Cited by 142Microbial Metabolic Engineering and BioproductionFermentation and Sensory AnalysisFungal and yeast genetics research

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Evolutionary engineered Saccharomyces cerevisiae wine yeast strains with increased in vivo flux through the pentose phosphate pathway

Cadière, Axelle, Ortiz-Julien, Anne, Camarasa, Carole, Dequin, Sylvie·2011·Metabolic Engineering

DOI 10.1016/j.ymben.2011.01.008

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Abstract

Amplification of the flux toward the pentose phosphate (PP) pathway might be of interest for various S. cerevisiae based industrial applications. We report an evolutionary engineering strategy based on a long-term batch culture on gluconate, a substrate that is poorly assimilated by S. cerevisiae cells and is metabolized by the PP pathway. After adaptation for various periods of time, we selected strains that had evolved a greater consumption capacity for gluconate. (13)C metabolic flux analysis on glucose revealed a redirection of carbon flux from glycolysis towards the PP pathway and a greater synthesis of lipids. The relative flux into the PP pathway was 17% for the evolved strain (ECA5) versus 11% for the parental strain (EC1118). During wine fermentation, the evolved strains displayed major metabolic changes, such as lower levels of acetate production, higher fermentation rates and enhanced production of aroma compounds. These represent a combination of novel traits, which are of great interest in the context of modern winemaking.

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Authors: Cadière, A., Ortiz-Julien, A., Camarasa, C., & Dequin, S.
Affiliations: Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
Lallemand (France) (FR)
Corresponding author: Dequin, Sylvie
ORCID: Cadière, Axelle
Camarasa, Carole
Dequin, Sylvie
Venue: Metabolic Engineering
Publisher: Elsevier BV
Published: 2011-05
Volume: 13
Issue: 3
Pages: 263-271
ISSN: 1096-7176 (ISSN-L)
DOI: 10.1016/j.ymben.2011.01.008
OpenAlex: W2058737346
Cited by: 141
References: 59
Citations by year: 2026: 4 · 2025: 7 · 2024: 12 · 2023: 7 · 2022: 3 · 2021: 8 · 2020: 9 · 2019: 8 · 2018: 9 · 2017: 17 · 2016: 10 · 2015: 9 · 2014: 18 · 2013: 7 · 2012: 8
FWCI: 4.92
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Metabolic Engineering (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Funders: Agence Nationale de la Recherche (ANR-05-PNRA-0011)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
Life Sciences › Agricultural and Biological Sciences › Food Science › Fermentation and Sensory Analysis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords: Saccharomyces cerevisiae, wine yeast, pentose phosphate pathway, evolutionary engineering, metabolic flux redirection, lipogenesis, acetate production, aroma production, fermentation rate, 13C metabolic flux analysis, industrial yeast strains
MeSH terms: Gluconates, Glucose, Glycolysis, Pentose Phosphate Pathway, Saccharomyces cerevisiae, Wine, Directed Molecular Evolution

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Evolutionary engineered Saccharomyces cerevisiae wine yeast strains with increased in vivo flux through the pentose phosphate pathway

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