Cited by 142Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyStress Responses and Cortisol

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Developmental experiences and the oxytocin receptor system

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Bales, Karen L., Perkeybile, Allison M.·2012·Hormones and Behavior

DOI 10.1016/j.yhbeh.2011.12.013

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Abstract

The long-term effects of developmental experiences on social behavior, and the neuropeptide systems such as oxytocin which subserve the behavior, are still little understood. In this article, we review various types of early experience, including normal development, knockout models, pharmacological exposures, and early social experiences. We consider the processes by which experience can affect oxytocin receptor binding, and what is known about the directionality of experience effects on oxytocin receptors. Finally, we attempt to synthesize the literature into a predictive model as to the direction of early experience effects on oxytocin receptor binding potential, and whether these changes have functional significance. These predictions are relevant to current human health practice, given proposals to use chronic intranasal oxytocin to treat developmental disorders including autism and schizophrenia. This article is part of a Special Issue entitled Oxytocin, Vasopressin, and Social Behavior.

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“OT may also modulate different stages depending on the social context or even on individual differences in developmental experiences between animals (Bales & Perkeybile, 2012), likely mediating some of the inconsistencies observed in the effects of OT on social behavior (Bartz, Zaki, et al., 2011).”
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Authors: Bales, K. L., & Perkeybile, A. M.
Affiliations: University of California, Davis (US)
Corresponding author: Bales, Karen L.
ORCID: Bales, Karen L.
Venue: Hormones and Behavior
Publisher: Elsevier BV
Published: 2012-03
Volume: 61
Issue: 3
Pages: 313-319
ISSN: 0018-506X (ISSN-L)
DOI: 10.1016/j.yhbeh.2011.12.013
OpenAlex: W1964035308
Cited by: 142
References: 92
Citations by year: 2026: 6 · 2025: 2 · 2024: 2 · 2023: 6 · 2022: 12 · 2021: 8 · 2020: 21 · 2019: 5 · 2018: 8 · 2017: 16 · 2016: 15 · 2015: 12 · 2014: 12 · 2013: 14 · 2012: 3
FWCI: 1.17
Type: journal article
Language: en
Open access: green
escholarship.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Hormones and Behavior (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion, cc-by-nc-nd)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: oxytocin receptor, developmental experiences, early social experience, receptor binding potential, knockout models, social behavior, autism spectrum disorder, schizophrenia, intranasal oxytocin, developmental disorders, neuropeptide systems
MeSH terms: Animals, Child, Child Development, Child, Preschool, Humans, Social Behavior, Receptors, Vasopressin, Receptors, Oxytocin, Mice, Knockout, Mice

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Developmental experiences and the oxytocin receptor system

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