu, W., Pappas, G. D., & Carter, C. S. (2005) · Neurological Research · doi:10.1179/016164105x35602 · Cited by 73
Early life stress disrupts peripubertal development of aggression in male mice
Tsuda, M. C., Yamaguchi, N., & Ogawa, S. (2011) · NeuroReport · doi:10.1097/wnr.0b013e328344495a · Cited by 72
Neonatal manipulation of oxytocin affects expression of estrogen receptor alpha
Yamamoto, Y., Carter, C. S., & Cushing, B. S. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.08.065 · Cited by 70
Differential expression of oxytocin receptor mRNA in the developing rat brain
YOSHIMURA, R., Kimura, T., Watanabe, D., & Kiyama, H. (1996) · Neuroscience Research · doi:10.1016/0168-0102(95)01003-3 · Cited by 68
Homologous regulation of brain oxytocin receptors.
Insel, T. R., Winslow, J. T., & Witt, D. M. (1992) · Endocrinology · doi:10.1210/endo.130.5.1315251 · Cited by 63
Developmental effects of oxytocin on neural activation and neuropeptide release in response to social stimuli
Kramer, K. M., Choe, C., Carter, C. S., & Cushing, B. S. (2005) · Hormones and Behavior · doi:10.1016/j.yhbeh.2005.07.001 · Cited by 60
Ontogenetic changes in vasopressin binding site distribution in rat brain: An autoradiographic study
Petracca, F. M., Baskin, D. G., Díaz, J., & Dorsa, D. M. (1986) · Developmental Brain Research · doi:10.1016/0165-3806(86)90065-9 · Cited by 60
Ontogeny of vasopressin and oxytocin binding sites in the brain of Wistar and Brattleboro rats as demonstrated by lightmicroscopical autoradiography.
Snijdewint, F. G. M., van Leeuwen, F. W. B., & Gj, B. (1989) · PubMed · Cited by 56
Ontogeny of oxytocin and vasopressin receptor binding in the lateral septum in prairie and montane voles
Wang, Z., & Young, L. J. (1997) · Developmental Brain Research · doi:10.1016/s0165-3806(97)00138-7 · Cited by 54
Receptor Dynamics in Neural Development
Shaw, C. (1996) · Cited by 53
Plastic changes induced by neonatal handling in the hypothalamus of female rats
Duarte, E. C. W., Todeschin, A. S., Fernandes, M. D. C., Bittencourt, L. C., Pereira, G. A. M., Samios, V. N., Schuh, A. F. S., Achaval, M., Xavier, L. L., Sanvitto, G. L., et al. (2007) · Brain Research · doi:10.1016/j.brainres.2007.07.030 · Cited by 47
The Brain Oxytocin Receptor(s?)
Verbalis, J. G. (1999) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1999.0178 · Cited by 47
Oxytocin Receptor-Mediated Activation of Phosphoinositidase C and Elevation of Cytosolic Calcium in the Gonadotrope-Derived αT3–1 Cell Line*
Evans, J. J., Forrest‐Owen, W., & McArdle, C. A. (1997) · Endocrinology · doi:10.1210/endo.138.5.5138 · Cited by 47
Systemic oxytocin treatment modulates glucocorticoid and mineralocorticoid receptor mRNA in the rat hippocampus
Petersson, M., & Uvnäs‐Moberg, K. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00334-3 · Cited by 47
The relative importance of experimenter contact in an effect produced by extrastimulation in infancy.
Levine, S., & Lewis, G. W. (1959) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0044637 · Cited by 42
Neonatal stress transiently alters the development of hippocampal oxytocin receptors
Noonan, L. R., Caldwell, J. D., Li, L., Walker, C. H., Pedersen, C. A., & Mason, G. (1994) · Developmental Brain Research · doi:10.1016/0165-3806(94)90094-9 · Cited by 42
Systemic oxytocin treatment modulates α2-adrenoceptors in telencephalic and diencephalic regions of the rat
Dı́az-Cabiale, Z., Petersson, M., Narváez, J. Á., Uvnäs-Moberg, K., & Fuxé, K. (2000) · Brain Research · doi:10.1016/s0006-8993(00)03017-1 · Cited by 41
Vasopressin Stimulates Ventromedial Hypothalamic Neurons via Oxytocin Receptors in Oxytocin Gene Knockout Male and Female Mice
Ragnauth, A. K., Goodwillie, A., Brewer, C., Muglia, L. J., Pfaff, D. W., & Kow, L.-M. (2004) · Neuroendocrinology · doi:10.1159/000081844 · Cited by 41
Perinatal exposure to endocrine disrupting compounds alters behavior and brain in the female pine vole
Engell, M. D., Godwin, J., Young, L. J., & Vandenbergh, J. G. (2006) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2005.10.002 · Cited by 40 · cited 1×
“In the female pine vole (Microtus pinetorum), exposure to methoxychlor (MXC), an EDC with estrogenic and anti-androgenic properties, throughout gestation and lactation results in a decrease in OTR binding in the CC in offspring (Engell et al., 2006).”
The organizational effects of oxytocin on the central expression of estrogen receptor α and oxytocin in adulthood
Kramer, K. M., Yoshida, S., Papademetriou, E., & Cushing, B. S. (2007) · BMC Neuroscience · doi:10.1186/1471-2202-8-71 · Cited by 36
Effects of Maternal Factors upon Growth and Behavior of the Rat
Denenberg, V. H., Ottinger, D. R., & Stephens, M. W. (1962) · Child Development · doi:10.2307/1126633 · Cited by 36
Modification of neurotransmitter receptor sensitivity in cat visual cortex during the critical period
Shaw, C., Needler, M. C., Wilkinson, M., Aoki, C. J., & Cynader, M. (1985) · Developmental Brain Research · doi:10.1016/0165-3806(85)90069-0 · Cited by 32
Oxytocin increases the density of high affinity α2-adrenoceptors within the hypothalamus, the amygdala and the nucleus of the solitary tract in ovariectomized rats
Petersson, M., Dı́az-Cabiale, Z., Narváez, J. Á., Fuxé, K., & Uvnäs‐Moberg, K. (2005) · Brain Research · doi:10.1016/j.brainres.2005.05.034 · Cited by 32
Homologous and Heterologous Phosphorylation of the Vasopressin V1a Receptor
Ancellin, N., Preisser, L., Maout, S. L., Barbado, M., Créminon, C., Corman, B., & Morel, A. (1999) · Cellular Signalling · doi:10.1016/s0898-6568(99)00035-2 · Cited by 30
Neonatal oxytocin alters subsequent estrogen receptor alpha protein expression and estrogen sensitivity in the female rat
Perry, A. N., Paramadilok, A., & Cushing, B. S. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.08.021 · Cited by 26
Oxytocin selectively increases ERα mRNA in the neonatal hypothalamus and hippocampus of female prairie voles
Pournajafi-Nazarloo, H., Carr, M. S., Papademeteriou, E., Schmidt, J. V., & Cushing, B. S. (2007) · Neuropeptides · doi:10.1016/j.npep.2006.10.002 · Cited by 23
Vasopressin and oxytocin receptor mRNA expression during rat telencephalon development
Chen, Q., Schreiber, S. S., & Brinton, R. D. (2000) · Neuropeptides · doi:10.1054/npep.2000.0809 · Cited by 23
Developmental Changes in Forebrain Vasopressin Receptor Binding in Prairie Voles (Microtus ochrogaster) and Montane Voles (Microtus montanus)
Wang, Z., LIU, Y., Young, L. J., & Insel, T. R. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb51954.x · Cited by 19
The neuroendocrinology of the social brain
Young, L. J. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.06.002 · Cited by 19
Early experience and the developmental programming of oxytocin and vasopressin
Sue carter, C., Boone, E. M., & Bales, K. L. (2008) · Neurobiology of the Parental Brain · doi:10.1016/b978-012374285-8.00027-5 · Cited by 14
Oxytocin Receptor-Mediated Activation of Phosphoinositidase C and Elevation of Cytosolic Calcium in the Gonadotrope-Derived T3-1 Cell Line
Evans, J. J. (1997) · Endocrinology · doi:10.1210/en.138.5.2049 · Cited by 14

