Matrix metalloproteinases as input and output signals for post-myocardial infarction remodeling
Open accessAbstract
Despite current optimal therapeutic regimens, approximately one in four patients diagnosed with myocardial infarction (MI) will go on to develop congestive heart failure, and heart failure has a high five-year mortality rate of 50%. Elucidating mechanisms whereby heart failure develops post-MI, therefore, is highly needed. Matrix metalloproteinases (MMPs) are key enzymes involved in post-MI remodeling of the left ventricle (LV). While MMPs process cytokine and extracellular matrix (ECM) substrates to regulate the inflammatory and fibrotic components of the wound healing response to MI, MMPs also serve as upstream signaling initiators with direct actions on cell signaling cascades. In this review, we summarize the current literature regarding MMP roles in post-MI LV remodeling. We also identify the current knowledge gaps and provide templates for experiments to fill these gaps. A more complete understanding of MMP roles, particularly with regards to upstream signaling roles, may provide new strategies to limit adverse LV remodeling.
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Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association
Tsao, C. W., Aday, A. W., Almarzooq, Z. I., Anderson, C. A. M., Arora, P., Avery, C. L., Baker-Smith, C. M., Beaton, A. Z., Boehme, A. K., Buxton, A. E., et al. (2023) · Circulation · doi:10.1161/cir.0000000000001123 · Cited by 8,300 · see citing works
Heart Disease and Stroke Statistics—2011 Update: A Report From the American Heart Association
Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Adams, R. J., Berry, J. D., Brown, T. M., Carnethon, M. R., Dai, S., de Simone, G., Ford, E. S., et al. (2011) · Circulation · doi:10.1161/cir.0b013e3182009701 · Cited by 6,149 · see citing works
Heart Disease and Stroke Statistics—2015 Update: A Report From the American Heart Association
Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., de Ferranti, S., Després, J.-P., Fullerton, H. J., Howard, V. J., et al. (2015) · Circulation · doi:10.1161/cir.0000000000000152 · Cited by 5,797 · see citing works
Structure and function of matrix metalloproteinases and TIMPs
Nagase, H., Visse, R., & MURPHY, G. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.12.002 · Cited by 3,416 · see citing works
Relation between Renal Dysfunction and Cardiovascular Outcomes after Myocardial Infarction
Anavekar, N. S., McMurray, J. J. V., Velazquez, E. J., Solomon, S. D., Køber, L., Rouleau, J. L., White, H. D., Nordlander, R., Maggioni, A. P., Dickstein, K., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa041365 · Cited by 1,913 · see citing works
Ducharme, A., Frantz, S., Aikawa, M., Aikawa, E. R., Lindsey, M. L., Rohde, L. E. P., Schöen, F. J., Kelly, R. A., Werb, Z., Libby, P., et al. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8768 · Cited by 808 · see citing works
Self-citationden Steen, P. E. V., Proost, P., Wuyts, A., Damme, J. V., & Opdenakker, G. (2000) · Blood · doi:10.1182/blood.v96.8.2673 · Cited by 680 · see citing works
Resolution of Lung Inflammation by CD44
Teder, P., Vandivier, R. W., Jiang, D., Liang, J., Cohn, L. E., Puré, E., Henson, P. M., & Noble, P. W. (2002) · Science · doi:10.1126/science.1069659 · Cited by 676 · see citing works
Heidt, T., Courties, G., Dutta, P., Sager, H. B., Sebas, M., Iwamoto, Y., Sun, Y., Da Silva, N., Panizzi, P., van der Laan, A. M., et al. (2014) · Circulation Research · doi:10.1161/circresaha.115.303567 · Cited by 607 · see citing works
Molecular Cloning and Characterization of Human Tissue Inhibitor of Metalloproteinase 4
Greene, J., Wang, M., Liu, Y. E., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.48.30375 · Cited by 558 · see citing works
Cardiovascular Death and Left Ventricular Remodeling Two Years After Myocardial Infarction
Sutton, M. S. J., Pfeffer, M. A., Moyé, L. A., Plappert, T. J., Rouleau, J. L., Lamas, G. A., Rouleau, J. R., Parker, J. O., Arnold, M. O., Sussex, B. A., et al. (1997) · Circulation · doi:10.1161/01.cir.96.10.3294 · Cited by 486 · see citing works
Matrix metalloproteinase interactions with collagen and elastin
Doren, S. R. V. (2015) · Matrix Biology · doi:10.1016/j.matbio.2015.01.005 · Cited by 463 · see citing works
Animal Models of Heart Failure: A Scientific Statement From the American Heart Association
Houser, S. R., Margulies, K. B., Murphy, A. M., Spinale, F. G., Francis, G. S., Prabhu, S. D., Rockman, H. A., Kass, D. A., Molkentin, J. D., Sussman, M. A., et al. (2012) · Circulation Research · doi:10.1161/res.0b013e3182582523 · Cited by 435 · see citing works
Ezekowitz, J. A., Kaul, P., Bakal, J. A., Armstrong, P. W., Welsh, R. C., & McAlister, F. A. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.08.067 · Cited by 374 · see citing works
Luttun, A., Lutgens, E., Manderveld, A., Maris, K., Collen, D., Carmeliet, P., & Moons, L. (2004) · Circulation · doi:10.1161/01.cir.0000121728.14930.de · Cited by 308 · see citing works
Peterson, J. T. (2000) · Cardiovascular Research · doi:10.1016/s0008-6363(00)00029-8 · Cited by 300 · see citing works
den Steen, P. E. V., Wuyts, A., Husson, S. J., Proost, P., Damme, J. V., & Opdenakker, G. (2003) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2003.03760.x · Cited by 289 · see citing works
Monocyte and macrophage contributions to cardiac remodeling
Hulsmans, M., Sam, F., & Nahrendorf, M. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.11.015 · Cited by 279 · see citing works
Lohi, J., Wilson, C. L., Roby, J. D., & Parks, W. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m001599200 · Cited by 270 · see citing works
A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity
Marchant, D., Bellac, C. L., Moraes, T. J., Wadsworth, S. J., Dufour, A., Butler, G. S., Bilawchuk, L. M., Hendry, R. G., Robertson, A. G., Cheung, C., et al. (2014) · Nature Medicine · doi:10.1038/nm.3508 · Cited by 265 · see citing works
Wells, J. M., Gaggar, A., & Blalock, J. E. (2015) · Matrix Biology · doi:10.1016/j.matbio.2015.01.016 · Cited by 263 · see citing works
The crossroads of inflammation, fibrosis, and arrhythmia following myocardial infarction
Stuart, S. D. F., Jesus, N. M. D., Lindsey, M. L., & Ripplinger, C. M. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.12.024 · Cited by 249 · see citing works
Self-citationTurner, N. A. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.11.002 · Cited by 215 · see citing works
Ma, Y., Halade, G. V., Zhang, J., Ramirez, T. A., Levin, D., Voorhees, A. P., Jin, Y.-F., Han, H., Manicone, A. M., & Lindsey, M. L. (2012) · Circulation Research · doi:10.1161/circresaha.111.300502 · Cited by 206 · see citing works
Self-citationMatrix metalloproteinase-9 gene deletion facilitates angiogenesis after myocardial infarction
Lindsey, M. L., Escobar, G. P., Dobrucki, L. W., Goshorn, D. K., Bouges, S., Mingoia, J. T., McClister, D. M., Su, H., Gannon, J., MacGillivray, C., et al. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00457.2005 · Cited by 199 · see citing works
Self-citationBergman, M. R., Teerlink, J. R., Mahimkar, R., et al. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00434.2006 · Cited by 193 · see citing works
CD44 Is Critically Involved in Infarct Healing by Regulating the Inflammatory and Fibrotic Response
Huebener, P., Abou-Khamis, T., Zymek, P. T., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.4.2625 · Cited by 190 · see citing works
MMP-12 has a role in abdominal aortic aneurysms in mice
Longo, G. M., Buda, S. J., Fiotta, N., Xiong, W., Griener, T., Shapiro, S. D., & Baxter, B. T. (2005) · Surgery · doi:10.1016/j.surg.2004.12.004 · Cited by 178 · see citing works
Chiao, Y. A., Ramirez, T. A., Zamilpa, R., Okoronkwo, S. M., Dai, Q., Zhang, J., Jin, Y.-F., & Lindsey, M. L. (2012) · Cardiovascular Research · doi:10.1093/cvr/cvs275 · Cited by 178 · see citing works
Self-citationTransformative Impact of Proteomics on Cardiovascular Health and Disease
Lindsey, M. L., Mayr, M., Gomes, A. V., Delles, C., Arrell, D. K., Murphy, A. M., Lange, R. A., Costello, C. E., Jin, Y.-F., Laskowitz, D. T., et al. (2015) · Circulation · doi:10.1161/cir.0000000000000226 · Cited by 174 · see citing works
Self-citationSakata, Y., Yamamoto, K., Mano, T., Nishikawa, N., Yoshida, J., Hori, M., Miwa, T., & Masuyama, T. (2004) · Circulation · doi:10.1161/01.cir.0000125741.88712.77 · Cited by 173 · see citing works
The history of matrix metalloproteinases: milestones, myths, and misperceptions
Iyer, R. P., Patterson, N. L., Fields, G. B., & Lindsey, M. L. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00577.2012 · Cited by 171 · see citing works
Self-citationJohnson, J. L., Devel, L., Czarny, B., George, S. J., Jackson, C. L., Rogakos, V., Beau, F., Yiotakis, A., Newby, A. C., & Dive, V. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.219147 · Cited by 171 · see citing works
Activation of Neutrophil Collagenase in Periodontitis
Romanelli, R., Mancini, S., Laschinger, C. A., Overall, C. M., Sodek, J., & McCulloch, C. A. (1999) · Infection and Immunity · doi:10.1128/iai.67.5.2319-2326.1999 · Cited by 170 · see citing works
Expression and Localization of Matrix Metalloproteinase-12 in the Aorta of Cholesterol-Fed Rabbits
Matsumoto, S., Kobayashi, T., Katoh, M., et al. (1998) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65551-4 · Cited by 163 · see citing works
Incidence of Heart Failure after Myocardial Infarction: Is It Changing over Time?
Hellermann, J. P. (2003) · American Journal of Epidemiology · doi:10.1093/aje/kwg078 · Cited by 162 · see citing works
Lindsey, M. L., Iyer, R. P., Zamilpa, R., Yabluchanskiy, A., DeLeon‐Pennell, K. Y., Hall, M. E., Kaplan, A., Zouein, F. A., Bratton, D. R., Flynn, E. R., et al. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.07.035 · Cited by 160 · see citing works
Self-citationLindsey, M. L., Escobar, G. P., Mukherjee, R. D., Goshorn, D. K., Sheats, N. J., Bruce, J. A., Mains, I. M., Hendrick, J. K., Hewett, K. W., Gourdie, R. G., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.612960 · Cited by 159 · see citing works
Self-citationHiller, O., Lichte, A., Oberpichler, A., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001836200 · Cited by 142 · see citing works
Lindsey, M. L., & Zamilpa, R. (2010) · Cardiovascular Therapeutics · doi:10.1111/j.1755-5922.2010.00207.x · Cited by 139 · see citing works
Self-citationMacrophage metalloelastase (MMP-12) as a target for inflammatory respiratory diseases
Lagente, V., Quément, C. L., & Boichot, E. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220902751632 · Cited by 133 · see citing works
Romanic, A. M., Burns-Kurtis, C. L., Gout, B., et al. (2001) · Life Sciences · doi:10.1016/s0024-3205(00)00982-6 · Cited by 131 · see citing works
Launay, G., Salza, R., Multedo, D., Thierry‐Mieg, N., & Ricard‐Blum, S. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku1091 · Cited by 124 · see citing works
Matrix metalloproteinases and myocardial infarction
Phatharajaree, W., Phrommintikul, A., & Chattipakorn, N. (2007) · Canadian Journal of Cardiology · doi:10.1016/s0828-282x(07)70818-8 · Cited by 122 · see citing works
Glycoproteomics and clinical applications
Tian, Y., & Zhang, H. (2010) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.200900161 · Cited by 119 · see citing works
Deriving a cardiac ageing signature to reveal MMP-9-dependent inflammatory signalling in senescence
Ma, Y., Chiao, Y. A., Clark, R., Flynn, E. R., Yabluchanskiy, A., Ghasemi, O., Zouein, F. A., Lindsey, M. L., & Jin, Y.-F. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv128 · Cited by 115 · see citing works
Self-citationMyocardial matrix metalloproteinase-2: inside out and upside down
DeCoux, A., Lindsey, M. L., Villarreal, F. J., Garcia, R. A., & Schulz, R. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.09.016 · Cited by 112 · see citing works
Self-citationLovett, D. H., Mahimkar, R., Raffaı̈, R. L., Cape, L., Maklashina, E., Cecchini, G., & Karliner, J. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034177 · Cited by 112 · see citing works
Role of inflammatory cells in fibroblast activation
Hartupee, J. C., & Mann, D. L. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.11.016 · Cited by 108 · see citing works
Peng, H., Troen, T., Ovejero, M. D. C., Kirkegaard, T., Andersen, T. L., Byrjalsen, I., Ferreras, M., Sato, T., Shapiro, S. D., Foged, N. T., et al. (2003) · Bone · doi:10.1016/j.bone.2003.08.011 · Cited by 107 · see citing works
Alfonso-Jaume, M., Bergman, M. R., Mahimkar, R., et al. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00026.2006 · Cited by 105 · see citing works
Lang, R., Kocourek, A., Braun, M., Tschesche, H., Huber, R., Bode, W., & Maskos, K. (2001) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.4954 · Cited by 103 · see citing works
Solomon, S. D., Sutton, M. S. J., Lamas, G. A., Plappert, T. J., Rouleau, J. L., Skali, H., Moyé, L. A., Braunwald, E., & Pfeffer, M. A. (2002) · Circulation · doi:10.1161/01.cir.0000032313.82552.e3 · Cited by 103 · see citing works
DeLeon‐Pennell, K. Y., Tian, Y., Zhang, B., Cates, C. A., Iyer, R. P., Cannon, P. L., Shah, P., Aiyetan, P., Halade, G. V., Ma, Y., et al. (2015) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.115.001249 · Cited by 102 · see citing works
Self-citationIyer, R. P., Patterson, N. L., Zouein, F. A., et al. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.03.054 · Cited by 99 · see citing works
Self-citationHeart Failure after Myocardial Infarction: Clinical Presentation and Survival
Hellermann, J. P., Jacobsen, S. J., Redfield, M. M., Reeder, G. S., Weston, S. A., & Roger, V. L. (2004) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2004.04.011 · Cited by 98 · see citing works
Zamilpa, R., Lopez, E. F., Chiao, Y. A., Dai, Q., Escobar, G. P., Hakala, K. W., Weintraub, S. T., & Lindsey, M. L. (2010) · PROTEOMICS · doi:10.1002/pmic.200900587 · Cited by 92 · see citing works
Self-citationWang, X., Liang, J., Koike, T., Sun, H., Ichikawa, T., Kitajima, S., Morimoto, M., Shikama, H., Watanabe, T., Sasaguri, Y., et al. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63395-0 · Cited by 90 · see citing works
Rosenblum, G., Meroueh, S. O., Tóth, M., Fisher, J. F., Fridman, R. A., Mobashery, S., & Sagi, I. (2007) · Journal of the American Chemical Society · doi:10.1021/ja073941l · Cited by 89 · see citing works
Zamilpa, R., Ibarra, J. M., Brás, L. E. D. C., Ramirez, T. A., Nguyen, N., Halade, G. V., Zhang, J., Dai, Q., Dayah, T. J., Chiao, Y. A., et al. (2012) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2012.07.017 · Cited by 88 · see citing works
Self-citationSelective Modulation of Matrix Metalloproteinase 9 (MMP-9) Functions via Exosite Inhibition
Lauer‐Fields, J. L., Whitehead, J. K., Li, S., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801438200 · Cited by 84 · see citing works
Direct Visualization of Protease Action on Collagen Triple Helical Structure
Rosenblum, G., den Steen, P. E. V., Cohen, S., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011043 · Cited by 78 · see citing works
Mukherjee, R. D., Mingoia, J. T., Bruce, J. A., et al. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01343.2005 · Cited by 77 · see citing works
Modifying the mechanics of healing infarcts: Is better the enemy of good?
Clarke, S. A., Richardson, W. J., & Holmes, J. W. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.11.028 · Cited by 71 · see citing works
Manso, A. M., Elsherif, L., Kang, S., et al. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.09.004 · Cited by 70 · see citing works
Skjøt-Arkil, H., Clausen, R. E., Nguyen, Q. H. T., Wang, Y., Zheng, Q., Martinez, F. J., Hogaboam, C. M., Han, M., Klickstein, L. B., Larsen, M. R., et al. (2012) · BMC Pulmonary Medicine · doi:10.1186/1471-2466-12-34 · Cited by 65 · see citing works
ADAMs family and relatives in cardiovascular physiology and pathology
Zhang, P., Shen, M., Fernández-Patrón, C., & Kassiri, Z. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.10.031 · Cited by 63 · see citing works
Computational modeling of cardiac fibroblasts and fibrosis
Zeigler, A. C., Richardson, W. J., Holmes, J. W., & Saucerman, J. J. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.11.020 · Cited by 63 · see citing works
Human intravenous immunoglobulin (IVIG) preparations degranulate human neutrophilsin vitro
Teeling, J. L., de Groot, E. R., Eerenberg, A. J. M., et al. (1998) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1998.00697.x · Cited by 60 · see citing works
Lovett, D. H., Mahimkar, R., Raffaı̈, R. L., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068154 · Cited by 59 · see citing works
MMP-2 is localized to the mitochondria-associated membrane of the heart
Hughes, B. G., Fan, X., Cho, W. J., & Schulz, R. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00909.2013 · Cited by 59 · see citing works
Trafficking of the Membrane Type-1 Matrix Metalloproteinase in Ischemia and Reperfusion
Deschamps, A. M., Yarbrough, W. M., Squires, C. E., Allen, R. A., McClister, D. M., Dowdy, K. B., McLean, J. E., Mingoia, J. T., Sample, J. A., Mukherjee, R. D., et al. (2005) · Circulation · doi:10.1161/01.cir.0000157149.71297.3a · Cited by 59 · see citing works
Osteopontin is proteolytically processed by matrix metalloproteinase 9
Lindsey, M. L., Zouein, F. A., Tian, Y., Iyer, R. P., & Brás, L. E. D. C. (2015) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2015-0019 · Cited by 57 · see citing works
Self-citationActivation of MMP-2 as a key event in oxidative stress injury to the heart
Schulz, R. (2009) · Frontiers in bioscience · doi:10.2741/3274 · Cited by 56 · see citing works
Chiao, Y. A., Zamilpa, R., Lopez, E. F., et al. (2010) · Journal of Proteome Research · doi:10.1021/pr100147r · Cited by 54 · see citing works
Nénan, S., Planquois, J., Berna, P. P., et al. (2004) · International Immunopharmacology · doi:10.1016/j.intimp.2004.10.011 · Cited by 53 · see citing works
Zhang, W., Voice, J. K., & Lachmann, P. J. (1995) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1995.tb03142.x · Cited by 46 · see citing works
Brás, L. E. D. C., Cates, C. A., DeLeon‐Pennell, K. Y., et al. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5411 · Cited by 43 · see citing works
Self-citationThrombospondins in the transition from myocardial infarction to heart failure
Kirk, J. A., & Cingolani, O. H. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.12.009 · Cited by 40 · see citing works
Neural MMP‐28 expression precedes myelination during development and peripheral nerve repair
Werner, S. R., Mescher, A. L., Neff, A. W., et al. (2007) · Developmental Dynamics · doi:10.1002/dvdy.21301 · Cited by 39 · see citing works
Zavadzkas, J. A., Mukherjee, R. D., Rivers, W. T., et al. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00141.2011 · Cited by 37 · see citing works
Ramirez, T. A., Iyer, R. P., Ghasemi, O., Lopez, E. F., Levin, D. B., Zhang, J., Zamilpa, R., Chou, Y.-M., Jin, Y.-F., & Lindsey, M. L. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.04.007 · Cited by 36 · see citing works
Self-citationPharmacological Implications of MMP-9 Inhibition by ACE Inhibitors
Yamamoto, D., & Takai, S. (2009) · Current Medicinal Chemistry · doi:10.2174/092986709787846514 · Cited by 35 · see citing works
Matrix Metalloproteinase (MMP)-7 Activates MMP-8 But Not MMP-13
Dozier, S. J., Escobar, G. P., & Lindsey, M. L. (2006) · Medicinal Chemistry · doi:10.2174/157340606778250261 · Cited by 31 · see citing works
Self-citationCardiac extracellular proteome profiling and membrane topology analysis using glycoproteomics
Tian, Y., Koganti, T., Yao, Z., et al. (2014) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201400009 · Cited by 28 · see citing works
Selective proteolysis of immunoglobulins by mouse macrophage elastase.
Banda, M. J., Clark, E. J., & Werb, Z. (1983) · The Journal of Experimental Medicine · doi:10.1084/jem.157.4.1184 · Cited by 28 · see citing works
Using proteomics to uncover extracellular matrix interactions during cardiac remodeling
Patterson, N. L., Iyer, R. P., Brás, L. E. D. C., et al. (2013) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201200100 · Cited by 23 · see citing works
Self-citationLavine, S. J. (2003) · Echocardiography · doi:10.1111/j.0742-2822.2003.02156.x · Cited by 21 · see citing works
Using Extracellular Matrix Proteomics to Understand Left Ventricular Remodeling
Lindsey, M. L., Weintraub, S. T., & Lange, R. A. (2012) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.110.957803 · Cited by 18 · see citing works
Self-citationKraft, P. J., Haynes‐Johnson, D., Patel, L., et al. (2001) · Connective Tissue Research · doi:10.3109/03008200109014256 · Cited by 14 · see citing works
Spinale, F. G. (2013) · Circulation Research · doi:10.1161/circresaha.113.300811 · Cited by 9 · see citing works
Plasma Fractionation Enriches Post-Myocardial Infarction Samples Prior to Proteomics Analysis
Brás, L. E. D. C., DeLeon‐Pennell, K. Y., Ma, Y., et al. (2012) · International Journal of Proteomics · doi:10.1155/2012/397103 · Cited by 6 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 7
- [34]Lindsey ML Escobar GP Dobrucki LW Goshorn DK Bouges S Mingoia JT Matrix metalloproteinase-9 gene deletion facilitates angiogenesis after myocardial infarction American journal of physiology: Heart and circulatory physiology 2006 290 H232 9 16126817
- [37]Ma Y Halade GV Zhang J Ramirez TA Levin D Voorhees A Matrix metalloproteinase-28 deletion exacerbates cardiac dysfunction and rupture after myocardial infarction in mice by inhibiting M2 macrophage activation Circulation research 2013 112 675 88 23261783 PMC3597388
- [38]Lindsey ML Zamilpa R Temporal and spatial expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases following myocardial infarction Cardiovascular therapeutics 2012 30 31 41 20645986 PMC2972388
- [53]Zamilpa R Ibarra J de Castro Bras LE Ramirez TA Nguyen N Halade GV Transgenic overexpression of matrix metalloproteinase-9 in macrophages attenuates the inflammatory response and improves left ventricular function post-myocardial infarction Journal of molecular and cellular cardiology 2012 53 599 608 22884843 PMC3472138
- [63]Zamilpa R Lopez EF Chiao YA Dai Q Escobar GP Hakala K Proteomic analysis identifies in vivo candidate matrix metalloproteinase-9 substrates in the left ventricle post-myocardial infarction Proteomics 2010 10 2214 23 20354994 PMC3017347
- [65]Chiao YA Zamilpa R Lopez EF Dai Q Escobar GP Hakala KW In vivo Matrix Metalloproteinase-7 Substrates Identified in the Left Ventricle Post-Myocardial Infarction Using Proteomics Journal of proteome research 2010 9 2649 57 20232908 PMC2866015
- [92]Lindsey ML Iyer RP Zamilpa R Yabluchanskiy A DeLeon-Pennell KY Hall ME A Novel Collagen Matricryptin Reduces Left Ventricular Dilation Post-Myocardial Infarction by Promoting Scar Formation and Angiogenesis J Am Coll Cardiol 2015 in press PMC4575409 26383724
Cited by
Sorted by citations
Fibrosis: from mechanisms to medicines
Henderson, N. C., Rieder, F., & Wynn, T. A. (2020) · Nature · doi:10.1038/s41586-020-2938-9 · Cited by 1,868 · see citing works
Guidelines for experimental models of myocardial ischemia and infarction
Lindsey, M. L., Bolli, R., Canty, J. M., Du, X.-J., Frangogiannis, N. G., Frantz, S., Gourdie, R. G., Holmes, J. W., Jones, S. P., Kloner, R. A., et al. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00335.2017 · Cited by 526 · see citing works
Self-citationThe big five in fibrosis: Macrophages, myofibroblasts, matrix, mechanics, and miscommunication
Pakshir, P., & Hinz, B. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.01.019 · Cited by 396 · see citing works
The impact of aging on cardiac extracellular matrix
Meschiari, C. A., Ero, O. K., Pan, H., Finkel, T., & Lindsey, M. L. (2017) · GeroScience · doi:10.1007/s11357-017-9959-9 · Cited by 237 · see citing works
Self-citationUnderstanding the cellular interactome of non-alcoholic fatty liver disease
Wallace, S. J., Tacke, F., Schwabe, R. F., & Henderson, N. C. (2022) · JHEP Reports · doi:10.1016/j.jhepr.2022.100524 · Cited by 116 · see citing works
Genau, M. C., Perreault, P. E., Romito, E., Doviak, H., Logdon, C. B., Ruble, S., & Spinale, F. G. (2018) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2018.01.104 · Cited by 6 · see citing works
- Authors
- Lindsey, M. L., Iyer, R. P., Jung, M., DeLeon-Pennell, K. Y., & Ma, Y.
- Affiliations
- University of Mississippi Medical Center (US)
- Corresponding author
- Lindsey, Merry L.
- Ma, Yonggang
- Venue
- Journal of Molecular and Cellular Cardiology
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 91
- Pages
- 134-140
- ISSN
- 0022-2828 (ISSN-L)
- PMC
- PMC4764435
- OpenAlex
- W2212574418
- Cited by
- 113
- References
- 92
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 4 · 2023: 9 · 2022: 10 · 2021: 9 · 2020: 13 · 2019: 8 · 2018: 16 · 2017: 13 · 2016: 10 · 2015: 7
- FWCI
- 2.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Molecular and Cellular Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Veterans Affairs (I01BX000505)
- American Heart Association
- Office of Research and Development
- National Institutes of Health
- U.S. Public Health Service (HHSN-268201000036C)
- National Heart, Lung, and Blood Institute (N01-HV-00244, HL075360, R01HL075360, HHSN268201000036C, P01HL051971)
- National Institute of General Medical Sciences (U54GM114833, GM114833, P20GM104357)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- matrix metalloproteinases, myocardial infarction, left ventricular remodeling, heart failure, extracellular matrix, cytokine processing, fibrosis, inflammation, signal transduction, wound healing
- MeSH terms
- Animals, Extracellular Matrix, Gene Expression Regulation, Heart Failure, Humans, Isoenzymes, Myocardial Infarction, Myocardium, Wound Healing, Signal Transduction, Cytokines, Extracellular Matrix Proteins, Ventricular Remodeling, Matrix Metalloproteinases, Proteomics
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