Cited by 162Microbial Metabolic Engineering and BioproductionBiofuel production and bioconversionBiochemical and biochemical processes

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Advances and prospects in metabolic engineering of Zymomonas mobilis

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Wang, Xia, He, Qiaoning, Yang, Yongfu, Wang, Jingwen, Haning, Katie, Hu, Yun, Wu, Bo, He, Mingxiong, Zhang, Yaoping, Bao, Jie, Contreras, Lydia M., Yang, Shihui·2018·Metabolic Engineering

DOI 10.1016/j.ymben.2018.04.001

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Abstract

Biorefinery of biomass-based biofuels and biochemicals by microorganisms is a competitive alternative of traditional petroleum refineries. Zymomonas mobilis is a natural ethanologen with many desirable characteristics, which makes it an ideal industrial microbial biocatalyst for commercial production of desirable bioproducts through metabolic engineering. In this review, we summarize the metabolic engineering progress achieved in Z. mobilis to expand its substrate and product ranges as well as to enhance its robustness against stressful conditions such as inhibitory compounds within the lignocellulosic hydrolysates and slurries. We also discuss a few metabolic engineering strategies that can be applied in Z. mobilis to further develop it as a robust workhorse for economic lignocellulosic bioproducts. In addition, we briefly review the progress of metabolic engineering in Z. mobilis related to the classical synthetic biology cycle of "Design-Build-Test-Learn", as well as the progress and potential to develop Z. mobilis as a model chassis for biorefinery practices in the synthetic biology era.

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See all 162

Authors: Wang, X., He, Q., Yang, Y., Wang, J., Haning, K., Hu, Y., Wu, B., He, M., Zhang, Y., Bao, J., Contreras, L. M., & Yang, S.
Affiliations: Hubei University (CN)
The University of Texas at Austin (US)
Biogas Institute of Ministry of Agriculture (CN)
University of Wisconsin–Madison (US)
East China University of Science and Technology (CN)
Corresponding author: Contreras, Lydia M.
Yang, Shihui
ORCID: Wang, Xia
Yang, Yongfu
Wang, Jingwen
Haning, Katie
Hu, Yun
Wu, Bo
He, Mingxiong
Zhang, Yaoping
Bao, Jie
Contreras, Lydia M.
Yang, Shihui
Venue: Metabolic Engineering
Publisher: Elsevier BV
Published: 2018-11
Volume: 50
Pages: 57-73
ISSN: 1096-7176 (ISSN-L)
DOI: 10.1016/j.ymben.2018.04.001
OpenAlex: W2796406316
Cited by: 154
References: 248
Citations by year: 2026: 9 · 2025: 12 · 2024: 20 · 2023: 16 · 2022: 16 · 2021: 37 · 2020: 23 · 2019: 18 · 2018: 3
FWCI: 2.01
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (am, 384 d)
Locations: Metabolic Engineering (acceptedVersion)
PubMed (publishedVersion)
OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
Funders: National Science Foundation (CBET-1254754)
Welch Foundation (F-1756, DGE-1610403)
Office of Science (DE-SC0018409, BER DE-FC02-07ER64494)
Great Lakes Bioenergy Research Center
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
Physical Sciences › Engineering › Biomedical Engineering › Biofuel production and bioconversion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Biochemical and biochemical processes
Keywords: Zymomonas mobilis, lignocellulosic biomass, biofuels, bio-based chemicals, ethanol production, inhibitors, lignocellulosic hydrolysates, synthetic biology, chassis organisms, biorefinery, microbial biocatalysts
MeSH terms: Lignin, Zymomonas, Synthetic Biology, Metabolic Engineering

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Advances and prospects in metabolic engineering of Zymomonas mobilis

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