Sorted by citations

Psychobiological mechanisms underlying the social buffering of the hypothalamic-pituitary-adrenocortical axis: a review of animal models and human studies across development
Hostinar, C. E., Sullivan, R. M., & Gunnar, M. R. (2014) · Psychological Bulletin · doi:10.1037/a0032671 · Cited by 739
The Hypothalamic-Pituitary-Adrenal Axis: Development, Programming Actions of Hormones, and Maternal-Fetal Interactions
Sheng, J. A., Bales, N. J., Myers, S. A., Bautista, A. I., Roueinfar, M., Hale, T. M., & Handa, R. J. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.601939 · Cited by 418
Autism, oxytocin and interoception
Quattrocki, E., & Friston, K. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.09.012 · Cited by 393
Sex differences in the neural and behavioral response to intranasal oxytocin and vasopressin during human social interaction
Rilling, J. K., DeMarco, A. C., Hackett, P. D., Chen, X., Gautam, P., Stair, S., Haroon, E., Thompson, R., Ditzen, B., Patel, R., et al. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.09.022 · Cited by 343
“Such effects may be attributable to developmental influences on OTreceptor expression (Bales and Perkeybile, 2012), which in turn should affect responsiveness to intranasal OT.”
Background
Chronic intranasal oxytocin causes long-term impairments in partner preference formation in male prairie voles
Bales, K. L., Perkeybile, A. M., Conley, O. G., Lee, M. H., Guoynes, C. D., Downing, G. M., Yun, C. R., Solomon, M., Jacob, S., & Mendoza, S. P. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.08.025 · Cited by 265

See all 142

Authors: Bales, K. L., & Perkeybile, A. M.
Affiliations: University of California, Davis (US)
Corresponding author: Bales, Karen L.
ORCID: Bales, Karen L.
Venue: Hormones and Behavior
Publisher: Elsevier BV
Published: 2012-03
Volume: 61
Issue: 3
Pages: 313-319
ISSN: 0018-506X (ISSN-L)
DOI: 10.1016/j.yhbeh.2011.12.013
OpenAlex: W1964035308
Cited by: 142
References: 92
Citations by year: 2026: 6 · 2025: 2 · 2024: 2 · 2023: 6 · 2022: 12 · 2021: 8 · 2020: 21 · 2019: 5 · 2018: 8 · 2017: 16 · 2016: 15 · 2015: 12 · 2014: 12 · 2013: 14 · 2012: 3
FWCI: 1.17
Type: journal article
Language: en
Open access: green
escholarship.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Hormones and Behavior (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion, cc-by-nc-nd)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: oxytocin receptor, developmental experiences, early social experience, receptor binding potential, knockout models, social behavior, autism spectrum disorder, schizophrenia, intranasal oxytocin, developmental disorders, neuropeptide systems
MeSH terms: Animals, Child, Child Development, Child, Preschool, Humans, Social Behavior, Receptors, Vasopressin, Receptors, Oxytocin, Mice, Knockout, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Developmental experiences and the oxytocin receptor system

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks