The DOI matches its Crossref record; 105 of the 105 references it cites were found in a registry or an index.
Developmental Effects of Oxytocin Neurons on Social Affiliation and Processing of Social Information
Open accessPublished version of a preprint
Abstract
Abstract Hormones regulate behavior either through activational effects that facilitate the acute expression of specific behaviors or through organizational effects that shape the development of the nervous system thereby altering adult behavior. Much research has implicated the neuropeptide oxytocin (OXT) in acute modulation of various aspects of social behaviors across vertebrate species, and OXT signaling is associated with the developmental social deficits observed in autism spectrum disorders, however, little is known about the role of OXT in the neurodevelopment of the social brain. We show that perturbation of OXT neurons during early zebrafish development led to a loss of dopaminergic neurons, associated with visual processing and reward, and blunted the neuronal response to social stimuli in the adult brain. Ultimately, adult fish whose OXT neurons were ablated in early life, displayed altered functional connectivity within social decision-making brain nuclei both in naïve state and in response to social stimulus and became less social. We propose that OXT neurons have an organizational role, namely to shape forebrain neuroarchitecture during development and to acquire an affiliative response towards conspecifics. Significance Statement Social behavior is developed over the lifetime of an organism and the neuropeptide oxytocin modulates social behaviors across vertebrate species, and is associated with neuro-developmental social deficits such as autism. However, whether oxytocin plays a role in the developmental maturation of neural systems that are necessary for social behavior remains poorly explored. We show that proper behavioral and neural response to social stimuli depends on a developmental process orchestrated by oxytocin neurons. Animals whose oxytocin system is ablated in early life show blunted neuronal and behavioral responses to social stimuli as well as wide ranging disruptions in the functional connectivity of the Social Brain. We provide a window into the mechanisms underlying oxytocin-dependent developmental processes that implement adult sociality.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In zebrafish, oxytocin and OXTR drive social behavior in a context-dependent manner, suggesting a broad role of OXT/OXTR in social grouping.
“In zebrafish, OXT and OXTR drive social behavior in a context-dependent manner, suggesting a broad role of OXT/ OXTR in social grouping (157, 158).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [158]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Fitting Linear Mixed-Effects Models Using lme4
Bates, D., Mächler, M., Bolker, B., & Walker, S. (2015) · Journal of Statistical Software · doi:10.18637/jss.v067.i01 · Cited by 86,835
Fiji: an open-source platform for biological-image analysis
Schindelin, J., Arganda-Carreras, I., Frise, E., Kaynig, V., Longair, M., Pietzsch, T., Preibisch, S., Rueden, C., Saalfeld, S., Schmid, B., et al. (2012) · Nature Methods · doi:10.1038/nmeth.2019 · Cited by 66,890
emmeans: Estimated Marginal Means, aka Least-Squares Means
Lenth, R. V., & Piaskowski, J. (2017) · doi:10.32614/cran.package.emmeans · Cited by 8,611
From Louvain to Leiden: guaranteeing well-connected communities
Traag, V. A., Waltman, L., & van Eck, N. J. (2019) · Scientific Reports · doi:10.1038/s41598-019-41695-z · Cited by 5,635
Cribari-Neto, F., & Zeileis, A. (2010) · Journal of Statistical Software · doi:10.18637/jss.v034.i02 · Cited by 2,505
Functional and effective connectivity in neuroimaging: a synthesis
Friston, K. J. (1994) · Human Brain Mapping · doi:10.1002/hbm.460020107 · Cited by 2,452
fitdistrplus : An R Package for Fitting Distributions
Delignette‐Muller, M. L., & Dutang, C. (2015) · Journal of Statistical Software · doi:10.18637/jss.v064.i04 · Cited by 2,391
Feiner, N., Motone, F., Meyer, A., & Kuraku, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-40055-1 · Cited by 1,988
Borgatti, S. P., Everett, M. G., Johnson, J. C., & Agneessens, F. (2024) · SAGE Publications Ltd eBooks · doi:10.4135/9781036236021 · Cited by 1,972
PHOENIX, C. H., GOY, R. W., GERALL, A. A., & YOUNG, W. C. (1959) · Endocrinology · doi:10.1210/endo-65-3-369 · Cited by 1,934
Oxytocin, vasopressin, and the neurogenetics of sociality
Donaldson, Z. R., & Young, L. J. (2008) · Science · doi:10.1126/science.1158668 · Cited by 1,645
Social effects of oxytocin in humans: context and person matter
Bartz, J. A., Zaki, J., Bolger, N., & Ochsner, K. N. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.05.002 · Cited by 1,581
SLIM: Simultaneous Logic-in-Memory Computing Exploiting Bilayer Analog OxRAM Devices
Kingra, S. K., Parmar, V., Chang, C., Hudec, B., Hou, T., & Suri, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-59121-0 · Cited by 1,445
Sawchenko, P. E., & Swanson, L. W. (1982) · Journal of Comparative Neurology · doi:10.1002/cne.902050306 · Cited by 1,150
Ventral tegmental area: cellular heterogeneity, connectivity and behaviour
Morales, M., & Margolis, E. B. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.165 · Cited by 1,108
The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999
afex: Analysis of Factorial Experiments
Singmann, H., Bolker, B. M., Westfall, J., Aust, F., & Ben‐Shachar, M. S. (2012) · doi:10.32614/cran.package.afex · Cited by 991
The Vertebrate mesolimbic reward system and social behavior network: A comparative synthesis
O'Connell, L. A., & Hofmann, H. A. (2011) · Journal of Comparative Neurology · doi:10.1002/cne.22735 · Cited by 986
Dendritic peptide release and peptide-dependent behaviours
Ludwig, M., & Leng, G. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1845 · Cited by 945
The Social Salience Hypothesis of Oxytocin
Shamay-Tsoory, S. G., & Abu-Akel, A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.07.020 · Cited by 904
Oxytocin receptor distribution reflects social organization in monogamous and polygamous voles
Insel, T. R., & Shapiro, L. E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.5981 · Cited by 833
Oxytocin, vasopressin, and human social behavior
Heinrichs, M., von Dawans, B., & Domes, G. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.05.005 · Cited by 799
Neuroanatomy of the Zebrafish Brain
Wullimann, M. F., Rupp, B., & Reichert, H. (1996) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8979-7 · Cited by 660
Evolution of a Vertebrate Social Decision-Making Network
O’Connell, L. A., & Hofmann, H. A. (2012) · Science · doi:10.1126/science.1218889 · Cited by 608
Gating of social reward by oxytocin in the ventral tegmental area
Hung, L. W., Neuner, S., Polepalli, J. S., Beier, K. T., Wright, M., Walsh, J. J., Lewis, E. M., Luo, L., Deisseroth, K., Dölen, G., et al. (2017) · Science · doi:10.1126/science.aan4994 · Cited by 578
Conditional targeted cell ablation in zebrafish: A new tool for regeneration studies
Curado, S., Anderson, R. M., Jungblut, B., Mumm, J. S., Schroeter, E. H., & Stainier, D. Y. R. (2007) · Developmental Dynamics · doi:10.1002/dvdy.21100 · Cited by 509
Teleostean and mammalian forebrains contrasted: Evidence from genes to behavior
Wullimann, M. F., & Mueller, T. (2004) · Journal of Comparative Neurology · doi:10.1002/cne.20183 · Cited by 491
Different amygdala subregions mediate valence-related and attentional effects of oxytocin in humans
Gamer, M., Zurowski, B., & Büchel, C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000985107 · Cited by 487
Panula, P., Chen, Y.-C., Priyadarshini, M., Kudo, H., Semenova, S. A., Sundvik, M., & Sallinen, V. J. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.05.010 · Cited by 477
Rink, E., & Wullimann, M. F. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03174-7 · Cited by 470
Curado, S., Stainier, D. Y. R., & Anderson, R. M. (2008) · Nature Protocols · doi:10.1038/nprot.2008.58 · Cited by 428
Davison, J. M., Akitake, C. M., Goll, M. G., Rhee, J. M., Gosse, N. J., Baier, H., Halpern, M. E., Leach, S. D., & Parsons, M. J. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.01.033 · Cited by 427
Lukas, M., Toth, I., Reber, S. O., Slattery, D. A., Veenema, A. H., & Neumann, I. D. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.95 · Cited by 403
Oxytocin, motivation and the role of dopamine
Love, T. M. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.06.011 · Cited by 369
Adult neurogenesis and brain regeneration in zebrafish
Kızıl, Ç., Kaslin, J., Kroehne, V., & Brand, M. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20918 · Cited by 368
Molecular Profiling of Activated Neurons by Phosphorylated Ribosome Capture
Knight, Z. A., Tan, K., Birsoy, K., Schmidt, S. F., Garrison, J. L., Wysocki, R. W., Emiliano, A. B., Ekstrand, M. I., & Friedman, J. M. (2012) · Cell · doi:10.1016/j.cell.2012.10.039 · Cited by 312
Development of social behavior in young zebrafish
Dreosti, E., Lopes, G., Kampff, A. R., & Wilson, S. W. (2015) · Frontiers in Neural Circuits · doi:10.3389/fncir.2015.00039 · Cited by 310
Assembling the puzzle: pathways of oxytocin signaling in the brain
Grinevich, V., Knobloch-Bollmann, H. S., Eliava, M., Busnelli, M., & Chini, B. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.04.013 · Cited by 309
Tay, T. L., Ronneberger, O., Ryu, S., Nitschke, R., & Driever, W. (2011) · Nature Communications · doi:10.1038/ncomms1171 · Cited by 307
Meyer, M. P., & Smith, S. J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0223-06.2006 · Cited by 283
Evolution of oxytocin pathways in the brain of vertebrates
Knobloch, H. S., & Grinevich, V. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00031 · Cited by 259
Nonapeptides and the evolutionary patterning of sociality
GOODSON, J. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00401-9 · Cited by 228
Guastella, A. J., & Hickie, I. B. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.028 · Cited by 223
Fear-enhancing effects of septal oxytocin receptors
Guzmán, Y. F., Tronson, N. C., Jovasevic, V., Sato, K., Guedea, A. L., Mizukami, H., Nishimori, K., & Radulovic, J. (2013) · Nature Neuroscience · doi:10.1038/nn.3465 · Cited by 215
Timing and plasticity of shoaling behaviour in the zebrafish, Danio rerio
Engeszer, R. E., da Barbiano, L. A., Ryan, M. J., & Parichy, D. M. (2007) · Animal Behaviour · doi:10.1016/j.anbehav.2007.01.032 · Cited by 212
Oxytocin signaling in the lateral septum prevents social fear during lactation
Menon, R., Grund, T., Zoicas, I., Althammer, F., Fiedler, D., Biermeier, V., Bosch, O. J., Hiraoka, Y., Nishimori, K., Eliava, M., et al. (2018) · Current Biology · doi:10.1016/j.cub.2018.02.044 · Cited by 211
Rink, E., & Wullimann, M. F. (2002) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00696-7 · Cited by 194
MPTP and MPP+ target specific aminergic cell populations in larval zebrafish
Sallinen, V. J., Torkko, V., Sundvik, M., Reenilä, I., Khrustalyov, D., Kaslin, J., & Panula, P. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05793.x · Cited by 190
Martin, L., Spicer, D., Lewis, M., Gluck, J., & Cork, L. C. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-11-03344.1991 · Cited by 186
Freeman, S. M., Inoue, K., Smith, A. L., Goodman, M. M., & Young, L. J. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.03.023 · Cited by 185
Developmental Perspectives on Oxytocin and Vasopressin
Hammock, E. A. D. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.120 · Cited by 184
Son, S. J., Filosa, J. A., Potapenko, E. S., Biancardi, V. C., Zheng, H., Patel, K. P., Tobin, V. A., Ludwig, M., & Stern, J. E. (2013) · Neuron · doi:10.1016/j.neuron.2013.04.025 · Cited by 173
Molliver, D. C., & Snider, W. D. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970519)381:4 · Cited by 171
Target selection and the superior colliculus: goals, choices and hypotheses
Krauzlis, R. J., Liston, D. B., & Carello, C. D. (2004) · Vision Research · doi:10.1016/j.visres.2004.01.005 · Cited by 160
Keebaugh, A. C., & Young, L. J. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.07.018 · Cited by 154
Rescue of oxytocin response and social behaviour in a mouse model of autism
Hörnberg, H., Pérez-Garci, E., Schreiner, D., Hatstatt-Burklé, L., Magara, F., Baudouin, S., Matter, A., Nacro, K., Pecho-Vrieseling, E., & Scheiffele, P. (2020) · Nature · doi:10.1038/s41586-020-2563-7 · Cited by 154
Freeman, S. M., Walum, H., Inoue, K., Smith, A. L., Goodman, M. M., Bales, K. L., & Young, L. J. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.04.055 · Cited by 153
Oxytocin enhances pupil dilation and sensitivity to 'hidden' emotional expressions
Leknes, S., Wessberg, J., Ellingsen, D.-M., Chelnokova, O., Olausson, H., & Laeng, B. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nss062 · Cited by 151
How can social network analysis contribute to social behavior research in applied ethology?
Makagon, M. M., McCowan, B., & Mench, J. A. (2012) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2012.02.003 · Cited by 144
Oxytocin receptor knockout mice display deficits in the expression of autism-related behaviors
Pobbe, R. L. H., Pearson, B. L., Defensor, E. B., Bolivar, V. J., Young, W. S., Lee, H., Blanchard, D. C., & Blanchard, R. J. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.10.010 · Cited by 143
The distribution of vasotocin and isotocin in the brain of the rainbow trout
van den Dungen, H. M., Buijs, R. M., Pool, C. W., & Terlou, M. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902120205 · Cited by 141
Interplay between Oxytocin and Sensory Systems in the Orchestration of Socio-Emotional Behaviors
Grinevich, V., & Stoop, R. (2018) · Neuron · doi:10.1016/j.neuron.2018.07.016 · Cited by 139
Parker, M. O., Brock, A. J., Walton, R. T., & Brennan, C. H. (2013) · Frontiers in Neural Circuits · doi:10.3389/fncir.2013.00063 · Cited by 133
Zhang, B., Qiu, L., Xiao, W., Ni, H., Chen, L., Wang, F., Mai, W., Wu, J., Bao, A., Hu, H., et al. (2021) · Neuron · doi:10.1016/j.neuron.2020.10.032 · Cited by 131
Emotions and motivated behavior converge on an amygdala‐like structure in the zebrafish
von Trotha, J. W., Vernier, P., & Bally‐Cuif, L. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12692 · Cited by 127
Saito, D., Komatsuda, M., & Urano, A. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.12.038 · Cited by 123
A Topological Criterion for Filtering Information in Complex Brain Networks
Fallani, F. D. V., Latora, V., & Chávez, M. (2017) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005305 · Cited by 119
The zebrafish brain: a neuroanatomical comparison with the goldfish
Rupp, B., Reichert, H., & Wullimann, M. F. (1996) · Anatomy and Embryology · doi:10.1007/bf00195012 · Cited by 113
Oxytocin receptors modulate a social salience neural network in male prairie voles
Johnson, Z. V., Walum, H., Xiao, Y., Riefkohl, P. C., & Young, L. J. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.10.009 · Cited by 113
Schorscher-Petcu, A., Dupré, A., & Tribollet, E. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.06.016 · Cited by 111
Ma, P. M. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903440207 · Cited by 109
Forebrain Control of Behaviorally Driven Social Orienting in Zebrafish
Stednitz, S. J., McDermott, E. M., Ncube, D., Tallafuß, A., Eisen, J. S., & Washbourne, P. (2018) · Current Biology · doi:10.1016/j.cub.2018.06.016 · Cited by 109
Diversity and overlap of parvalbumin and somatostatin expressing interneurons in mouse presubiculum
Nassar, M., Simonnet, J., Lofredi, R., Cohen, I., Savary, E., Yanagawa, Y., Miles, R., & Fricker, D. (2015) · Frontiers in Neural Circuits · doi:10.3389/fncir.2015.00020 · Cited by 104
Ma, P. M. (1997) · PubMed · Cited by 101
Teles, M. C., Almeida, O., Lopes, J. S., & Oliveira, R. F. (2015) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2015.1099 · Cited by 87
Self-citationRebalancing the Addicted Brain: Oxytocin Interference with the Neural Substrates of Addiction
Bowen, M. T., & Neumann, I. D. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.10.003 · Cited by 87
Pretectal neurons control hunting behaviour
Antinucci, P., Folgueira, M., & Bianco, I. H. (2019) · eLife · doi:10.7554/elife.48114 · Cited by 86
Freeman, S. M., Palumbo, M. C., Lawrence, R. H., Smith, A. L., Goodman, M. M., & Bales, K. L. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0315-3 · Cited by 82
Ma, P. M. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903440206 · Cited by 80
Eickhoff, S. B., & Müller, V. I. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-397025-1.00212-8 · Cited by 80
Oxytocin during Development: Possible Organizational Effects on Behavior
Miller, T. V., & Caldwell, H. K. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00076 · Cited by 79
Pupil-mimicry conditions trust in partners: moderation by oxytocin and group membership
Kret, M. E., & De Dreu, C. K. W. (2017) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2016.2554 · Cited by 75
Perceptual mechanisms of social affiliation in zebrafish
Nunes, A. R., Carreira, L. I. F., Anbalagan, S., Blechman, J., Levkowitz, G., & Oliveira, R. F. (2020) · Scientific Reports · doi:10.1038/s41598-020-60154-8 · Cited by 72
Self-citationJúnior, G. A. F., de Oliveira, H. N., Carvalheiro, R., Cardoso, D. F., Fonseca, L. F. S., Ventura, R. V., & de Albuquerque, L. G. (2020) · Scientific Reports · doi:10.1038/s41598-020-66272-7 · Cited by 70
Zebrafish oxytocin neurons drive nocifensive behavior via brainstem premotor targets
Wee, C. L., Nikitchenko, M., Wang, W., Luks-Morgan, S. J., Song, E. Y., Gagnon, J. A., Randlett, O., Bianco, I. H., Lacoste, A. M. B., Glushenkova, E., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0452-x · Cited by 69
Lorenzi, E., Mayer, U., Salva, O. R., & Vallortígara, G. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.04.022 · Cited by 64
Pituicyte Cues Regulate the Development of Permeable Neuro-Vascular Interfaces
Anbalagan, S., Gordon, L., Blechman, J., Matsuoka, R. L., Rajamannar, P., Wircer, E., Biran, J., Reuveny, A., Leshkowitz, D., Stainier, D. Y. R., et al. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.10.017 · Cited by 64
Self-citationWircer, E., Blechman, J., Borodovsky, N., Tsoory, M., Nunes, A. R., Oliveira, R. F., & Levkowitz, G. (2017) · eLife · doi:10.7554/elife.22170 · Cited by 63
Self-citationPark, M., Seo, B. A., Lee, B., Shin, H., & Kang, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-33410-1 · Cited by 57
Oxytocin as a Modulator of Synaptic Plasticity: Implications for Neurodevelopmental Disorders
Rajamani, K. T., Wagner, S., Grinevich, V., & Harony-Nicolas, H. (2018) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2018.00017 · Cited by 53
Revealing Consensus and Dissensus between Network Partitions
Peixoto, T. P. (2021) · Physical Review X · doi:10.1103/physrevx.11.021003 · Cited by 53
Vega‐Quiroga, I., Yarur, H. E., & Gysling, K. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.09.034 · Cited by 49
Oxytocin receptor signalling modulates novelty recognition but not social preference in zebrafish
Ribeiro, D., Nunes, A. R., Gliksberg, M., Anbalagan, S., Levkowitz, G., & Oliveira, R. F. (2020) · Journal of Neuroendocrinology · doi:10.1111/jne.12834 · Cited by 49
Self-citationThe Emerging Role of Nucleus Accumbens Oxytocin in Social Cognition
Dölen, G., & Malenka, R. C. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.06.009 · Cited by 45
Implementation of a Zebrafish Health Program in a Research Facility: A 4-Year Retrospective Study
Borges, C., Pereira, N., Franco, M., Vale, L., Pereira, M., Cunha, M. V., Amaro, A., Albuquerque, T., & Rebelo, M. (2016) · Zebrafish · doi:10.1089/zeb.2015.1230 · Cited by 45
Blechman, J., Amir-Zilberstein, L., Gutnick, A., Ben‐Dor, S., & Levkowitz, G. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1798-11.2011 · Cited by 43
Self-citationAssociations between oxytocin-related genes and autistic-like traits
Hovey, D., Zettergren, A., Jonsson, L., Melke, J., Anckarsäter, H., Lichtenstein, P., & Westberg, L. (2014) · Social Neuroscience · doi:10.1080/17470919.2014.897995 · Cited by 37
Robinson, K. J., Bosch, O. J., Levkowitz, G., Busch, K. E., Jarman, A. P., & Ludwig, M. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12807 · Cited by 33
Self-citationNeonatal administration of oxytocin increases novelty-induced grooming in the adult rat
Noonan, L. R., Continella, G., & Pedersen, C. A. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90386-9 · Cited by 24
Social Phenotypes in Zebrafish
Nunes, A. R., Ruhl, N., Winberg, S., & Oliveira, R. F. (2017) · Springer eBooks · doi:10.1007/978-3-319-33774-6_5 · Cited by 23
Self-citationRobo2 regulates synaptic oxytocin content by affecting actin dynamics
Anbalagan, S., Blechman, J., Gliksberg, M., Gordon, L., Rotkopf, R., Dadosh, T., Shimoni, E., & Levkowitz, G. (2019) · eLife · doi:10.7554/elife.45650 · Cited by 19
Self-citationRibeiro, D., Nunes, A. R., Teles, M. C., Anbalagan, S., Blechman, J., Levkowitz, G., & Oliveira, R. F. (2020) · eLife · doi:10.7554/elife.56973 · Cited by 19
Self-citationVisualization of mRNA Expression in the Zebrafish Embryo
Machluf, Y., & Levkowitz, G. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-005-8_6 · Cited by 14
Self-citationBlechman, J., Anbalagan, S., Matthews, G., & Levkowitz, G. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00117 · Cited by 12
Self-citationBiswal (1997) · doi:10.1002/(sici)1099-1492(199706/08)10:4/5
Flagged first, then by citations
Cited by
Sorted by citations
Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities
Rigney, N., de Vries, G. J., Petrulis, A., & Young, L. J. (2022) · Endocrinology · doi:10.1210/endocr/bqac111 · Cited by 191
Mendes, H. W., Neelakantan, U., Liu, Y., Fitzpatrick, S. E., Chen, T., Wu, W., Pruitt, A., Jin, D. S., Jamadagni, P., Carlson, M., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112243 · Cited by 82
Gemmer, A., Mirkes, K., Anneser, L., Eilers, T., Kibat, C., Mathuru, A., Ryu, S., & Schuman, E. (2022) · Scientific Reports · doi:10.1038/s41598-022-07990-y · Cited by 56
Therapeutic uses of oxytocin in stress-related neuropsychiatric disorders
Zhang, S., Zhang, Y., Shi, D., & Wang, Z. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01173-6 · Cited by 29
Egr1 Is Necessary for Forebrain Dopaminergic Signaling during Social Behavior
Tallafuß, A., Stednitz, S. J., Voeun, M., Levichev, A., Larsch, J., Eisen, J. S., & Washbourne, P. (2022) · eNeuro · doi:10.1523/eneuro.0035-22.2022 · Cited by 27
Penalva-Tena, A., Bedke, J., Gaudin, A., Barrios, J. P., Bertram, E. P. L., & Douglass, A. D. (2018) · doi:10.1101/444026 · Cited by 41
Social zebrafish: Danio rerio as an emerging model in social neuroendocrinology
Kareklas, K., Teles, M. C., Nunes, A. R., & Oliveira, R. F. (2023) · Journal of Neuroendocrinology · doi:10.1111/jne.13280 · Cited by 23
Self-citationScaia, M. F., Akinrinade, I. D., Petri, G., & Oliveira, R. F. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.784835 · Cited by 21
Self-citationSaad, A. K., Akour, A. A., Mahboob, A. A., Aburuz, S., & Sadek, B. S. (2022) · Pharmaceuticals · doi:10.3390/ph15050612 · Cited by 25
The dopamine hypothesis of autism spectrum disorder: A comprehensive analysis of the evidence
Pavăl, D. (2023) · International review of neurobiology · doi:10.1016/bs.irn.2023.08.009 · Cited by 25
Penalva-Tena, A., Bedke, J., Gaudin, A., Barrios, J. P., Bertram, E. P., & Douglass, A. D. (2024) · Current Biology · doi:10.1016/j.cub.2024.11.037 · Cited by 41
Oxytocin, GABA, and dopamine interplay in autism
Havránek, T., Bačová, Z., & Bakoš, J. (2024) · Endocrine Regulations · doi:10.2478/enr-2024-0012 · Cited by 16
Emotional contagion and prosocial behaviour in fish: An evolutionary and mechanistic approach
Kareklas, K., & Oliveira, R. F. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105780 · Cited by 14
Self-citationClarke, L., Zyga, O., Pineo-Cavanaugh, P. L., Jeng, M., Fischbein, N. J., Partap, S., Katznelson, L. J., & Parker, K. J. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104770 · Cited by 13
Zhang, S., Mi, P., Luan, J., Sun, M., Zhao, X. J., & Feng, X. (2024) · Environmental Research · doi:10.1016/j.envres.2024.119169 · Cited by 13
Brain areas activated during visual learning in the cichlid fish Pseudotropheus zebra
Calvo, R. A., Hofmann, M. H., & Schluessel, V. (2023) · Brain Structure and Function · doi:10.1007/s00429-023-02627-w · Cited by 13
An atlas and database of neuropeptide gene expression in the adult zebrafish forebrain
Hiraki‐Kajiyama, T., Miyasaka, N., Ando, R., Wakisaka, N., Itoga, H., Onami, S., & Yoshihara, Y. (2024) · The Journal of Comparative Neurology · doi:10.1002/cne.25619 · Cited by 12
Perdikaris, P., & Dermon, C. R. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1120993 · Cited by 11
Reddon, A. R., Aubin‐Horth, N., & Reader, S. M. (2021) · Journal of Zoology · doi:10.1111/jzo.12937 · Cited by 9
Cantabella, E., Camilleri, V., Cavalié, I., Dubourg, N., Gagnaire, B., Charlier, T. D., Adam‐Guillermin, C., Cousin, X., & Armant, O. (2022) · Cancers · doi:10.3390/cancers14153793 · Cited by 11
Social stimuli increase activity of adult-born cells in the telencephalon of zebrafish (Danio rerio)
Dunlap, K. D., Teles, M. C., & Oliveira, R. F. (2021) · Journal of Experimental Biology · doi:10.1242/jeb.242253 · Cited by 9
Self-citationGryksa, K., Schäfer, T., Gareis, F., Fuchs, E., Royer, M., Schmidtner, A. K., Bludau, A., & Neumann, I. D. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1493619 · Cited by 5
Shen, Q., Zhao, F., Zhang, N., Zheng, L., Su, D., Qian, Y., Liu, X., Mingxia, S., Hongxu, Z., Chen, F., et al. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111293 · Cited by 5
Neuropeptide oxytocin facilitates its own brain-to-periphery uptake
Rajamannar, P., Blechman, J., Raz, O., & Levkowitz, G. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115491 · Cited by 5
Self-citationJiang, P., Wang, J., Wang, X., Zou, L., Wu, D., Xu, Q., Jiang, Y., Yao, M., Hong, Q., & Chi, X. (2025) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2025.1564694 · Cited by 5
Maciąg, M., Doszyn, O., Wnorowski, A., Zmorzyńska, J., & Budzyńska, B. (2025) · Journal of Psychopharmacology · doi:10.1177/02698811251324596 · Cited by 4
Dietert, R. R., & Dietert, J. M. (2023) · American Journal of Biomedical Science & Research · doi:10.34297/ajbsr.2023.20.002708 · Cited by 3
Distinct distributed neural dynamics predict pallium-dependent social approach
Lifshitz, I., Prag, A., Livneh, N., Moshkovitz, M., Karmi, A., & Avitan, L. (2026) · Nature Communications · doi:10.1038/s41467-026-71666-8 · Cited by 3
Oxytocin and Social Isolation: Nonapeptide Regulation of Social Homeostasis
Kareklas, K., & Oliveira, R. F. (2024) · Masterclass in neuroendocrinology · doi:10.1007/978-3-031-51112-7_8 · Cited by 3
Self-citationThe Neurohypophysis and Urophysis: Ancient Piscine Neurovascular Interfaces
Rajamannar, P., Iswarya, A., Levkowitz, G., & Biran, J. (2021) · Masterclass in neuroendocrinology · doi:10.1007/978-3-030-86630-3_4 · Cited by 3
Self-citationSingle-Cell Peptide Profiling to Distinguish Stickleback Ecotypes with Divergent Breeding Behavior
Bell, S. E., Xie, Y. R., Maciejewski, M. F., Rubakhin, S. S., Romanova, E. V., Bell, A. M., & Sweedler, J. V. (2025) · Journal of Proteome Research · doi:10.1021/acs.jproteome.4c00832 · Cited by 3
The Impact of Oxytocin on Stimulus Discrimination of Zebrafish Albino and Non-Albino Models
Dănilă, A.-M., Săvucă, A., Ciobica, A. S., Gurzu, I. L., Nicoară, M., & Gurzu, B. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26052070 · Cited by 3
Kareklas, K., Sorigue, P., & Oliveira, R. F. (2025) · Masterclass in neuroendocrinology · doi:10.1007/978-3-031-80209-6_15 · Cited by 3
Self-citationOxytocin Enhances Time-Dependent Responses in the Aggressive Zebrafish (Danio rerio)
Robea, M. A., Oprea, G., Plavan, G. I., Nicoară, M., Mavroudis, I. A., Burlui, V., & Ciobica, A. S. (2024) · Brain Sciences · doi:10.3390/brainsci14030203 · Cited by 2
Remembering the opponent: neuronal activation associated with social memory in zebrafish
Cavallino, L., Pedreira, M. E., Pozzi, A. G., & Scaia, M. F. (2026) · Frontiers in Veterinary Science · doi:10.3389/fvets.2026.1793342 · Cited by 2
Social Enhancement of Adult Neurogenesis in Zebrafish is Not Regulated by Cortisol
Teles, M. C., Faustino, F., Chanfana, C., Cunha, A., Esteves, M., & Oliveira, R. F. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.11.007 · Cited by 2
Self-citationRacca, A., Ciabattoni, F., Alleva, E., & Santucci, D. (2026) · International Journal of Translational Medicine · doi:10.3390/ijtm6010008 · Cited by 1
Comparative Perspectives on the Function of Oxytocin in Fish and Mammals
Yokoi, S., Young, L. J., & Takeuchi, H. (2022) · Springer eBooks · doi:10.1007/978-981-19-5359-0_8 · Cited by 1
Distinct brain-wide neural dynamics predict social approach behaviorPreprint
Lifshitz, I., Livneh, N., Moshkovitz, M., Karmi, A., & Avitan, L. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.09.663340 · Cited by 1
Die Latenzphase: Ein bio-psychosozialer Übergang
Schwaighofer, E.-M. (2022) · Hebamme · doi:10.1055/a-1906-8322
Remembering the opponent: neuronal activation associated with social memory in ZebrafishPreprint
Cavallino, L., Pedreira, M. E., Pozzi, A. G., & Scaia, M. F. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.24.639917
Evolutionarily conserved role of oxytocin in zebrafish social reward encoding
Kareklas, K., Herrera-Castillo, L., Levkowitz, G., & Oliveira, R. F. (2025) · Biology Letters · doi:10.1098/rsbl.2025.0628 · Cited by 1
Self-citationReddon, A. R., WYLIE, D. R. W., & Hurd, P. L. (2025) · Journal of Fish Biology · doi:10.1111/jfb.70306
Stress, health and social behavior
Kareklas, K., & Oliveira, R. F. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-29068-8.00216-6
Self-citationGenome-wide DNA methylation profiling of the zebrafish forebrain
Sorigue, P., Pinget, M., Costa, J., Teles, M. C., & Oliveira, R. F. (2026) · Scientific Data · doi:10.1038/s41597-026-08399-2
Self-citationThe role of oxytocin receptors in social conditioned place preference
Stall, J., & Leong, K.-C. (2026) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2026.174279
Yokoi, S., & Takeuchi, H. (2026) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2026.115035
Metadata
- Authors
- Nunes, A. R., Gliksberg, M., Varela, S. A. M., Teles, M., Wircer, E., Blechman, J., Petri, G., Levkowitz, G., & Oliveira, R. F.
- Affiliations
- Instituto Gulbenkian de Ciência (PT)
- Weizmann Institute of Science (IL)
- ISPA - Instituto Universitário (PT)
- Institute for Scientific Interchange (IT)
- Champalimaud Foundation (PT)
- Corresponding author
- Levkowitz, Gil
- Oliveira, Rui F.
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2021-09-01
- Volume
- 41
- Issue
- 42
- Pages
- 8742-8760
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC8528494
- OpenAlex
- W3196956916
- Cited by
- 47
- References
- 105
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 8 · 2023: 7 · 2022: 10 · 2021: 3
- FWCI
- 6.86
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Molecular Biology Organization (ASTF 420-2013)
- Israel Science Foundation (#1511/16)
- Ministry of Education and Science | Fundação para a Ciência e a Tecnologia (LISBOA-01-0145-FEDER-030627)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin neurons, social affiliation, social behavior development, organizational effects, activational effects, dopaminergic neurons, social decision-making, functional connectivity, social brain, autism spectrum disorder, zebrafish, neuronal ablation
- MeSH terms
- Animals, Female, Male, Metronidazole, Neurons, Oxytocin, Social Behavior, Zebrafish, Receptors, Oxytocin, Animals, Genetically Modified
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
