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Rapid Ngn2-induction of excitatory neurons from hiPSC-derived neural progenitor cells
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The iPSC-derived human neurons (iNeurons) used were produced using a protocol that yields predominantly excitatory cortical neurons.
“using a protocol, which produces predominantly excitatory cortical neurons [22, 55].”
From Neurodegenerative disease-associated microRNAs acting as signaling molecules modulate CNS neuron structure and viability (2025) · cites this paper as [55]
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A Guide to Generating and Using hiPSC Derived NPCs for the Study of Neurological Diseases
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Self-citationThe innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease
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Human iPSC application in Alzheimer’s disease and tau-related neurodegenerative diseases
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“To confirm successful differentiation of each line, a modified version of the direct differentiation protocol described previously by others was used (Thoma et al., 2012; Zhang et al., 2013; Ho et al., 2016).”
MethodInfluentialKumbol, V., Ivanov, A., McGurran, H., Schüler, J., Zhai, Y., Ludwik, K., Hinkelmann, L., Brehm, M., Krüger, C., Küchler, J., et al. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02199-8 · Cited by 8
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TMEM55B downregulation promotes neurodegeneration in Alzheimer’s disease models
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Metadata
- Authors
- Ho, S.-M., Hartley, B. J., TCW, J., Beaumont, M., Stafford, K., Slesinger, P. A., & Brennand, K. J.
- ORCID
- Brennand, Kristen J.
- Venue
- Methods
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 101
- Pages
- 113-124
- ISSN
- 1046-2023
- PMC
- PMC4860098
- Cited by
- 184
- References
- 4
- Language
- en
- Funders
- Brain and Behavior Young Investigator Grant
- National Institute of Health (R01 MH101454)
- New York Stem Cell Foundation
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